BIO-FLUID'S LIGAND LIBRARY ENRICHMENT TECHNOLOGY AND USES THEREOF

WIPO Patent Application WO/2024/009960

A1

The present disclosure, at least in part, provides methods for generating aptamer libraries capable from binding to multiple target molecules (e.g., one or more biomolecules) in a complexed sample (e.g., biological sample) using electrophoresis mobility shift (e.g., 2-dimensional electrophoresis). The present disclosure also provides databases comprising information from one or more aptamer library (e.g., aptamer library generated by the methods described herein) and methods of utilizing such aptamer libraries (e.g., by comparing the information of a reference aptamer library and a target aptamer library to discern the differences).

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SAKAKIBARA YOGO (JP)

PCT/JP2023/024651

January 11, 2024

July 03, 2023

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EISAI R&D MAN CO LTD (JP)

C12Q1/686

WO2011060557A1

2011-05-26

GOTO, Shinichi et al., Development of aptamers against unpurified proteins, Biotechnology and Bioengineering, 2017, Vol.114, p.2706-2716, DOI: 10.1002/bit.26389
DEMBOWSKI SEAN K, BOWSER MICHAEL T: "CE-SELEX: Rapid Aptamer Selection Using Capillary Electrophoresis", SCIEX, 1 May 2016 (2016-05-01), pages 1 - 10, XP093125533

HASEGAWA Yoshiki et al. (JP)

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