Title:
BIOMARKERS AND USES THEREOF IN THE TREATMENT OF CHRONIC HBV INFECTION
Document Type and Number:
WIPO Patent Application WO/2022/049504
Kind Code:
A3
Abstract:
Immunogenetic biomarkers of viral control of chronic hepatitis B (CHB) infection that are indicative of relapse after a viral suppression treatment, such as a NUC treatment, in CHB infected subject are described. Also described are methods and compositions of using the immunogenetic biomarkers in predicting the relapse in the viral suppression treatment of CHB infection.
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Inventors:
TUEFFERD MARIANNE ISABELLE (BE)
CRABBE MARJOLEIN (BE)
BOLLEKENS JACQUES ARMAND HENRI (BE)
AERSSENS JEROEN MARCEL MARIA ROGER (BE)
DI CARA ALESSANDRO (CH)
CRABBE MARJOLEIN (BE)
BOLLEKENS JACQUES ARMAND HENRI (BE)
AERSSENS JEROEN MARCEL MARIA ROGER (BE)
DI CARA ALESSANDRO (CH)
Application Number:
PCT/IB2021/057990
Publication Date:
June 09, 2022
Filing Date:
September 01, 2021
Export Citation:
Assignee:
JANSSEN SCIENCES IRELAND UNLIMITED CO (IE)
International Classes:
C12Q1/6881; C12Q1/70
Domestic Patent References:
| WO2018223185A1 | 2018-12-13 | |||
| WO2021156828A2 | 2021-08-12 |
Other References:
TUNG-HUNG SU ET AL: "Distinct Relapse Rates and Risk Predictors After Discontinuing Tenofovir and Entecavir Therapy", THE JOURNAL OF INFECTIOUS DISEASES, INFECTIOUS DISEASES SOCIETY OF AMERICA, US, vol. 217, no. 8, 28 March 2018 (2018-03-28), pages 1193 - 1201, XP002800103, ISSN: 1537-6613, DOI: 10.1093/INFDIS/JIX690
O'BRIEN THOMAS R ET AL: "Genetic Factors That Affect Spontaneous Clearance of Hepatitis C or B Virus, Response to Treatment, and Disease Progression", GASTROENTEROLOGY, ELSEVIER INC, US, vol. 156, no. 2, 1 October 2018 (2018-10-01), pages 400 - 417, XP085581734, ISSN: 0016-5085, DOI: 10.1053/J.GASTRO.2018.09.052
PIERINI FEDERICA ET AL: "Divergent Allele Advantage at Human MHC Genes: Signatures of Past and Ongoing Selection", MOLECULAR BIOLOGY AND EVOLUTION, vol. 35, no. 9, 1 September 2018 (2018-09-01), US, pages 2145 - 2158, XP055862421, ISSN: 0737-4038, Retrieved from the Internet DOI: 10.1093/molbev/msy116
O'BRIEN THOMAS R ET AL: "Genetic Factors That Affect Spontaneous Clearance of Hepatitis C or B Virus, Response to Treatment, and Disease Progression", GASTROENTEROLOGY, ELSEVIER INC, US, vol. 156, no. 2, 1 October 2018 (2018-10-01), pages 400 - 417, XP085581734, ISSN: 0016-5085, DOI: 10.1053/J.GASTRO.2018.09.052
PIERINI FEDERICA ET AL: "Divergent Allele Advantage at Human MHC Genes: Signatures of Past and Ongoing Selection", MOLECULAR BIOLOGY AND EVOLUTION, vol. 35, no. 9, 1 September 2018 (2018-09-01), US, pages 2145 - 2158, XP055862421, ISSN: 0737-4038, Retrieved from the Internet
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