Title:
BIO-MARKER COMPOSITION FOR DIAGNOSIS OF BRAIN DISEASE CAUSED BY BRAIN MICROVASCULAR DAMAGE
Document Type and Number:
WIPO Patent Application WO/2020/262937
Kind Code:
A1
Abstract:
The present invention relates to a bio-marker composition for diagnosis of a brain disease caused by brain microvascular damage and, more specifically, to a method for constructing an animal model of a brain microvascular damage-caused brain disease by inducing blood brain barrier degeneration only in a corresponding local area after the brain local areas are precisely classified on the basis of an MRI image, to a method for screening a bio-marker for diagnosis of a brain disease caused by brain microvascular damage due to blood brain barrier degeneration, using the animal model, and to a bio-marker composition for diagnosis of a brain disease caused by brain microvascular damage due to blood brain barrier degeneration.
Inventors:
PARK JU YOUNG (KR)
LEE EUN HEE (KR)
HAN MUN (KR)
CHOI HYO JIN (KR)
LEE EUN HEE (KR)
HAN MUN (KR)
CHOI HYO JIN (KR)
Application Number:
PCT/KR2020/008165
Publication Date:
December 30, 2020
Filing Date:
June 23, 2020
Export Citation:
Assignee:
DAEGU GYEONGBUK MEDICAL INNOVATION FOUND (KR)
International Classes:
C12Q1/6883; A01K67/027; G01N33/68
Foreign References:
| KR20190031072A | 2019-03-25 | |||
| JP2009020049A | 2009-01-29 | |||
| JP2006517181A | 2006-07-20 | |||
| KR102100588B1 | 2020-04-13 |
Other References:
RAMAEKERS MARIËLLE G., LUNING PIETERNEL A., RUIJSCHOP RIANNE M. A. J., LAKEMOND CATRIONA M. M., BULT JOHANNES H. F., GORT GERRIT, : "Aroma exposure time and aroma concentration in relation to satiation", BRITISH JOURNAL OF NUTRITION, vol. 111, no. 3, 14 February 2014 (2014-02-14), pages 554 - 562, XP055772852, ISSN: 0007-1145, DOI: 10.1017/S0007114513002729
LYUDMILAV. DERGUNOVA;IVANB. FILIPPENKOV;VASILYV. STAVCHANSKY;ALINAE. DENISOVA;VADIMV. YUZHAKOV;SERGEYA. MOZEROV;LEONIDV. GUBSKY;SV: "Genome-wide transcriptome analysis using RNA-Seq reveals a large number of differentially expressed genes in a transient MCAO rat model", BMC GENOMICS, BIOMED CENTRAL LTD, LONDON, UK, vol. 19, no. 1, 5 September 2018 (2018-09-05), London, UK, pages 1 - 16, XP021260318, DOI: 10.1186/s12864-018-5039-5
LYUDMILAV. DERGUNOVA;IVANB. FILIPPENKOV;VASILYV. STAVCHANSKY;ALINAE. DENISOVA;VADIMV. YUZHAKOV;SERGEYA. MOZEROV;LEONIDV. GUBSKY;SV: "Genome-wide transcriptome analysis using RNA-Seq reveals a large number of differentially expressed genes in a transient MCAO rat model", BMC GENOMICS, BIOMED CENTRAL LTD, LONDON, UK, vol. 19, no. 1, 5 September 2018 (2018-09-05), London, UK, pages 1 - 16, XP021260318, DOI: 10.1186/s12864-018-5039-5
Attorney, Agent or Firm:
ERUUM & LEEON INTELLECTUAL PROPERTY LAW FIRM (KR)
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