Title:
BIFUNCTIONAL COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING THE BIFUNCTIONAL COMPOUND, AND METHOD FOR TREATING ANDROGEN RECEPTOR RELATED DISEASES BY USING THE SAME
Document Type and Number:
WIPO Patent Application WO/2024/002206
Kind Code:
A1
Abstract:
Provided is a bifunctional compound, or a pharmaceutically acceptable salt, hydrate, solvate, metabolite or prodrug thereof, wherein the bifunctional compound is represented by Formula (I) : ABM-L-CLM (I); wherein: ABM is an androgen receptor binding moiety; -L-is a linking moiety; and CLM is a cereblon E3 ubiquitin ligase binding moiety represented by Formula (II) -1: wherein one end of the -L-is covalently joined to Q3, Q4, Q5 or Q6; and the other end of the -L-is covalently joined to the ABM. Also provided are a pharmaceutical composition comprising the bifunctional compound and a method for treating an androgen receptor related disease or disorder by administering the bifunctional compound.
Inventors:
LIN CHU-CHIANG (CN)
CHEN HUNG-CHUAN (CN)
CHENG PEI-CHIN (CN)
CHOU CHIH-CHANG (CN)
CHEN HUNG-CHUAN (CN)
CHENG PEI-CHIN (CN)
CHOU CHIH-CHANG (CN)
Application Number:
PCT/CN2023/103576
Publication Date:
January 04, 2024
Filing Date:
June 29, 2023
Export Citation:
Assignee:
ANHORN MEDICINES CO LTD (CN)
International Classes:
C07D487/04; A61K31/4545; A61K31/496; A61P13/08; A61P17/00; A61P17/10; A61P17/14; A61P35/00; C07D401/14; C07D403/14
Domestic Patent References:
| WO2021143816A1 | 2021-07-22 | |||
| WO2022011205A1 | 2022-01-13 | |||
| WO2022025640A1 | 2022-02-03 | |||
| WO2022087125A1 | 2022-04-28 |
Foreign References:
| CN114163444A | 2022-03-11 | |||
| CN106458993A | 2017-02-22 | |||
| CN108136044A | 2018-06-08 | |||
| CN110506039A | 2019-11-26 | |||
| CN110612294A | 2019-12-24 | |||
| CN111212835A | 2020-05-29 |
Attorney, Agent or Firm:
BEIJING SANYOU INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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