Title:
BIFUNCTIONAL PROTEIN AGAINST PD-1 AND TGF-β
Document Type and Number:
WIPO Patent Application WO/2021/218895
Kind Code:
A1
Abstract:
Provided in the present application are a bifunctional protein which can bind to PD-1 (programmed death receptor-1) and TGF-β (transforming growth factor-β), the medical use of the bifunctional protein, and a preparation method therefor.
Inventors:
ZHAO WEI (CN)
LI YINGCHUN (CN)
LV HAILI (CN)
XIE LIANXIANG (CN)
ZHANG ZHEWEN (CN)
QIN YU (CN)
ZHANG XIQUAN (CN)
CHENG YANJU (CN)
LV PENG (CN)
LI TIANTIAN (CN)
LI YINGCHUN (CN)
LV HAILI (CN)
XIE LIANXIANG (CN)
ZHANG ZHEWEN (CN)
QIN YU (CN)
ZHANG XIQUAN (CN)
CHENG YANJU (CN)
LV PENG (CN)
LI TIANTIAN (CN)
Application Number:
PCT/CN2021/089837
Publication Date:
November 04, 2021
Filing Date:
April 26, 2021
Export Citation:
Assignee:
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN)
International Classes:
C07K19/00; A61K39/395; A61P35/00; C07K1/00; C07K16/28; C12N15/62
Domestic Patent References:
| WO2020014285A2 | 2020-01-16 | |||
| WO2019211489A1 | 2019-11-07 |
Foreign References:
| CN106977602A | 2017-07-25 | |||
| CN110734498A | 2020-01-31 | |||
| CN201610705763A | 2016-08-23 | |||
| CN106977602A | 2017-07-25 | |||
| DD120103A1 | 1976-05-20 |
Other References:
DAVID CHARLES J ET AL.: "TGF-β Tumor Suppression through a Lethal EMT. [J", CELL, vol. 164, no. 5, 2016, XP029433852, DOI: 10.1016/j.cell.2016.01.009
SHEN YINAN ET AL.: "TGF-β regulates hepatocellular carcinoma progression by inducing Treg cell polarization. [J", CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, vol. 35, no. 4, 2015
KABAT: "Sequences of Proteins of Immunological Interest", 1991, NATIONAL INSTITUTES OF HEALTH
AL-LAZIKAM ET AL., J. MOL. BIOL., vol. 273, 1997, pages 927 - 948
MARTIN ET AL., PROC. NATL. ACAD. SCI.USA, vol. 86, 1989, pages 9268 - 9272
SHEN YINAN ET AL.: "TGF-β regulates hepatocellular carcinoma progression by inducing Treg cell polarization. [J", CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, vol. 35, no. 4, 2015
KABAT: "Sequences of Proteins of Immunological Interest", 1991, NATIONAL INSTITUTES OF HEALTH
AL-LAZIKAM ET AL., J. MOL. BIOL., vol. 273, 1997, pages 927 - 948
MARTIN ET AL., PROC. NATL. ACAD. SCI.USA, vol. 86, 1989, pages 9268 - 9272
Attorney, Agent or Firm:
INSIGHT INTELLECTUAL PROPERTY LIMITED (CN)
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