Title:
BICYCLIC HETEROCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION AND APPLICATION
Document Type and Number:
WIPO Patent Application WO/2023/207911
Kind Code:
A1
Abstract:
Disclosed are a bicyclic heterocyclic compound, a pharmaceutical composition and an application. Specifically, a compound represented by formula I, a pharmaceutically acceptable salt thereof, a solvate thereof, or a solvate of the pharmaceutically acceptable salt thereof are disclosed. The compound of the present invention has good inhibitory activity on HPK1 kinase, and has relatively good selectivity.
Inventors:
SHI CHEN (CN)
XIA GUANGXIN (CN)
LIAO GUOHUI (CN)
LI GONGSHENG (CN)
CAO FEI (CN)
ZHAI LUHAN (CN)
XIANG ZHIJUN (CN)
ZHANG ZHENGYU (CN)
PENG YAYUAN (CN)
LI DI (CN)
XIA GUANGXIN (CN)
LIAO GUOHUI (CN)
LI GONGSHENG (CN)
CAO FEI (CN)
ZHAI LUHAN (CN)
XIANG ZHIJUN (CN)
ZHANG ZHENGYU (CN)
PENG YAYUAN (CN)
LI DI (CN)
Application Number:
PCT/CN2023/090330
Publication Date:
November 02, 2023
Filing Date:
April 24, 2023
Export Citation:
Assignee:
SHANGHAI PHARMACEUTICALS HOLDING CO LTD (CN)
International Classes:
C07D519/00; A61K31/496; A61P35/00; C07D471/04; C07D487/04
Domestic Patent References:
| WO2017023987A1 | 2017-02-09 | |||
| WO2017023996A1 | 2017-02-09 |
Foreign References:
| CN102264743A | 2011-11-30 | |||
| CN112243439A | 2021-01-19 | |||
| CN113166139A | 2021-07-23 | |||
| CN114096536A | 2022-02-25 | |||
| US20090048249A1 | 2009-02-19 | |||
| US20180208594A1 | 2018-07-26 |
Other References:
DATABASE Registry 20 December 2021 (2021-12-20), ANONYMOUS: "Isoquinoline, 5-[3-(7-methyl-1H-benzimidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-", XP009550396, Database accession no. 1349796-26-4
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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