Title:
BIOMARKER COMPOSITION FOR DIAGNOSING OR PREDICTING PROGNOSIS OF THYROID CANCER, COMPRISING PREPARATION CAPABLE OF DETECTING MUTATION IN PLEKHS1 GENE, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/091130
Kind Code:
A1
Abstract:
The present invention relates to: a biomarker composition for diagnosing or predicting the prognosis of thyroid cancer, comprising a preparation capable of detecting a mutation in the PLEKHS1 promoter gene; and a use thereof. The biomarker composition for diagnosing or predicting the prognosis of thyroid cancer of the present invention checks whether a mutation is present in the PLEKHS1 promoter gene, and thus may provide information needed for diagnosing metastatic (distant metastatic) differentiated thyroid cancer, and, other than for the PLEKHS1 promoter gene, also checks whether a mutation is present in BRAF, the TERT promoter, the three types of RAS and the TP53 gene, and thus, with respect to radioactive iodine therapy response and survival, can categorize the prognoses of a metastatic differentiated thyroid cancer patient into three prognostic groups, and predict same.
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Inventors:
JUNG CHAN KWON (KR)
JUNG SEUNG HYUN (KR)
CHUNG YEUN JUN (KR)
JUNG SEUNG HYUN (KR)
CHUNG YEUN JUN (KR)
Application Number:
PCT/KR2020/014570
Publication Date:
May 14, 2021
Filing Date:
October 23, 2020
Export Citation:
Assignee:
CATHOLIC UNIV KOREA IND ACADEMIC COOPERATION FOUNDATION (KR)
International Classes:
C12Q1/6886; C12Q1/6827
Foreign References:
| US20150038376A1 | 2015-02-05 | |||
| US20090068171A1 | 2009-03-12 |
Other References:
FREDRIKSSON NILS J, NY LARS, NILSSON JONAS A, LARSSON ERIK: "Systematic analysis of noncoding somatic mutations and gene expression alterations across 14 tumor types", NATURE GENETICS, NATURE PUBLISHING GROUP US, NEW YORK, vol. 46, no. 12, 1 December 2014 (2014-12-01), New York, pages 1258 - 1263, XP055810295, ISSN: 1061-4036, DOI: 10.1038/ng.3141
KITAMURA YUTAKA, SHIMIZU KAZUO, TANAKA SHIGEO, ITO KOICHI, EMI MITSURU, Y K: "Association of Allelic Loss on 1q, 4p, 7q, 9p, 9q, and 16q with Postoperative Death in Papillary Thyroid Carcinoma 1", CLINICAL CANCER RESEARCH, vol. 6, 1 May 2000 (2000-05-01), pages 1819 - 1825, XP055810297
CACCIATO INSILLA ANDREA, PROIETTI AGNESE, BORRELLI NICLA, MACEROLA ELISABETTA, NICCOLI CRISTINA, VITTI PAOLO, MICCOLI PAOLO, BASOL: "TERT promoter mutations and their correlation with BRAF and RAS mutations in a consecutive cohort of 145 thyroid cancer cases", ONCOLOGY LETTERS, SPANDIDOS PUBLICATIONS, GR, vol. 15, 1 January 2018 (2018-01-01), GR, pages 2763 - 2770, XP055810298, ISSN: 1792-1074, DOI: 10.3892/ol.2017.7675
XING XIANGLING, MU NINNI, YUAN XIAOTIAN, WANG NA, JUHLIN C. CHRISTOFER, STRÅÅT KLAS, LARSSON CATHARINA, XU DAWEI: "PLEKHS1 Over-Expression is Associated with Metastases and Poor Outcomes in Papillary Thyroid Carcinoma", CANCERS, vol. 12, no. 8, pages 2133, XP055810299, DOI: 10.3390/cancers12082133
KITAMURA YUTAKA, SHIMIZU KAZUO, TANAKA SHIGEO, ITO KOICHI, EMI MITSURU, Y K: "Association of Allelic Loss on 1q, 4p, 7q, 9p, 9q, and 16q with Postoperative Death in Papillary Thyroid Carcinoma 1", CLINICAL CANCER RESEARCH, vol. 6, 1 May 2000 (2000-05-01), pages 1819 - 1825, XP055810297
CACCIATO INSILLA ANDREA, PROIETTI AGNESE, BORRELLI NICLA, MACEROLA ELISABETTA, NICCOLI CRISTINA, VITTI PAOLO, MICCOLI PAOLO, BASOL: "TERT promoter mutations and their correlation with BRAF and RAS mutations in a consecutive cohort of 145 thyroid cancer cases", ONCOLOGY LETTERS, SPANDIDOS PUBLICATIONS, GR, vol. 15, 1 January 2018 (2018-01-01), GR, pages 2763 - 2770, XP055810298, ISSN: 1792-1074, DOI: 10.3892/ol.2017.7675
XING XIANGLING, MU NINNI, YUAN XIAOTIAN, WANG NA, JUHLIN C. CHRISTOFER, STRÅÅT KLAS, LARSSON CATHARINA, XU DAWEI: "PLEKHS1 Over-Expression is Associated with Metastases and Poor Outcomes in Papillary Thyroid Carcinoma", CANCERS, vol. 12, no. 8, pages 2133, XP055810299, DOI: 10.3390/cancers12082133
Attorney, Agent or Firm:
ERUUM & LEEON INTELLECTUAL PROPERTY LAW FIRM (KR)
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