Title:
BICYCLIC PRMT5 INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2024/051816
Kind Code:
A1
Abstract:
Provided is a bicyclic PRMT5 inhibitor, which is a compound having a structure represented by formula (I). Further provided are a preparation method for the compound and use of the compound in regulating PRMT5 activity or treating PRMT5-related diseases. Formula (I).
Inventors:
NIU CHENGSHAN (CN)
CHEN MINGTAO (CN)
ZHENG MAOLIN (CN)
WANG GUOHUI (CN)
DONG SHENGLI (CN)
LIANG APENG (CN)
CHEN SHAOQING (CN)
LI JUN (CN)
WU YUSHENG (CN)
CHEN MINGTAO (CN)
ZHENG MAOLIN (CN)
WANG GUOHUI (CN)
DONG SHENGLI (CN)
LIANG APENG (CN)
CHEN SHAOQING (CN)
LI JUN (CN)
WU YUSHENG (CN)
Application Number:
PCT/CN2023/117714
Publication Date:
March 14, 2024
Filing Date:
September 08, 2023
Export Citation:
Assignee:
TYK MEDICINES ZHENGZHOU INC (CN)
TYK MEDICINES INC (CN)
TYK MEDICINES INC (CN)
International Classes:
C07D487/04; A61K31/4353; A61K31/5375; A61P35/00; C07D401/06; C07D401/14; C07D403/06; C07D403/14; C07D405/14; C07D407/14; C07D413/06; C07D413/14; C07D417/14
Domestic Patent References:
| WO2013096681A1 | 2013-06-27 | |||
| WO2022132914A1 | 2022-06-23 | |||
| WO2021163344A1 | 2021-08-19 | |||
| WO2022026892A1 | 2022-02-03 | |||
| WO2023146989A1 | 2023-08-03 |
Other References:
DATABASE Registry CAS; 1 September 2022 (2022-09-01), ANONYMOUS : "Methanone, [2-[1-(aminomethyl) cyclobutyl]-1-piperidinyl]-1, 8-naphthyridin3-yl-", XP093147991, retrieved from STN Database accession no. 2816569-29-4
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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