Title:
BIONIC NANOPARTICLE COATED WITH MESENCHYMAL STEM CELL MEMBRANE HAVING SURFACE OVEREXPRESSING PD-L1 MOLECULE, AND PREPARATION THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/174738
Kind Code:
A1
Abstract:
The present invention relates to a bionic nanoparticle coated with a mesenchymal stem cell membrane having a surface overexpressing a PD-L1 molecule, and preparation therefor and an application thereof. In the present invention, the bionic nanoparticle coated with the mesenchymal stem cell membrane having the surface overexpressing the PD-L1 molecule comprises a nanocore and a mesenchymal stem cell membrane wrapping the nanocore; the nanocore comprises a polymer having biocompatibility; and the PD-L1 molecule is overexpressed by the membrane surface of the mesenchymal stem cell membrane. Also disclosed in the present invention is an application of the bionic nanoparticle coated with the mesenchymal stem cell membrane having the surface overexpressing the PD-L1 molecule in preparation of an inflammation treatment preparation. The bionic nanoparticle of the present invention has a remarkable immunosuppressive effect, is good in biocompatibility, and simple and mature in preparation process, and may be used for preparing the inflammation treatment preparation; the preparation may be effectively concentrated in an inflammatory site, and exhibits an excellent treatment effect in inflammation treatment by suppressing excessively activated immune response and cytokine storm of the inflammatory site.
Inventors:
WANG CHAO (CN)
SEHN SHUFANG (CN)
SEHN SHUFANG (CN)
Application Number:
PCT/CN2020/100632
Publication Date:
September 10, 2021
Filing Date:
July 07, 2020
Export Citation:
Assignee:
UNIV SOOCHOW (CN)
International Classes:
A61K35/28; A61K9/16; A61K47/34; A61K47/36; A61P1/00; A61P1/16; A61P9/00; A61P11/00; A61P13/12; A61P25/00; A61P29/00; A61P31/04; A61P31/10; A61P31/12; A61P33/02; A61P33/10; A61P37/06; C12N5/0775
Foreign References:
| CN111265549A | 2020-06-12 | |||
| CN109715787A | 2019-05-03 | |||
| CN108699253A | 2018-10-23 | |||
| CN103857387A | 2014-06-11 | |||
| CN110088623A | 2019-08-02 |
Other References:
GONÇALVES FABIANY DA C., LUK FRANKA, KOREVAAR SANDER S., BOUZID RACHID, PAZ ANA H., LÓPEZ-IGLESIAS CARMEN, BAAN CARLA C., MERINO A: "Membrane particles generated from mesenchymal stromal cells modulate immune responses by selective targeting of pro-inflammatory monocytes", SCIENTIFIC REPORTS, vol. 7, no. 1, 1 December 2017 (2017-12-01), US, pages 12100, 1 - 12100, 13, XP055842289, ISSN: 2045-2322, DOI: 10.1038/s41598-017-12121-z
Attorney, Agent or Firm:
CENTRAL SOUTH WELL INTELLECTUAL PROPERTY OFFICE (CN)
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