Title:
BIOMARKER, SYSTEM, METHOD, AND KIT FOR ASSESSING EFFICACY OF TUMOR IBC THERAPY
Document Type and Number:
WIPO Patent Application WO/2023/185985
Kind Code:
A1
Abstract:
Provided are a biomarker, a system, a method, and a kit for assessing the efficacy of tumor IBC therapy. The biomarker comprises circ-TMTC3 and/or circ-FAM117B. The biomarker, on the basis of circRNA development, has more stable tissue-specific expression and evolutionary conservation than linear mRNA, thus being stronger in specificity and higher in stability for assessing the efficacy of the tumor IBC therapy.
Inventors:
YE YOUQIONG (CN)
DONG YU (CN)
LIU HONG (CN)
GAO QIAN (CN)
DONG YU (CN)
LIU HONG (CN)
GAO QIAN (CN)
Application Number:
PCT/CN2023/084977
Publication Date:
October 05, 2023
Filing Date:
March 30, 2023
Export Citation:
Assignee:
SUZHOU JIZHI MEDICAL CORP (CN)
International Classes:
C12N15/11; C12Q1/6886; G16B25/10; G16B25/20; G16B30/10; G16B40/10; G16H50/30
Domestic Patent References:
| WO2009027524A1 | 2009-03-05 | |||
| WO2020243329A1 | 2020-12-03 |
Foreign References:
| CN114875144A | 2022-08-09 | |||
| US20150218640A1 | 2015-08-06 | |||
| US20210079474A1 | 2021-03-18 |
Other References:
SU HUA, WANG GUOWEN, WU LINGFANG, MA XIUQING, YING KEJING, ZHANG RUIFENG: "Transcriptome-wide map of m6A circRNAs identified in a rat model of hypoxia mediated pulmonary hypertension", BMC GENOMICS, vol. 21, no. 1, 13 January 2020 (2020-01-13), pages 39, XP093097380, DOI: 10.1186/s12864-020-6462-y
DATABASE Nucleotide 2 January 2022 (2022-01-02), ANONYMOUS : "Homo sapiens transmembrane O-mannosyltransferase targeting cadherins 3 (TMTC3), transcript variant 6, non-coding RNA", XP093097741, retrieved from NCBI Database accession no. NR_159381.1
DATABASE Nucleotide 2 January 2022 (2022-01-02), ANONYMOUS : "Homo sapiens transmembrane O-mannosyltransferase targeting cadherins 3 (TMTC3), transcript variant 6, non-coding RNA", XP093097741, retrieved from NCBI Database accession no. NR_159381.1
Attorney, Agent or Firm:
SHANGHAI GOOIP CO., LTD. (CN)
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