Title:
A BISPECIFIC ANTI-PD-L1/VEGF ANTIBODY AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/147829
Kind Code:
A1
Abstract:
Provided are bispecific anti-VEGF x PD-L1 antibody or antigen-binding portion thereof, methods of producing the bispecific antibody or antigen-binding portion thereof, and methods of treating diseases or conditions using the bispecific antibody or antigen-binding portion thereof.
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Inventors:
WANG ZHUOZHI (CN)
CHEN YUNYING (CN)
LI DONG (CN)
LI JING (CN)
CHEN YUNYING (CN)
LI DONG (CN)
LI JING (CN)
Application Number:
PCT/CN2021/072584
Publication Date:
July 29, 2021
Filing Date:
January 19, 2021
Export Citation:
Assignee:
WUXI BIOLOGICS SHANGHAI CO LTD (CN)
International Classes:
C07K16/22; A61K39/395; A61K47/68; A61P35/00; A61P37/02; C07K16/28; C12N15/13; C12N15/85
Domestic Patent References:
| WO2019154349A1 | 2019-08-15 |
Foreign References:
| CN110305210A | 2019-10-08 | |||
| CN109942712A | 2019-06-28 | |||
| CN109575140A | 2019-04-05 |
Other References:
MIKAMI SHUJI, MIKAMI SHUJI, MIZUNO RYUICHI, KONDO TSUNENORI, SHINOHARA NOBUO, NONOMURA NORIO, OZONO SEIICHIRO, ETO MASATOSHI, TATS: "Clinical significance of programmed death‐1 and programmed death‐ligand 1 expression in the tumor microenvironment of clear cell renal cell carcinoma", CANCER SCIENCE, JAPANESE CANCER ASSOCIATION, TOKYO, JP, vol. 110, no. 6, JP, pages 1820 - 1828, XP055832946, ISSN: 1347-9032, DOI: 10.1111/cas.14019
CHENGHAO XIONG, YINGQING MAO, TAO WU, NANNAN KANG, MINGJUN ZHAO, RONGRONG DI, XIAOPING LI, XUEMEI JI, YU LIU: "Optimized Expression and Characterization of a Novel Fully Human Bispecific Single-Chain Diabody Targeting Vascular Endothelial Growth Factor165 and Programmed Death-1 in Pichia pastoris and Evaluation of Antitumor Activity In Vivo", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 19, no. 10, pages 2900, XP055626522, DOI: 10.3390/ijms19102900
See also references of EP 4093765A4
CHENGHAO XIONG, YINGQING MAO, TAO WU, NANNAN KANG, MINGJUN ZHAO, RONGRONG DI, XIAOPING LI, XUEMEI JI, YU LIU: "Optimized Expression and Characterization of a Novel Fully Human Bispecific Single-Chain Diabody Targeting Vascular Endothelial Growth Factor165 and Programmed Death-1 in Pichia pastoris and Evaluation of Antitumor Activity In Vivo", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 19, no. 10, pages 2900, XP055626522, DOI: 10.3390/ijms19102900
See also references of EP 4093765A4
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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