Title:
BIOMARKER FOR PROGNOSIS PREDICTION OF NEURODEGENERATIVE DISEASES, COMPRISING MIRNAS, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/240251
Kind Code:
A1
Abstract:
The present invention relates to a biomarker for predicting the prognosis of neurodegenerative diseases, and a use thereof, and, more particularly, to: a marker composition for prognosis prediction of neurodegenerative diseases, comprising miRNA-214 and/or miRNA-34c; a composition and a kit for prognosis prediction of neurodegenerative diseases, comprising an agent for measuring the expression level of the miRNAs; and a method for predicting the prognosis of neurodegenerative diseases by using the marker. It has been identified that the miRNA-214 and/or miRNA-34c according to the present invention can regulate phagocytic capacity modulator of microglia, NKCAP1 so that the prognosis of neurodegenerative diseases can be predicted, and thus it is expected that the present invention can be effectively used as a biomarker for predicting the prognosis of neurodegenerative diseases.
Inventors:
KIM SEUNG HYUN (KR)
NOH MIN YOUNG (KR)
NOH MIN YOUNG (KR)
Application Number:
PCT/KR2022/006918
Publication Date:
November 17, 2022
Filing Date:
May 13, 2022
Export Citation:
Assignee:
IUCF HYU (KR)
International Classes:
C12Q1/6883
Domestic Patent References:
| WO2020113271A1 | 2020-06-11 | |||
| WO2017161256A1 | 2017-09-21 |
Foreign References:
| CN103028122A | 2013-04-10 | |||
| US20190002982A1 | 2019-01-03 | |||
| US20190249250A1 | 2019-08-15 |
Other References:
XIAO CHENG-ZUO; WEI WEI; GUO ZHI-XING; ZHANG MEI-YIN; ZHANG YONG-FA; WANG JIA-HONG; SHI MING; WANG HUI-YUN; GUO RONG-PING: "MicroRNA-34c-3p promotes cell proliferation and invasion in hepatocellular carcinoma by regulation of NCKAP1 expression", JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, SPRINGER INTERNATIONAL, BERLIN., DE, vol. 143, no. 2, 4 October 2016 (2016-10-04), DE , pages 263 - 273, XP036142962, ISSN: 0171-5216, DOI: 10.1007/s00432-016-2280-7
NOH MIN-YOUNG, KWON MIN-SOO, OH KI-WOOK, NAHM MINYEOP, PARK JINSEOK, KIM YOUNG-EUN, KI CHANG-SEOK, JIN HEE KYUNG, BAE JAE-SUNG, KI: "Defective phagocytic function of induced microglia-like cells is correlated with rapid progression of sporadic ALS", RESEARCH SQUARE, 19 May 2020 (2020-05-19), pages 1 - 42, XP093003891, [retrieved on 20221201], DOI: 10.21203/rs.3.rs-29976/v1
AFZAL TAYYAB ADEEL, LUONG LE ANH, CHEN DAN, ZHANG CHENG, YANG FENG, CHEN QISHAN, AN WEIWEI, WILKES EDMUND, YASHIRO KENTA, CUTILLAS: "NCK Associated Protein 1 Modulated by miRNA‐214 Determines Vascular Smooth Muscle Cell Migration, Proliferation, and Neointima Hyperplasia", JOURNAL OF THE AMERICAN HEART ASSOCIATION, vol. 5, no. 12, 19 December 2016 (2016-12-19), XP093004757, DOI: 10.1161/JAHA.116.004629
NOH MIN-YOUNG, KWON MIN-SOO, OH KI-WOOK, NAHM MINYEOP, PARK JINSEOK, KIM YOUNG-EUN, JIN HEE KYUNG, BAE JAE-SUNG, KI CHANG-SEOK, KI: "Plasma miRNA-214 is a predictive candidate biomarker of progression speed in patients with ALS", BIORXIV, 4 May 2022 (2022-05-04), XP093004760, Retrieved from the Internet [retrieved on 20221205], DOI: 10.1101/2022.05.04.490596
NOH MIN-YOUNG, KWON MIN-SOO, OH KI-WOOK, NAHM MINYEOP, PARK JINSEOK, KIM YOUNG-EUN, KI CHANG-SEOK, JIN HEE KYUNG, BAE JAE-SUNG, KI: "Defective phagocytic function of induced microglia-like cells is correlated with rapid progression of sporadic ALS", RESEARCH SQUARE, 19 May 2020 (2020-05-19), pages 1 - 42, XP093003891, [retrieved on 20221201], DOI: 10.21203/rs.3.rs-29976/v1
AFZAL TAYYAB ADEEL, LUONG LE ANH, CHEN DAN, ZHANG CHENG, YANG FENG, CHEN QISHAN, AN WEIWEI, WILKES EDMUND, YASHIRO KENTA, CUTILLAS: "NCK Associated Protein 1 Modulated by miRNA‐214 Determines Vascular Smooth Muscle Cell Migration, Proliferation, and Neointima Hyperplasia", JOURNAL OF THE AMERICAN HEART ASSOCIATION, vol. 5, no. 12, 19 December 2016 (2016-12-19), XP093004757, DOI: 10.1161/JAHA.116.004629
NOH MIN-YOUNG, KWON MIN-SOO, OH KI-WOOK, NAHM MINYEOP, PARK JINSEOK, KIM YOUNG-EUN, JIN HEE KYUNG, BAE JAE-SUNG, KI CHANG-SEOK, KI: "Plasma miRNA-214 is a predictive candidate biomarker of progression speed in patients with ALS", BIORXIV, 4 May 2022 (2022-05-04), XP093004760, Retrieved from the Internet
Attorney, Agent or Firm:
ISIS IP LAW LLC (KR)
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