Title:
BISPECIFIC ANTIBODIES AGAINST PD-1 AND LAG-3
Document Type and Number:
WIPO Patent Application WO/2020/216348
Kind Code:
A1
Abstract:
Bispecific antibodies comprising a first targeting moiety which specifically binds to PD-1 and a second targeting moiety which specifically binds to LAG-3, wherein the first targeting moiety comprises a first VHH domain and the second targeting moiety comprises a second VHH domain. Amino acid sequences of the antibodies of the invention, cloning or expression vectors, host cells and methods for expressing or isolating the antibodies. Therapeutic compositions comprising the antibodies of the invention are also provided and methods for treating cancers and other diseases with the bispecific antibodies.
Inventors:
WU QIONG (CN)
ZHENG YONG (CN)
CHEN YUNYING (CN)
LI JING (CN)
ZHENG YONG (CN)
CHEN YUNYING (CN)
LI JING (CN)
Application Number:
PCT/CN2020/086830
Publication Date:
October 29, 2020
Filing Date:
April 24, 2020
Export Citation:
Assignee:
WUXI BIOLOGICS SHANGHAI CO LTD (CN)
WUXI BIOLOGICS IRELAND LTD (IE)
WUXI BIOLOGICS IRELAND LTD (IE)
International Classes:
A61K39/395; A61P31/00; A61P35/00; C07K16/28
Domestic Patent References:
| WO2017214092A1 | 2017-12-14 | |||
| WO2016200782A1 | 2016-12-15 |
Foreign References:
| CN106715470A | 2017-05-24 | |||
| CN108025051A | 2018-05-11 | |||
| CN106103484A | 2016-11-09 | |||
| CN108350082A | 2018-07-31 | |||
| CN107207594A | 2017-09-26 | |||
| CN103396481A | 2013-11-20 | |||
| CN106279410A | 2017-01-04 |
Other References:
See also references of EP 3958900A4
Attorney, Agent or Firm:
ANJIE LAW FIRM (CN)
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