Title:
BIOSYNTHESIS OF APOCAROTENOIDS BY CONTROLLING OXIDATIVE STRESS
Document Type and Number:
WIPO Patent Application WO/2023/167638
Kind Code:
A3
Abstract:
The present invention relates to host cells comprising genes of the mevalonate, lycopene and α-ionone pathways and the hydroperoxide reductase or catalase genes. The present invention also relates to methods of producing apocarotenoids as well as kits for producing apocarotenoids comprising the host cells. In one embodiment, the hydroperoxide reductase isolated from Escherichia coli is alkyl hydroperoxide reductase (ahpC/F), wherein the catalase isolated from Escherichia coli is catalase G (KatG).
Inventors:
HUANG CHING-NING (SG)
CHEN XIXIAN (SG)
ZHANG CONGQIANG (SG)
CHEN XIXIAN (SG)
ZHANG CONGQIANG (SG)
Application Number:
PCT/SG2023/050123
Publication Date:
October 05, 2023
Filing Date:
March 01, 2023
Export Citation:
Assignee:
AGENCY SCIENCE TECH & RES (SG)
FERMATICS PTE LTD (SG)
FERMATICS PTE LTD (SG)
International Classes:
C12P7/24; C12N1/21; C12R1/19
Domestic Patent References:
| WO2018156086A1 | 2018-08-30 | |||
| WO2021067974A1 | 2021-04-08 |
Other References:
HUANG CHING-NING, LIM XIAOHUI, ONG LEONARD, LIM CHINCHIN, CHEN XIXIAN, ZHANG CONGQIANG: "Mediating oxidative stress enhances α-ionone biosynthesis and strain robustness during process scaling up", MICROBIAL CELL FACTORIES, vol. 21, no. 1, XP093098924, DOI: 10.1186/s12934-022-01968-1
Attorney, Agent or Firm:
SPRUSON & FERGUSON (ASIA) PTE LTD (SG)
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