Title:
BICYCLIC HETEROARYL DERIVATIVE AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/237178
Kind Code:
A1
Abstract:
The present invention relates to a bicyclic heteroaryl derivative and a preparation method therefor and a use thereof in medicine. Specifically, the present invention relates to a bicyclic heteroaryl derivative represented by formula (AI) and a preparation method therefor and a pharmaceutically acceptable salt thereof, and a use thereof as therapeutic agents, especially SHP2 allosteric inhibitors, wherein substituents in formula (AI) have the same definitions as those in the description.
Inventors:
HUANG XIANGUI (CN)
BIE PINGYAN (CN)
GUO YANGHUI (CN)
YAN QINGYAN (CN)
CAO QI (CN)
XING QINGNA (CN)
WANG XIN (CN)
MENG LICHEN (CN)
WU NUOYI (CN)
LI WENPENG (CN)
QIU ZONGXING (CN)
YE CHENG (CN)
HU TAISHAN (CN)
CHEN LEI (CN)
BIE PINGYAN (CN)
GUO YANGHUI (CN)
YAN QINGYAN (CN)
CAO QI (CN)
XING QINGNA (CN)
WANG XIN (CN)
MENG LICHEN (CN)
WU NUOYI (CN)
LI WENPENG (CN)
QIU ZONGXING (CN)
YE CHENG (CN)
HU TAISHAN (CN)
CHEN LEI (CN)
Application Number:
PCT/CN2021/141085
Publication Date:
November 17, 2022
Filing Date:
December 24, 2021
Export Citation:
Assignee:
ZHEJIANG HISUN PHARM CO LTD (CN)
SHANGHAI ARYL PHARMTECH CO LTD (CN)
SHANGHAI ARYL PHARMTECH CO LTD (CN)
International Classes:
C07D487/04; A61K31/519; A61P9/00; A61P27/02; A61P35/00; A61P35/02; A61P35/04; A61P37/02; C07D519/00
Domestic Patent References:
| WO2021143680A1 | 2021-07-22 | |||
| WO2021249449A1 | 2021-12-16 | |||
| WO2020063760A1 | 2020-04-02 | |||
| WO2018057884A1 | 2018-03-29 |
Foreign References:
| CN111138412A | 2020-05-12 | |||
| CN112166110A | 2021-01-01 | |||
| CN111902415A | 2020-11-06 |
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