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Title:
BIFUNCTIONAL PROTEIN, AND PREPARATION THEREOF AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/221936
Kind Code:
A1
Abstract:
Provided are a protein comprising a PD-L1 binding moiety linked to a TGF β binding moiety, an IL-1 binding moiety, an immunostimulating polypeptide (such as soluble LAG3 or soluble CD4) or a CD47 binding moiety, and a pharmaceutical preparation thereof, a preparation method therefor and the use thereof.

Inventors:
ZHANG FAN (CN)
MENG PAN (CN)
QIAN XUEMING (CN)
LI HONGJUN (CN)
TENG FEI (CN)
GUO HUANHUAN (CN)
GU YI (CN)
Application Number:
PCT/CN2023/094267
Publication Date:
November 23, 2023
Filing Date:
May 15, 2023
Export Citation:
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Assignee:
SUZHOU TRANSCENTA THERAPEUTICS CO LTD (CN)
International Classes:
C07K19/00; A61K39/395; A61P35/00; C07K14/71; C07K16/28
Domestic Patent References:
WO2022105817A12022-05-27
Foreign References:
US20220289825A12022-09-15
CN111363041A2020-07-03
CN113573782A2021-10-29
CN110734498A2020-01-31
Other References:
JIANG, H. ET AL.: "PD-L1/LAG-3 bispecific antibody enhances tumor-specific immunity", ONCOIMMUNOLOGY, vol. 10, no. 1, 24 June 2021 (2021-06-24), pages 1 - 11, XP055974043, DOI: 10.1080/2162402X.2021.1943180
LIU, X. ET AL.: "Dual Targeting of Innate and Adaptive Checkpoints on Tumor Cells Limits Immune Evasion", CELL REPORTS, vol. 24, 21 August 2018 (2018-08-21), pages 2101 - 2111, XP055593953, DOI: 10.1016/j.celrep.2018.07.062
Attorney, Agent or Firm:
ZHONGZI LAW OFFICE (CN)
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