Title:
BIOMARKER COMPOSITION, KIT AND INFORMATION PROVISION METHOD FOR PREDICTING CORONARY COLLATERAL CIRCULATION BY USING CELL-FREE DNA
Document Type and Number:
WIPO Patent Application WO/2024/029988
Kind Code:
A1
Abstract:
The present invention relates to a composition, kit and information provision method for predicting coronary collateral circulation by using cell-free DNA through determination of the methylation level of differentially methylated regions in heart disease patients. Specifically, when the methylation level of DMR in at least one gene selected from the group consisting of ST7, EPN1, LOC101927914, SENP3, TCERG1L, LINC02233, MAGI2-AS3, TEX51, ALG10B, C10orf71-AS1, SKI, FREM1, SMURF2, NTRK3, RAB11FIP3, HLTF, MYH3, SKIV2L, GUSBP10, and STAB1 is measured and thus hypomethylation is determined, good coronary collateral circulation can be predicted, which can thus be used as excellent personalized medicine in predicting coronary collateral circulation in heart disease patients.
Inventors:
LEE SANG HAK (KR)
BANG DUHEE (KR)
AHN JONGSEONG (KR)
BANG DUHEE (KR)
AHN JONGSEONG (KR)
Application Number:
PCT/KR2023/011487
Publication Date:
February 08, 2024
Filing Date:
August 04, 2023
Export Citation:
Assignee:
UIF UNIV INDUSTRY FOUNDATION YONSEI UNIV (KR)
International Classes:
C12Q1/6883
Foreign References:
| US20200181703A1 | 2020-06-11 | |||
| JP2018143178A | 2018-09-20 | |||
| KR102277510B1 | 2021-07-14 |
Other References:
HAI ZEMMOUR, PLANER DAVID, MAGENHEIM JUDITH, MOSS JOSHUA, NEIMAN DANIEL, GILON DAN, KORACH AMIT, GLASER BENJAMIN, SHEMER RUTH, LAN: "Non-invasive detection of human cardiomyocyte death using methylation patterns of circulating DNA", NATURE COMMUNICATIONS, vol. 9, no. 1, 24 April 2018 (2018-04-24), XP055513857, DOI: 10.1038/s41467-018-03961-y
GHOSE SUBHOSHREE; GHOSH SOURAV; TANWAR VINAY SINGH; TOLANI PRIYA; KUTUM RINTU; SHARMA ANJU; BHARDWAJ NITIN; SHAMSUDHEEN K.V.; VERM: "Investigating Coronary Artery Disease methylome through targeted bisulfite sequencing", GENE, ELSEVIER AMSTERDAM, NL, vol. 721, 6 September 2019 (2019-09-06), NL , XP085879451, ISSN: 0378-1119, DOI: 10.1016/j.gene.2019.144107
GHOSE SUBHOSHREE; GHOSH SOURAV; TANWAR VINAY SINGH; TOLANI PRIYA; KUTUM RINTU; SHARMA ANJU; BHARDWAJ NITIN; SHAMSUDHEEN K.V.; VERM: "Investigating Coronary Artery Disease methylome through targeted bisulfite sequencing", GENE, ELSEVIER AMSTERDAM, NL, vol. 721, 6 September 2019 (2019-09-06), NL , XP085879451, ISSN: 0378-1119, DOI: 10.1016/j.gene.2019.144107
Attorney, Agent or Firm:
ERUUM & LEEON INTELLECTUAL PROPERTY LAW FIRM (KR)
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