Title:
BIOLOGICAL ANGSTROM PORE SYSTEM BASED ON MECHANOSENSITIVE CHANNEL OF SMALL CONDUCTANCE
Document Type and Number:
WIPO Patent Application WO/2023/030180
Kind Code:
A1
Abstract:
A biological angstrom pore system based on a mechanosensitive channel of small conductance (MscS), and the application of the angstrom pore system to the detection of charged molecules, which belong to the field of nanopore detection. The angstrom pore system includes MscS angstrom pores, an insulating film, a first medium and a second medium, wherein the pore size of the MscS angstrom pore can be reversibly adjusted in situ simply by means of changing external conditions, and is applicable to direct detection of molecules of various types and sizes, e.g. nucleotides, amino acids, peptides and drug molecules.
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Inventors:
GENG JIA (CN)
BAO RUI (CN)
KE BOWEN (CN)
CHEN LU (CN)
ZHAO CHANGJIAN (CN)
LI KAIJU (CN)
BAO RUI (CN)
KE BOWEN (CN)
CHEN LU (CN)
ZHAO CHANGJIAN (CN)
LI KAIJU (CN)
Application Number:
PCT/CN2022/115022
Publication Date:
March 09, 2023
Filing Date:
August 26, 2022
Export Citation:
Assignee:
UNIV SICHUAN (CN)
International Classes:
C12Q1/68; C12M1/34; G01N33/487
Domestic Patent References:
| WO2020168286A1 | 2020-08-20 |
Foreign References:
| CN101680873A | 2010-03-24 | |||
| CN112739712A | 2021-04-30 | |||
| US20190383720A1 | 2019-12-19 | |||
| CN109996888A | 2019-07-09 | |||
| CN111521766A | 2020-08-11 | |||
| CN104011866A | 2014-08-27 | |||
| CN112041331A | 2020-12-04 |
Attorney, Agent or Firm:
CHONGQING ENZHOU INTELLECTUAL PROPERTY AGENCY (SPECIAL GENERAL PARTNERSHIP) (CN)
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