Title:
BIFIDOBACTERIUM LONGUM CCFM1206 FOR PRODUCING SULFORAPHANE AND CAPABLE OF RELIEVING INFLAMMATION
Document Type and Number:
WIPO Patent Application WO/2023/202353
Kind Code:
A1
Abstract:
The present invention belongs to the technical field of microorganisms. Disclosed is a bifidobacterium longum CCFM1206 strain for producing sulforaphane and capable of relieving inflammation. The bifidobacterium longum CCFM1206 provided by the present invention can convert glucoraphanin into sulforaphane, promoting the metabolism of glucoraphanin and the generation of sulforaphane in mammals. The bifidobacterium longum CCFM1206 of the present invention can be used alone or in combination with glucoraphanin to reduce weight loss during ulcerative colitis, reduce the release of colonic pro-inflammatory factors, improve colonic barrier function, relieve splenomegaly caused by systemic inflammation, reduce the level of pro-inflammatory factors in serum, reduce the content of pro-inflammatory factors and increase the content of anti-inflammatory factors in liver tissues, and increase the content of short-chain fatty acids.
Inventors:
MAO BINGYONG (CN)
WU JIAYING (CN)
CUI SHUMAO (CN)
TANG XIN (CN)
ZHANG QIUXIANG (CN)
ZHAO JIANXIN (CN)
CHEN WEI (CN)
WU JIAYING (CN)
CUI SHUMAO (CN)
TANG XIN (CN)
ZHANG QIUXIANG (CN)
ZHAO JIANXIN (CN)
CHEN WEI (CN)
Application Number:
PCT/CN2023/085418
Publication Date:
October 26, 2023
Filing Date:
March 31, 2023
Export Citation:
Assignee:
UNIV JIANGNAN (CN)
International Classes:
A23L33/135; C12N1/20; A61K35/745; A61K36/31; A61P1/04; A61P29/00; C12P13/00; C12R1/01
Foreign References:
| CN114657105A | 2022-06-24 | |||
| CN111419857A | 2020-07-17 | |||
| US20160279090A1 | 2016-09-29 |
Other References:
YAO SHUNYU, ZHAO ZIXI, WANG WEIJUN, LIU XIAOLU: "Bifidobacterium Longum: Protection against Inflammatory Bowel Disease", JOURNAL OF IMMUNOLOGY RESEARCH, HINDAWI PUBLISHING CORPORATION, US, vol. 2021, 23 July 2021 (2021-07-23), US , pages 1 - 11, XP093101557, ISSN: 2314-8861, DOI: 10.1155/2021/8030297
DAI MEI; GAO LIN; WU JI-HONG: "Research Progress of Glucosinolates in Broccoli", FOOD RESEARCH AND DEVELOPMENT, TIANJIN SHI SHIPIN YANJIUSUO, CN, vol. 38, no. 6, 20 March 2017 (2017-03-20), CN , pages 212 - 217, XP009549734, ISSN: 1005-6521
DAI MEI; GAO LIN; WU JI-HONG: "Research Progress of Glucosinolates in Broccoli", FOOD RESEARCH AND DEVELOPMENT, TIANJIN SHI SHIPIN YANJIUSUO, CN, vol. 38, no. 6, 20 March 2017 (2017-03-20), CN , pages 212 - 217, XP009549734, ISSN: 1005-6521
Attorney, Agent or Firm:
HARBIN SHINEIP INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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