Title:
BISPECIFIC ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2021/200857
Kind Code:
A1
Abstract:
Provided are a novel antibody usable as an antitumor agent and an antitumor agent that comprises a molecule containing the antibody, etc. as an active ingredient. An antibody that contains heavy chain CDRH1 comprising the amino acid sequence represented by SEQ ID NO: 54, heavy chain CDRH2 comprising the amino acid sequence represented by SEQ ID NO: 55, heavy chain CDRH3 comprising the amino acid sequence represented by SEQ ID NO: 56, light chain CDRL1 comprising the amino acid sequence represented by SEQ ID NO: 57 or light chain CDRL1 comprising an amino acid sequence that is identical with the amino acid sequence represented by SEQ ID NO: 57 except that the seventh amino acid is W and/or the eighth amino acid is K, light chain CDRL2 comprising the amino acid sequence represented by SEQ ID NO: 58, and light chain CDRL3 comprising the amino acid sequence represented by SEQ ID NO: 59 or light chain CDRL3 comprising an amino acid sequence that is identical with the amino acid sequence represented by SEQ ID NO: 57 except that the second amino acid is A or S; or a binding fragment of the antibody.
Inventors:
SHIKU HIROSHI (JP)
AKAHORI YASUSHI (JP)
TANAKA KENTO (JP)
YATSU AYAKA (JP)
ICHIKAWA JUNYA (JP)
OHTSUKA TOSHIAKI (JP)
KOZUMA SHIHO (JP)
HASHIMOTO RYUJI (JP)
NAKAYAMA MAKIKO (JP)
SHINOZAKI NAOYA (JP)
NAKAMURA KENSUKE (JP)
WATANABE ICHIRO (JP)
FURUZONO SHINJI (JP)
AKAHORI YASUSHI (JP)
TANAKA KENTO (JP)
YATSU AYAKA (JP)
ICHIKAWA JUNYA (JP)
OHTSUKA TOSHIAKI (JP)
KOZUMA SHIHO (JP)
HASHIMOTO RYUJI (JP)
NAKAYAMA MAKIKO (JP)
SHINOZAKI NAOYA (JP)
NAKAMURA KENSUKE (JP)
WATANABE ICHIRO (JP)
FURUZONO SHINJI (JP)
Application Number:
PCT/JP2021/013378
Publication Date:
October 07, 2021
Filing Date:
March 29, 2021
Export Citation:
Assignee:
UNIV MIE (JP)
DAIICHI SANKYO CO LTD (JP)
DAIICHI SANKYO CO LTD (JP)
International Classes:
A61K39/395; A61K31/7088; A61K35/76; A61K48/00; A61P35/00; C07K16/30; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/13; C12N15/63; C12P21/08
Domestic Patent References:
| WO2010106431A2 | 2010-09-23 | |||
| WO2018117237A1 | 2018-06-28 | |||
| WO2021003357A1 | 2021-01-07 | |||
| WO2005113595A2 | 2005-12-01 | |||
| WO2017109496A1 | 2017-06-29 | |||
| WO2010106431A2 | 2010-09-23 | |||
| WO1998050431A2 | 1998-11-12 | |||
| WO2006106905A1 | 2006-10-12 | |||
| WO2011028952A1 | 2011-03-10 | |||
| WO2011131746A2 | 2011-10-27 | |||
| WO2021003357A1 | 2021-01-07 | |||
| WO2013063702A1 | 2013-05-10 | |||
| WO1996027011A1 | 1996-09-06 | |||
| WO2009089004A1 | 2009-07-16 | |||
| WO2014110601A1 | 2014-07-17 | |||
| WO2010151792A1 | 2010-12-29 | |||
| WO1992001047A1 | 1992-01-23 | |||
| WO1992020791A1 | 1992-11-26 | |||
| WO1993006213A1 | 1993-04-01 | |||
| WO1993011236A1 | 1993-06-10 | |||
| WO1993019172A1 | 1993-09-30 | |||
| WO1995001438A1 | 1995-01-12 | |||
| WO1995015388A1 | 1995-06-08 | |||
| WO2013147153A1 | 2013-10-03 | |||
| WO1999054342A1 | 1999-10-28 | |||
| WO2000061739A1 | 2000-10-19 | |||
| WO2002031140A1 | 2002-04-18 | |||
| WO2018117237A1 | 2018-06-28 | |||
| WO2014190441A1 | 2014-12-04 |
Foreign References:
| JP2018525973A | 2018-09-13 | |||
| JP2016520598A | 2016-07-14 | |||
| JP2020061476A | 2020-04-16 | |||
| JP2017046006W | 2017-12-21 |
Other References:
G. STEWART-JONES ET AL.: "Rational development of high-affinity T-cell receptor-like antibodies.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 106, no. 14, 7 April 2009 (2009-04-07), pages 5784 - 5788, XP002597799, ISSN: 0027-8424, DOI: 10.1073/PNAS.0901425106
HELD, G. ET AL.: "Dissecting cytotoxic T cell responses towards the NY -ESO-1 protein by peptide/MHC-specific antibody fragments", EUR. J. IMMUNOL., vol. 34, 2004, pages 2919 - 2929, XP009063063, DOI: 10.1002/eji.200425297
PROC. NATL. ACAD. SCI., U.S.A., vol. 94, no. 5, 1997, pages 1914 - 8
INT. J. CANCER, vol. 76, no. 6, 1998, pages 903 - 8
IMMUNOL. CELL BIOL., vol. 84, no. 3, 2006, pages 303 - 17
J. SURG. RES., vol. 98, no. 2, 2001, pages 76 - 80
CANCER RES., vol. 61, no. 12, 2001, pages 4671 - 4
BLOOD, vol. 105, no. 10, 2005, pages 3939 - 44
J. EXP. MED., vol. 187, no. 2, 1998, pages 265 - 70
J. IMMUNOL., vol. 176, no. 12, 2006, pages 7308 - 16
NATURE, vol. 314, no. 6012, 1985, pages 628 - 31
INT. REV. IMMUNOL., vol. 4, no. 2, 1989, pages 159 - 73
DRUG DES. DEVEL. THER., vol. 10, 2016, pages 757 - 765
ABSTRACTS OF THE 21ST ANNUAL MEETING OF THE JAPANESE ASSOCIATION OF CANCER IMMUNOLOGY, pages 013 - 4
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, vol. 27, 2003, pages 55 - 77
SAIKI, R. K. ET AL., SCIENCE, vol. 239, 1988, pages 487 - 49
ANNU. REV. IMMUNOL., vol. 12, 1994, pages 433 - 455
MUYLDEMANS S. ET AL., PROTEIN ENG., vol. 113, no. 9, 1994, pages 1129 - 315
NATURE BIOTECHNOLOGY, vol. 23, no. 9, 2005, pages 1137 - 1146
HAMERS-CASTERMAN C. ET AL., NATURE, vol. 363, no. 6428, 1993, pages 446 - 448
LEE, H-S ET AL., MOLECULAR IMMUNOLOGY, vol. 36, 1999, pages 61 - 71
SHIRRMANN, T. ET AL., MABS, vol. 2, no. 1, 2010, pages 1 - 4
JOURNAL OF CHROMATOGRAPHY A, vol. 705, 1995, pages 129 - 134
BIOCHEMISTRY, vol. 360, 2007, pages 75 - 83
METHODS MOL. BIOL., vol. 1045, 2013, pages 1 - 27
QUEEN ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 86, 1989, pages 10029 - 10033
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, PUBLIC HEALTH SERVICE NATIONAL INSTITUTES OF HEALTH
NAT. BIOTECHNOL., vol. 16, no. 7, July 1998 (1998-07-01), pages 677 - 81
HELD, G. ET AL.: "Dissecting cytotoxic T cell responses towards the NY -ESO-1 protein by peptide/MHC-specific antibody fragments", EUR. J. IMMUNOL., vol. 34, 2004, pages 2919 - 2929, XP009063063, DOI: 10.1002/eji.200425297
PROC. NATL. ACAD. SCI., U.S.A., vol. 94, no. 5, 1997, pages 1914 - 8
INT. J. CANCER, vol. 76, no. 6, 1998, pages 903 - 8
IMMUNOL. CELL BIOL., vol. 84, no. 3, 2006, pages 303 - 17
J. SURG. RES., vol. 98, no. 2, 2001, pages 76 - 80
CANCER RES., vol. 61, no. 12, 2001, pages 4671 - 4
BLOOD, vol. 105, no. 10, 2005, pages 3939 - 44
J. EXP. MED., vol. 187, no. 2, 1998, pages 265 - 70
J. IMMUNOL., vol. 176, no. 12, 2006, pages 7308 - 16
NATURE, vol. 314, no. 6012, 1985, pages 628 - 31
INT. REV. IMMUNOL., vol. 4, no. 2, 1989, pages 159 - 73
DRUG DES. DEVEL. THER., vol. 10, 2016, pages 757 - 765
ABSTRACTS OF THE 21ST ANNUAL MEETING OF THE JAPANESE ASSOCIATION OF CANCER IMMUNOLOGY, pages 013 - 4
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, vol. 27, 2003, pages 55 - 77
SAIKI, R. K. ET AL., SCIENCE, vol. 239, 1988, pages 487 - 49
ANNU. REV. IMMUNOL., vol. 12, 1994, pages 433 - 455
MUYLDEMANS S. ET AL., PROTEIN ENG., vol. 113, no. 9, 1994, pages 1129 - 315
NATURE BIOTECHNOLOGY, vol. 23, no. 9, 2005, pages 1137 - 1146
HAMERS-CASTERMAN C. ET AL., NATURE, vol. 363, no. 6428, 1993, pages 446 - 448
LEE, H-S ET AL., MOLECULAR IMMUNOLOGY, vol. 36, 1999, pages 61 - 71
SHIRRMANN, T. ET AL., MABS, vol. 2, no. 1, 2010, pages 1 - 4
JOURNAL OF CHROMATOGRAPHY A, vol. 705, 1995, pages 129 - 134
BIOCHEMISTRY, vol. 360, 2007, pages 75 - 83
METHODS MOL. BIOL., vol. 1045, 2013, pages 1 - 27
QUEEN ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 86, 1989, pages 10029 - 10033
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, PUBLIC HEALTH SERVICE NATIONAL INSTITUTES OF HEALTH
NAT. BIOTECHNOL., vol. 16, no. 7, July 1998 (1998-07-01), pages 677 - 81
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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