BIFIDOBACTERIUM INFANTIS FORMULATIONS - WASHINGTON UNIVERSITY ST LOUIS

Title:

BIFIDOBACTERIUM INFANTIS FORMULATIONS

Document Type and Number:

WIPO Patent Application WO/2023/137381

Kind Code:

A3

Abstract:

The current disclosure provides compositions comprising Bifidobacterium longum subspecies infantis (B. infantis) strains with enhanced ability to uptake or utilize N-glycan and plant-based polysaccharides, and methods of using these compositions.

Inventors:

AHMED TAHMEED (BD)
GORDON JEFFREY I (US)
BARRATT MICHAEL (US)
NAKSHATRI SWETHA (US)
AHSAN KAZI (US)

Application Number:

PCT/US2023/060562

Publication Date:

September 28, 2023

Filing Date:

January 12, 2023

Export Citation:

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Assignee:

WASHINGTON UNIVERSITY ST LOUIS (US)
AHMED TAHMEED (BD)
INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RES BANGLADESH (BD)

International Classes:

A61K35/745; A23L33/105; A23L33/135; A61P1/00

Domestic Patent References:

WO2019055717A1

2019-03-21

Foreign References:

US20210308235A1	2021-10-07
US20200377961A1	2020-12-03

Other References:

TIELS ET AL.: "A bacterial glycosidase enables mannose-6-phosphate modification and improved cellular uptake of yeast-produced recombinant human lysosomal enzymes", NATURE, vol. 30, no. 12, 18 November 2012 (2012-11-18), pages 1225 - 1231, XP055078446, DOI: 10.1038/nbt.2427
BARRATT MICHAEL J., NUZHAT SHARIKA, AHSAN KAZI, FRESE STEVEN A., ARZAMASOV ALEKSANDR A., SARKER SHAFIQUL ALAM, ISLAM M. MUNIRUL, P: "Bifidobacterium infantis treatment promotes weight gain in Bangladeshi infants with severe acute malnutrition", SCIENCE TRANSLATIONAL MEDICINE, vol. 14, no. 640, 13 April 2022 (2022-04-13), XP093096290, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.abk1107