Title:
BIOMARKER COMPOSITION FOR DIAGNOSING BRAIN DISEASE DUE TO BRAIN MICROVASCULAR DAMAGE
Document Type and Number:
WIPO Patent Application WO/2020/262939
Kind Code:
A1
Abstract:
The present invention relates to a biomarker composition for diagnosing a brain disease due to brain microvascular damage. More specifically, the present invention relates to: a method for constructing an animal model having a brain disease due to brain microvascular damage by precisely demarcating a brain local area on the basis of an MRI image, and inducing blood brain barrier degeneration only in said local area; a method for using the animal model to screen a biomarker for diagnosing a brain disease due to brain microvascular damage caused by blood brain barrier degeneration; and a biomarker composition for diagnosing a brain disease due to brain microvascular damage caused by blood brain barrier degeneration.
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Inventors:
PARK JU YOUNG (KR)
LEE EUN HEE (KR)
HAN MUN (KR)
CHOI HYO JIN (KR)
LEE EUN HEE (KR)
HAN MUN (KR)
CHOI HYO JIN (KR)
Application Number:
PCT/KR2020/008167
Publication Date:
December 30, 2020
Filing Date:
June 23, 2020
Export Citation:
Assignee:
DAEGU GYEONGBUK MEDICAL INNOVATION FOUND (KR)
International Classes:
C12Q1/6883; G01N33/68
Foreign References:
| JP2009020049A | 2009-01-29 |
Other References:
DALLAN MCMAHON, REINA BENDAYAN, KULLERVO HYNYNEN: "Acute effects of focused ultrasound-induced increases in blood-brain barrier permeability on rat microvascular transcriptome", SCIENTIFIC REPORTS, vol. 7, no. 1, 1 May 2017 (2017-05-01), XP055771971, DOI: 10.1038/srep45657
HONGMEI MENG, YUEJIA SONG, JIYUAN ZHU, QI LIU, PENGTIAN LU, NA YE, ZHEN ZHANG, YUXIN PANG, JIPING QI, HE WU: "LRG1 promotes angiogenesis through upregulating the TGF-β1 pathway in ischemic rat brain", MOLECULAR MEDICINE REPORTS, SPANDIDOS PUBLICATIONS, GR, vol. 14, no. 6, 1 December 2016 (2016-12-01), GR, pages 5535 - 5543, XP055771982, ISSN: 1791-2997, DOI: 10.3892/mmr.2016.5925
AKIHIRO SHINDO, TAKAKUNI MAKI, EMIRI T. MANDEVILLE, ANNA C. LIANG, NAOHIRO EGAWA, KANAKO ITOH, NAOKI ITOH, MIA BORLONGAN, JULIE C.: "Astrocyte-Derived Pentraxin 3 Supports Blood–Brain Barrier Integrity Under Acute Phase of Stroke", STROKE, LIPPINCOTT WILLIAMS & WILKINS, US, vol. 47, no. 4, 1 April 2016 (2016-04-01), US, pages 1094 - 1100, XP055771985, ISSN: 0039-2499, DOI: 10.1161/STROKEAHA.115.012133
CHENGJIE ZHANG, YANBING ZHU, SONG WANG, ZHENG ZACHORY WEI, MICHAEL QIZE JIANG, YONGBO ZHANG, YUHUALEI PAN, SHAOXIN TAO, JIMEI LI, : "Temporal Gene Expression Profiles after Focal Cerebral Ischemia in Mice", AGING AND DISEASE, BUCK INSTITUTE FOR AGE RESEARCH, US, vol. 9, no. 2, 1 January 2018 (2018-01-01), US, pages 249, XP055771986, ISSN: 2152-5250, DOI: 10.14336/AD.2017.0424
HONGMEI MENG, YUEJIA SONG, JIYUAN ZHU, QI LIU, PENGTIAN LU, NA YE, ZHEN ZHANG, YUXIN PANG, JIPING QI, HE WU: "LRG1 promotes angiogenesis through upregulating the TGF-β1 pathway in ischemic rat brain", MOLECULAR MEDICINE REPORTS, SPANDIDOS PUBLICATIONS, GR, vol. 14, no. 6, 1 December 2016 (2016-12-01), GR, pages 5535 - 5543, XP055771982, ISSN: 1791-2997, DOI: 10.3892/mmr.2016.5925
AKIHIRO SHINDO, TAKAKUNI MAKI, EMIRI T. MANDEVILLE, ANNA C. LIANG, NAOHIRO EGAWA, KANAKO ITOH, NAOKI ITOH, MIA BORLONGAN, JULIE C.: "Astrocyte-Derived Pentraxin 3 Supports Blood–Brain Barrier Integrity Under Acute Phase of Stroke", STROKE, LIPPINCOTT WILLIAMS & WILKINS, US, vol. 47, no. 4, 1 April 2016 (2016-04-01), US, pages 1094 - 1100, XP055771985, ISSN: 0039-2499, DOI: 10.1161/STROKEAHA.115.012133
CHENGJIE ZHANG, YANBING ZHU, SONG WANG, ZHENG ZACHORY WEI, MICHAEL QIZE JIANG, YONGBO ZHANG, YUHUALEI PAN, SHAOXIN TAO, JIMEI LI, : "Temporal Gene Expression Profiles after Focal Cerebral Ischemia in Mice", AGING AND DISEASE, BUCK INSTITUTE FOR AGE RESEARCH, US, vol. 9, no. 2, 1 January 2018 (2018-01-01), US, pages 249, XP055771986, ISSN: 2152-5250, DOI: 10.14336/AD.2017.0424
Attorney, Agent or Firm:
ERUUM & LEEON INTELLECTUAL PROPERTY LAW FIRM (KR)
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