Title:
BIOMARKER FOR PREDICTING PROGNOSIS OF RADIOTHERAPY FOR LUNG CANCER
Document Type and Number:
WIPO Patent Application WO/2021/167352
Kind Code:
A1
Abstract:
The present invention provides a method for providing information for diagnosis of metastasis of radiotherapy-treated lung cancer, the method comprising the steps of: (a) measuring an expression level of receptor-interacting protein 1 (RIP1) in a sample from a lung cancer patient who has undergone radiotherapy; (b) measuring an expression level of RIP1 in a normal control sample; and (c) comparing the expression levels of step (a) and step (b).
Inventors:
PARK JONG KUK (KR)
UM HONG DUCK (KR)
HWANG SANG GU (KR)
SONG JIE YOUNG (KR)
CHO JEONG HYUN (KR)
UM HONG DUCK (KR)
HWANG SANG GU (KR)
SONG JIE YOUNG (KR)
CHO JEONG HYUN (KR)
Application Number:
PCT/KR2021/002039
Publication Date:
August 26, 2021
Filing Date:
February 17, 2021
Export Citation:
Assignee:
KOREA INST RADIOLOGICAL & MEDICAL SCIENCES (KR)
International Classes:
G01N33/68; G01N33/574
Foreign References:
| KR102028967B1 | 2019-10-07 | |||
| KR20150028965A | 2015-03-17 |
Other References:
CHO JEONG HYUN; HONG WAN GI; JUNG YU-JIN; LEE JAESEOK; LEE EUNAH; HWANG SANG-GU; UM HONG-DUCK; PARK JONG KUK: "Γ-Ionizing radiation-induced activation of the EGFR-p38/ERK-STAT3/CREB-1-EMT pathway promotes the migration/invasion of non-small cell lung cancer cells and is inhibited by podophyllotoxin acetate", TUMOR BIOLOGY, vol. 37, no. 6, 15 December 2015 (2015-12-15), pages 7315 - 7325, XP035795963, ISSN: 1010-4283, DOI: 10.1007/s13277-015-4548-y
ANONYMOUS: "Investigation of RIPK protein family as a target of personalized medicine against lung cancer metastasis", KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES, 22 May 2017 (2017-05-22), pages 1 - 18
JONG KUK PARK;SU JIN JANG;SUNG WOOK KANG;SUNHOO PARK;SANG-GU HWANG;WUN-JAE KIM;JOO HYUN KANG;HONG-DUCK UM: "Establishment of animal model for the analysis of cancer cell metastasis during radiotherapy", RADIATION ONCOLOGY, vol. 7, no. 153, 11 September 2012 (2012-09-11), pages 1 - 11, XP021122457, ISSN: 1748-717X, DOI: 10.1186/1748-717X-7-153
JEONG HYUN CHO, JUNG LIM KIM, HONG-DUCK UM, SANG-GU HWANG, EUNAH LEE, SANG-CHURL OH AND JONG KUK PARK: "Abstract 1973: RIP1 and its signaling network regulate radiation-induced modification of cancer microenvironment", AACR ANNUAL MEETING, vol. 79, no. 13, Suppl., 1 July 2019 (2019-07-01), pages 1 - 3, XP009529877, DOI: 10.1158/1538-7445.AM2019-1973
ANONYMOUS: "Investigation of RIPK protein family as a target of personalized medicine against lung cancer metastasis", KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES, 22 May 2017 (2017-05-22), pages 1 - 18
JONG KUK PARK;SU JIN JANG;SUNG WOOK KANG;SUNHOO PARK;SANG-GU HWANG;WUN-JAE KIM;JOO HYUN KANG;HONG-DUCK UM: "Establishment of animal model for the analysis of cancer cell metastasis during radiotherapy", RADIATION ONCOLOGY, vol. 7, no. 153, 11 September 2012 (2012-09-11), pages 1 - 11, XP021122457, ISSN: 1748-717X, DOI: 10.1186/1748-717X-7-153
JEONG HYUN CHO, JUNG LIM KIM, HONG-DUCK UM, SANG-GU HWANG, EUNAH LEE, SANG-CHURL OH AND JONG KUK PARK: "Abstract 1973: RIP1 and its signaling network regulate radiation-induced modification of cancer microenvironment", AACR ANNUAL MEETING, vol. 79, no. 13, Suppl., 1 July 2019 (2019-07-01), pages 1 - 3, XP009529877, DOI: 10.1158/1538-7445.AM2019-1973
Attorney, Agent or Firm:
KIM, Soon Woong (KR)
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