BICYCLIC PYRAZOLE DERIVATIVE

WIPO Patent Application WO/2005/021550

A1

A compound represented by the following formula (I), a prodrug thereof, or a pharmaceutically acceptable salt of either. These are compounds having high DPP-IV inhibitory activity and improved in safety, nontoxicity, etc. (I) [In the formula, R¹ represents hydrogen, optionally substituted alkyl, etc.; the solid line and dotted line between A¹ and A² indicate a double bond (A¹=A²), etc.; A¹ represents a group represented by the formula C(R²), etc.; A² represents a group represented by the formula C(R⁴), etc.; R² represents hydrogen, optionally substituted alkyl, etc.; R⁴ represents hydrogen, optionally substituted alkyl, etc.; R⁶ represents hydrogen, optionally substituted aryl, etc.; and -Y represents, e.g., a group represented by the formula (A): (A) (wherein m1 is 0, 1, 2, or 3; and R⁷ is absent, or one or two R⁷'s are present and each independently represents optionally substituted alkyl, etc.).]

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NAKAHIRA HIROYUKI (JP)
HOCHIGAI HITOSHI (JP)
TAKEDA TATSUYA (JP)
KOBAYASHI TOMONORI (JP)
HUME WILLIAM EWAN (JP)

PCT/JP2004/012617

March 10, 2005

August 25, 2004

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SUMITOMO PHARMA (JP)
NAKAHIRA HIROYUKI (JP)
HOCHIGAI HITOSHI (JP)
TAKEDA TATSUYA (JP)
KOBAYASHI TOMONORI (JP)
HUME WILLIAM EWAN (JP)

A61P3/10; A61P43/00; C07D487/04; (IPC1-7): C07D487/04; A61K31/4985; A61P3/10; A61P43/00

WO2002068420A1	2002-09-06
WO2002024698A1	2002-03-28

JP2004043429A

2004-02-12

Isobe, Yutaka (Dainippon Sumitomo Pharma Co. Ltd., 1-98, Kasugadenaka 3-chome, Konohana-k, Osaka-shi Osaka 22, JP)

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