Title:
BIOMARKER OF DEMENTIA WITH LEWY BODIES
Document Type and Number:
WIPO Patent Application WO/2016/143703
Kind Code:
A1
Abstract:
Cholesterol, desmosterol and a ratio of the levels thereof are usable as a blood biomarker of Alzheimer's disease, frontotemporal lobar degeneration or dementia with Lewy bodies.
Inventors:
IKEUCHI TAKESHI (JP)
KUWANO RYOZO (JP)
SATO YOSHIAKI (JP)
BERNIER FRANCOIS (JP)
KUWANO RYOZO (JP)
SATO YOSHIAKI (JP)
BERNIER FRANCOIS (JP)
Application Number:
PCT/JP2016/056828
Publication Date:
September 15, 2016
Filing Date:
March 04, 2016
Export Citation:
Assignee:
UNIV NIIGATA (JP)
EISAI R&D MAN CO LTD (JP)
EISAI R&D MAN CO LTD (JP)
International Classes:
G01N33/92; G01N33/50
Domestic Patent References:
| WO2012053255A1 | 2012-04-26 |
Foreign References:
| JP2012520344A | 2012-09-06 |
Other References:
KOLSCH HEIKE: "ALTERATIONS OF CHOLESTEROL PRECURSOR LEVELS IN ALZHEIMER'S DISEASE", BIOCHIM BIOPHYS ACTA, vol. 1801, no. 8, 2010, pages 945 - 950, XP027086284
SATO YOSHIAKI: "IDENTIFICATION OF A NEW PLASMA BIOMARKER OF ALZHEIMER'S DISEASE USING METABOLOMICS TECHNOLOGY", J LIPID RES, vol. 53, no. 3, 2012, pages 567 - 576, XP027086284
BORRONI B: "APOE GENOTYPE AND CHOLESTEROL LEVELS IN LEWY BODY DEMENTIA AND ALZHEIMER DISEASE: INVESTIGATING GENOTYPE-PHENOTYPE EFFECT ON DISEASE RISK", AM J GERIATR PSYCHIATRY, vol. 14, no. 12, 2006, pages 1022 - 1031, XP009505686
LEVI OFIR: "REGULATION OF HIPPOCAMPAL CHOLESTEROL METABOLISM BY APOE AND ENVIRONMENTAL STIMULATION", J NEUROCHEM, vol. 95, no. 4, 2005, pages 987 - 997, XP055087692
BENVENUTI SUSANNA: "NEURONAL DIFFERENTIATION OF HUMAN MESENCHYMAL STEM CELLS: CHANGES IN THE EXPRESSION OF THE ALZHEIMER'S DISEASE-RELATED GENE SELADIN-1", EXP CELL RES, vol. 312, no. 13, 2006, pages 2592 - 2604, XP024945144
See also references of EP 3267200A4
SATO YOSHIAKI: "IDENTIFICATION OF A NEW PLASMA BIOMARKER OF ALZHEIMER'S DISEASE USING METABOLOMICS TECHNOLOGY", J LIPID RES, vol. 53, no. 3, 2012, pages 567 - 576, XP027086284
BORRONI B: "APOE GENOTYPE AND CHOLESTEROL LEVELS IN LEWY BODY DEMENTIA AND ALZHEIMER DISEASE: INVESTIGATING GENOTYPE-PHENOTYPE EFFECT ON DISEASE RISK", AM J GERIATR PSYCHIATRY, vol. 14, no. 12, 2006, pages 1022 - 1031, XP009505686
LEVI OFIR: "REGULATION OF HIPPOCAMPAL CHOLESTEROL METABOLISM BY APOE AND ENVIRONMENTAL STIMULATION", J NEUROCHEM, vol. 95, no. 4, 2005, pages 987 - 997, XP055087692
BENVENUTI SUSANNA: "NEURONAL DIFFERENTIATION OF HUMAN MESENCHYMAL STEM CELLS: CHANGES IN THE EXPRESSION OF THE ALZHEIMER'S DISEASE-RELATED GENE SELADIN-1", EXP CELL RES, vol. 312, no. 13, 2006, pages 2592 - 2604, XP024945144
See also references of EP 3267200A4
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
Yoshiki Hasegawa (JP)
Yoshiki Hasegawa (JP)
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