Title:
BIS AROMATIC COMPOUNDS FOR USE AS LTC4 SYNTHASE INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2010/103278
Kind Code:
A1
Abstract:
There is provided compounds of formula (I), wherein E1, E2a, E2b, E2c, E4, D1, D2, D3, L1, Y1, L2 and Y2 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C4 synthase is desired and/or required, and particularly in the treatment of a respiratory disorder and/or inflammation.
Inventors:
NILSSON PETER (SE)
PELCMAN BENJAMIN (SE)
KATKEVICS MARTINS (LV)
PELCMAN BENJAMIN (SE)
KATKEVICS MARTINS (LV)
Application Number:
PCT/GB2010/000438
Publication Date:
September 16, 2010
Filing Date:
March 12, 2010
Export Citation:
Assignee:
BIOLIPOX AB (SE)
NILSSON PETER (SE)
PELCMAN BENJAMIN (SE)
KATKEVICS MARTINS (LV)
NILSSON PETER (SE)
PELCMAN BENJAMIN (SE)
KATKEVICS MARTINS (LV)
International Classes:
A61K31/4406; C07D213/50; A61P11/00; A61P29/00; C07D213/65; C07D213/74; C07D401/10; C07D405/12; C07D409/12
Domestic Patent References:
| WO2008107661A1 | 2008-09-12 | |||
| WO2009030887A2 | 2009-03-12 | |||
| WO2008107661A1 | 2008-09-12 | |||
| WO2009030887A2 | 2009-03-12 | |||
| WO2006077366A1 | 2006-07-27 |
Foreign References:
| US20050256102A1 | 2005-11-17 |
Other References:
S.-E. DAHLEN, J. INTERNAL MED., vol. 245, 1999, pages 205
ORGANIC AND BIOMOLECULAR CHEMISTRY, vol. 5, no. 3, 2007, pages 494 - 500
TETRAHEDRON LETTERS, vol. 47, no. 34, 2006, pages 6063 - 6066
SYNTHESIS, vol. 21, 2006, pages 3547 - 3574
TETRAHEDRON LETTERS, vol. 62, no. 50, 2006, pages 11675 - 11678
SYNTHESIS, 2006, pages 2618 - 2623
PHARMAZIE, vol. 61, no. 6, 2006, pages 505 - 510
SYNTHETIC COMMUNICATIONS, vol. 36, no. 10, 2006, pages 1405 - 1411
BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 14, no. 4, 2004, pages 1023 - 1026
ORGANIC LETTERS, vol. 8, no. 26, 2006, pages 5987 - 5990
JOURNAL OF ORGANIC CHEMISTRY, vol. 71, no. 9, 2006, pages 3551 - 3558
TAKEMIYA ET AL., J. AM. CHEM. SOC., vol. 128, 2006, pages 14800
B. M. TROST; I. FLEMING: "Comprehensive Organic Synthesis", 1991, PERGAMON PRESS
A. R. KATRITZKY; O. METH-COHN; C. W. REES: "Comprehensive Organic Functional Group Transformations", 1995, PERGAMON PRESS
J. A. JOULE; K. MILLS; G. F. SMITH: "Heterocyclic Chemistry", CHAPMAN & HALL
A. R. KATRITZKY; C. W. REES; E. F. V. SCRIVEN: "Comprehensive Heterocyclic Chemistry If", 1996, PERGAMON PRESS
"Science of Synthesis", vol. 9-17, 2006, GEORG THIEME VERLAG, article "Hetarenes and Related Ring Systems"
T.W. GREENE; P.G.M. WUTZ: "Protective Groups in Organic Synthesis", 1999, WILEY-INTERSCIENCE
MOL. PHARMACOL., vol. 41, 1992, pages 873 - 879
ORGANIC AND BIOMOLECULAR CHEMISTRY, vol. 5, no. 3, 2007, pages 494 - 500
TETRAHEDRON LETTERS, vol. 47, no. 34, 2006, pages 6063 - 6066
SYNTHESIS, vol. 21, 2006, pages 3547 - 3574
TETRAHEDRON LETTERS, vol. 62, no. 50, 2006, pages 11675 - 11678
SYNTHESIS, 2006, pages 2618 - 2623
PHARMAZIE, vol. 61, no. 6, 2006, pages 505 - 510
SYNTHETIC COMMUNICATIONS, vol. 36, no. 10, 2006, pages 1405 - 1411
BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 14, no. 4, 2004, pages 1023 - 1026
ORGANIC LETTERS, vol. 8, no. 26, 2006, pages 5987 - 5990
JOURNAL OF ORGANIC CHEMISTRY, vol. 71, no. 9, 2006, pages 3551 - 3558
TAKEMIYA ET AL., J. AM. CHEM. SOC., vol. 128, 2006, pages 14800
B. M. TROST; I. FLEMING: "Comprehensive Organic Synthesis", 1991, PERGAMON PRESS
A. R. KATRITZKY; O. METH-COHN; C. W. REES: "Comprehensive Organic Functional Group Transformations", 1995, PERGAMON PRESS
J. A. JOULE; K. MILLS; G. F. SMITH: "Heterocyclic Chemistry", CHAPMAN & HALL
A. R. KATRITZKY; C. W. REES; E. F. V. SCRIVEN: "Comprehensive Heterocyclic Chemistry If", 1996, PERGAMON PRESS
"Science of Synthesis", vol. 9-17, 2006, GEORG THIEME VERLAG, article "Hetarenes and Related Ring Systems"
T.W. GREENE; P.G.M. WUTZ: "Protective Groups in Organic Synthesis", 1999, WILEY-INTERSCIENCE
MOL. PHARMACOL., vol. 41, 1992, pages 873 - 879
Attorney, Agent or Firm:
MCNEENEY, Stephen (Park View House58 The Ropewalk, Nottingham NG1 5DD, GB)
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