Title:
BIOACTIVE GLASS AS NUCLEIC ACID CARRIERS WITH PH SWITCH CONTROL-RELEASING
Document Type and Number:
WIPO Patent Application WO/2021/119043
Kind Code:
A3
Abstract:
A pH-switchable carrier composition includes a plurality of bioactive glass particles, wherein each of the bioactive glass particle is optionally at least a partially coated with a surface modifier; wherein the bioactive glass particles, with or without, the surface modifier can bind to a nucleic acid compound upon contact at pH in the range of about 7 to about 11, and exhibit controlled release of the nucleic acid compound at pH in the range of about 5 to 6.
Inventors:
CHIANG PEI-CHEN (TW)
FU QIANG (US)
HSU CHENG-I (TW)
HSU WEI-LUN (TW)
FU QIANG (US)
HSU CHENG-I (TW)
HSU WEI-LUN (TW)
Application Number:
PCT/US2020/063861
Publication Date:
August 05, 2021
Filing Date:
December 09, 2020
Export Citation:
Assignee:
CORNING INC (US)
International Classes:
C03C3/064; C03C3/097; C03C3/112; C03C4/00; C03C8/06; C03C8/08; C03C8/14; C03C8/16; C03C12/00; C03C17/28
Domestic Patent References:
| WO2011000865A2 | 2011-01-06 | |||
| WO2018025020A1 | 2018-02-08 | |||
| WO2020106514A1 | 2020-05-28 |
Foreign References:
| US20020114768A1 | 2002-08-22 | |||
| US8137697B1 | 2012-03-20 |
Other References:
KAMEGAWA RIMPEI ET AL: "Functionalization of silica nanoparticles for nucleic acid delivery", NANO RESEARCH, TSINGHUA UNIVERSITY PRESS, CN, vol. 11, no. 10, 27 June 2018 (2018-06-27), pages 5219 - 5239, XP036607482, ISSN: 1998-0124, [retrieved on 20180627], DOI: 10.1007/S12274-018-2116-7
XIONG LIN ET AL: "Magnetic Core-Shell Silica Nanoparticles with Large Radial Mesopores for siRNA Delivery", SMALL, vol. 12, no. 34, 19 May 2016 (2016-05-19), pages 4735 - 4742, XP055785358, ISSN: 1613-6810, DOI: 10.1002/smll.201600531
EL-FIQI AHMED ET AL: "Capacity of mesoporous bioactive glass nanoparticles to deliver therapeutic molecules", NANOSCALE, vol. 4, no. 23, 1 January 2012 (2012-01-01), United Kingdom, pages 7475, XP055785565, ISSN: 2040-3364, Retrieved from the Internet [retrieved on 20210312], DOI: 10.1039/c2nr31775c
TIAN XIA ET AL: "Polyethyleneimine Coating Enhances the Cellular Uptake of Mesoporous Silica Nanoparticles and Allows Safe Delivery of siRNA and DNA Constructs", ACS NANO, vol. 3, no. 10, 27 October 2009 (2009-10-27), pages 3273 - 3286, XP055077005, ISSN: 1936-0851, DOI: 10.1021/nn900918w
XIONG LIN ET AL: "Magnetic Core-Shell Silica Nanoparticles with Large Radial Mesopores for siRNA Delivery", SMALL, vol. 12, no. 34, 19 May 2016 (2016-05-19), pages 4735 - 4742, XP055785358, ISSN: 1613-6810, DOI: 10.1002/smll.201600531
EL-FIQI AHMED ET AL: "Capacity of mesoporous bioactive glass nanoparticles to deliver therapeutic molecules", NANOSCALE, vol. 4, no. 23, 1 January 2012 (2012-01-01), United Kingdom, pages 7475, XP055785565, ISSN: 2040-3364, Retrieved from the Internet
TIAN XIA ET AL: "Polyethyleneimine Coating Enhances the Cellular Uptake of Mesoporous Silica Nanoparticles and Allows Safe Delivery of siRNA and DNA Constructs", ACS NANO, vol. 3, no. 10, 27 October 2009 (2009-10-27), pages 3273 - 3286, XP055077005, ISSN: 1936-0851, DOI: 10.1021/nn900918w
Attorney, Agent or Firm:
SHORT, Svetlana Z. (US)
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