Title:
BIOMARKERS AND METHODS TO PREDICT RESPONSE TO INHIBITORS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2014/055543
Kind Code:
A3
Abstract:
Disclosed herein are markers associated with sensitivity to treatment with therapeutic agents. Methods to identify markers for predicting outcome to treatment with a therapeutic agent are disclosed as well as methods to predict outcome of treatment using markers. Compositions and methods are provided to predict response to NAE inhibition or EGFR inhibition treatment.
Inventors:
BLAKEMORE STEPHEN J (US)
LI BIN (US)
SHIN HYUNJIN (US)
TREPICCHIO WILLIAM L (US)
LI BIN (US)
SHIN HYUNJIN (US)
TREPICCHIO WILLIAM L (US)
Application Number:
PCT/US2013/062902
Publication Date:
June 19, 2014
Filing Date:
October 01, 2013
Export Citation:
Assignee:
MILLENNIUM PHARM INC (US)
International Classes:
C12Q1/68; G01N33/53; G16B5/00
Domestic Patent References:
| WO2011130402A2 | 2011-10-20 |
Foreign References:
| US20110287974A1 | 2011-11-24 | |||
| US20120214829A1 | 2012-08-23 | |||
| US20110081362A1 | 2011-04-07 |
Other References:
LI ET AL.: "Investigation of efficacy of the NAE inhibitor MLN4924 across large-scale cell line panels reveals potentially sensitive cancer indications and candidate predictive biomarkers.", MOLECULAR CANCER THERAPEUTICS, vol. 10, no. 11, 2011, pages A45, XP055153902
MILHOLLEN ET AL.: "Treatment-emergent mutations in NAEbeta confer resistance to the NEDDB-activating enzyme inhibitor MLN4924.", CANCER CELL, vol. 21, no. 3, 20 March 2012 (2012-03-20), pages 388 - 401, XP028473640
GUIHARD ET AL.: "The NEDD8 conjugation pathway regulates p53 transcriptional activity and head and neck cancer cell sensitivity to ionizing radiation.", I NT J ONCOL., vol. 41, no. 4, 7 August 2012 (2012-08-07), pages 1531 - 40, XP055243698
LUO ET AL.: "Inactivation of the Cullin (CUL)-RING E3 ligase by the NEDD8-activating enzyme inhibitor MLN4924 triggers protective autophagy in cancer cells.", AUTOPHAGY, vol. 8, no. 11, 9 August 2012 (2012-08-09), pages 1677 - 9, XP055243701
TANAKA ET AL.: "Inhibition of NEDD8-conjugation pathway by novel molecules: potential approaches to anticancer therapy.", MOL ONCOL., vol. 6, no. 3, 21 January 2012 (2012-01-21), pages 267 - 75, XP055033291
TOTH ET AL.: "A Gatekeeper Residue for NEDD8-Activating Enzyme Inhibition by MLN4924.", CELL REPORTS, vol. 1, no. 4, 19 March 2012 (2012-03-19), pages 309 - 316, XP055243705
LIAO ET AL.: "Quantitative proteomic analysis of cellular protein modulation upon inhibition of the NEDD8*-activating enzyme by MLN4924.", MOL CELL PROTEOMICS, vol. 10, no. 11, 2011, pages M111 - 009183, XP055151079
MACKINTOSH ET AL.: "WEE1 accumulation and deregulation of S-phase proteins mediate MLN4924 potent inhibitory effect on Ewing sarcoma cells.", ONCOGENE, vol. 32, no. 11, 28 May 2012 (2012-05-28), pages 1441 - 1451, XP055243714
WEI ET AL.: "Radiosensitization of human pancreatic cancer cells by MLN4924, an investigational NEDD8-activating enzyme inhibitor.", CANCER RES., vol. 72, no. 1, 9 November 2011 (2011-11-09), pages 282 - 293, XP055243715
MILHOLLEN ET AL.: "Treatment-emergent mutations in NAEbeta confer resistance to the NEDDB-activating enzyme inhibitor MLN4924.", CANCER CELL, vol. 21, no. 3, 20 March 2012 (2012-03-20), pages 388 - 401, XP028473640
GUIHARD ET AL.: "The NEDD8 conjugation pathway regulates p53 transcriptional activity and head and neck cancer cell sensitivity to ionizing radiation.", I NT J ONCOL., vol. 41, no. 4, 7 August 2012 (2012-08-07), pages 1531 - 40, XP055243698
LUO ET AL.: "Inactivation of the Cullin (CUL)-RING E3 ligase by the NEDD8-activating enzyme inhibitor MLN4924 triggers protective autophagy in cancer cells.", AUTOPHAGY, vol. 8, no. 11, 9 August 2012 (2012-08-09), pages 1677 - 9, XP055243701
TANAKA ET AL.: "Inhibition of NEDD8-conjugation pathway by novel molecules: potential approaches to anticancer therapy.", MOL ONCOL., vol. 6, no. 3, 21 January 2012 (2012-01-21), pages 267 - 75, XP055033291
TOTH ET AL.: "A Gatekeeper Residue for NEDD8-Activating Enzyme Inhibition by MLN4924.", CELL REPORTS, vol. 1, no. 4, 19 March 2012 (2012-03-19), pages 309 - 316, XP055243705
LIAO ET AL.: "Quantitative proteomic analysis of cellular protein modulation upon inhibition of the NEDD8*-activating enzyme by MLN4924.", MOL CELL PROTEOMICS, vol. 10, no. 11, 2011, pages M111 - 009183, XP055151079
MACKINTOSH ET AL.: "WEE1 accumulation and deregulation of S-phase proteins mediate MLN4924 potent inhibitory effect on Ewing sarcoma cells.", ONCOGENE, vol. 32, no. 11, 28 May 2012 (2012-05-28), pages 1441 - 1451, XP055243714
WEI ET AL.: "Radiosensitization of human pancreatic cancer cells by MLN4924, an investigational NEDD8-activating enzyme inhibitor.", CANCER RES., vol. 72, no. 1, 9 November 2011 (2011-11-09), pages 282 - 293, XP055243715
Attorney, Agent or Firm:
SIOUSSAT, Tracy, M. et al. (INC.40 Landsdowne Stree, Cambridge MA, US)
Download PDF:
Previous Patent: MEMS PRESSURE SENSOR ASSEMBLY
Next Patent: TREATING VASCULAR DISEASE AND COMPLICATIONS THEREOF
Next Patent: TREATING VASCULAR DISEASE AND COMPLICATIONS THEREOF