BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUND OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF - CSPC ZHONGQI PHARMACEUTICAL TECH SHIJIAZHUANG CO LTD

Title:

BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUND OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2023/186069

Kind Code:

A1

Abstract:

A bifunctional chimeric heterocyclic compound of interleukin-1 receptor-associated kinase 4 (IRAK4) represented by formula (I), a preparation method therefor, a pharmaceutical composition thereof and use thereof. The compound recruits IRAK4 to ubiquitin ligases, thereby promoting IRAK4 ubiquitination and IRAK4 degradation by proteasomes. Research findings show that the compound demonstrates relatively good IRAK4 degradation activity and thus can be used for treating IRAK4-mediated diseases.

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Inventors:

ZHANG CHAOZAI (CN)
ZHAO CHUANWU (CN)
FAN LIXUE (CN)
LI ZIZHEN (CN)
ZHANG XUEMING (CN)
YANG YINPING (CN)
ZHANG HONGFEN (CN)
XIN LINGLING (CN)
WANG CHEN (CN)
MI GUORUI (CN)

Application Number:

PCT/CN2023/085387

Publication Date:

October 05, 2023

Filing Date:

March 31, 2023

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Assignee:

CSPC ZHONGQI PHARMACEUTICAL TECH SHIJIAZHUANG CO LTD (CN)

International Classes:

A61K31/5025; C07D417/14; A61P35/02; C07D487/04; C07D519/00

Domestic Patent References:

WO2021168197A1	2021-08-26
WO2023023255A1	2023-02-23

Foreign References:

CN114437035A	2022-05-06
CN112566915A	2021-03-26
CN112105385A	2020-12-18

Attorney, Agent or Firm:

LINDA LIU & PARTNERS (CN)

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