Title:
BIOMARKER FOR PREDICTING IMMUNOTHERAPEUTIC RESPONSIVENESS BASED ON SPATIAL TRANSCRIPTOME ANALYSIS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/101823
Kind Code:
A1
Abstract:
The present invention relates to a biomarker for predicting immunotherapeutic responsiveness based on spatial transcriptome analysis and uses thereof and, in particular, to: a marker composition for predicting the responsiveness of cancer patients to immunotherapy; a composition for predicting the responsiveness of cancer patients to immunotherapy; a kit for predicting the responsiveness of cancer patients to immunotherapy, comprising the composition; a method for providing information for predicting the responsiveness of cancer patients to immunotherapy; and a method for providing information for predicting the survival prognosis of cancer patients. The biomarker for predicting immunotherapeutic responsiveness, according to the present invention, was discovered by applying spatial transcriptome technology and analyzing cell group-specific gene expression values according to location information of cells in tissue sections, and can more precisely and accurately predict the responsiveness of cancer patients to immunotherapy and the survival prognosis of patients, thus enabling suitable treatments for patient groups, which may result in improved therapeutic effects and a reduction in pain and costs for patients.
Inventors:
JOUNG JE GUN (KR)
KANG HAE YOUN (KR)
AN HEE JUNG (KR)
HWANG SO HYUN (KR)
PARK HYUN (KR)
CHOI MIN CHUL (KR)
JOO WON DUK (KR)
JEONG JU YEON (KR)
KANG HAE YOUN (KR)
AN HEE JUNG (KR)
HWANG SO HYUN (KR)
PARK HYUN (KR)
CHOI MIN CHUL (KR)
JOO WON DUK (KR)
JEONG JU YEON (KR)
Application Number:
PCT/KR2023/017681
Publication Date:
May 16, 2024
Filing Date:
November 06, 2023
Export Citation:
Assignee:
SUNGKWANG MEDICAL FOUND (KR)
UNIV CHA IND ACAD COOP FOUND (KR)
UNIV CHA IND ACAD COOP FOUND (KR)
International Classes:
C12Q1/6886; G01N33/574
Foreign References:
| KR20210068304A | 2021-06-09 | |||
| KR20220067657A | 2022-05-25 | |||
| KR20200140207A | 2020-12-15 | |||
| US20190038734A1 | 2019-02-07 |
Other References:
LARROQUETTE MATHIEU, GUEGAN JEAN-PHILIPPE, BESSE BENJAMIN, COUSIN SOPHIE, BRUNET MAXIME, LE MOULEC SYLVESTRE, LE LOARER FRANÇOIS, : "Spatial transcriptomics of macrophage infiltration in non-small cell lung cancer reveals determinants of sensitivity and resistance to anti-PD1/PD-L1 antibodies", JOURNAL FOR IMMUNOTHERAPY OF CANCER, vol. 10, no. 5, 1 May 2022 (2022-05-01), pages e003890, XP093046993, DOI: 10.1136/jitc-2021-003890
Attorney, Agent or Firm:
NAM IP GROUP (KR)
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