BIONIC AORTIC BAROREFLEX SYSTEM FOR TREATING DISEASE ASSOCIATED WITH AORTIC BAROREFLEX DYSFUNCTION

WIPO Patent Application WO/2012/039420

A1

The present invention provides a bionic aortic baroreflex system which restores normal volume tolerance in the absence of physiological aortic baroreflex and, therefore, is useful in treating HFpEF. More specifically, the invention provides a bionic aortic baroreflex system comprising: an aortic pressure sensing means (aortic pressure (AP) sensor) for sensing aortic pressure data from a living organism and outputting an aortic pressure signal; a calculation means (regulator) for inputting the aortic pressure signal, which is sensed by the aortic pressure sensing means, calculating a clinically effective aortic depressor nerve stimulation signal and outputting the aortic depressor nerve stimulation signal; and an aortic depressor nerve stimulation means (electrical nerve stimulator) for inputting the aortic depressor nerve stimulation signal, which is calculated by the calculation means, and stimulating the aortic depressor nerve of the living organism on the basis of the aortic depressor nerve stimulation signal.

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SUNAGAWA KENJI (JP)
FUNAKOSHI KOUTA (JP)
HOSOKAWA KAZUYA (JP)

PCT/JP2011/071470

March 29, 2012

September 21, 2011

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UNIV KYUSHU NAT UNIV CORP (JP)
SUNAGAWA KENJI (JP)
FUNAKOSHI KOUTA (JP)
HOSOKAWA KAZUYA (JP)

A61N1/36

WO2004012814A1

2004-02-12

JP2009512505A	2009-03-26
JP2007537823A	2007-12-27

ONO, Shinjiro et al. (JP)
Ono Shinjiro (JP)

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