BIFLAVONOID-MANGANESE COMPLEX AND PREPARATION METHOD AND APPLICATION THEREOF

WIPO Patent Application WO/2018/153333

A1

The present invention provides a biflavonoid-manganese complex and a preparation method and application thereof. The present invention uses amentoflavone as a ligand and a manganese ion as a central ion for reaction to obtain an amentoflavone-manganese complex. The structure of the complex was characterized by infrared spectroscopy, ultraviolet-visible absorption spectroscopy, and high-resolution mass spectrometry. Moreover, antitumor and antioxidant activity of the amentoflavone-manganese complex were studied in the present invention. An MTT method shows that the amentoflavone-manganese complex has stronger antitumor activity than amentoflavone. Both a pyrogallol autoxidation method and an ABTS method show that the antioxidant activity of the amentoflavone-manganese complex is stronger than amentoflavone itself. The antitumor and antioxidant activity of amentoflavone are improved due to the formation of the biflavonoid-manganese complex, and the biflavonoid-manganese complex is expected to be used in drug development.

CAO FULIANG (CN)
YANG SHILONG (CN)
XU LI (CN)
ZHOU MENGYI (CN)
TANG YING (CN)
LU WEN (CN)
ZHAO FENGYI (CN)

PCT/CN2018/076751

August 30, 2018

February 13, 2018

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UNIV NANJING FORESTRY (CN)

C07F13/00; A61P35/00; A61P39/06

CN106905371A	2017-06-30
CN101857583A	2010-10-13
US20060024691A1	2006-02-02

QAMAR UDDIN ET AL.: "The Biflavonoid, Amentoflavone Degrades DNA in the Presence of Copper Ions", TOXICOLOGY IN VITRO, vol. 18, 31 August 2004 (2004-08-31), pages 435 - 440, XP055532214

NANJING SHENYUN INTELLECTUAL PROPERTY OFFICE (GENERAL PARTNERSHIP) (CN)

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