BIS-DIOXOPIPERAZINE DERIVATIVES

Title:

BIS-DIOXOPIPERAZINE DERIVATIVES

Document Type and Number:

WIPO Patent Application WO/1987/004707

Kind Code:

A1

Abstract:

Novel bis-dioxopiperazine derivatives represented by formula (I), (wherein, R1 represents a lower alkyl group; R2 represents a hydrogen atom or a group of formula (II), R3 represents a lower alkyl group, a substituted or unsubstituted phenyl group, a substituted or unsubstituted furyl group, a substituted or unsubstituted styryl group, or a group of -(CH2)n-R4, formula (III), or -OR7 (wherein R4 represents a carboxyl group, a substituted or unsubstituted phenyl group or a substituted or unsubstituted phenoxy group, R5 and R6 each represents a hydrogen atom or a protective group of the amino group, R7 represents a lower alkyl group or a substituted or unsubstituted benzyl group, and n represents an integer of 1 or 2)) or the pharmaceutically acceptable salts thereof are disclosed. These compounds have a wide antineoplastic spectrum.

Inventors:

TAKASE MUNEAKI (JP)
CAI JUN-CHAO (JP)

Application Number:

PCT/JP1987/000074

Publication Date:

August 13, 1987

Filing Date:

February 05, 1987

Export Citation:

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Assignee:

ZENYAKU KOGYO KK (JP)

International Classes:

A61K31/495; A61P35/00; C07D241/06; C07D241/08; C07D405/14; (IPC1-7): C07D241/08; C07D405/14

Foreign References:

JPH0697963A	1994-04-08
FR2012129A1	1970-03-13
JPS61152660A	1986-07-11

Other References: