Title:
BIFUNCTIONAL PRODRUGS AND DRUGS
Document Type and Number:
WIPO Patent Application WO/2011/054837
Kind Code:
A3
Abstract:
The present invention relates to novel compounds, more precisely to novel bifunctional prodrugs and drugs. In a further aspect, the invention relates to pharmaceutical compositions comprising said prodrugs and drugs, and to the use thereof as cytostatic agents in tumor therapy. The compounds according to the invention thereby are based on CC- 1065 analogously.
Inventors:
TIETZE LUTZ (DE)
VON HOF JAN MARIAN (DE)
VON HOF JAN MARIAN (DE)
Application Number:
PCT/EP2010/066688
Publication Date:
September 15, 2011
Filing Date:
November 03, 2010
Export Citation:
Assignee:
GEORG AUGUST UNI GOETTINGEN STIFTUNG OEFFENLICHEN RECHTS (DE)
TIETZE LUTZ (DE)
VON HOF JAN MARIAN (DE)
TIETZE LUTZ (DE)
VON HOF JAN MARIAN (DE)
International Classes:
A61K47/48; A61P35/00; C07D209/60; C07H17/02
Other References:
FUKUDA Y ET AL: "The novel cyclopropapyrroloindole(CPI) bisalkylators bearing 3,3'-(1,4-phenylene)diacryloyl group as a linker", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 8, no. 15, 4 August 1998 (1998-08-04), pages 2003 - 2004, XP004137175, ISSN: 0960-894X, DOI: DOI:10.1016/S0960-894X(98)00346-1
SCHWARTZ G H ET AL: "A phase I study of bizelesin, a highly potent and selective DNA-interactive agent, in patients with advanced solid malignancies", ANNALS OF ONCOLOGY 20030501 GB LNKD- DOI:10.1093/ANNONC/MDG215, vol. 14, no. 5, 1 May 2003 (2003-05-01), pages 775 - 782, XP002624233, ISSN: 0923-7534
MITCHELL M A ET AL: "Synthesis and DNA cross-linking by a rigid CPI dimer", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 1991 US, vol. 113, no. 23, 1991, pages 8994 - 8995, XP002624234, ISSN: 0002-7863
JIA G ET AL: "Design, synthesis and cytotoxicity evaluation of 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benz[e]indole (seco-CBI) dimers", BIOORGANIC AND MEDICINAL CHEMISTRY 200007 GB LNKD- DOI:10.1016/S0968-0896(00)00088-2, vol. 8, no. 7, July 2000 (2000-07-01), pages 1607 - 1617, XP002624235, ISSN: 0968-0896
TIETZE L F ET AL: "ENZYME AND PROTON-ACTIVATED PRODRUGS FOR A SELECTIVE CANCER THERAPY", CURRENT PHARMACEUTICAL DESIGN, BENTHAM SCIENCE PUBLISHERS, NL, vol. 9, no. 26, 1 January 2003 (2003-01-01), pages 2155 - 2175, XP008028312, ISSN: 1381-6128, DOI: DOI:10.2174/1381612033454072
KUMAR ROHTASH ET AL: "Synthesis and cytotoxicity evaluation of novel C7-c7, C7-N3 and N3-N3 dimers of 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benzo[e]indole (seco-CBI) with pyrrole and imidazole polyamide conjugates.", ORGANIC & BIOMOLECULAR CHEMISTRY 7 AUG 2003 LNKD- PUBMED:12948187, vol. 1, no. 15, 7 August 2003 (2003-08-07), pages 2630 - 2647, XP002624236, ISSN: 1477-0520
SCHWARTZ G H ET AL: "A phase I study of bizelesin, a highly potent and selective DNA-interactive agent, in patients with advanced solid malignancies", ANNALS OF ONCOLOGY 20030501 GB LNKD- DOI:10.1093/ANNONC/MDG215, vol. 14, no. 5, 1 May 2003 (2003-05-01), pages 775 - 782, XP002624233, ISSN: 0923-7534
MITCHELL M A ET AL: "Synthesis and DNA cross-linking by a rigid CPI dimer", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 1991 US, vol. 113, no. 23, 1991, pages 8994 - 8995, XP002624234, ISSN: 0002-7863
JIA G ET AL: "Design, synthesis and cytotoxicity evaluation of 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benz[e]indole (seco-CBI) dimers", BIOORGANIC AND MEDICINAL CHEMISTRY 200007 GB LNKD- DOI:10.1016/S0968-0896(00)00088-2, vol. 8, no. 7, July 2000 (2000-07-01), pages 1607 - 1617, XP002624235, ISSN: 0968-0896
TIETZE L F ET AL: "ENZYME AND PROTON-ACTIVATED PRODRUGS FOR A SELECTIVE CANCER THERAPY", CURRENT PHARMACEUTICAL DESIGN, BENTHAM SCIENCE PUBLISHERS, NL, vol. 9, no. 26, 1 January 2003 (2003-01-01), pages 2155 - 2175, XP008028312, ISSN: 1381-6128, DOI: DOI:10.2174/1381612033454072
KUMAR ROHTASH ET AL: "Synthesis and cytotoxicity evaluation of novel C7-c7, C7-N3 and N3-N3 dimers of 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benzo[e]indole (seco-CBI) with pyrrole and imidazole polyamide conjugates.", ORGANIC & BIOMOLECULAR CHEMISTRY 7 AUG 2003 LNKD- PUBMED:12948187, vol. 1, no. 15, 7 August 2003 (2003-08-07), pages 2630 - 2647, XP002624236, ISSN: 1477-0520
Attorney, Agent or Firm:
Gramm, Lins Partner, GbR (Hannover, DE)
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