Title:
BIOMARKER COMPOSITION FOR DIAGNOSING HEMOSTATIC DISORDERS, COMPRISING MIRNAS IN EXTRACELLULAR VESICLES
Document Type and Number:
WIPO Patent Application WO/2023/177275
Kind Code:
A1
Abstract:
The present invention relates to biomarkers for diagnosing hemostatic disorders, comprising miRNAs in extracellular vesicles. It has been experimentally identified that miRNAs in extracellular vesicles, according to the present invention, exhibit expression patterns in hemostatic disorder patients that are more specific than those of normal groups. Therefore, it is indicated that miRNAs in extracellular vesicles of the present invention can be used as biomarkers of hemostatic disorders, and thus the miRNAs can be variously used in the field of hemostatic disorder diagnosis.
Inventors:
BANG OH YOUNG (KR)
KIM EUN HEE (KR)
SUNG JI HEE (KR)
SHIN EUN KYOUNG (KR)
CHUNG JONG WON (KR)
SEO WOO KEUN (KR)
KIM GYEONG MOON (KR)
AHN MYUNG JU (KR)
KIM EUN HEE (KR)
SUNG JI HEE (KR)
SHIN EUN KYOUNG (KR)
CHUNG JONG WON (KR)
SEO WOO KEUN (KR)
KIM GYEONG MOON (KR)
AHN MYUNG JU (KR)
Application Number:
PCT/KR2023/003670
Publication Date:
September 21, 2023
Filing Date:
March 20, 2023
Export Citation:
Assignee:
S＆E BIO CO LTD (KR)
SAMSUNG LIFE PUBLIC WELFARE FOUNDATION (KR)
XENOHELIX CO LTD (KR)
SAMSUNG LIFE PUBLIC WELFARE FOUNDATION (KR)
XENOHELIX CO LTD (KR)
International Classes:
C12Q1/6883
Foreign References:
| CN112043837A | 2020-12-08 |
Other References:
WANG YUTING, ZHANG ZEGAO, TAO PENGCAI, REYILA MAIMAITIYIMIN, QI XIAOLI, YANG JIE: "The Abnormal Expression of miR-205-5p, miR-195-5p, and VEGF-A in Human Cervical Cancer Is Related to the Treatment of Venous Thromboembolism", BIOMED RESEARCH INTERNATIONAL, HINDAWI PUBLISHING CORPORATION, vol. 2020, 10 August 2020 (2020-08-10), pages 1 - 7, XP093091336, ISSN: 2314-6133, DOI: 10.1155/2020/3929435
LI YUE, WEN QIANG, CHEN HUAISHENG, WU XINHUI, LIU BIN, LI HUI, SU LEI, TONG HUASHENG: "Exosomes Derived From Heat Stroke Cases Carry miRNAs Associated With Inflammation and Coagulation Cascade", FRONTIERS IN IMMUNOLOGY, vol. 12, XP093091340, DOI: 10.3389/fimmu.2021.624753
BUIJS JEROEN T.; VERSTEEG HENRI H.: "Genes and proteins associated with the risk for cancer-associated thrombosis", THROMBOSIS RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 191, 1 July 2020 (2020-07-01), AMSTERDAM, NL , XP086230580, ISSN: 0049-3848, DOI: 10.1016/S0049-3848(20)30396-0
JANKOWSKA KATARZYNA I., SAUNA ZUBEN E., ATREYA CHINTAMANI D.: "Role of microRNAs in Hemophilia and Thrombosis in Humans", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 21, no. 10, pages 3598, XP093091341, DOI: 10.3390/ijms21103598
MENG XIANDONG; YIN JIANJIAO; YU XINLI; GUO YONGGANG: "MicroRNA-205-5p Promotes Unstable Atherosclerotic Plaque Formation In Vivo", CARDIOVASCULAR DRUGS AND THERAPY., KLUWER ACADEMIC PUBLISHERS, BOSTON., US, vol. 34, no. 1, 1 February 2020 (2020-02-01), US , pages 25 - 39, XP037077162, ISSN: 0920-3206, DOI: 10.1007/s10557-020-06935-9
LI YUE, WEN QIANG, CHEN HUAISHENG, WU XINHUI, LIU BIN, LI HUI, SU LEI, TONG HUASHENG: "Exosomes Derived From Heat Stroke Cases Carry miRNAs Associated With Inflammation and Coagulation Cascade", FRONTIERS IN IMMUNOLOGY, vol. 12, XP093091340, DOI: 10.3389/fimmu.2021.624753
BUIJS JEROEN T.; VERSTEEG HENRI H.: "Genes and proteins associated with the risk for cancer-associated thrombosis", THROMBOSIS RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 191, 1 July 2020 (2020-07-01), AMSTERDAM, NL , XP086230580, ISSN: 0049-3848, DOI: 10.1016/S0049-3848(20)30396-0
JANKOWSKA KATARZYNA I., SAUNA ZUBEN E., ATREYA CHINTAMANI D.: "Role of microRNAs in Hemophilia and Thrombosis in Humans", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 21, no. 10, pages 3598, XP093091341, DOI: 10.3390/ijms21103598
MENG XIANDONG; YIN JIANJIAO; YU XINLI; GUO YONGGANG: "MicroRNA-205-5p Promotes Unstable Atherosclerotic Plaque Formation In Vivo", CARDIOVASCULAR DRUGS AND THERAPY., KLUWER ACADEMIC PUBLISHERS, BOSTON., US, vol. 34, no. 1, 1 February 2020 (2020-02-01), US , pages 25 - 39, XP037077162, ISSN: 0920-3206, DOI: 10.1007/s10557-020-06935-9
Attorney, Agent or Firm:
KAI INTERNATIONAL IP LAW FIRM (KR)
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