Title:
BISPECIFIC ANTIBODY AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/051656
Kind Code:
A1
Abstract:
A bispecific antibody and an application thereof are provided. The provided bispecific antibody can specifically bind to TGF-β, GARP or a GARP-TGF-β complex individually or simultaneously, and can also specifically bind to PD-L1. The provided bispecific antibody exhibits high affinity and specificity to an antigen, has tumor killing effects, and can be applied to treat tumors.
Inventors:
XU WENXIN (CN)
FANG XUEFEI (CN)
XU DEYU (CN)
XU JIEYING (CN)
DING LIEMING (CN)
FANG XUEFEI (CN)
XU DEYU (CN)
XU JIEYING (CN)
DING LIEMING (CN)
Application Number:
PCT/CN2022/122367
Publication Date:
April 06, 2023
Filing Date:
September 29, 2022
Export Citation:
Assignee:
BETTA PHARMACEUTICALS CO LTD (CN)
International Classes:
C07K16/46; A61K39/00; A61K39/395; A61P35/00; C07K16/22; C07K16/28; C12N15/62; C12N15/63
Domestic Patent References:
| WO2021104434A1 | 2021-06-03 |
Foreign References:
| CN112851819A | 2021-05-28 | |||
| CN110049773A | 2019-07-23 | |||
| CN109476762A | 2019-03-15 | |||
| CN108136001A | 2018-06-08 | |||
| CN107216389A | 2017-09-29 | |||
| CN202110903293A | 2021-08-06 | |||
| CN2022110423W | 2022-08-05 |
Other References:
KARIN M. KNUDSON, KRISTIN C. HICKS, XIAOLING LUO, JIN-QIU CHEN, JEFFREY SCHLOM, SOFIA R. GAMEIRO: "M7824, a novel bifunctional anti-PD-L1/TGFβ Trap fusion protein, promotes anti-tumor efficacy as monotherapy and in combination with vaccine", ONCOIMMUNOLOGY, vol. 7, no. 5, 4 May 2018 (2018-05-04), pages 1 - 14, XP055665440, ISSN: 2162-402X, DOI: 10.1080/2162402X.2018.1426519
HANNE LIND, SOFIA R GAMEIRO, CAROLINE JOCHEMS, RENEE N. DONAHUE, JULIUS STRAUSS, JAMES L GULLEY, CLAUDIA PALENA, JEFFREY SCHLOM: "Dual targeting of TGF-β and PD-L1 via a bifunctional anti-PD-L1/TGF-βRII agent: status of preclinical and clinical advances", JOURNAL FOR IMMUNOTHERAPY OF CANCER, vol. 8, no. 1, 19 December 2019 (2019-12-19), pages 1 - 10, XP055686662, DOI: 10.1136/jitc-2019-000433
CUENDE, J. ET AL.: "Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo.", SCIENCE TRANSLATIONAL MEDICINE, vol. 7, no. 284, 22 April 2015 (2015-04-22), XP055268336, DOI: 10.1126/scitranslmed.aaa1983
COLD SPRING HARB. PERSPECT. BIOL., vol. 8, 2016
CYTOKINE GROWTH FACTOR REV., vol. 24, 2013, pages 355 - 372
PROC NATL ACAD SCI USA., vol. 106, no. 32, 2009, pages 13445 - 50
"Sequences of Proteins of Immunological Interest", 1983, U.S. DEPT. OF HEALTH AND HUMAN SERVIES
J. MOL. BIOL., vol. 196, 1987, pages 901 - 917
HANNE LIND, SOFIA R GAMEIRO, CAROLINE JOCHEMS, RENEE N. DONAHUE, JULIUS STRAUSS, JAMES L GULLEY, CLAUDIA PALENA, JEFFREY SCHLOM: "Dual targeting of TGF-β and PD-L1 via a bifunctional anti-PD-L1/TGF-βRII agent: status of preclinical and clinical advances", JOURNAL FOR IMMUNOTHERAPY OF CANCER, vol. 8, no. 1, 19 December 2019 (2019-12-19), pages 1 - 10, XP055686662, DOI: 10.1136/jitc-2019-000433
CUENDE, J. ET AL.: "Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo.", SCIENCE TRANSLATIONAL MEDICINE, vol. 7, no. 284, 22 April 2015 (2015-04-22), XP055268336, DOI: 10.1126/scitranslmed.aaa1983
COLD SPRING HARB. PERSPECT. BIOL., vol. 8, 2016
CYTOKINE GROWTH FACTOR REV., vol. 24, 2013, pages 355 - 372
PROC NATL ACAD SCI USA., vol. 106, no. 32, 2009, pages 13445 - 50
"Sequences of Proteins of Immunological Interest", 1983, U.S. DEPT. OF HEALTH AND HUMAN SERVIES
J. MOL. BIOL., vol. 196, 1987, pages 901 - 917
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