1. A bistable genetic toggle switch comprising a pair of mutual repressors and a positive feedback loop based on modular DNA-binding proteins.

2. A bistable genetic toggle switch according to claim 1 that comprises a pair of repressors which mutually repress each other and a pair of activators which are reinforced in a positive feedback loop manner and also activate the repressor of the opposing element in the pair of repressors.

3. A bistable genetic toggle switch according to claim 2 wherein the repressors comprise a DNA-binding domain and a repression domain, whereas the activators comprise a DNA- binding domain and an activation domain.

4. A bistable genetic toggle switch according to claim 3, wherein the repression domain is the KRAB domain and the activation domain is either the VP 16 or the VP 64 domain.

5. A bistable genetic toggle switch according to claims 1 to 4 where the DNA-binding domain binds DNA as a monomer.

6. A bistable genetic toggle switch according to any of the claims 1 to 5 which can occupy stable states 1 or 2 and comprises: a) An operon for maintaining state 1 by a positive feedback loop that includes a structural gene for an activator A, which forms a positive feedback loop and where transcription of the structural gene for the activator A is regulated by an operator that comprises the DNA binding element A and a promoter; b) An operon for maintaining state 1 with a repressor B, which inhibits state 2 by repressing the gene, regulated by the operator B and where transcription of the structural gene for repressor B is regulated by an operator that comprises the DNA binding element A and a promoter; c) An operon exhibiting an activation of state 1 with an effector gene 1 that can be any gene or a group of genes e.g. different enzymes, fluorescent proteins, signaling proteins etc. and where transcription of this effector gene 1 is regulated by an operator that comprises the DNA binding element A and a promoter; d) An operon for maintaining state 2 by a positive feedback loop that includes a structural gene for an activator B, which forms a positive feedback loop and where transcription of the structural gene for the activator B is regulated by an operator that comprises the DNA binding element B and a promoter; e) An operon for maintaining state 2 with a repressor A, which inhibits state 1 by repressing the gene, regulated by the operator A and where transcription of the structural gene for repressor A is regulated by an operator that comprises the DNA binding element B and a promoter; f) An operon exhibiting an activation of state 2 with an effector gene 2 that can be any gene or a group of genes e.g. different enzymes, fluorescent proteins, signaling proteins etc. and where transcription of this effector gene 2 is regulated by an operator that comprises the DNA binding element B and a promoter; g) Operons of inducer-dependent activators or repressors that include structural genes for inducer-dependent proteins regulated by a promoter, preferentially constitutive or minimal, and optionally an operator. where A represents a selected recognition site for the DNA-binding domain A, that is included in the activator A and the repressor A, whereas B represents a selected recognition site for the DNA-binding domain B, that is included in the activator B and the repressor B.

7. A bistable genetic toggle switch according to any of the claims 1 to 6 wherein two or more structural genes are regulated by the same operator: activator A, repressor B, effector 1 and activator B, repressor A, effector 2; joined together so that they are regulated by the same operator and linked together by a self-cleaving 2A peptide. They are transcribed from a structural gene as a single RNA molecule and are translated into a polypeptide chain that autocatalitically cleaves at the positions of self-cleaving peptides, leading to synthesis of separate individual proteins in an equal stoichiometric ratio.

8. Bistable genetic toggle switch according to any of the claims 1 to 7 that comprises a) operons of repressor B, activator A and effector 1 for expressing state 1 by a positive feedback loop, that comprises structural genes for the repressor B, activator A and effector 1 at aseparate operon or in any combination the repressor B, activator A and effector 1 separated by a self-cleaving peptide and where the operons for state 1 are regulated by the same operator A that comprises the DNA binding element A and a promoter. b) operons of repressor A, activator B and effector 2 for expressing state 2 by a positive feedback loop, that comprises structural genes for the repressor A, activator B and effector 2 at aseparate operon or in any combination the repressor A, activator B and effector 2 separated by a self-cleaving peptide and where the operons for state 2 are regulated by the same operator B that comprises the DNA binding element B and a promoter. c) operon for switching to state 1 , which comprises a structural gene for the activator A for activation of state 1 and an operon for switching to state 1 , that comprises a structural gene for the repressor B for inhibition of state 2, where transcription of these structural genes on separate operons is under control of same operator, which activates in the presence if inducer A, and a promoter, which can be either constitutive or minimal. d) operon for switching to state 2, which comprises a structural gene for the activator B for activation of state 2 and an operon for switching to state 2, that comprises a structural gene for the repressor A for inhibition of state 1, where transcription of these structural genes on separate operons is under control of same operator, which activates in the presence if inducer B, and a promoter, which can be either constitutive or minimal. e) operons of the inducer-dependent activators and repressors, which comprise structural genes for inducer-dependent proteins under regulation of a promoter, preferably constitutive or minimal, and optionally an operator.

9. Bistable genetic toggle switch according to any of the claims from 1 to 8, where the operator of the operon includes any number of equal or different type of DNA binding elements, which can be joined into clusters or distributed in alternating order, the operator preferably includes 1 to 20 DNA-binding elements, which are separated with nucleotide sequence of any length, and where operators A of operons for expression of state 1 differ from operators B of operons for expression of state 2 and differ from operators A of operons for switching to state 1 and operators B of operons for switching to state 2 and a) DNA binding elements in operators A are designed to bind the DNA-binding domain of repressor A and activator A. b) DNA binding elements in operators B are designed to bind the DNA-binding domain of repressor B and activator B.

10. A bistable genetic toggle switch according to any claim from 1 to 9 which can be used for controlled synthesis of effectors 1 or effectors 2, depending of the state of the switch and the presence of inducers for activation of a specific state, where the effectors can be any type of protein or a group of proteins.

11. A bistable genetic toggle switch according to any claim from 1 to 10 which can be used as indicator which through synthesis of effector 1 or effector 2 reports the presence of inducer for activation of a specific state where the effectors can be any type of protein or a group of proteins.

12. A bistable genetic toggle switch, where the DNA with the sequence SEQ ID NO.: 1, 2, 4, 5, 7, 8, 9, 10 and pCMV-tTR-KRAB, pCMV-ECD-KRAB is introduced to mammalian cells transiently or permanently.

13. Prokaryotic or eukaryotic host cells, that contain a bistable genetic toggle switch according to any of the claims from 1 to 12.

14. Method for effector gene expression, that comprises (a) host cells according to claim 13 containing a bistable genetic toggle switch according to any of the claims from 1 to 12 and (b) cultivation of the cells in such a way that they express an effector protein when the switch is switched to state 1 in the presence of inducer 1 or when switch is switched to state 2 in the presence of inducer 2. 1/65

SEQUENCE LISTING

<110> Kemijski institut, Ljubljana, Slovenia and EN-FIST Center odlicnosti, Ljubljana, Slovenia

<120> Bistable genetic toggle switch comprising a pair of reciprocal

Repressors and a positive feedback loop based on DNA-binding

Proteins

<130> 301-P31PC/13

<140> -

<141> 2013-09-11

<150> SI P-201200285

<151> 2012-09-20

<160> 22

<170> Patentln version 3.5

<210> 1

<211> 3465

<212> DNA

<213> Unknown

<220>

<223> Operon composed of operator DNA-binding elements, minimal or

constitutive promoter, structural genes

<400> 1

taaagagcag aaactcatct tccgtttcca catcttgctg gcagccgggg taccgcaggc 60 aagtcgctaa agagcagaaa ctcatcttcc gtttccacat ctatggaatc acggcggccg 120 cccgtatctc atcctaaaga gcagaaactc atcttccgtt tccacatcta atgcgtcggc 180 gtgcggccgc tgccagttgc ataaagagca gaaactcatc ttccgtttcc acatctttgg 240 ctgtcctagg gtacctggac gctccttgta aagagcagaa actcatcttc cgtttccaca 300 tcttggctgg tgccgcaccg gtaagcagaa ctagaggtgg caccggtttg attgcacagc 360 taaagagcag aaactcatct tccgtttcca catcttgctg gcagccgggg taccgcaggc 420 aagtcgctaa agagcagaaa ctcatcttcc gtttccacat ctatggaatc acggcggccg 480 cccgtatctc atcctaaaga gcagaaactc atcttccgtt tccacatcta atgcgtcggc 540 gtgcggccgc tgccagttgc ataaagagca gaaactcatc ttccgtttcc acatctttgg 600 ctgtcctagg gtacctggac gctccttgta aagagcagaa actcatcttc cgtttccaca 660 tcttggctgg tgccgcaccg gtaagcagag gatcttagag ggtatataat ggaagctcga 720 cttccagctc gagggcaatc cggtactgtt ggtaaagcca ccgaattcgc caccatgcac 780 caccaccacc accacgacta caaagaccat gacggtgatt ataaagatca tgacatcgat 840 tacaaggatg acgatgacaa gatggccccc aagaagaaga ggaaggtggg cattcaccgc 900 ggggtaccta tggtggactt gaggacactc ggttattcgc aacagcaaca ggagaaaatc 960 aagcctaagg tcaggagcac cgtcgcgcaa caccacgagg cgcttgtggg gcatggcttc 1020 actcatgcgc atattgtcgc gctttcacag caccctgcgg cgcttgggac ggtggctgtc 1080 aaataccaag atatgattgc ggccctgccc gaagccacgc acgaggcaat tgtaggggtc 1140 ggtaaacagt ggtcgggagc gcgagcactt gaggcgctgc tgactgtggc gggtgagctt 1200 agggggcctc cgctccagct cgacaccggg cagctgctga agatcgcgaa gagaggggga 1260 gtaacagcgg tagaggcagt gcacgcctgg cgcaatgcgc tcaccggggc ccccttgaac 1320 ctgaccccag accaggtagt cgcaatcgcg tcacatgacg ggggaaagca agccctggaa 1380 accgtgcaaa ggttgttgcc ggtcctttgt caagaccacg gccttacacc ggagcaagtc 1440 gtggccattg caagcaatgg gggtggcaaa caggctcttg agacggttca gagacttctc 1500 ccagttctct gtcaagccca cgggctgact cccgatcaag ttgtagcgat tgcgtccaac 1560 ggtggaggga aacaagcatt ggagactgtc caacggctcc ttcccgtgtt gtgtcaagcc 1620 cacggtttga cgcctgcaca agtggtcgcc atcgccagcc atgatggcgg taagcaggcg 1680 ctggaaacag tacagcgcct gctgcctgta ctgtgccagg atcatggact gaccccagac 1740 caggtagtcg caatcgcgtc acatgacggg ggaaagcaag ccctggaaac cgtgcaaagg 1800 ttgttgccgg tcctttgtca agaccacggc cttacaccgg agcaagtcgt ggccattgca 1860 aataataacg gtggcaaaca ggctcttgag acggttcaga gacttctccc agttctctgt 1920 caagcccacg ggctgactcc cgatcaagtt gtagcgattg cgtccaacgg tggagggaaa 1980 caagcattgg agactgtcca acggctcctt cccgtgttgt gtcaagccca cggtttgacg 2040 cctgcacaag tggtcgccat cgcctcgaat ggcggcggta agcaggcgct ggaaacagta 2100 cagcgcctgc tgcctgtact gtgccaggat catggactga ccccagacca ggtagtcgca 2160 atcgcgtcaa acggaggggg aaagcaagcc ctggaaaccg tgcaaaggtt gttgccggtc 2220 ctttgtcaag accacggcct tacaccggag caagtcgtgg ccattgcatc ccacgacggt 2280 ggcaaacagg ctcttgagac ggttcagaga cttctcccag ttctctgtca agcccacggg 2340 ctgactcccg atcaagttgt agcgattgcg tcgcatgacg gagggaaaca agcattggag 2400 actgtccaac ggctccttcc cgtgttgtgt caagcccacg gtttgacgcc tgcacaagtg 2460 gtcgccatcg cctccaatat tggcggtaag caggcgctgg aaacagtaca gcgcctgctg 2520 cctgtactgt gccaggatca tggactgacc ccagaccagg tagtcgcaat cgcgtcacat 2580 gacgggggaa agcaagccct ggaaaccgtg caaaggttgt tgccggtcct ttgtcaagac 2640 cacggcctta caccggagca agtcgtggcc attgcaagca acatcggtgg caaacaggct 2700 cttgagacgg ttcagagact tctcccagtt ctctgtcaag cccacgggct gactcccgat 2760 caagttgtag cgattgcgtc caacggtgga gggaaacaag cattggagac tgtccaacgg 2820 ctccttcccg tgttgtgtca agcccacggt ttgacgcctg cacaagtggt cgccatcgcc 2880 agccatgatg gcggtaagca ggcgctggaa acagtacagc gcctgctgcc tgtactgtgc 2940 caggatcatg gactgacacc cgaacaggtg gtcgccattg cttctaatgg gggaggacgg 3000 ccagccttgg agtccatcgt agcccaattg tccaggcccg atcccgcgtt ggctgcgtta 3060 acgaatgacc atctggtggc gttggcatgt cttggtggac gacccgcgct cgatgcagtc 3120 aaaaagggtc tgcctcatgc tcccgcattg atcaaaagaa ccaaccggcg gattcccgag 3180 agaacttccc atcgagtcgc gggatccgat ccaaaaaaga agagaaaggt agcccccccg 3240 accgatgtca gcctggggga cgagctccac ttagacggcg aggacgtggc gatggcgcat 3300 gccgacgcgc tagacgattt cgatctggac atgttggggg acggggattc cccgggtccg 3360 ggatttaccc cccacgactc cgccccctac ggcgctctgg atatggccga cttcgagttt 3420 gagcagatgt ttaccgatgc ccttggaatt gacgagtacg gtggg 3465

<210> 2

<211> 4395

<212> DNA

<213> Unknown

<220>

<223> Synthetic genetic construct

<400> 2

taaagagcag aaactcatct tccgtttcca catcttgctg gcagccgggg taccgcaggc 60 aagtcgctaa agagcagaaa ctcatcttcc gtttccacat ctatggaatc acggcggccg 120 cccgtatctc atcctaaaga gcagaaactc atcttccgtt tccacatcta atgcgtcggc 180 gtgcggccgc tgccagttgc ataaagagca gaaactcatc ttccgtttcc acatctttgg 240 ctgtcctagg gtacctggac gctccttgta aagagcagaa actcatcttc cgtttccaca 300 tcttggctgg tgccgcaccg gtaagcagaa ctagaggtgg caccggtttg attgcacagc 360 taaagagcag aaactcatct tccgtttcca catcttgctg gcagccgggg taccgcaggc 420 aagtcgctaa agagcagaaa ctcatcttcc gtttccacat ctatggaatc acggcggccg 480 cccgtatctc atcctaaaga gcagaaactc atcttccgtt tccacatcta atgcgtcggc 540 gtgcggccgc tgccagttgc ataaagagca gaaactcatc ttccgtttcc acatctttgg 600 ctgtcctagg gtacctggac gctccttgta aagagcagaa actcatcttc cgtttccaca 660 tcttggctgg tgccgcaccg gtaagcagag gatcttagag ggtatataat ggaagctcga 720 cttccagctc gagggcaatc cggtactgtt ggtaaagcca ccgaattcgc caccatgcac 780 caccaccacc accacgacta caaagaccat gacggtgatt ataaagatca tgacatcgat 840 tacaaggatg acgatgacaa gatggccccc aagaagaaga ggaaggtggg cattcaccgc 900 ggggtaccta tggtggactt gaggacactc ggttattcgc aacagcaaca ggagaaaatc 960 aagcctaagg tcaggagcac cgtcgcgcaa caccacgagg cgcttgtggg gcatggcttc 1020 actcatgcgc atattgtcgc gctttcacag caccctgcgg cgcttgggac ggtggctgtc 1080 aaataccaag atatgattgc ggccctgccc gaagccacgc acgaggcaat tgtaggggtc 1140 ggtaaacagt ggtcgggagc gcgagcactt gaggcgctgc tgactgtggc gggtgagctt 1200 agggggcctc cgctccagct cgacaccggg cagctgctga agatcgcgaa gagaggggga 1260 gtaacagcgg tagaggcagt gcacgcctgg cgcaatgcgc tcaccggggc ccccttgaac 1320 ctgaccccag accaggtagt cgcaatcgcg tcaaacggag ggggaaagca agccctggaa 1380 accgtgcaaa ggttgttgcc ggtcctttgt caagaccacg gccttacacc ggagcaagtc 1440 gtggccattg caagcaatgg gggtggcaaa caggctcttg agacggttca gagacttctc 1500 ccagttctct gtcaagccca cgggctgact cccgatcaag ttgtagcgat tgcgtcgaac 1560 attggaggga aacaagcatt ggagactgtc caacggctcc ttcccgtgtt gtgtcaagcc 1620 cacggtttga cgcctgcaca agtggtcgcc atcgccagcc atgatggcgg taagcaggcg 1680 ctggaaacag tacagcgcct gctgcctgta ctgtgccagg atcatggact gaccccagac 1740 caggtagtcg caatcgcgtc aaacggaggg ggaaagcaag ccctggaaac cgtgcaaagg 1800 ttgttgccgg tcctttgtca agaccacggc cttacaccgg agcaagtcgt ggccattgca 1860 aataataacg gtggcaaaca ggctcttgag acggttcaga gacttctccc agttctctgt 1920 caagcccacg ggctgactcc cgatcaagtt gtagcgattg cgtcgcatga cggagggaaa 1980 caagcattgg agactgtcca acggctcctt cccgtgttgt gtcaagccca cggtttgacg 2040 cctgcacaag tggtcgccat cgcctcgaat ggcggcggta agcaggcgct ggaaacagta 2100 cagcgcctgc tgcctgtact gtgccaggat catggactga ccccagacca ggtagtcgca 2160 atcgcgaaca ataatggggg aaagcaagcc ctggaaaccg tgcaaaggtt gttgccggtc 2220 3/65 ctttgtcaag accacggcct tacaccggag caagtcgtgg ccattgcatc ccacgacggt 2280 ggcaaacagg ctcttgagac ggttcagaga cttctcccag ttctctgtca agcccacggg 2340 ctgactcccg atcaagttgt agcgattgcg tccaacggtg gagggaaaca agcattggag 2400 actgtccaac ggctccttcc cgtgttgtgt caagcccacg gtttgacgcc tgcacaagtg 2460 gtcgccatcg ccagccatga tggcggtaag caggcgctgg aaacagtaca gcgcctgctg 2520 cctgtactgt gccaggatca tggactgacc ccagaccagg tagtcgcaat cgcgtcacat 2580 gacgggggaa agcaagccct ggaaaccgtg caaaggttgt tgccggtcct ttgtcaagac 2640 cacggcctta caccggagca agtcgtggcc attgcatccc acgacggtgg caaacaggct 2700 cttgagacgg ttcagagact tctcccagtt ctctgtcaag cccacgggct gactcccgat 2760 caagttgtag cgattgcgaa taacaatgga gggaaacaag cattggagac tgtccaacgg 2820 ctccttcccg tgttgtgtca agcccacggt ttgacgcctg cacaagtggt cgccatcgcc 2880 agccatgatg gcggtaagca ggcgctggaa acagtacagc gcctgctgcc tgtactgtgc 2940 caggatcatg gactgacacc cgaacaggtg gtcgccattg cttctaatgg gggaggacgg 3000 ccagccttgg agtccatcgt agcccaattg tccaggcccg atcccgcgtt ggctgcgtta 3060 acgaatgacc atctggtggc gttggcatgt cttggtggac gacccgcgct cgatgcagtc 3120 aaaaagggtc tgcctcatgc tcccgcattg atcaaaagaa ccaaccggcg gattcccgag 3180 agaacttccc atcgagtcgc gggatccgat ccaaaaaaga agagaaaggt accaaaaaag 3240 aagagaaagg tcgacggcgg tggtgctttg tctcctcagc actctgctgt cactcaagga 3300 agtatcatca agaacaagga gggcatggat gctaagtcac taactgcctg gtcccggaca 3360 ctggtgacct tcaaggatgt atttgtggac ttcaccaggg aggagtggaa gctgctggac 3420 actgctcagc agatcgtgta cagaaatgtg atgctggaga actataagaa cctggtttcc 3480 ttgggttatc agcttactaa gccagatgtg atcctccggt tggagaaggg agaagagccc 3540 tggctggtgg agagagaaat tcaccaagag acccatcctg attcagagac tgcatttgaa 3600 atcaaatcat cagttagagc cgaggggaga ggaagtcttc tgacctgcgg agacgtcgaa 3660 gagaatcctg gacccatggt gagcaagggc gaggagctgt tcaccggggt ggtgcccatc 3720 ctggtcgagc tggacggcga cgtaaacggc cacaagttca gcgtgtccgg cgagggcgag 3780 ggcgatgcca cctacggcaa gctgaccctg aagttcatct gcaccaccgg caagctgccc 3840 gtgccctggc ccaccctcgt gaccaccttc ggctacggcc tgatgtgctt cgcccgctac 3900 cccgaccaca tgaagcagca cgacttcttc aagtccgcca tgcccgaagg ctacgtccag 3960 gagcgcacca tcttcttcaa ggacgacggc aactacaaga cccgcgccga ggtgaagttc 4020 gagggcgaca ccctggtgaa ccgcatcgag ctgaagggca tcgacttcaa ggaggacggc 4080 aacatcctgg ggcacaagct ggagtacaac tacaacagcc acaacgtcta tatcatggcc 4140 gacaagcaga agaacggcat caaggtgaac ttcaagatcc gccacaacat cgaggacggc 4200 agcgtgcagc tcgccgacca ctaccagcag aacaccccca tcggcgacgg ccccgtgctg 4260 ctgcccgaca accactacct gagctaccag tccgccctga gcaaagaccc caacgagaag 4320 cgcgatcaca tggtcctgct ggagttcgtg accgccgccg ggatcactct cggcatggac 4380 gagctgtaca agtaa 4395

<210> 3

<211> 7125

<212> DNA

<213> Unknown

<220>

<223> Operon composed of operator DNA-binding elements, minimal or

constitutive promoter, structural genes

<400> 3

taaagagcag aaactcatct tccgtttcca catcttgctg gcagccgggg taccgcaggc 60 aagtcgctaa agagcagaaa ctcatcttcc gtttccacat ctatggaatc acggcggccg 120 cccgtatctc atcctaaaga gcagaaactc atcttccgtt tccacatcta atgcgtcggc 180 gtgcggccgc tgccagttgc ataaagagca gaaactcatc ttccgtttcc acatctttgg 240 ctgtcctagg gtacctggac gctccttgta aagagcagaa actcatcttc cgtttccaca 300 tcttggctgg tgccgcaccg gtaagcagaa ctagaggtgg caccggtttg attgcacagc 360 taaagagcag aaactcatct tccgtttcca catcttgctg gcagccgggg taccgcaggc 420 aagtcgctaa agagcagaaa ctcatcttcc gtttccacat ctatggaatc acggcggccg 480 cccgtatctc atcctaaaga gcagaaactc atcttccgtt tccacatcta atgcgtcggc 540 gtgcggccgc tgccagttgc ataaagagca gaaactcatc ttccgtttcc acatctttgg 600 ctgtcctagg gtacctggac gctccttgta aagagcagaa actcatcttc cgtttccaca 660 tcttggctgg tgccgcaccg gtaagcagag gatcttagag ggtatataat ggaagctcga 720 cttccagctc gagggcaatc cggtactgtt ggtaaagcca ccgaattcgc caccatgcac 780 caccaccacc accacgacta caaagaccat gacggtgatt ataaagatca tgacatcgat 840 tacaaggatg acgatgacaa gatggccccc aagaagaaga ggaaggtggg cattcaccgc 900 ggggtaccta tggtggactt gaggacactc ggttattcgc aacagcaaca ggagaaaatc 960 aagcctaagg tcaggagcac cgtcgcgcaa caccacgagg cgcttgtggg gcatggcttc 1020 actcatgcgc atattgtcgc gctttcacag caccctgcgg cgcttgggac ggtggctgtc 1080 aaataccaag atatgattgc ggccctgccc gaagccacgc acgaggcaat tgtaggggtc 1140 ggtaaacagt ggtcgggagc gcgagcactt gaggcgctgc tgactgtggc gggtgagctt 1200 agggggcctc cgctccagct cgacaccggg cagctgctga agatcgcgaa gagaggggga 1260 4/65 gtaacagcgg tagaggcagt gcacgcctgg cgcaatgcgc tcaccggggc ccccttgaac 1320 ctgaccccag accaggtagt cgcaatcgcg tcaaacggag ggggaaagca agccctggaa 1380 accgtgcaaa ggttgttgcc ggtcctttgt caagaccacg gccttacacc ggagcaagtc 1440 gtggccattg caagcaatgg gggtggcaaa caggctcttg agacggttca gagacttctc 1500 ccagttctct gtcaagccca cgggctgact cccgatcaag ttgtagcgat tgcgtcgaac 1560 attggaggga aacaagcatt ggagactgtc caacggctcc ttcccgtgtt gtgtcaagcc 1620 cacggtttga cgcctgcaca agtggtcgcc atcgccagcc atgatggcgg taagcaggcg 1680 ctggaaacag tacagcgcct gctgcctgta ctgtgccagg atcatggact gaccccagac 1740 caggtagtcg caatcgcgtc aaacggaggg ggaaagcaag ccctggaaac cgtgcaaagg 1800 ttgttgccgg tcctttgtca agaccacggc cttacaccgg agcaagtcgt ggccattgca 1860 aataataacg gtggcaaaca ggctcttgag acggttcaga gacttctccc agttctctgt 1920 caagcccacg ggctgactcc cgatcaagtt gtagcgattg cgtcgcatga cggagggaaa 1980 caagcattgg agactgtcca acggctcctt cccgtgttgt gtcaagccca cggtttgacg 2040 cctgcacaag tggtcgccat cgcctcgaat ggcggcggta agcaggcgct ggaaacagta 2100 cagcgcctgc tgcctgtact gtgccaggat catggactga ccccagacca ggtagtcgca 2160 atcgcgaaca ataatggggg aaagcaagcc ctggaaaccg tgcaaaggtt gttgccggtc 2220 ctttgtcaag accacggcct tacaccggag caagtcgtgg ccattgcatc ccacgacggt 2280 ggcaaacagg ctcttgagac ggttcagaga cttctcccag ttctctgtca agcccacggg 2340 ctgactcccg atcaagttgt agcgattgcg tccaacggtg gagggaaaca agcattggag 2400 actgtccaac ggctccttcc cgtgttgtgt caagcccacg gtttgacgcc tgcacaagtg 2460 gtcgccatcg ccagccatga tggcggtaag caggcgctgg aaacagtaca gcgcctgctg 2520 cctgtactgt gccaggatca tggactgacc ccagaccagg tagtcgcaat cgcgtcacat 2580 gacgggggaa agcaagccct ggaaaccgtg caaaggttgt tgccggtcct ttgtcaagac 2640 cacggcctta caccggagca agtcgtggcc attgcatccc acgacggtgg caaacaggct 2700 cttgagacgg ttcagagact tctcccagtt ctctgtcaag cccacgggct gactcccgat 2760 caagttgtag cgattgcgaa taacaatgga gggaaacaag cattggagac tgtccaacgg 2820 ctccttcccg tgttgtgtca agcccacggt ttgacgcctg cacaagtggt cgccatcgcc 2880 agccatgatg gcggtaagca ggcgctggaa acagtacagc gcctgctgcc tgtactgtgc 2940 caggatcatg gactgacacc cgaacaggtg gtcgccattg cttctaatgg gggaggacgg 3000 ccagccttgg agtccatcgt agcccaattg tccaggcccg atcccgcgtt ggctgcgtta 3060 acgaatgacc atctggtggc gttggcatgt cttggtggac gacccgcgct cgatgcagtc 3120 aaaaagggtc tgcctcatgc tcccgcattg atcaaaagaa ccaaccggcg gattcccgag 3180 agaacttccc atcgagtcgc gggatccgat ccaaaaaaga agagaaaggt accaaaaaag 3240 aagagaaagg tcgacggcgg tggtgctttg tctcctcagc actctgctgt cactcaagga 3300 agtatcatca agaacaagga gggcatggat gctaagtcac taactgcctg gtcccggaca 3360 ctggtgacct tcaaggatgt atttgtggac ttcaccaggg aggagtggaa gctgctggac 3420 actgctcagc agatcgtgta cagaaatgtg atgctggaga actataagaa cctggtttcc 3480 ttgggttatc agcttactaa gccagatgtg atcctccggt tggagaaggg agaagagccc 3540 tggctggtgg agagagaaat tcaccaagag acccatcctg attcagagac tgcatttgaa 3600 atcaaatcat cagttagagc cgaggggaga ggaagtcttc tgacctgcgg agacgtcgaa 3660 gagaatcctg gacccgacta caaagaccat gacggtgatt ataaagatca tgacatcgat 3720 tacaaggatg acgatgacaa gatggccccc aagaagaaga ggaaggtggg cattcaccgc 3780 ggggtaccta tggtggactt gaggacactc ggttattcgc aacagcaaca ggagaaaatc 3840 aagcctaagg tcaggagcac cgtcgcgcaa caccacgagg cgcttgtggg gcatggcttc 3900 actcatgcgc atattgtcgc gctttcacag caccctgcgg cgcttgggac ggtggctgtc 3960 aaataccaag atatgattgc ggccctgccc gaagccacgc acgaggcaat tgtaggggtc 4020 ggtaaacagt ggtcgggagc gcgagcactt gaggcgctgc tgactgtggc gggtgagctt 4080 agggggcctc cgctccagct cgacaccggg cagctgctga agatcgcgaa gagaggggga 4140 gtaacagcgg tagaggcagt gcacgcctgg cgcaatgcgc tcaccggggc ccccttgaac 4200 ctgaccccag accaggtagt cgcaatcgcg tcacatgacg ggggaaagca agccctggaa 4260 accgtgcaaa ggttgttgcc ggtcctttgt caagaccacg gccttacacc ggagcaagtc 4320 gtggccattg caagcaatgg gggtggcaaa caggctcttg agacggttca gagacttctc 4380 ccagttctct gtcaagccca cgggctgact cccgatcaag ttgtagcgat tgcgtccaac 4440 ggtggaggga aacaagcatt ggagactgtc caacggctcc ttcccgtgtt gtgtcaagcc 4500 cacggtttga cgcctgcaca agtggtcgcc atcgccagcc atgatggcgg taagcaggcg 4560 ctggaaacag tacagcgcct gctgcctgta ctgtgccagg atcatggact gaccccagac 4620 caggtagtcg caatcgcgtc acatgacggg ggaaagcaag ccctggaaac cgtgcaaagg 4680 ttgttgccgg tcctttgtca agaccacggc cttacaccgg agcaagtcgt ggccattgca 4740 aataataacg gtggcaaaca ggctcttgag acggttcaga gacttctccc agttctctgt 4800 caagcccacg ggctgactcc cgatcaagtt gtagcgattg cgtccaacgg tggagggaaa 4860 caagcattgg agactgtcca acggctcctt cccgtgttgt gtcaagccca cggtttgacg 4920 cctgcacaag tggtcgccat cgcctcgaat ggcggcggta agcaggcgct ggaaacagta 4980 cagcgcctgc tgcctgtact gtgccaggat catggactga ccccagacca ggtagtcgca 5040 atcgcgtcaa acggaggggg aaagcaagcc ctggaaaccg tgcaaaggtt gttgccggtc 5100 ctttgtcaag accacggcct tacaccggag caagtcgtgg ccattgcatc ccacgacggt 5160 ggcaaacagg ctcttgagac ggttcagaga cttctcccag ttctctgtca agcccacggg 5220 ctgactcccg atcaagttgt agcgattgcg tcgcatgacg gagggaaaca agcattggag 5280 actgtccaac ggctccttcc cgtgttgtgt caagcccacg gtttgacgcc tgcacaagtg 5340 5/65 gtcgccatcg cctccaatat tggcggtaag caggcgctgg aaacagtaca gcgcctgctg 5400 cctgtactgt gccaggatca tggactgacc ccagaccagg tagtcgcaat cgcgtcacat 5460 gacgggggaa agcaagccct ggaaaccgtg caaaggttgt tgccggtcct ttgtcaagac 5520 cacggcctta caccggagca agtcgtggcc attgcaagca acatcggtgg caaacaggct 5580 cttgagacgg ttcagagact tctcccagtt ctctgtcaag cccacgggct gactcccgat 5640 caagttgtag cgattgcgtc caacggtgga gggaaacaag cattggagac tgtccaacgg 5700 ctccttcccg tgttgtgtca agcccacggt ttgacgcctg cacaagtggt cgccatcgcc 5760 agccatgatg gcggtaagca ggcgctggaa acagtacagc gcctgctgcc tgtactgtgc 5820 caggatcatg gactgacacc cgaacaggtg gtcgccattg cttctaatgg gggaggacgg 5880 ccagccttgg agtccatcgt agcccaattg tccaggcccg atcccgcgtt ggctgcgtta 5940 acgaatgacc atctggtggc gttggcatgt cttggtggac gacccgcgct cgatgcagtc 6000 aaaaagggtc tgcctcatgc tcccgcattg atcaaaagaa ccaaccggcg gattcccgag 6060 agaacttccc atcgagtcgc gggatccgat ccaaaaaaga agagaaaggt agcccccccg 6120 accgatgtca gcctggggga cgagctccac ttagacggcg aggacgtggc gatggcgcat 6180 gccgacgcgc tagacgattt cgatctggac atgttggggg acggggattc cccgggtccg 6240 ggatttaccc cccacgactc cgccccctac ggcgctctgg atatggccga cttcgagttt 6300 gagcagatgt ttaccgatgc ccttggaatt gacgagtacg gtgggagagc cgaggggaga 6360 ggaagtcttc tgacctgcgg agacgtcgaa gagaatcctg gacccatggt gagcaagggc 6420 gaggagctgt tcaccggggt ggtgcccatc ctggtcgagc tggacggcga cgtaaacggc 6480 cacaagttca gcgtgtccgg cgagggcgag ggcgatgcca cctacggcaa gctgaccctg 6540 aagttcatct gcaccaccgg caagctgccc gtgccctggc ccaccctcgt gaccaccttc 6600 ggctacggcc tgatgtgctt cgcccgctac cccgaccaca tgaagcagca cgacttcttc 6660 aagtccgcca tgcccgaagg ctacgtccag gagcgcacca tcttcttcaa ggacgacggc 6720 aactacaaga cccgcgccga ggtgaagttc gagggcgaca^■■ ccctggtgaa ccgcatcgag 6780 ctgaagggca tcgacttcaa ggaggacggc aacatcctgg ggcacaagct ggagtacaac 6840 tacaacagcc acaacgtcta tatcatggcc gacaagcaga agaacggcat caaggtgaac 6900 ttcaagatcc gccacaacat cgaggacggc agcgtgcagc tcgccgacca ctaccagcag 6960 aacaccccca tcggcgacgg ccccgtgctg ctgcccgaca accactacct gagctaccag 7020 tccgccctga gcaaagaccc caacgagaag cgcgatcaca tggtcctgct ggagttcgtg 7080 accgccgccg ggatcactct cggcatggac gagctgtaca agtaa 7125

<210> 4

<211> 3615

<212> DNA

<213> Unknown

<220>

<223> Operon composed of operator DNA-binding elements, minimal or

constitutive promoter, structural genes

<400> 4 ^■

tttactgctg ctcccgctta aagagcagaa actcatgctg gcagccgggg taccgcaggc 60 aagtcgcttt actgctgctc ccgcttaaag agcagaaact caatggaatc acggcggccg 120 cccgtatctc atcctttact gctgctcccg cttaaagagc agaaactcaa atgcgtcggc 180 gtgcggccgc tgccagttgc atttactgct gctcccgctt aaagagcaga aactcattgg 240 ctgtcctagg gtacctggac gctccttgtt tactgctgct cccgcttaaa gagcagaaac 300 tcatggctgg tgccgcaccg gtaagcagaa ctagaggtgg caccggtttg attgcacagc 360 tttactgctg ctcccgctta aagagcagaa actcatgctg gcagccgggg taccgcaggc 420 aagtcgcttt actgctgctc ccgcttaaag agcagaaact caatggaatc acggcggccg 480 cccgtatctc atcctttact gctgctcccg cttaaagagc agaaactcaa atgcgtcggc 540 gtgcggccgc tgccagttgc atttactgct gctcccgctt aaagagcaga aactcattgg 600 ctgtcctagg gtacctggac gctccttgtt tactgctgct cccgcttaaa gagcagaaac 660 tcatggctgg tgccgcaccg gtaagcagag gatcttagag ggtatataat ggaagctcga 720 cttccagctc gagggcaatc cggtactgtt ggtaaagcca ccgaattcgc caccatgcac 780 caccaccacc accacgacta caaagaccat gacggtgatt ataaagatca tgacatcgat 840 tacaaggatg acgatgacaa gatggccccc aagaagaaga ggaaggtggg cattcaccgc 900 ggggtaccta tggtggactt gaggacactc ggttattcgc aacagcaaca ggagaaaatc 960 aagcctaagg tcaggagcac cgtcgcgcaa caccacgagg cgcttgtggg gcatggcttc 1020 actcatgcgc atattgtcgc gctttcacag caccctgcgg cgcttgggac ggtggctgtc 1080 aaataccaag atatgattgc ggccctgccc gaagccacgc acgaggcaat tgtaggggtc 1140 ggtaaacagt ggtcgggagc gcgagcactt gaggcgctgc tgactgtggc gggtgagctt 1200 agggggcctc cgctccagct cgacaccggg cagctgctga agatcgcgaa gagaggggga 1260 gtaacagcgg tagaggcagt gcacgcctgg cgcaatgcgc tcaccggggc ccccttgaac 1320 ctgaccccag accaggtagt cgcaatcgcg tcacatgacg ggggaaagca agccctggaa 1380 accgtgcaaa ggttgttgcc ggtcctttgt caagaccacg gccttacacc ggagcaagtc 1440 gtggccattg caagcaatgg gggtggcaaa caggctcttg agacggttca gagacttctc 1500 ccagttctct gtcaagccca cgggctgact cccgatcaag ttgtagcgat tgcgtccaac 1560 ggtggaggga aacaagcatt ggagactgtc caacggctcc ttcccgtgtt gtgtcaagcc 1620 cacggtttga cgcctgcaca agtggtcgcc atcgccagcc atgatggcgg taagcaggcg 1680 6/65

ctggaaacag tacagcgcct gctgcctgta ctgtgccagg atcatggact gaccccagac 1740 caggtagtcg caatcgcgtc acatgacggg ggaaagcaag ccctggaaac cgtgcaaagg 1800 ttgttgccgg tcctttgtca agaccacggc cttacaccgg agcaagtcgt ggccattgca 1860 aataataacg gtggcaaaca ggctcttgag acggttcaga gacttctccc agttctctgt 1920 caagcccacg ggctgactcc cgatcaagtt gtagcgattg cgtccaacgg tggagggaaa 1980 caagcattgg agactgtcca acggctcctt cccgtgttgt gtcaagccca cggtttgacg 2040 cctgcacaag tggtcgccat cgcctcgaat ggcggcggta agcaggcgct ggaaacagta 2100 cagcgcctgc tgcctgtact gtgccaggat catggactga ccccagacca ggtagtcgca 2160 atcgcgtcaa acggaggggg aaagcaagcc ctggaaaccg tgcaaaggtt gttgccggtc 2220 ctttgtcaag accacggcct tacaccggag caagtcgtgg ccattgcatc ccacgacggt 2280 ggcaaacagg ctcttgagac ggttcagaga cttctcccag ttctctgtca agcccacggg 2340 ctgactcccg atcaagttgt agcgattgcg tcgcatgacg gagggaaaca agcattggag 2400 actgtccaac ggctccttcc cgtgttgtgt caagcccacg gtttgacgcc tgcacaagtg 2460 gtcgccatcg cctccaatat tggcggtaag caggcgctgg aaacagtaca gcgcctgctg 2520 cctgtactgt gccaggatca tggactgacc ccagaccagg tagtcgcaat cgcgtcacat 2580 gacgggggaa agcaagccct ggaaaccgtg caaaggttgt tgccggtcct ttgtcaagac 2640 cacggcctta caccggagca agtcgtggcc attgcaagca acatcggtgg caaacaggct 2700 cttgagacgg ttcagagact tctcccagtt ctctgtcaag cccacgggct gactcccgat 2760 caagttgtag cgattgcgtc caacggtgga gggaaacaag cattggagac tgtccaacgg 2820 ctccttcccg tgttgtgtca agcccacggt ttgacgcctg cacaagtggt cgccatcgcc 2880 agccatgatg gcggtaagca ggcgctggaa acagtacagc gcctgctgcc tgtactgtgc 2940 caggatcatg gactgacacc cgaacaggtg gtcgccattg cttctaatgg gggaggacgg 3000 ccagccttgg agtccatcgt agcccaattg tccaggcccg atcccgcgtt ggctgcgtta 3060 acgaatgacc atctggtggc gttggcatgt cttggtggac gacccgcgct cgatgcagtc 3120 aaaaagggtc tgcctcatgc tcccgcattg atcaaaagaa ccaaccggcg gattcccgag 3180 agaacttccc atcgagtcgc gggatccgat ccaaaaaaga agagaaaggt accaaaaaag 3240 aagagaaagg tcgacggcgg tggtgctttg tctcctcagc actctgctgt cactcaagga 3300 agtatcatca agaacaagga gggcatggat gctaagtcac taactgcctg gtcccggaca 3360 ctggtgacct tcaaggatgt atttgtggac ttcaccaggg aggagtggaa gctgctggac 3420 actgctcagc agatcgtgta cagaaatgtg atgctggaga actataagaa cctggtttcc 3480 ttgggttatc agcttactaa gccagatgtg atcctccggt tggagaaggg agaagagccc 3540 tggctggtgg agagagaaat tcaccaagag acccatcctg attcagagac tgcatttgaa 3600 atcaaatcat cagtt 3615

<210> 5

<211> 4224

<212> DNA

<213> Unknown

<220>

<223> Operon composed of operator DNA-binding elements, minimal or

constitutive promoter, structural genes

<400> 5

tttactgctg ctcccgctta aagagcagaa actcatgctg gcagccgggg taccgcaggc 60 aagtcgcttt actgctgctc ccgcttaaag agcagaaact caatggaatc acggcggccg 120 cccgtatctc atcctttact gctgctcccg cttaaagagc agaaactcaa atgcgtcggc 180 gtgcggccgc tgccagttgc atttactgct gctcccgctt aaagagcaga aactcattgg 240 ctgtcctagg gtacctggac gctccttgtt tactgctgct cccgcttaaa gagcagaaac 300 tcatggctgg tgccgcaccg gtaagcagaa ctagaggtgg caccggtttg attgcacagc 360 tttactgctg ctcccgctta aagagcagaa actcatgctg gcagccgggg taccgcaggc 420 aagtcgcttt actgctgctc ccgcttaaag agcagaaact caatggaatc acggcggccg 480 cccgtatctc atcctttact gctgctcccg cttaaagagc agaaactcaa atgcgtcggc 540 gtgcggccgc tgccagttgc atttactgct gctcccgctt aaagagcaga aactcattgg 600 ctgtcctagg gtacctggac gctccttgtt tactgctgct cccgcttaaa gagcagaaac 660 tcatggctgg tgccgcaccg gtaagcagag gatcttagag ggtatataat ggaagctcga 720 cttccagctc gagggcaatc cggtactgtt ggtaaagcca ccgaattcgc caccatgcac 780 caccaccacc accacgacta caaagaccat gacggtgatt ataaagatca tgacatcgat 840 tacaaggatg acgatgacaa gatggccccc aagaagaaga ggaaggtggg cattcaccgc 900 ggggtaccta tggtggactt gaggacactc ggttattcgc aacagcaaca ggagaaaatc 960 aagcctaagg tcaggagcac cgtcgcgcaa caccacgagg cgcttgtggg gcatggcttc 1020 actcatgcgc atattgtcgc gctttcacag caccctgcgg cgcttgggac ggtggctgtc 1080 aaataccaag atatgattgc ggccctgccc gaagccacgc acgaggcaat tgtaggggtc 1140 ggtaaacagt ggtcgggagc gcgagcactt gaggcgctgc tgactgtggc gggtgagctt 1200 agggggcctc cgctccagct cgacaccggg cagctgctga agatcgcgaa gagaggggga 1260 gtaacagcgg tagaggcagt gcacgcctgg cgcaatgcgc tcaccggggc ccccttgaac 1320 ctgaccccag accaggtagt cgcaatcgcg tcaaacggag ggggaaagca agccctggaa 1380 accgtgcaaa ggttgttgcc ggtcctttgt caagaccacg gccttacacc ggagcaagtc 1440 gtggccattg caagcaatgg gggtggcaaa caggctcttg agacggttca gagacttctc 1500 7/65 ccagttctct gtcaagccca cgggctgact cccgatcaag ttgtagcgat tgcgtcgaac 1560 attggaggga aacaagcatt ggagactgtc caacggctcc ttcccgtgtt gtgtcaagcc 1620 cacggtttga cgcctgcaca agtggtcgcc atcgccagcc atgatggcgg taagcaggcg 1680 ctggaaacag tacagcgcct gctgcctgta ctgtgccagg atcatggact gaccccagac 1740 caggtagtcg caatcgcgtc aaacggaggg ggaaagcaag ccctggaaac cgtgcaaagg 1800 ttgttgccgg tcctttgtca agaccacggc cttacaccgg agcaagtcgt ggccattgca 1860 aataataacg gtggcaaaca ggctcttgag acggttcaga gacttctccc agttctctgt 1920 caagcccacg ggctgactcc cgatcaagtt gtagcgattg cgtcgcatga cggagggaaa 1980 caagcattgg agactgtcca acggctcctt cccgtgttgt gtcaagccca cggtttgacg 2040 cctgcacaag tggtcgccat cgcctcgaat ggcggcggta agcaggcgct ggaaacagta 2100 cagcgcctgc tgcctgtact gtgccaggat catggactga ccccagacca ggtagtcgca 2160 atcgcgaaca ataatggggg aaagcaagcc ctggaaaccg tgcaaaggtt gttgccggtc 2220 ctttgtcaag accacggcct tacaccggag caagtcgtgg ccattgcatc ccacgacggt 2280 ggcaaacagg ctcttgagac ggttcagaga cttctcccag ttctctgtca agcccacggg 2340 ctgactcccg atcaagttgt agcgattgcg tccaacggtg gagggaaaca agcattggag 2400 actgtccaac ggctccttcc cgtgttgtgt caagcccacg gtttgacgcc tgcacaagtg 2460 gtcgccatcg ccagccatga tggcggtaag caggcgctgg aaacagtaca gcgcctgctg 2520 cctgtactgt gccaggatca tggactgacc ccagaccagg tagtcgcaat cgcgtcacat 2580 gacgggggaa agcaagccct ggaaaccgtg caaaggttgt tgccggtcct ttgtcaagac 2640 cacggcctta caccggagca agtcgtggcc attgcatccc acgacggtgg caaacaggct 2700 cttgagacgg ttcagagact tctcccagtt ctctgtcaag cccacgggct gactcccgat 2760 caagttgtag cgattgcgaa taacaatgga gggaaacaag cattggagac tgtccaacgg 2820 ctccttcccg tgttgtgtca agcccacggt ttgacgcctg cacaagtggt cgccatcgcc 2880 agccatgatg gcggtaagca ggcgctggaa acagtacagc gcctgctgcc tgtactgtgc 2940 caggatcatg gactgacacc cgaacaggtg gtcgccattg cttctaatgg gggaggacgg 3000 ccagccttgg agtccatcgt agcccaattg tccaggcccg atcccgcgtt ggctgcgtta 3060 acgaatgacc atctggtggc gttggcatgt cttggtggac gacccgcgct cgatgcagtc 3120 aaaaagggtc tgcctcatgc tcccgcattg atcaaaagaa ccaaccggcg gattcccgag 3180 agaacttccc atcgagtcgc gggatccgat ccaaaaaaga agagaaaggt agcccccccg 3240 accgatgtca gcctggggga cgagctccac ttagacggcg aggacgtggc gatggcgcat 3300 gccgacgcgc tagacgattt cgatctggac atgttggggg acggggattc cccgggtccg 3360 ggatttaccc cccacgactc cgccccctac ggcgctctgg atatggccga cttcgagttt 3420 gagcagatgt ttaccgatgc ccttggaatt gacgagtacg gtgggagagc cgaggggaga 3480 ggaagtcttc tgacctgcgg agacgtcgaa gagaatcctg gacccatgag cgagctgatt 3540 aaggagaaca tgcacatgaa gctgtacatg gagggcaccg tggacaacca tcacttcaag 3600 tgcacatccg agggcgaagg caagccctac gagggcaccc agaccatgag aatcaaggtg 3660 gtcgagggcg gccctctccc cttcgccttc gacatcctgg ctactagctt cctctacggc 3720 agcaagacct tcatcaacca cacccagggc atccccgact tcttcaagca gtccttccct 3780 gagggcttca catgggagag agtcaccaca tacgaagacg ggggcgtgct gaccgctacc 3840 caggacacca gcctccagga cggctgcctc atctacaacg tcaagatcag aggggtgaac 3900 ttcacatcca acggccctgt gatgcagaag aaaacactcg gctgggaggc cttcaccgag 3960 acgctgtacc ccgctgacgg cggcctggaa ggcagaaacg acatggccct gaagctcgtg 4020 ggcgggagcc atctgatcgc aaacatcaag accacatata gatccaagaa acccgctaag 4080 aacctcaaga tgcctggcgt ctactatgtg gactacagac tggaaagaat caaggaggcc 4140 aacaacgaga cctacgtcga gcagcacgag gtggcagtgg ccagatactg cgacctccct 4200 agcaaactgg ggcacaagct caat 4224

<210> 6

<211> 7104

<212> DNA

<213> Unknown

<220>

<223> Operon composed of operator DNA-binding elements, minimal or

constitutive promoter, structural genes

<400> 6

tttactgctg ctcccgctta aagagcagaa actcatgctg gcagccgggg taccgcaggc 60 aagtcgcttt actgctgctc ccgcttaaag agcagaaact caatggaatc acggcggccg 120 cccgtatctc atcctttact gctgctcccg cttaaagagc agaaactcaa atgcgtcggc 180 gtgcggccgc tgccagttgc atttactgct gctcccgctt aaagagcaga aactcattgg 240 ctgtcctagg gtacctggac gctccttgtt tactgctgct cccgcttaaa gagcagaaac 300 tcatggctgg tgccgcaccg gtaagcagaa ctagaggtgg caccggtttg attgcacagc 360 tttactgctg ctcccgctta aagagcagaa actcatgctg gcagccgggg taccgcaggc 420 aagtcgcttt actgctgctc ccgcttaaag agcagaaact caatggaatc acggcggccg 480 cccgtatctc atcctttact gctgctcccg cttaaagagc agaaactcaa atgcgtcggc 540 gtgcggccgc tgccagttgc atttactgct gctcccgctt aaagagcaga aactcattgg 600 ctgtcctagg gtacctggac gctccttgtt tactgctgct cccgcttaaa gagcagaaac 660 tcatggctgg tgccgcaccg gtaagcagag gatcttagag ggtatataat ggaagctcga 720 8/65 cttccagctc gagggcaatc cggtactgtt ggtaaagcca ccgaattcgc caccatgcac 780 caccaccacc accacgacta caaagaccat gacggtgatt ataaagatca tgacatcgat 840 tacaaggatg acgatgacaa gatggccccc aagaagaaga ggaaggtggg cattcaccgc 900 ggggtaccta tggtggactt gaggacactc ggttattcgc aacagcaaca ggagaaaatc 960 aagcctaagg tcaggagcac cgtcgcgcaa caccacgagg cgcttgtggg gcatggcttc 1020 actcatgcgc atattgtcgc gctttcacag caccctgcgg cgcttgggac ggtggctgtc 1080 aaataccaag atatgattgc ggccctgccc gaagccacgc acgaggcaat tgtaggggtc 1140 ggtaaacagt ggtcgggagc gcgagcactt gaggcgctgc tgactgtggc gggtgagctt 1200 agggggcctc cgctccagct cgacaccggg cagctgctga agatcgcgaa gagaggggga 1260 gtaacagcgg tagaggcagt gcacgcctgg cgcaatgcgc tcaccggggc ccccttgaac 1320 ctgaccccag accaggtagt cgcaatcgcg tcacatgacg ggggaaagca agccctggaa 1380 accgtgcaaa ggttgttgcc ggtcctttgt caagaccacg gccttacacc ggagcaagtc 1440 gtggccattg caagcaatgg gggtggcaaa caggctcttg agacggttca gagacttctc 1500 ccagttctct gtcaagccca cgggctgact cccgatcaag ttgtagcgat tgcgtccaac 1560 ggtggaggga aacaagcatt ggagactgtc caacggctcc ttcccgtgtt gtgtcaagcc 1620 cacggtttga cgcctgcaca agtggtcgcc atcgccagcc atgatggcgg taagcaggcg 1680 ctggaaacag tacagcgcct gctgcctgta ctgtgccagg atcatggact gaccccagac 1740 caggtagtcg caatcgcgtc acatgacggg ggaaagcaag ccctggaaac cgtgcaaagg 1800 ttgttgccgg tcctttgtca agaccacggc cttacaccgg agcaagtcgt ggccattgca 1860 aataataacg gtggcaaaca ggctcttgag acggttcaga gacttctccc agttctctgt 1920 caagcccacg ggctgactcc cgatcaagtt gtagcgattg cgtccaacgg tggagggaaa 1980 caagcattgg agactgtcca acggctcctt cccgtgttgt gtcaagccca cggtttgacg 2040 cctgcacaag tggtcgccat cgcctcgaat ggcggcggta agcaggcgct ggaaacagta 2100 cagcgcctgc tgcctgtact gtgccaggat catggactga ccccagacca ggtagtcgca 2160 atcgcgtcaa acggaggggg aaagcaagcc ctggaaaccg tgcaaaggtt gttgccggtc 2220 ctttgtcaag accacggcct tacaccggag caagtcgtgg ccattgcatc ccacgacggt 2280 ggcaaacagg ctcttgagac ggttcagaga cttctcccag ttctctgtca agcccacggg 2340 ctgactcccg atcaagttgt agcgattgcg tcgcatgacg gagggaaaca agcattggag 2400 actgtccaac ggctccttcc cgtgttgtgt caagcccacg gtttgacgcc tgcacaagtg 2460 gtcgccatcg cctccaatat tggcggtaag caggcgctgg aaacagtaca gcgcctgctg 2520 cctgtactgt gccaggatca tggactgacc ccagaccagg tagtcgcaat cgcgtcacat 2580 gacgggggaa agcaagccct ggaaaccgtg caaaggttgt tgccggtcct ttgtcaagac 2640 cacggcctta caccggagca agtcgtggcc attgcaagca acatcggtgg caaacaggct 2700 cttgagacgg ttcagagact tctcccagtt ctctgtcaag cccacgggct gactcccgat 2760 caagttgtag cgattgcgtc caacggtgga gggaaacaag cattggagac tgtccaacgg 2820 ctccttcccg tgttgtgtca agcccacggt ttgacgcctg cacaagtggt cgccatcgcc 2880 agccatgatg gcggtaagca ggcgctggaa acagtacagc gcctgctgcc tgtactgtgc 2940 caggatcatg gactgacacc cgaacaggtg gtcgccattg cttctaatgg gggaggacgg 3000 ccagccttgg agtccatcgt agcccaattg tccaggcccg atcccgcgtt ggctgcgtta 3060 acgaatgacc atctggtggc gttggcatgt cttggtggac gacccgcgct cgatgcagtc 3120 aaaaagggtc tgcctcatgc tcccgcattg atcaaaagaa ccaaccggcg gattcccgag 3180 agaacttccc atcgagtcgc gggatccgat ccaaaaaaga agagaaaggt accaaaaaag 3240 aagagaaagg tcgacggcgg tggtgctttg tctcctcagc actctgctgt cactcaagga 3300 agtatcatca agaacaagga gggcatggat gctaagtcac taactgcctg gtcccggaca 3360 ctggtgacct tcaaggatgt atttgtggac ttcaccaggg aggagtggaa gctgctggac 3420 actgctcagc agatcgtgta cagaaatgtg atgctggaga actataagaa cctggtttcc 3480 ttgggttatc agcttactaa gccagatgtg atcctccggt tggagaaggg agaagagccc 3540 tggctggtgg agagagaaat tcaccaagag acccatcctg attcagagac tgcatttgaa 3600 atcaaatcat cagttagagc cgaggggaga ggaagtcttc tgacctgcgg agacgtcgaa 3660 gagaatcctg gacccgacta caaagaccat gacggtgatt ataaagatca tgacatcgat 3720 tacaaggatg acgatgacaa gatggccccc aagaagaaga ggaaggtggg cattcaccgc 3780 ggggtaccta tggtggactt gaggacactc ggttattcgc aacagcaaca ggagaaaatc 3840 aagcctaagg tcaggagcac cgtcgcgcaa caccacgagg cgcttgtggg gcatggcttc 3900 actcatgcgc atattgtcgc gctttcacag caccctgcgg cgcttgggac ggtggctgtc 3960 aaataccaag atatgattgc ggccctgccc gaagccacgc acgaggcaat tgtaggggtc 4020 ggtaaacagt ggtcgggagc gcgagcactt gaggcgctgc tgactgtggc gggtgagctt 4080 agggggcctc cgctccagct cgacaccggg cagctgctga agatcgcgaa gagaggggga 4140 gtaacagcgg tagaggcagt gcacgcctgg cgcaatgcgc tcaccggggc ccccttgaac 4200 ctgaccccag accaggtagt cgcaatcgcg tcaaacggag ggggaaagca agccctggaa 4260 accgtgcaaa ggttgttgcc ggtcctttgt caagaccacg gccttacacc ggagcaagtc 4320 gtggccattg caagcaatgg gggtggcaaa caggctcttg agacggttca gagacttctc 4380 ccagttctct gtcaagccca cgggctgact cccgatcaag ttgtagcgat tgcgtcgaac 4440 attggaggga aacaagcatt ggagactgtc caacggctcc ttcccgtgtt gtgtcaagcc 4500 cacggtttga cgcctgcaca agtggtcgcc atcgccagcc atgatggcgg taagcaggcg 4560 ctggaaacag tacagcgcct gctgcctgta ctgtgccagg atcatggact gaccccagac 4620 caggtagtcg caatcgcgtc aaacggaggg ggaaagcaag ccctggaaac cgtgcaaagg 4680 ttgttgccgg tcctttgtca agaccacggc cttacaccgg agcaagtcgt ggccattgca 4740 aataataacg- gtggcaaaca ggctcttgag acggttcaga gacttctccc agttctctgt 4800 9/65 caagcccacg ggctgactcc cgatcaagtt gtagcgattg cgtcgcatga cggagggaaa 4860 caagcattgg agactgtcca acggctcctt cccgtgttgt gtcaagccca cggtttgacg 4920 cctgcacaag tggtcgccat cgcctcgaat ggcggcggta agcaggcgct ggaaacagta 4980 cagcgcctgc tgcctgtact gtgccaggat catggactga ccccagacca ggtagtcgca 5040 atcgcgaaca ataatggggg aaagcaagcc ctggaaaccg tgcaaaggtt gttgccggtc 5100 ctttgtcaag accacggcct tacaccggag caagtcgtgg ccattgcatc ccacgacggt 5160 ggcaaacagg ctcttgagac ggttcagaga cttctcccag ttctctgtca agcccacggg 5220 ctgactcccg atcaagttgt agcgattgcg tccaacggtg gagggaaaca agcattggag 5280 actgtccaac ggctccttcc cgtgttgtgt caagcccacg gtttgacgcc tgcacaagtg 5340 gtcgccatcg ccagccatga tggcggtaag caggcgctgg aaacagtaca gcgcctgctg 5400 cctgtactgt gccaggatca tggactgacc ccagaccagg tagtcgcaat cgcgtcacat 5460 gacgggggaa agcaagccct ggaaaccgtg caaaggttgt tgccggtcct ttgtcaagac 5520 cacggcctta caccggagca agtcgtggcc attgcatccc acgacggtgg caaacaggct 5580 cttgagacgg ttcagagact tctcccagtt ctctgtcaag cccacgggct gactcccgat 5640 caagttgtag cgattgcgaa taacaatgga gggaaacaag cattggagac tgtccaacgg 5700 ctccttcccg tgttgtgtca agcccacggt ttgacgcctg cacaagtggt cgccatcgcc 5760 agccatgatg gcggtaagca ggcgctggaa acagtacagc gcctgctgcc tgtactgtgc 5820 caggatcatg gactgacacc cgaacaggtg gtcgccattg cttctaatgg gggaggacgg 5880 ccagccttgg agtccatcgt agcccaattg tccaggcccg atcccgcgtt ggctgcgtta 5940 acgaatgacc atctggtggc gttggcatgt cttggtggac gacccgcgct cgatgcagtc 6000 aaaaagggtc tgcctcatgc tcccgcattg atcaaaagaa ccaaccggcg gattcccgag 6060 agaacttccc atcgagtcgc gggatccgat ccaaaaaaga agagaaaggt agcccccccg 6120 accgatgtca gcctggggga cgagctccac ttagacggcg aggacgtggc gatggcgcat 6180 gccgacgcgc tagacgattt cgatctggac atgttggggg acggggattc cccgggtccg 6240 ggatttaccc cccacgactc cgccccctac ggcgctctgg atatggccga cttcgagttt 6300 gagcagatgt ttaccgatgc ccttggaatt gacgagtacg gtgggagagc cgaggggaga 6360 ggaagtcttc tgacctgcgg agacgtcgaa gagaatcctg gacccatgag cgagctgatt 6420 aaggagaaca tgcacatgaa gctgtacatg gagggcaccg tggacaacca tcacttcaag 6480 tgcacatccg agggcgaagg caagccctac gagggcaccc agaccatgag aatcaaggtg 6540 gtcgagggcg gccctctccc cttcgccttc gacatcctgg ctactagctt cctctacggc 6600 agcaagacct tcatcaacca cacccagggc atccccgact tcttcaagca gtccttccct 6660 gagggcttca catgggagag agtcaccaca tacgaagacg ggggcgtgct gaccgctacc 6720 caggacacca gcctccagga cggctgcctc atctacaacg tcaagatcag aggggtgaac 6780 ttcacatcca acggccctgt gatgcagaag aaaacactcg gctgggaggc cttcaccgag 6840 acgctgtacc ccgctgacgg cggcctggaa ggcagaaacg acatggccct gaagctcgtg 6900 ggcgggagcc atctgatcgc aaacatcaag accacatata gatccaagaa acccgctaag 6960 aacctcaaga tgcctggcgt ctactatgtg gactacagac tggaaagaat caaggaggcc 7020 aacaacgaga cctacgtcga gcagcacgag gtggcagtgg ccagatactg cgacctccct 7080 agcaaactgg ggcacaagct caat 7104

<210> 7

<211> 3645

<212> DNA

<213> Unknown

<220>

<223> Operon composed of operator DNA-binding elements, minimal or

constitutive promoter, structural genes

<400> 7

acattgatta ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc 60 atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa 120 cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac 180 tttccattga cgtcaatggg tggactattt acggtaaact gcccacttgg cagtacatca 240 agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg 300 gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt 360 agtcatcgct attaccatgg tgatgcggtt ttggcagtac atcaatgggc gtggatagcg 420 gtttgactca cggggatttc caagtctcca ccccattgac gtcaatggga gtttgttttg 480 gcaccaaaat caacgggact ttccaaaatg tcgtaacaac tccgccccat tgacgcaaat 540 gggcggtagg cgtgtacggt gggaggtcta tataagcaga gctctctggc taactagaga 600 acccactgct tactggctta tcgaaattaa tacgactcac tatagggaga cccaagctta 660 tcgataggta ccctcgagtt taccactccc tatcagtgat agagaaaagt gaaagtcgag 720 tttaccactc cctatcagtg atagagaaaa gtgaaagtcg agtttaccac tccctatcag 780 tgatagagaa aagtgaaagt cgagtttacc actccctatc agtgatagag aaaagtgaaa 840 gtcgagttta ccactcccta tcagtgatag agaaaagtga aagtcgagtt taccactccc 900 tatcagtgat agagaaaagt gaaagtcgag ctcgctagcg aattcgccac catgcaccac 960 caccaccacc acgactacaa agaccatgac ggtgattata aagatcatga catcgattac 1020 aaggatgacg atgacaagat ggcccccaag aagaagagga aggtgggcat tcaccgcggg 1080 gtacctatgg tggacttgag gacactcggt tattcgcaac agcaacagga gaaaatcaag 1140 10/65 cctaaggtca ggagcaccgt cgcgcaacac cacgaggcgc ttgtggggc^'a tggcttcact 1200 catgcgcata ttgtcgcgct ttcacagcac cctgcggcgc ttgggacggt ggctgtcaaa 1260 taccaagata tgattgcggc cctgcccgaa gccacgcacg aggcaattgt aggggtcggt 1320 aaacagtggt cgggagcgcg agcacttgag gcgctgctga ctgtggcggg tgagcttagg 1380 gggcctccgc tccagctcga caccgggcag ctgctgaaga tcgcgaagag agggggagta 1440 acagcggtag aggcagtgca cgcctggcgc aatgcgctca ccggggcccc cttgaacctg 1500 accccagacc aggtagtcgc aatcgcgtca catgacgggg gaaagcaagc cctggaaacc 1560 gtgcaaaggt tgttgccggt cctttgtcaa gaccacggcc ttacaccgga gcaagtcgtg 1620 gccattgcaa gcaatggggg tggcaaacag gctcttgaga cggttcagag acttctccca 1680 gttctctgtc aagcccacgg gctgactccc gatcaagttg tagcgattgc gtccaacggt 1740 ggagggaaac aagcattgga gactgtccaa cggctccttc ccgtgttgtg tcaagcccac 1800 ggtttgacgc ctgcacaagt ggtcgccatc gccagccatg atggcggtaa gcaggcgctg 1860 gaaacagtac agcgcctgct gcctgtactg tgccaggatc atggactgac cccagaccag 1920 gtagtcgcaa tcgcgtcaca tgacggggga aagcaagccc tggaaaccgt gcaaaggttg 1980 ttgccggtcc tttgtcaaga ccacggcctt acaccggagc aagtcgtggc cattgcaaat 2040 aataacggtg gcaaacaggc tcttgagacg gttcagagac ttctcccagt tctctgtcaa 2100 gcccacgggc tgactcccga tcaagttgta gcgattgcgt ccaacggtgg agggaaacaa 2160 gcattggaga ctgtccaacg gctccttccc gtgttgtgtc aagcccacgg tttgacgcct 2220 gcacaagtgg tcgccatcgc ctcgaatggc ggcggtaagc aggcgctgga aacagtacag 2280 cgcctgctgc ctgtactgtg ccaggatcat ggactgaccc cagaccaggt agtcgcaatc 2340 gcgtcaaacg gagggggaaa gcaagccctg gaaaccgtgc aaaggttgtt gccggtcctt 2400 tgtcaagacc acggccttac accggagcaa gtcgtggcca ttgcatccca cgacggtggc 2460 aaacaggctc ttgagacggt tcagagactt ctcccagttc tctgtcaagc ccacgggctg 2520 actcccgatc aagttgtagc gattgcgtcg catgacggag ggaaacaagc attggagact 2580 gtccaacggc tccttcccgt gttgtgtcaa gcccacggtt tgacgcctgc acaagtggtc 2640 gccatcgcct ccaatattgg cggtaagcag gcgctggaaa cagtacagcg cctgctgcct 2700 gtactgtgcc aggatcatgg actgacccca gaccaggtag tcgcaatcgc gtcacatgac 2760 gggggaaagc aagccctgga aaccgtgcaa aggttgttgc cggtcctttg tcaagaccac 2820 ggccttacac cggagcaagt cgtggccatt gcaagcaaca tcggtggcaa acaggctctt 2880 gagacggttc agagacttct cccagttctc tgtcaagccc acgggctgac tcccgatcaa 2940 gttgtagcga ttgcgtccaa cggtggaggg aaacaagcat tggagactgt ccaacggctc 3000 cttcccgtgt tgtgtcaagc ccacggtttg acgcctgcac aagtggtcgc catcgccagc 3060 catgatggcg gtaagcaggc gctggaaaca gtacagcgcc tgctgcctgt actgtgccag 3120 gatcatggac tgacacccga acaggtggtc gccattgctt ctaatggggg aggacggcca 3180 gccttggagt ccatcgtagc ccaattgtcc aggcccgatc ccgcgttggc tgcgttaacg 3240 aatgaccatc tggtggcgtt ggcatgtctt ggtggacgac ccgcgctcga tgcagtcaaa 3300 aagggtctgc ctcatgctcc cgcattgatc aaaagaacca accggcggat tcccgagaga 3360 acttcccatc gagtcgcggg atccgatcca aaaaagaaga gaaaggtagc acccccgacc 3420 gatgtcagcc tgggggacga gctccactta gacggcgagg acgtggcgat ggcgcatgcc 3480 gacgcgctag acgatttcga tctggacatg ttgggggacg gggattcccc gggtccggga 3540 tttacccccc acgactccgc cccctacggc gctctggata tggccgactt cgagtttgag 3600 cagatgttta ccgatgccct tggaattgac gagtacggtg ggtag 3645

<210> 8

<211> 3792

<212> DNA

<213> Unknown

<220>

<223> Operon composed of operator DNA-binding elements, minimal or

constitutive promoter, structural genes

<400> 8

acattgatta ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc 60 atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa 120 cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac 180 tttccattga cgtcaatggg tggactattt acggtaaact gcccacttgg cagtacatca 240 agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg 300 gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt 360 agtcatcgct attaccatgg tgatgcggtt ttggcagtac atcaatgggc gtggatagcg 420 gtttgactca cggggatttc caagtctcca ccccattgac gtcaatggga gtttgttttg 480 gcaccaaaat caacgggact ttccaaaatg tcgtaacaac tccgccccat tgacgcaaat 540 gggcggtagg cgtgtacggt gggaggtcta tataagcaga gctctctggc taactagaga 600 acccactgct tactggctta tcgaaattaa tacgactcac tatagggaga cccaagctta 660 tcgataggta ccctcgagtt taccactccc tatcagtgat agagaaaagt gaaagtcgag 720 tttaccactc cctatcagtg atagagaaaa gtgaaagtcg agtttaccac tccctatcag 780 tgatagagaa aagtgaaagt cgagtttacc actccctatc agtgatagag aaaagtgaaa 840 gtcgagttta ccactcccta tcagtgatag agaaaagtga aagtcgagtt taccactccc 900 tatcagtgat agagaaaagt gaaagtcgag ctcgctagcg aattcgccac catgcaccac 960 11/65 caccaccacc acgactacaa agaccatgac ggtgattata aagatcatga catcgattac 1020 aaggatgacg atgacaagat ggcccccaag aagaagagga aggtgggcat tcaccgcggg 1080 gtacctatgg tggacttgag gacactcggt tattcgcaac agcaacagga gaaaatcaag 1140 cctaaggtca ggagcaccgt cgcgcaacac cacgaggcgc ttgtggggca tggcttcact 1200 catgcgcata ttgtcgcgct ttcacagcac cctgcggcgc ttgggacggt ggctgtcaaa 1260 taccaagata tgattgcggc cctgcccgaa gccacgcacg aggcaattgt aggggtcggt 1320 aaacagtggt cgggagcgcg agcacttgag gcgctgctga ctgtggcggg tgagcttagg 1380 gggcctccgc tccagctcga caccgggcag ctgctgaaga tcgcgaagag agggggagta 1440 acagcggtag aggcagtgca cgcctggcgc aatgcgctca ccggggcccc cttgaacctg 1500 accccagacc aggtagtcgc aatcgcgtca aacggagggg gaaagcaagc cctggaaacc 1560 gtgcaaaggt tgttgccggt cctttgtcaa gaccacggcc ttacaccgga gcaagtcgtg 1620 gccattgcaa gcaatggggg tggcaaacag gctcttgaga cggttcagag acttctccca 1680 gttctctgtc aagcccacgg gctgactccc gatcaagttg tagcgattgc gtcgaacatt 1740 ggagggaaac aagcattgga gactgtccaa cggctccttc ccgtgttgtg tcaagcccac 1800 ggtttgacgc ctgcacaagt ggtcgccatc gccagccatg atggcggtaa gcaggcgctg 1860 gaaacagtac agcgcctgct gcctgtactg tgccaggatc atggactgac cccagaccag 1920 gtagtcgcaa tcgcgtcaaa cggaggggga aagcaagccc tggaaaccgt gcaaaggttg 1980 ttgccggtcc tttgtcaaga ccacggcctt acaccggagc aagtcgtggc cattgcaaat 2040 aataacggtg gcaaacaggc tcttgagacg gttcagagac ttctcccagt tctctgtcaa 2100 gcccacgggc tgactcccga tcaagttgta gcgattgcgt cgcatgacgg agggaaacaa 2160 gcattggaga ctgtccaacg gctccttccc gtgttgtgtc aagcccacgg tttgacgcct 2220 gcacaagtgg tcgccatcgc ctcgaatggc ggcggtaagc aggcgctgga aacagtacag 2280 cgcctgctgc ctgtactgtg ccaggatcat ggactgaccc cagaccaggt agtcgcaatc 2340 gcgaacaata atgggggaaa gcaagccctg gaaaccgtgc aaaggttgtt gccggtcctt 2400 tgtcaagacc acggccttac accggagcaa gtcgtggcca ttgcatccca cgacggtggc 2460 aaacaggctc ttgagacggt tcagagactt ctcccagttc tctgtcaagc ccacgggctg 2520 actcccgatc aagttgtagc gattgcgtcc aacggtggag ggaaacaagc attggagact 2580 gtccaacggc tccttcccgt gttgtgtcaa gcccacggtt tgacgcctgc acaagtggtc 2640 gccatcgcca gccatgatgg cggtaagcag gcgctggaaa cagtacagcg cctgctgcct 2700 gtactgtgcc aggatcatgg actgacccca gaccaggtag tcgcaatcgc gtcacatgac 2760 gggggaaagc aagccctgga aaccgtgcaa aggttgttgc cggtcctttg tcaagaccac 2820 ggccttacac cggagcaagt cgtggccatt gcatcccacg acggtggcaa acaggctctt 2880 gagacggttc agagacttct cccagttctc tgtcaagccc acgggctgac tcccgatcaa 2940 gttgtagcga ttgcgaataa caatggaggg aaacaagcat tggagactgt ccaacggctc 3000 cttcccgtgt tgtgtcaagc ccacggtttg acgcctgcac aagtggtcgc catcgccagc 3060 catgatggcg gtaagcaggc gctggaaaca gtacagcgcc tgctgcctgt actgtgccag 3120 gatcatggac tgacacccga acaggtggtc gccattgctt ctaatggggg aggacggcca 3180 gccttggagt ccatcgtagc ccaattgtcc aggcccgatc ccgcgttggc tgcgttaacg 3240 aatgaccatc tggtggcgtt ggcatgtctt ggtggacgac ccgcgctcga tgcagtcaaa 3300 aagggtctgc ctcatgctcc cgcattgatc aaaagaacca accggcggat tcccgagaga 3360 acttcccatc gagtcgcggg atccgatcca aaaaagaaga gaaaggtacc aaaaaagaag 3420 agaaaggtcg acggcggtgg tgctttgtct cctcagcact ctgctgtcac tcaaggaagt 3480 atcatcaaga acaaggaggg catggatgct aagtcactaa ctgcctggtc ccggacactg 3540 gtgaccttca aggatgtatt tgtggacttc accagggagg agtggaagct gctggacact 3600 gctcagcaga tcgtgtacag aaatgtgatg ctggagaact ataagaacct ggtttccttg 3660 ggttatcagc ttactaagcc agatgtgatc ctccggttgg agaagggaga agagccctgg 3720 ctggtggaga gagaaattca ccaagagacc catcctgatt cagagactgc atttgaaatc 3780 aaatcatcag tt 3792

<210> 9

<211> 3170

<212> DNA

<213> Unknown

<220>

<223> Synthetic construct/combination of sequences

<400> 9

gatctcggcc gcatattaag tgcattgttc tcgataccgc taagtgcatt gttctcgtta 60 gctcgatgga caagtgcatt gttctcttgc tgaaagctcg atggacaagt gcattgttct 120 cttgctgaaa gctcgatgga caagtgcatt gttctcttgc tgaaagctca gtacccgggt 180 cggagtactg ccccgcccct agcgattagc cccggccccg catagctccg ccccgggagt 240 accttcgacc tagagggtat ataatggaag ctcgacttcc agctcgaggg caatccggta 300 ctgttggtaa agccaccgaa ttcgccacca tgcaccacca ccaccaccac gactacaaag 360 accatgacgg tgattataaa gatcatgaca tcgattacaa ggatgacgat gacaagatgg 420 cccccaagaa gaagaggaag gtgggcattc accgcggggt acctatggtg gacttgagga 480 cactcggtta ttcgcaacag caacaggaga aaatcaagcc taaggtcagg agcaccgtcg 540 cgcaacacca cgaggcgctt gtggggcatg gcttcactca tgcgcatatt gtcgcgcttt 600 cacagcaccc tgcggcgctt gggacggtgg ctgtcaaata ccaagatatg attgcggccc 660 12/65 tgcccgaagc cacgcacgag gcaattgtag gggtcggtaa acagtggtcg ggagcgcgag 720 cacttgaggc gctgctgact gtggcgggtg agcttagggg gcctccgctc cagctcgaca 780 ccgggcagct gctgaagatc gcgaagagag ggggagtaac agcggtagag gcagtgcacg 840 cctggcgcaa tgcgctcacc ggggccccct tgaacctgac cccagaccag gtagtcgcaa 900 tcgcgtcaca tgacggggga aagcaagccc tggaaaccgt gcaaaggttg ttgccggtcc 960 tttgtcaaga ccacggcctt acaccggagc aagtcgtggc cattgcaagc aatgggggtg 1020 gcaaacaggc tcttgagacg gttcagagac ttctcccagt tctct^'gtcaa gcccacgggc 1080 tgactcccga tcaagttgta gcgattgcgt ccaacggtgg agggaaacaa gcattggaga 1140 ctgtccaacg gctccttccc gtgttgtgtc aagcccacgg tttgacgcct gcacaagtgg 1200 tcgccatcgc cagccatgat ggcggtaagc aggcgctgga aacagtacag cgcctgctgc 1260 ctgtactgtg ccaggatcat ggactgaccc cagaccaggt agtcgcaatc gcgtcacatg 1320 acgggggaaa gcaagccctg gaaaccgtgc aaaggttgtt gccggtcctt tg^'tcaagacc 1380 acggccttac accggagcaa gtcgtggcca ttgcaaataa taacggtggc aaacaggctc 1440 ttgagacggt tcagagactt ctcccagttc tctgtcaagc ccacgggctg actcccgatc 1500 aagttgtagc gattgcgtcc aacggtggag ggaaacaagc attggagact gtccaacggc 1560 tccttcccgt gttgtgtcaa gcccacggtt tgacgcctgc acaagtggtc gccatcgcct 1620 cgaatggcgg cggtaagcag gcgctggaaa cagtacagcg cctgctgcct gtactgtgcc 1680 aggatcatgg actgacccca gaccaggtag tcgcaatcgc gtcaaacgga gggggaaagc 1740 aagccctgga aaccgtgcaa aggttgttgc cggtcctttg tcaagaccac ggccttacac 1800 cggagcaagt cgtggccatt gcatcccacg acggtggcaa acaggctctt gagacggttc 1860 agagacttct cccagttctc tgtcaagccc acgggctgac tcccgatcaa gttgtagcga 1920 ttgcgtcgca tgacggaggg aaacaagcat tggagactgt ccaacggctc cttcccgtgt 1980 tgtgtcaagc ccacggtttg acgcctgcac aagtggtcgc catcgcctcc aatattggcg 2040 gtaagcaggc gctggaaaca gtacagcgcc tgctgcctgt actgtgccag gatcatggac 2100 tgaccccaga ccaggtagtc gcaatcgcgt cacatgacgg gggaaagcaa gccctggaaa 2160 ccgtgcaaag gttgttgccg gtcctttgtc aagaccacgg ccttacaccg gagcaagtcg 2220 tggccattgc aagcaacatc ggtggcaaac aggctcttga gacggttcag agacttctcc 2280 cagttctctg tcaagcccac gggctgactc ccgatcaagt tgtagcgatt gcgtccaacg 2340 gtggagggaa acaagcattg gagactgtcc aacggctcct tcccgrtgttg tgtcaagccc 2400 acggtttgac gcctgcacaa gtggtcgcca tcgccagcca tgatggcggt aagcaggcgc 2460 tggaaacagt acagcgcctg ctgcctgtac tgtgccagga tcatggactg acacccgaac 2520 aggtggtcgc cattgcttct aatgggggag gacggccagc cttggagtcc atcgtagccc 2580 aattgtccag gcccgatccc gcgttggctg cgttaacgaa tgaccatctg gtggcgttgg 2640 catgtcttgg tggacgaccc gcgctcgatg cagtcaaaaa gggtctgcct catgctcccg 2700 cattgatcaa aagaaccaac cggcggattc ccgagagaac ttcccatcga gtcgcgggat 2760 ccgatccaaa aaagaagaga aaggtaccaa aaaagaagag aaaggtcgac ggcggtggtg 2820 ctttgtctcc tcagcactct gctgtcactc aaggaagtat catcaagaac aaggagggca 2880 tggatgctaa gtcactaact gcctggtccc ggacactggt gaccttcaag gatgtatttg 2940 tggacttcac cagggaggag tggaagctgc tggacactgc tcagcagatc gtgtacagaa 3000 atgtgatgct ggagaactat aagaacctgg tttccttggg ttatcagctt actaagccag 3060 atgtgatcct ccggttggag aagggagaag agccctggct ggtggagaga gaaattcacc 3120 aagagaccca tcctgattca gagactgcat ttgaaatcaa atcatcagtt 3170

<210> 10

<211> 3020

<212> DNA

<213> Unknown

<220>

<223> Operon composed of operator DNA-binding elements, minimal or

constitutive promoter, structural genes

<400> 10

gatctcggcc gcatattaag tgcattgttc tcgataccgc taagtgcatt gttctcgtta 60 gctcgatgga caagtgcatt gttctcttgc tgaaagctcg atggacaagt gcattgttct 120 cttgctgaaa gctcgatgga caagtgcatt gttctcttgc tgaaagctca gtacccgggt 180 cggagtactg ccccgcccct agcgattagc cccggccccg catagctccg ccccgggagt 240 accttcgacc tagagggtat ataatggaag ctcgacttcc agctcgaggg caatccggta 300 ctgttggtaa agccaccgaa ttcgccacca tgcaccacca ccaccaccac gactacaaag 360 accatgacgg tgattataaa gatcatgaca tcgattacaa ggatgacgat gacaagatgg 420 cccccaagaa gaagaggaag gtgggcattc accgcggggt acctatggtg gacttgagga 480 cactcggtta ttcgcaacag caacaggaga aaatcaagcc taaggtcagg agcaccgtcg 540 cgcaacacca cgaggcgctt gtggggcatg gcttcactca tgcgcatatt gtcgcgcttt 600 cacagcaccc tgcggcgctt gggacggtgg ctgtcaaata ccaagatatg attgcggccc 660 tgcccgaagc cacgcacgag gcaattgtag gggtcggtaa acagtggtcg ggagcgcgag 720 cacttgaggc gctgctgact gtggcgggtg agcttagggg gcctccgctc cagctcgaca 780 ccgggcagct gctgaagatc gcgaagagag ggggagtaac agcggtagag gcagtgcacg 840 cctggcgcaa tgcgctcacc ggggccccct tgaacctgac cccagaccag gtagtcgcaa 900 tcgcgtcaaa cggaggggga aagcaagccc tggaaaccgt gcaaaggttg ttgccggtcc 960 tttgtcaaga ccacggcctt acaccggagc aagtcgtggc cattgcaagc aatgggggtg 1020 gcaaacaggc tcttgagacg gttcagagac ttctcccagt tctctgtcaa gcccacgggc 1080 tgactcccga tcaagttgta gcgattgcgt cgaacattgg agggaaacaa gcattggaga 1140 ctgtccaacg gctccttccc gtgttgtgtc aagcccacgg tttgacgcct gcacaagtgg 1200 tcgccatcgc cagccatgat ggcggtaagc aggcgctgga aacagtacag cgcctgctgc 1260 ctgtactgtg ccaggatcat ggactgaccc cagaccaggt agtcgcaatc gcgtcaaacg 1320 gagggggaaa gcaagccctg gaaaccgtgc aaaggttgtt gccggtcctt tgtcaagacc 1380 acggccttac accggagcaa gtcgtggcca ttgcaaataa taacggtggc aaacaggctc 1440 ttgagacggt tcagagactt ctcccagttc tctgtcaagc ccacgggctg actcccgatc 1500 aagttgtagc gattgcgtcg catgacggag ggaaacaagc attggagact gtccaacggc 1560 tccttcccgt gttgtgtcaa gcccacggtt tgacgcctgc acaagtggtc gccatcgcct 1620 cgaatggcgg cggtaagcag gcgctggaaa cagtacagcg cctgctgcct gtactgtgcc 1680 aggatcatgg actgacccca gaccaggtag tcgcaatcgc gaacaataat gggggaaagc 1740 aagccctgga aaccgtgcaa aggttgttgc cggtcctttg tcaagaccac ggccttacac 1800 cggagcaagt cgtggccatt gcatcccacg acggtggcaa acaggctctt gagacggttc 1860 agagacttct cccagttctc tgtcaagccc acgggctgac tcccgatcaa gttgtagcga 1920 ttgcgtccaa cggtggaggg aaacaagcat tggagactgt ccaacggctc cttcccgtgt 1980 tgtgtcaagc ccacggtttg acgcctgcac aagtggtcgc catcgccagc catgatggcg 2040 gtaagcaggc gctggaaaca gtacagcgcc tgctgcctgt actgtgccag gatcatggac 2100 tgaccccaga ccaggtagtc gcaatcgcgt cacatgacgg gggaaagcaa gccctggaaa 2160 ccgtgcaaag gttgttgccg gtcctttgtc aagaccacgg ccttacaccg gagcaagtcg 2220 tggccattgc atcccacgac ggtggcaaac aggctcttga gacggttcag agacttctcc 2280 cagttctctg tcaagcccac gggctgactc ccgatcaagt tgtagcgatt gcgaataaca 2340 atggagggaa acaagcattg gagactgtcc aacggctcct tcccgtgttg tgtcaagccc 2400 acggtttgac gcctgcacaa gtggtcgcca tcgccagcca tgatggcggt aagcaggcgc 2460 tggaaacagt acagcgcctg ctgcctgtac tgtgccagga tcatggactg acacccgaac 2520 aggtggtcgc cattgcttct aatgggggag gacggccagc cttggagtcc atcgtagccc 2580 aattgtccag gcccgatccc gcgttggctg cgttaacgaa tgaccatctg gtggcgttgg 2640 catgtcttgg tggacgaccc gcgctcgatg cagtcaaaaa gggtctgcct catgctcccg 2700 cattgatcaa aagaaccaac cggcggattc ccgagagaac ttcccatcga gtcgcgggat 2760 ccgatccaaa aaagaagaga aaggtagccc ccccgaccga tgtcagcctg ggggacgagc 2820 tccacttaga cggcgaggac gtggcgatgg cgcatgccga cgcgctagac gatttcgatc 2880 tggacatgtt gggggacggg gattccccgg gtccgggatt taccccccac gactccgccc 2940 cctacggcgc tctggatatg gccgacttcg agtttgagca gatgtttacc gatgcccttg 3000 gaattgacga gtacggtggg 3020

<210> 11

<211> 2670

<212> PRT

<213> Unknown

<220>

<223> Synthetic genetic construct

<400> 11

Gly Ala Cys Thr Ala Cys Ala Ala Ala Gly Ala Cys Cys Ala Thr Gly

1 5 10 15

Ala Cys Gly Gly Thr Gly Ala Thr Thr Ala Thr Ala Ala Ala Gly Ala

20 25 30

Thr Cys Ala Thr Gly Ala Cys Ala Thr Cys Gly Ala Thr Thr Ala Cys

35 40 45

Ala Ala Gly Gly Ala Thr Gly Ala Cys Gly Ala Thr Gly Ala Cys Ala

50 55 60

Ala Gly Ala Thr Gly Gly Cys Cys Cys Cys Cys Ala Ala Gly Ala Ala

65 70 75 80

Gly Ala Ala Gly Ala Gly Gly Ala Ala Gly Gly Thr Gly Gly Gly Cys

85 90 95

Ala Thr Thr Cys Ala Cys Cys Gly Cys Gly Gl Gly Gly Thr Ala Cys

100 105 110

Cys Thr Ala Thr Gly Gly Thr Gly Gly Ala Cys Thr Thr Gly Ala Gly

115 120 125

Gly Ala Cys Ala Cys Thr Cys Gly Gly Thr Thr Ala Thr Thr Cys Gly

130 135 140

Cys Ala Ala Cys Ala Gly Cys Ala Ala Cys Ala Gly Gly Ala Gly Ala

145 150 155 160

Ala Ala Ala Thr Cys Ala Ala Gly Cys Cys Thr Ala Ala Gl Gly Thr

165 170 175

Cys Ala Gly Gly Ala Gly Cys Ala Cys Cys Gly Thr Cys Gly Cys Gly

180 185 190 14/65

Cys Ala Ala Cys Ala Cys Cys Ala Cys Gly Ala Gly Gly Cys Gly Cys

195 200 205

Thr Thr Gly Thr Gly Gly Gly Gly Cys Ala Thr Gly Gly Cys Thr Thr

210 215 220

Cys Ala Cys Thr Cys Ala Thr Gly Cys Gly Cys Ala Thr Ala Thr Thr

225 230 235 240

Gly Thr Cys Gl Cys Gly Cys Thr Thr Thr Cys Ala Cys Ala Gly Cys

245 250 255

Ala Cys Cys Cys Thr Gly Cys Gly Gly Cys Gly Cys Thr Thr Gly Gly

260 265 270

Gly Ala Cys Gly Gly Thr Gly Gly Cys Thr Gly Thr Cys Ala Ala Ala

275 280 285

Thr Ala Cys Cys Ala Ala Gly Ala Thr Ala Thr Gly Ala Thr Thr Gly

290 295 300

Cys Gly Gly Cys Cys Cys Thr Gly Cys Cys Cys Gly Ala Ala Gly Cys

305 310 315 320

Cys Ala Cys Gly Cys Ala Cys Gly Ala Gly Gly Cys Ala Ala Thr Thr

325 330 335

Gly Thr Ala Gly Gly Gly Gly Thr Cys Gly Gly Thr Ala Ala Ala Cys

340 345 350

Ala Gly Thr Gly Gly Thr Cys Gly Gly Gly Ala Gly Cys Gly Cys Gly

355 360 365

Ala Gly Cys Ala Cys Thr Thr Gly Ala Gly Gly Cys Gly Cys Thr Gly

370 375 380

Cys Thr Gly Ala Cys Thr Gly Thr Gly Gly Cys Gly Gly Gly Thr Gly

385 390 395 400

Ala Gly Cys Thr Thr Ala Gly Gly Gly Gly Gly Cys Cys Thr Cys Cys

405 410 415

Gly Cys Thr Cys Cys Ala Gly Cys Thr Cys Gly Ala Cys Ala Cys Cys

420 425 430

Gly Gly Gly Cys Ala Gly Cys Thr Gly Cys Thr Gly Ala Ala Gly Ala

435 440 445

Thr Cys Gly Cys Gly Ala Ala Gly Ala Gly Ala Gly Gly Gly Gly Gly

450 455 460

Ala Gly Thr Ala Ala Cys Ala Gly Cys Gly Gly Thr Ala Gly Ala Gly

465 470 475 480

Gly Cys Ala Gly Thr Gly Cys Ala Cys Gly Cys Cys Thr Gly Gly Cys

485 490 495

Gly Cys Ala Ala Thr Gly Cys Gly Cys Thr Cys Ala Cys Cys Gly Gly

500 505 510

Gly Gly Cys Cys Cys Cys Cys Thr Thr Gly Ala Ala Cys Cys Thr Gly

515 520 525

Ala Cys Cys Cys Cys Ala Gly Ala Cys Cys Ala Gly Gly Thr Ala Gly

530 535 540

Thr Cys Gly Cys Ala Ala Thr Cys Gly Cys Gly Thr Cys Ala Ala Ala

545 550 555 560

Cys Gly Gly Ala Gly Gly Gly Gly Gly Ala Ala Ala Gly Cys Ala Ala

565 570 575

Gly Cys Cys Cys Thr Gly Gly Ala Ala Ala Cys Cys Gly Thr Gly Cys

580 585 590

Ala Ala Ala Gly Gly Thr Thr Gly Thr Thr Gly Cys Cys Gly Gly Thr

595 600 605

Cys Cys Thr Thr Thr Gly Thr Cys Ala Ala Gly Ala Cys Cys Ala Cys

610 615 620

Gly Gly Cys Cys Thr Thr Ala Cys Ala Cys Cys Gly Gly Ala Gly Cys

625 630 635 640

Ala Ala Gly Thr Cys Gly Thr Gly Gly Cys Cys Ala Thr Thr Gly Cys

645 650 655

Ala Ala Gly Cys Ala Ala Thr Gly Gly Gly Gly Gly Thr Gly Gly Cys

660 665 670

Ala Ala Ala Cys Ala Gly Gly Cys Thr Cys Thr Thr Gly Ala Gly Ala

675 680 685

Cys Gly Gly Thr Thr Cys Ala Gly Ala Gly Ala Cys Thr Thr Cys Thr

690 695 700

Cys Cys Cys Ala Gly Thr Thr Cys Thr Cys Thr Gly Thr Cys Ala Ala

705 710 715 720

Gly Cys Cys Cys Ala Cys Gly Gly Gly Cys Thr Gly Ala Cys Thr Cys

725 730 735 15/65

Cys Cys Gly Ala Thr Cys Ala Ala Gly Thr Thr Gly Thr Ala Gly Cys

740 745 750

Gly Ala Thr Thr Gly Cys Gly Thr Cys Gly Ala Ala Cys Ala Thr Thr

755 760 765

Gly Gly Ala Gly Gly Gly Ala Ala Ala Cys Ala Ala Gly Cys Ala Thr

770 775 780

Thr Gly Gly Ala Gly Ala Cys Thr Gly Thr Cys Cys Ala Ala Cys Gly

785 790 795 800

Gly Cys Thr Cys Cys Thr Thr Cys Cys Cys Gly Thr Gly Thr Thr Gly

805 810 815

Thr Gly Thr Cys Ala Ala Gly Cys Cys Cys Ala Cys Gly Gly Thr Thr

820 825 830

Thr Gly Ala Cys Gly Cys Cys Thr Gly Cys Ala Cys Ala Ala Gly Thr

835 840 845

Gly Gly Thr Cys Gly Cys Cys Ala Thr Cys Gly Cys Cys Ala Gly Cys

850 855 860

Cys Ala Thr Gly Ala Thr Gly Gly Cys Gly Gly Thr Ala Ala Gly Cys

865 870 875 880

Ala Gly Gly Cys Gly Cys Thr Gly Gly Ala Ala Ala Cys Ala Gly Thr

885 890 895

Ala Cys Ala Gly Cys Gly Cys Cys Thr Gly Cys Thr Gly Cys Cys Thr

900 905 910

Gly Thr Ala Cys Thr Gly Thr Gly Cys Cys Ala Gly Gly Ala Thr Cys

915 920 925

Ala Thr Gly Gly Ala Cys Thr Gly Ala Cys Cys Cys Cys Ala Gly Ala

930 935 940

Cys Cys Ala Gly Gly Thr Ala Gly Thr Cys Gly Cys Ala Ala Thr Cys

945 950 955 960

Gly Cys Gly Thr Cys Ala Ala Ala Cys Gly Gly Ala Gly Gly Gly Gly

965 970 975

Gly Ala Ala Ala Gly Cys Ala Ala Gly Cys Cys Cys Thr Gly Gly Ala

980 985 990

Ala Ala Cys Cys Gly Thr Gly Cys Ala Ala Ala Gly Gly Thr Thr Gly

995 1000 1005

Thr Thr Gly Cys Cys Gly Gly Thr Cys Cys Thr Thr Thr Gly Thr 1010 1015 1020

Cys Ala Ala Gly Ala Cys Cys Ala Cys Gly Gly Cys Cys Thr Thr 1025 1030 1035

Ala Cys Ala Cys Cys Gly Gly Ala Gly Cys Ala Ala Gly Thr Cys 1040 1045 1050

Gly Thr Gly Gly Cys Cys Ala Thr Thr Gly Cys Ala Ala Ala Thr 1055 1060 1065

Ala Ala Thr Ala Ala Cys Gly Gly Thr Gly Gly Cys Ala Ala Ala 1070 1075 1080

Cys Ala Gly Gly Cys Thr Cys Thr Thr Gly Ala Gly Ala Cys Gly 1085 1090 1095

Gly Thr Thr Cys Ala Gly Ala Gly Ala Cys Thr Thr Cys Thr Cys 1100 1105 1110

Cys Cys Ala Gly Thr Thr Cys Thr Cys Thr Gly Thr Cys Ala Ala 1115 1120 1125

Gly Cys Cys Cys Ala Cys Gly Gly Gly Cys Thr Gly Ala Cys Thr 1130 1135 1140

Cys Cys Cys Gly Ala Thr Cys Ala Ala Gly Thr Thr Gly Thr Ala

1145 1150 1155

Gly Cys Gly Ala Thr Thr Gly Cys Gly Thr Cys Gly Cys Ala Thr 1160 1165 1170

Gly Ala Cys Gly Gly Ala Gly Gly Gly Ala Ala Ala Cys Ala Ala 1175 1180 1185

Gly Cys Ala Thr Thr Gly Gly Ala Gly Ala Cys Thr Gly Thr Cys 1190 1195 1200

Cys Ala Ala Cys Gly Gly Cys Thr Cys Cys Thr Thr Cys Cys Cys 1205 1210 1215

Gly Thr Gly Thr Thr Gly Thr Gly Thr Cys Ala Ala Gly Cys Cys 1220 1225 1230

Cys Ala Cys Gly Gly Thr Thr Thr Gly Ala Cys Gly Cys Cys Thr 1235 1240 1245

Gly Cys Ala Cys Ala Ala Gly Thr Gly Gly Thr Cys Gly Cys Cys 1250 1255 1260 16/65

Ala Thr Cys Gly Cys Cys Thr Cys Gly Ala Ala Thr Gly Gly Cys 1265 1270 1275

Gly Gly Cys Gly Gly Thr Ala Ala Gly Cys Ala Gly Gly Cys Gly 1280 1285 1290

Cys Thr Gly Gly Ala Ala Ala Cys Ala Gly Thr Ala Cys Ala Gly 1295 1300 1305

Cys Gly Cys Cys Thr Gly Cys Thr Gly Cys Cys Thr Gly Thr Ala 1310 1315 1320

Cys Thr Gly Thr Gly Cys Cys Ala Gly Gly Ala Thr Cys Ala Thr

1325 1330 1335

Gly Gly Ala Cys Thr Gly Ala Cys Cys Cys Cys Ala Gly Ala Cys 1340 1345 1350

Cys Ala Gly Gly Thr Ala Gly Thr Cys Gly Cys Ala Ala Thr Cys 1355 1360 1365

Gly Cys Gly Ala Ala Cys Ala Ala Thr Ala Ala Thr Gly Gly Gly 1370 1375 1380

Gly Gly Ala Ala Ala Gly Cys Ala Ala Gly Cys Cys Cys Thr Gly 1385 1390 1395

Gly Ala Ala Ala Cys Cys Gly Thr Gly Cys Ala Ala Ala Gly Gly 1400 1405 1410

Thr Thr Gly Thr Thr Gly Cys Cys Gly Gly Thr Cys Cys Thr Thr 1415 1420 1425

Thr Gly Thr Cys Ala Ala Gly Ala Cys Cys Ala Cys Gly Gly Cys 1430 1435 1440

Cys Thr Thr Ala Cys Ala Cys Cys Gly Gly Ala Gly Cys Ala Ala

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Ala Ala Ala Cys Ala Gly Gly Cys Thr Cys Thr Thr Gly Ala Gly 1490 1495 1500

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Gly Thr Cys Cys Ala Ala Cys Gly Gly Cys Thr Cys Cys Thr Thr 1610 1615 1620

Cys Cys Cys Gly Thr Gly Thr Thr Gly Thr Gly Thr Cys Ala Ala 1625 1630 1635

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Gly Cys Cys Ala Thr Cys Gly Cys Cys Ala Gly Cys Cys Ala Thr 1670 1675 1680

Gly Ala Thr Gly Gly Cys Gly Gly Thr Ala Ala Gly Cys Ala Gly

1685 1690 1695

Gly Cys Gly Cys Thr Gly Gly Ala Ala Ala Cys Ala Gly Thr Ala 1700 1705 1710

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1730 1735 1740

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Ala Thr Cys Gly Cys Gly Thr Cys Ala Cys Ala Thr Gly Ala Cys 1775 1780 1785

Gly Gly Gly Gly Gly Ala Ala Ala Gly Cys Ala Ala Gly Cys Cys 1790 1795 1800

Cys Thr Gly Gly Ala Ala Ala Cys Cys Gly Thr Gly Cys Ala Ala 1805 1810 1815

Ala Gly Gly Thr Thr Gly Thr Thr Gly Cys Cys Gly Gly Thr Cys 1820 1825 1830

Cys Thr Thr Thr Gly Thr Cys Ala Ala Gly Ala Cys Cys Ala Cys 1835 1840 1845

Gly Gly Cys Cys Thr Thr Ala Cys Ala Cys Cys Gly Gly Ala Gly 1850 1855 1860

Cys Ala Ala Gly Thr Cys Gly Thr Gly Gly Cys Cys Ala Thr Thr 1865 1870 1875

Gly Cys Ala Thr Cys Cys Cys Ala Cys Gly Ala Cys Gly Gly Thr 1880 1885 1890

Gly Gly Cys Ala Ala Ala Cys Ala Gly Gly Cys Thr Cys Thr Thr 1895 1900 1905

Gly Ala Gly Ala Cys Gly Gly Thr Thr Cys Ala Gly Ala Gly Ala

1910 1915 1920

Cys Thr Thr Cys Thr Cys Cys Cys Ala Gly Thr Thr Cys Thr Cys 1925 1930 1935

Thr Gly Thr Cys Ala Ala Gly Cys Cys Cys Ala Cys Gly Gly Gly 1940 1945 1950

Cys Thr Gly Ala Cys Thr Cys Cys Cys Gly Ala Thr Cys Ala Ala

1955 1960 1965

Gly Thr Thr Gly Thr Ala Gly Cys Gly Ala Thr Thr Gly Cys Gly 1970 1975 1980

Ala Ala Thr Ala Ala Cys Ala Ala Thr Gly Gly Ala Gly Gly Gly 1985 1990 1995

Ala Ala Ala Cys Ala Ala Gly Cys Ala Thr Thr Gly Gly Ala Gly 2000 2005 2010

Ala Cys Thr Gly Thr Cys Cys Ala Ala Cys Gly Gly Cys Thr Cys 2015 2020 2025

Cys Thr Thr Cys Cys Cys Gly Thr Gly Thr Thr Gly Thr Gly Thr 2030 2035 2040

Cys Ala Ala Gly Cys Cys Cys Ala Cys Gly Gly Thr Thr Thr Gly 2045 2050 2055

Ala Cys Gly Cys Cys Thr Gly Cys Ala Cys Ala Ala Gly Thr Gly 2060 2065 2070

Gly Thr Cys Gly Cys Cys Ala Thr Cys Gly Cys Cys Ala Gly Cys 2075 2080 2085

Cys Ala Thr Gly Ala Thr Gly Gly Cys Gly Gly Thr Ala Ala Gly 2090 2095 2100

Cys Ala Gly Gly Cys Gly Cys Thr Gly Gly Ala Ala Ala Cys Ala 2105 2110 2115

Gly Thr Ala Cys Ala Gly Cys Gly Cys Cys Thr Gly Cys Thr Gly 2120 2125 2130

Cys Cys Thr Gly Thr Ala Cys Thr Gly Thr Gly Cys Cys Ala Gly 2135 2140 2145

Gly Ala Thr Cys Ala Thr Gly Gly Ala Cys Thr Gly Ala Cys Ala 2150 2155 2160

Cys Cys Cys Gly Ala Ala Cys Ala Gly Gly Thr Gly Gly Thr Cys 2165 2170 2175

Gly Cys Cys Ala Thr Thr Gly Cys Thr Thr Cys Thr Ala Ala Thr 2180 2185 2190

Gly Gly Gly Gly Gly Ala Gly Gly Ala Cys Gly Gly Cys Cys Ala 2195 2200 2205

Gly Cys Cys Thr Thr Gly Gly Ala Gly Thr Cys Cys Ala Thr Cys 2210 2215 2220

Gly Thr Ala Gly Cys Cys Cys Ala Ala Thr Thr Gly Thr Cys Cys 2225 2230 2235

Ala Gly Gly Cys Cys Cys Gly Ala Thr Cys Cys Cys Gly Cys Gly 2240 2245 2250

Thr Thr Gly Gly Cys Thr Gly Cys Gly Thr Thr Ala Ala Cys Gly 2255 2260 2265

Ala Ala Thr Gly Ala Cys Cys Ala Thr Cys Thr Gly Gly Thr Gly 2270 2275 2280 18/65

Gly Cys Gly Thr Thr Gly Gly Cys Ala Thr Gly Thr Cys Thr Thr 2285 2290 2295

Gly Gly Thr Gly Gly Ala Cys Gly Ala Cys Cys Cys Gly Cys Gl 2300 2305 2310

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Gly Cys Thr Cys Cys Cys Gly Cys Ala Thr Thr Gly Ala Thr Cys 2345 2350 2355

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2360 2365 2370

Cys Gly Gly Ala Thr Thr Cys Cys Cys Gly Ala Gly Ala Gly Ala 2375 2380 2385

Ala Cys Thr Thr Cys Cys Cys Ala Thr Cys Gly Ala Gly Thr Cys 2390 2395 2400

Gly Cys Gly Gly Gly Ala Thr Cys Cys Gly Ala Thr Cys Cys Ala 2405 2410 2415

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Gly Thr Ala Gly Cys Cys Cys Cys Cys Cys Cys Gly Ala Cys Cys 2435 2440 2445

Gly Ala Thr Gly Thr Cys Ala Gly Cys Cys Thr Gly Gly Gly Gly 2450 2455 2460

Gly Ala Cys Gly Ala Gly Cys Thr Cys Cys Ala Cys Thr Thr Ala 2465 2470 2475

Gly Ala ■ Cys Gly Gly Cys Gly Ala Gly Gly Ala Cys Gly Thr Gly 2480 2485 2490

Gly Cys Gly Ala Thr Gly Gly Cys Gly Cys Ala Thr Gly Cys Cys

2495 2500 2505

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Thr Thr Cys Gly Ala Thr Cys Thr Gly Gly Ala Cys Ala Thr Gly

2525 2530 2535

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2540 2545 2550

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Thr Thr Thr Ala Cys Cys Cys Cys Cys Cys Ala Cys Gly Ala Cys 2570 2575 2580

Thr Cys Cys Gly Cys Cys Cys Cys Cys Thr Ala Cys Gly Gly Cys 2585 2590 2595

Gly Cys Thr Cys Thr Gly Gly Ala Thr Ala Thr Gly Gly Cys Cys 2600 2605 2610

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35 40 45

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85 90 95

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100 105 110

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115 120 125

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130 135 140

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145 150 155 160

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165 170 175

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180 185 190

Cys Ala Ala Cys Ala Cys Cys Ala Cys Gly Ala Gly Gly C s Gly Cys

195 200 205

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210 215 220

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225 230 235 240

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245 250 255

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260 265 270

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275 280 285

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290 295 300

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305 310 315 320

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325 330 335

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340 345 350

Ala Gly Thr Gly Gly Thr Cys Gly Gly Gly Ala Gly Cys Gly Cys Gly

355 360 365

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370 375 380

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385 390 395 400

Ala Gly Cys Thr Thr Ala Gly Gly Gly Gly Gly Cys Cys Thr Cys Cys

405 410 415

Gly Cys Thr Cys Cys Ala Gly Cys Thr Cys Gly Ala Cys Ala Cys Cys

420 425 430

Gly Gly Gly Cys Ala Gly Cys Thr Gly Cys Thr Gly Ala Ala Gly Ala

435 440 445

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450 455 460

Ala Gly Thr Ala Ala Cys Ala Gly Cys Gly Gly Thr Ala Gly Ala Gly

465 470 475 480

Gly Cys Ala Gly Thr Gly Cys Ala Cys Gly Cys Cys Thr Gly Gly Cys

485 490 495

Gly Cys Ala Ala Thr Gly Cys Gly Cys Thr Cys Ala Cys Cys Gly Gly

500 505 510

Gly Gly Cys Cys Cys Cys Cys Thr Thr Gly Ala Ala Cys Cys Thr Gly

515 520 525

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530 535 540

Thr Cys Gly Cys Ala Al Thr Cys Gly Cys Gly Thr Cys Ala Cys Ala

545 550 555 560

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565 570 575

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580 585 590

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595 600 605

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610 615 620

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625 630 635 640

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645 650 655

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660 665 670

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675 680 685

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690 695 700

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705 710 715 720

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725 730 735

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740 745 750

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755 ¹ 760 765

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770 775 780

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785 790 795 800

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805 810 815

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820 825 830

Thr Gly Ala Cys Gly Cys Cys Thr Gly Cys Ala Cys Ala Ala Gly Thr

835 840 845

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850 855 860

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^'865 870 875 880

Ala Gly Gly Cys Gly Cys Thr Gly Gly Ala Ala Ala Cys Ala Gly Thr

885 890 895

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900 905 910

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915 920 925

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930 935 940

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945 950 955 960

Gly Cys Gly Thr Cys Ala Cys Ala Thr Gly Ala Cys Gly Gly Gly Gly

965 970 975

Gly Ala Ala Ala Gly Cys Ala Ala Gly Cys Cys Cys Thr Gly Gly Ala

980 985 990

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995 1000 1005

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1010 1015 1020

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1025 1030 1035

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1040 1045 1050

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1055 1060 1065

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1070 1075 1080

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1085 1090 1095

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1100 1105 1110

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1115 1120 1125

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1130 1135 1140

Cys Cys Cys Gly Ala Thr Cys Ala Ala Gly Thr Thr Gly Thr Ala 1145 1150 1155

Gly Cys Gly Ala Thr Thr Gly Cys Gly Thr Cys Cys Ala Ala Cys 1160 1165 1170

Gly Gly Thr Gly Gly Ala Gly Gly Gly Ala Ala Ala Cys Ala Ala 1175 1180 1185

Gly Cys Ala Thr Thr Gly Gly Ala Gly Ala Cys Thr Gly Thr Cys 1190 1195 1200

Cys Ala Ala Cys Gly Gly Cys Thr Cys Cys Thr Thr Cys Cys Cys 1205 1210 1215

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1220 1225 1230

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Ala Thr Cys Gly Cys Cys Thr Cys Gly Ala Ala Thr Gly Gly Cys 1265 1270 1275

Gly Gly Cys Gly Gly Thr Ala Ala Gly Cys Ala Gly Gly Cys Gly 1280 1285 1290

Cys Thr Gly Gly Ala Ala Ala Cys Ala Gly Thr Ala Cys Ala Gly 1295 1300 1305

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1310 1315 1320

Cys Thr Gly Thr Gly Cys Cys Ala Gly Gly Ala Thr Cys Ala Thr 1325 1330 1335

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1340 1345 1350

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Gly Cys Gly Thr Cys Ala Ala Ala Cys Gly Gly Ala Gly Gly Gly 1370 1375 1380

Gly Gly Ala Ala Ala Gly Cys Ala Ala Gly Cys Cys Cys Thr Gly 1385 1390 1395

Gly Ala Ala Ala Cys Cys Gly Thr Gly Cys Ala Ala Ala Gly Gly

1400 1405 1410

Thr Thr Gly Thr Thr Gly Cys Cys Gly Gly Thr Cys Cys Thr Thr 1415 1420 1425

Thr Gly Thr Cys Ala Ala Gly Ala Cys Cys Ala Cys Gly Gly Cys 1430 1435 1440

Cys Thr Thr Ala Cys Ala Cys Cys Gly Gly Ala Gly Cys Ala Ala 1445 1450 1455

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Thr Cys Cys Cys Ala Cys Gly Ala Cys Gly Gly Thr Gly Gly Cys 1475 1480 1485

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1490 1495 1500

Ala Cys Gly Gly Thr Thr Cys Ala Gly Ala Gly Ala Cys Thr Thr 1505 1510 1515

Cys Thr Cys Cys Cys Ala Gly Thr Thr Cys Thr Cys Thr Gly Thr 1520 1525 1530

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1640 1645 1650

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1655 1660 1665

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1685 1690 1695

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1775 1780 1785

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1790 1795 1800

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1805 1810 1815

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1820 1825 1830

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1835 1840 1845

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1850 1855 1860

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1865 1870 1875

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1880 1885 1890

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1895 1900 1905

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1910 1915 1920

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1925 1930 1935

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1940 1945 1950

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1955 1960 1965

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1970 1975 1980

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1985 1990 1995

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2000 2005 2010

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2015 2020 2025

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2030 2035 2040

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2045 2050 2055

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2060 2065 2070

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2075 2080 2085

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2090 2095 2100

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2105 2110 2115

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2120 2125 2130

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2135 2140 2145

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2150 2155 2160

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2165 2170 2175

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2180 2185 2190

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2195 2200 2205

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2210 2215 2220

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2225 2230 2235

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2240 2245 2250

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2255 2260 2265

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2270 2275 2280

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2285 2290 2295

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2300 2305 2310

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2315 2320 2325

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2330 2335 2340

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2345 2350 2355

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2360 2365 2370

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2375 2380 2385

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2390 2395 2400

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2405 2410 2415

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2435 2440 2445

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2450 2455 2460

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2465 2470 2475

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2480 2485 2490

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2495 2500 2505

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2510 2515 2520

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2525 2530 2535

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2540 2545 2550

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2555 2560 2565

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2570 2575 2580

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2585 2590 2595

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2615 2620 2625

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2630 2635 2640

Gly Cys Cys Cys Thr Thr Gly Gly Ala Ala Thr Thr Gly Ala Cys

2645 2650 2655

Gly Ala Gly Thr Ala Cys Gly Gly Thr Gly Gly Gly 24/65

2660 2665

<210> 13

<211> 2820

<212> PRT

<213> Unknown

<220>

<223> Synthetic genetic construct

<400> 13

Gly Ala Cys Thr Ala Cys Ala Ala Ala Gly Ala Cys Cys Ala Thr Gly

1 5 10 15

Ala Cys Gly Gly Thr Gly Ala Thr Thr Ala Thr Ala Ala Ala Gly Ala

20 25 30

Thr Cys Ala Thr Gly Ala Cys Ala Thr Cys Gly Ala Thr Thr Ala Cys

35 40 45

Ala Ala Gly Gly Ala Thr Gly Ala Cys Gly Ala Thr Gly Ala Cys Ala

50 55 60

Ala Gly Ala Thr Gly Gly Cys Cys Cys Cys Cys Ala Ala Gly Ala Ala

65 70 75 80

Gly Ala Ala Gly Ala Gly Gly Ala Ala Gly Gly Thr Gly Gly Gly Cys

85 90 95

Ala Thr Thr Cys Ala Cys Cys Gly Cys Gly Gly Gly Gly Thr Ala Cys

100 105 110

Cys Thr Ala Thr Gly Gly Thr Gly Gly Ala Cys Thr Thr Gly Ala Gly

115 120 125

Gly Ala Cys Ala Cys Thr Cys Gly Gly Thr Thr Ala Thr Thr Cys Gly

130 135 140

Cys Ala Ala Cys Ala Gly Cys Ala Ala Cys Ala Gly Gly Ala Gly Ala

145 150 155 160

Ala Ala Ala Thr Cys Ala Ala Gly Cys Cys Thr Ala Ala Gly Gly Thr

165 170 175

Cys Ala Gly Gly Ala Gly Cys Ala Cys Cys Gly Thr Cys Gly Cys Gly

180 185 190

Cys Ala Ala Cys Ala Cys Cys Ala Cys Gly Ala Gly Gly Cys Gly Cys

195 200 205

Thr Thr Gly Thr Gly Gly Gly Gly Cys Ala Thr Gly Gly Cys Thr Thr

210 215 220

Cys Ala Cys Thr Cys Ala Thr Gly Cys Gly Cys Ala Thr Ala Thr Thr

225 230 235 240

Gly Thr Cys Gly Cys Gly Cys Thr Thr Thr Cys Ala Cys Ala Gly Cys

245 250 255

Ala Cys Cys Cys Thr Gly Cys Gly Gly Cys Gly Cys Thr Thr Gly Gly

260 265 270

Gly Ala Cys Gly Gly Thr Gly Gly Cys Thr Gly Thr Cys Ala Ala Ala

275 280 285

Thr Ala Cys Cys Ala Ala Gly Ala Thr Ala Thr Gly Ala Thr Thr Gly

290 295 300

Cys Gly Gly Cys Cys Cys Thr Gly Cys Cys Cys Gly Ala Ala Gly Cys

305 310 315 320

Cys Ala Cys Gly Cys Ala Cys Gly Ala Gly Gly Cys Ala Ala Thr Thr

325 330 335

Gly Thr Ala Gly Gly Gly Gly Thr Cys Gly Gly Thr Ala Ala Ala Cys

340 345 350

Ala Gly Thr Gly Gly Thr Cys Gly Gl Gly Ala Gly Cys Gly Cys Gly

355 360 365

Ala Gly Cys Ala Cys Thr Thr Gly Ala Gly Gly Cys Gly Cys Thr Gly

370 375 380

Cys Thr Gly Ala Cys Thr Gly Thr Gly Gly Cys Gly Gly Gly Thr Gly

385 390 395 400

Ala Gly Cys Thr Thr Ala Gly Gly Gly Gly Gly Cys Cys Thr Cys Cys

405 410 415

Gly Cys Thr Cys Cys Ala Gly Cys Thr Cys Gly Ala Cys Ala Cys Cys

420 425 430

Gly Gly Gly Cys Ala Gly Cys Thr Gly Cys Thr Gly Ala Ala Gly Ala

435 440 445

Thr Cys Gly Cys Gly Ala Ala Gly Ala Gly Ala Gly Gly Gly Gly Gly

450 455 460 25/65

Ala Gly Thr Ala Ala Cys Ala Gly Cys Gly Gly Thr Ala Gly Ala Gly 465 470 475 480

Gly Cys Ala Gly Thr Gly Cys Ala Cys Gly Cys Cys Thr Gly Gly Cys

485 490 495

Gly Cys Ala Ala Thr Gly Cys Gly Cys Thr Cys Ala Cys Cys Gly Gly

500 505 510

Gly Gly Cys Cys Cys Cys Cys Thr Thr Gly Ala Ala Cys Cys Thr Gly

515 520 525

Ala Cys Cys Cys Cys Ala Gly Ala Cys Cys Ala Gly Gly Thr Ala Gly

530 535 540

Thr Cys Gly Cys Ala Ala Thr Cys Gly Cys Gly Thr Cys Ala Ala Ala 545 550 555 560

Cys Gly Gly Ala Gly Gly Gly Gly Gly Ala Ala Ala Gly Cys Ala Ala

565 570 575

Gly Cys Cys Cys Thr Gly Gly Ala Ala Ala Cys Cys Gly Thr Gly Cys

580 585 590

Ala Ala Ala Gly Gly Thr Thr Gly Thr Thr Gly Cys Cys Gly Gly Thr

595 600 . 605

Cys Cys Thr Thr Thr Gly Thr Cys Ala Ala Gly Ala Cys Cys Ala Cys

610 615 620

Gly Gly Cys Cys Thr Thr Ala Cys Ala Cys Cys Gly Gly Ala Gly Cys 625 630 635 640

Ala Ala Gly Thr Cys Gly Thr Gly Gly Cys Cys Ala Thr Thr Gly Cys

645 650 655

Ala Ala Gly Cys Ala Ala Thr Gly Gly Gly Gly Gly Thr Gly Gly Cys

660 665 670

Ala Ala Ala Cys Ala Gly Gly Cys Thr Cys Thr Thr Gly Ala Gly Ala

675 680 685

Cys Gly Gly Thr Thr Cys Ala Gly Ala Gly Ala Cys Thr Thr Cys Thr

690 695 700

Cys Cys Cys Ala Gly Thr Thr Cys Thr Cys Thr Gly Thr Cys Ala Ala 705 710 715 720

Gly Cys Cys Cys Ala Cys Gly Gly Gly Cys Thr Gly Ala Cys Thr Cys

725 730 735

Cys Cys Gly Ala Thr Cys Ala Ala Gly Thr Thr Gly Thr Ala Gly Cys

740 745 750

Gly Ala Thr Thr Gly Cys Gly Thr Cys Gly Ala Ala Cys Ala Thr Thr

755 760 765

Gly Gly Ala Gly Gly Gly Ala Ala Ala Cys Ala Ala Gly Cys Ala Thr

770 775 780

Thr Gly Gly Ala Gly Ala Cys Thr Gly Thr Cys Cys Ala Ala Cys Gly 785 790 795 800

Gly Cys Thr Cys Cys Thr Thr Cys Cys Cys Gly Thr Gly Thr Thr Gly

805 810 815

Thr Gly Thr Cys Ala Ala Gly Cys Cys Cys Ala Cys Gly Gly Thr Thr

820 825 830

Thr Gly Ala Cys Gly Cys Cys Thr Gly Cys Ala Cys Ala Ala Gly Thr

835 840 845

Gly Gly Thr Cys Gly Cys Cys Ala Thr Cys Gly Cys Cys Ala Gly Cys

850 855 860

Cys Ala Thr Gly Ala Thr Gly Gly Cys Gly Gly Thr Ala Ala Gly Cys 865 870 875 880

Ala Gly Gly Cys Gly Cys Thr Gly Gly Ala Ala Ala Cys Ala Gly Thr

885 890 895

Ala Cys Ala Gly Cys Gly Cys Cys Thr Gly Cys Thr Gly Cys Cys Thr

900 905 910

Gly Thr Ala Cys Thr Gly Thr Gly Cys Cys Ala Gly Gly Ala Thr Cys

915 920 925

Ala Thr Gly Gly Ala Cys Thr Gly Ala Cys Cys Cys Cys Ala Gly Ala

930 935 940

Cys Cys Ala Gly Gly Thr Ala Gly Thr Cys Gly Cys Ala Ala Thr Cys 945 950 955 960

Gly Cys Gly Thr Cys Ala Ala Ala Cys Gly Gly Ala Gly Gly Gly Gly

965 970 975

Gly Ala Ala Ala Gly Cys Ala Ala Gly Cys Cys Cys Thr Gly Gly Ala

980 985 990

Ala Ala Cys Cys Gly Thr Gly Cys Ala Ala Ala Gly Gly Thr Thr Gly 995 1000 1005 26/65

Thr Thr Gly Cys Cys Gly Gly Thr Cys Cys Thr Thr Thr Gly Thr

1010 1015 1020

Cys Ala Ala Gly Ala Cys Cys Ala Cys Gly Gly Cys Cys Thr Thr

1025 1030 1035

Ala Cys Ala Cys Cys Gly Gly Ala Gly Cys Ala Ala Gly Thr Cys

1040 1045 1050

Gly Thr Gly Gly Cys Cys Ala Thr Thr Gly Cys Ala Ala Ala Thr

1055 1060 1065

Ala Ala Thr Ala Ala Cys Gly Gly Thr Gly Gly Cys Ala Ala Ala

1070 1075 1080

Cys Ala Gly Gly Cys Thr Cys Thr Thr Gly Ala Gly Ala Cys Gly

1085 1090 1095

Gly Thr Thr Cys Ala Gly Ala Gly Ala Cys Thr Thr Cys Thr Cys

1100 1105 1110

Cys Cys Ala Gly Thr Thr Cys Thr Cys Thr Gly Thr Cys Ala Ala

1115 1120 1125

Gly Cys Cys Cys Ala Cys Gly Gly Gly Cys Thr Gly Ala Cys Thr

1130 1135 1140

Cys Cys Cys Gly Ala Thr Cys Ala Ala Gly Thr Thr Gly Thr Ala

1145 1150 1155

Gly Cys Gly Ala Thr Thr Gly Cys Gly Thr Cys Gly Cys Ala Thr

1160 1165 1170

Gly Ala Cys Gly Gly Ala Gly Gly Gly Ala Ala Ala Cys Ala Ala

1175 1180 1185

Gly Cys Ala Thr Thr Gly Gly Ala Gly Ala Cys Thr Gly Thr Cys

1190 1195 1200

Cys Ala Ala Cys Gly Gly Cys Thr Cys Cys Thr Thr Cys Cys Cys

1205 1210 1215

Gly Thr Gly Thr Thr Gly Thr Gly Thr Cys Ala Ala Gly Cys Cys

1220 1225 1230

Cys Ala Cys Gly Gly Thr Thr Thr Gly Ala Cys Gly Cys Cys Thr

1235 1240 1245

Gly Cys Ala Cys Ala Ala Gly Thr Gly Gly Thr Cys Gly Cys Cys

1250 1255 1260

Ala Thr Cys Gly Cys Cys Thr Cys Gly Ala Ala Thr Gly Gly Cys

1265 1270 1275

Gly Gly Cys Gly Gly Thr Ala Ala Gly Cys Ala Gly Gly Cys Gly

1280 1285 1290

Cys Thr Gly Gly Ala Ala Ala Cys Ala Gly Thr Ala Cys Ala Gly

1295 1300 1305

Cys Gly Cys Cys Thr Gly Cys Thr Gly Cys Cys Thr Gly Thr Ala

1310 1315 1320

Cys Thr Gly Thr Gly Cys Cys Ala Gly Gly Ala Thr Cys Ala Thr

1325 1330 1335

Gly Gly Ala Cys Thr Gly Ala Cys Cys Cys Cys Ala Gly Ala Cys

1340 1345 1350

Cys Ala Gly Gly Thr Ala Gly Thr Cys Gly Cys Ala Ala Thr Cys

1355 1360 1365

Gly Cys Gly Ala Ala Cys Ala Ala Thr Ala Ala Thr Gly Gly Gly

1370 1375 1380

Gly Gly Ala Ala Ala Gly Cys Ala Ala Gly Cys Cys Cys Thr Gly

1385 1390 1395

Gly Ala Ala Ala Cys Cys Gly Thr Gly Cys Ala Ala Ala Gly Gly

1400 1405 1410

Thr Thr Gly Thr Thr Gly Cys Cys Gly Gly Thr Cys Cys Thr Thr

1415 1420 1425

Thr Gly Thr Cys Ala Ala Gly Ala Cys Cys Ala Cys Gly Gly Cys

1430 1435 1440

Cys Thr Thr Ala Cys Ala Cys Cys Gly Gly Ala Gly Cys Ala Ala

1445 1450 1455

Gly Thr Cys Gly Thr Gly Gly Cys Cys Ala Thr Thr Gly Cys Ala

1460 1465 1470

Thr Cys Cys Cys Ala Cys Gly Ala Cys Gly Gly Thr Gly Gly Cys

1475 1480 1485

Ala Ala Ala Cys Ala Gly Gly Cys Thr Cys Thr Thr Gly Ala Gly

1490 1495 1500

Ala Cys Gly Gly Thr Thr Cys Ala Gly Ala Gly Ala Cys Thr Thr

1505 1510 1515 27/65

Cys Thr Cys Cys Cys Ala Gly Thr Thr Cys Thr Cys Thr Gly Thr 1520 1525 1530

Cys Ala Ala Gly Cys Cys Cys Ala Cys Gly Gly Gly Cys Thr Gly 1535 1540 1545

Ala Cys Thr Cys Cys Cys Gly Ala Thr Cys Ala Ala Gly Thr Thr 1550 1555 1560

Gly Thr Ala Gly Cys Gly Ala Thr Thr Gly Cys Gly Thr Cys Cys 1565 1570 1575

Ala Ala Cys Gly Gly Thr Gly Gly Ala Gly Gly Gly Ala Ala Ala 1580 1585 1590

Cys Ala Ala Gly Cys Ala Thr Thr Gly Gly Ala Gly Ala Cys Thr 1595 1600 1605

Gly Thr Cys Cys Ala Ala Cys Gly Gly Cys Thr Cys Cys Thr Thr 1610 1615 1620

Cys Cys Cys Gly Thr Gly Thr Thr Gly Thr Gly Thr Cys Ala Ala

1625 1630 1635

Gly Cys Cys Cys Ala Cys Gly Gly Thr Thr Thr Gly Ala Cys Gly 1640 1645 1650

Cys Cys Thr Gly Cys Ala Cys Ala Ala Gly Thr Gly Gly Thr Cys 1655 1660 1665

Gly Cys Cys Ala Thr Cys Gly Cys Cys Ala Gly Cys Cys Ala Thr 1670 1675 1680

Gly Ala Thr Gly Gly Cys Gly Gly Thr Ala Ala Gly Cys Ala Gly 1685 1690 1695

Gly Cys Gly Cys Thr Gly Gly Ala Ala Ala Cys Ala Gly Thr Ala 1700 1705 1710

Cys Ala Gly Cys Gly Cys Cys Thr Gly Cys Thr Gly Cys Cys Thr 1715 1720 1725

Gly Thr Ala Cys Thr Gly Thr Gly Cys Cys Ala Gly Gly Ala Thr 1730 1735 1740

Cys Ala Thr Gly Gly Ala Cys Thr Gly Ala Cys Cys Cys Cys Ala 1745 1750 1755

Gly Ala Cys Cys Ala Gly Gly Thr Ala Gly Thr Cys Gly Cys Ala

1760 1765 1770

Ala Thr Cys Gly Cys Gly Thr Cys Ala Cys Ala Thr Gly Ala Cys 1775 1780 1785

Gly Gly Gly Gly Gly Ala Ala Ala Gly Cys Ala Ala Gly Cys Cys

1790 1795 1800

Cys Thr Gly Gly Ala Ala Ala Cys Cys Gly Thr Gly Cys Ala Ala 1805 1810 1815

Ala Gly Gly Thr Thr Gly Thr Thr Gly Cys Cys Gly Gly Thr Cys

1820 1825 1830

Cys Thr Thr Thr Gly Thr Cys Ala Ala Gly Ala Cys Cys Ala Cys 1835 1840 1845

Gly Gly Cys Cys Thr Thr Ala Cys Ala Cys Cys Gly Gly Ala Gly 1850 1855 1860

Cys Ala Ala Gly Thr Cys Gly Thr Gly Gly Cys Cys Ala Thr Thr 1865 1870 1875

Gly Cys Ala Thr Cys Cys Cys Ala Cys Gly Ala Cys Gly Gly Thr

1880 1885 1890

Gly Gly Cys Ala Ala Ala Cys Ala Gly Gly Cys Thr Cys Thr Thr 1895 1900 1905

Gly Ala Gly Ala Cys Gly Gly Thr Thr Cys Ala Gly Ala Gly Ala

1910 1915 1920

Cys Thr Thr Cys Thr Cys Cys Cys Ala Gly Thr Thr Cys Thr Cys 1925 1930 1935

Thr Gly Thr Cys Ala Ala Gly Cys Cys Cys Ala Cys Gly Gly Gly 1940 1945 1950

Cys Thr Gly Ala Cys Thr Cys Cys Cys Gly Ala Thr Cys Ala Ala 1955 1960 1965

Gly Thr Thr Gly Thr Ala Gly Cys Gly Ala Thr Thr Gly Cys Gly 1970 1975 1980

Ala Ala Thr Ala Ala Cys Ala Ala Thr Gly Gly Ala Gly Gly Gly 1985 1990 1995

Ala Ala Ala Cys Ala Ala Gly Cys Ala Thr Thr Gly Gly Ala Gly 2000 2005 2010

Ala Cys Thr Gly Thr Cys Cys Ala Ala Cys Gly Gly Cys Thr Cys 2015 2020 2025 28/65

Cys Thr Thr Cys Cys Cys Gly Thr Gly Thr Thr Gly Thr Gly Thr 2030 2035 2040

Cys Ala Ala Gly Cys Cys Cys Ala Cys Gly Gly Thr Thr Thr Gly 2045 2050 2055

Ala Cys Gly Cys Cys Thr Gly Cys Ala Cys Ala Ala Gly Thr Gly 2060 2065 2070

Gly Thr Cys Gly Cys Cys Ala Thr Cys Gly Cys Cys Ala Gly Cys 2075 2080 2085

Cys Ala Thr Gly Ala Thr Gly Gly Cys Gly Gly Thr Ala Ala Gly 2090 2095 2100

Cys Ala Gly Gly Cys Gly Cys Thr Gly Gly Ala Ala Ala Cys Ala 2105 2110 2115

Gly Thr Ala Cys Ala Gly Cys Gly Cys Cys Thr Gly Cys Thr Gly 2120 2125 2130

Cys Cys Thr Gly Thr Ala Cys Thr Gly Thr Gly Cys Cys Ala Gly 2135 2140 2145

Gly Ala Thr Cys Ala Thr Gly Gly Ala Cys Thr Gly Ala Cys Ala

2150 2155 2160

Cys Cys Cys Gly Ala Ala Cys Ala Gly Gly Thr Gly Gly Thr Cys

2165 2170 2175

Gly Cys Cys Ala Thr Thr Gly Cys Thr Thr Cys Thr Ala Ala Thr 2180 2185 2190

Gly Gly Gly Gly Gly Ala Gly Gly Ala Cys Gly Gly Cys Cys Ala

2195 2200 2205

Gly Cys Cys Thr Thr Gly Gly Ala Gly Thr Cys Cys Ala Thr Cys 2210 2215 2220

Gly Thr Ala Gly Cys Cys Cys Ala Ala Thr Thr Gly Thr Cys Cys 2225 2230 2235

Ala Gly Gly Cys Cys Cys Gly Ala Thr Cys • Cys Cys Gly Cys Gly 2240 2245 2250

Thr Thr Gly Gly Cys Thr Gly Cys Gly Thr Thr Ala Ala Cys Gly 2255 2260 2265

Ala Ala Thr Gly Ala Cys Cys Ala Thr Cys Thr Gly Gly Thr Gly 2270 2275 2280

Gly Cys Gly Thr Thr Gly Gly Cys Ala Thr Gly Thr Cys Thr Thr 2285 2290 2295

Gly Gly Thr Gly Gly Ala Cys Gly Ala Cys Cys Cys Gly Cys Gly 2300 2305 2310

Cys Thr Cys Gly Ala Thr Gly Cys Ala Gly Thr Cys Ala Ala Ala 2315 2320 2325

Ala Ala Gly Gly Gly Thr Cys Thr Gly Cys Cys Thr Cys Ala Thr 2330 2335 2340

Gly Cys Thr Cys Cys Cys Gly Cys Ala Thr Thr Gly Ala Thr Cys 2345 2350 2355

Ala Ala Ala Ala Gly Ala Ala Cys Cys Ala Ala Cys Cys Gly Gly 2360 2365 2370

Cys Gly Gly Ala Thr Thr Cys Cys Cys Gly Ala Gly Ala Gly Ala

2375 2380 2385

Ala Cys Thr Thr Cys Cys Cys Ala Thr Cys Gly Ala Gly Thr Cys 2390 2395 2400

Gly Cys Gly Gly Gly Ala Thr Cys Cys Gly Ala Thr Cys Cys Ala 2405 2410 2415

Ala Ala Ala Ala Ala Gly Ala Ala Gly Ala Gly Ala Ala Ala Gly 2420 2425 2430

Gly Thr Ala Cys Cys Ala Ala Ala Ala Ala Ala Gly Ala Ala Gly 2435 2440 2445

Ala Gly Ala Ala Ala Gly Gly Thr Cys Gly Ala Cys Gly Gly Cys 2450 2455 2460

Gly Gly Thr Gly Gly Thr Gly Cys Thr Thr Thr Gly Thr Cys Thr 2465 2470 2475

Cys Cys Thr Cys Ala Gly Cys Ala Cys Thr Cys Thr Gly Cys Thr 2480 2485 2490

Gly Thr Cys Ala Cys Thr Cys Ala Ala Gly Gly Ala Ala Gly Thr 2495 2500 2505

Ala Thr Cys Ala Thr Cys Ala Ala Gly Ala Ala Cys Ala Ala Gly 2510 2515 2520

Gly Ala Gly Gly Gly Cys Ala Thr Gly Gly Ala Thr Gly Cys Thr

2525 2530 2535 29/65

Ala Ala Gly Thr Cys Ala Cys Thr Ala Ala Cys Thr Gly Cys Cys

2540 2545 2550

Thr Gly Gly Thr Cys Cys Cys Gly Gly Ala Cys Ala Cys Thr Gly

2555 2560 2565

Gly Thr Gly Ala Cys Cys Thr Thr Cys Ala Ala Gly Gly Ala Thr

2570 2575 2580

Gly Thr Ala Thr Thr Thr Gly Thr Gly Gly Ala Cys Thr Thr Cys

2585 2590 2595

Ala Cys Cys Ala Gly Gly Gly Ala Gly Gly Ala Gly Thr Gly Gly

2600 2605 2610

Ala Ala Gly Cys Thr Gly Cys Thr Gly Gly Ala Cys Ala Cys Thr

2615 2620 2625

Gly Cys Thr Cys Ala Gly Cys Ala Gly Ala Thr Cys Gly Thr Gly

2630 2635 2640

Thr Ala Cys Ala Gly Ala Ala Ala Thr Gly Thr Gly Ala Thr Gly

2645 2650 2655

Cys Thr Gly Gly Ala Gly Ala Ala Cys Thr Ala Thr Ala Ala Gly

2660 2665 2670

Ala Ala Cys Cys Thr Gly Gly Thr Thr Thr Cys Cys Thr Thr Gly

2675 2680 2685

Gly Gl Thr Thr Ala Thr Cys Ala Gly Cys Thr Thr Ala Cys Thr

2690 2695 2700

Ala Ala Gly Cys Cys Ala Gly Ala Thr Gly Thr Gly Ala Thr Cys

2705 2710 2715

Cys Thr Cys Cys Gly Gly Thr Thr Gly Gly Ala Gly Ala Ala Gly

2720 2725 2730

Gly Gly Ala Gly Ala Ala Gly Ala Gly Cys Cys Cys Thr Gly Gly

2735 2740 2745

Cys Thr Gly Gly Thr Gly Gly Ala Gly Ala Gly Ala Gly Ala Ala

2750 2755 2760

Ala Thr Thr Cys Ala Cys Cys Ala Ala Gly Ala Gly Ala Cys Cys

2765 2770 2775

Cys Ala Thr Cys Cys Thr Gly Ala Thr Thr Cys Ala Gly Ala Gly

2780 2785 2790

Ala Cys Thr Gly Cys Ala Thr Thr Thr Gly Ala Ala Ala Thr Cys

2795 2800 2805

Ala Ala Ala Thr Cys Ala Thr Cys Ala Gly Thr Thr

2810 2815 2820

<210> 14

<211> 2820

<212> PRT

<213> Unknown

<220>

<223> Synthetic genetic construct

<400> 14

Gly Ala Cys Thr Ala Cys Ala Ala Ala Gly Ala Cys Cys Ala Thr Gly

1 5 10 15

Ala Cys Gly Gly Thr Gly Ala Thr Thr Ala Thr Ala Ala Ala Gly Ala

20 25 30

Thr Cys Ala Thr Gly Ala Cys Ala Thr Cys Gly Ala Thr Thr Ala Cys

35 40 45

Ala Ala Gly Gly Ala Thr Gly Ala Cys Gly Ala Thr Gly Ala Cys Ala

50 55 60

Ala Gly Ala Thr Gly Gly Cys Cys Cys Cys Cys Ala Ala Gly Ala Ala

65 70 75 80

Gly Ala Ala Gly Ala Gly Gly Ala Ala Gly Gly Thr Gly Gly Gly Cys

85 90 95

Ala Thr Thr Cys Ala Cys Cys Gly Cys Gly Gly Gly Gly Thr Ala Cys

100 105 110

Cys Thr Ala Thr Gly Gly Thr Gly Gly Ala Cys Thr Thr Gly Ala Gly

115 120 125

Gly Ala Cys Ala Cys Thr Cys Gly Gly Thr Thr Ala Thr Thr Cys Gly

130 135 140

Cys Ala Ala Cys Ala Gly Cys Ala Ala Cys Ala Gly Gly Ala Gly Ala

145 150 155 160

Ala Ala Ala Thr Cys Ala Ala Gly Cys Cys Thr Ala Ala Gly Gly Thr 30/65

165 170 175

Cys Ala Gly Gly Ala Gly Cys Ala Cys Cys Gly Thr Cys Gly Cys Gly

180 185 190

Cys Ala Ala Cys Ala Cys Cys Ala Cys Gly Ala Gly Gly Cys Gly Cys

195 200 205

Thr Thr Gly Thr Gly Gly Gly Gly Cys Ala Thr Gly Gly Cys Thr Thr

210 215 220

Cys Ala Cys Thr Cys Ala Thr Gly Cys Gly Cys Ala Thr Ala Thr Thr

225 230 235 240

Gly Thr Cys Gly Cys Gly Cys Thr Thr Thr Cys Ala Cys Ala Gly Cys

245 250 255

Ala Cys Cys Cys Thr Gly Cys Gly Gly Cys Gly Cys Thr Thr Gly Gly

260 265 270

Gly Ala Cys Gly Gly Thr Gly Gly Cys Thr Gly Thr Cys Ala Ala Ala

275 280 285

Thr Ala Cys Cys Ala Ala Gly Ala Thr Ala Thr Gly Ala Thr Thr Gly

290 295 300

Cys Gly Gly Cys Cys Cys Thr Gly Cys Cys Cys Gly Ala Ala Gly Cys

305 310 315 320

Cys Ala Cys Gly Cys Ala Cys Gly Ala Gly Gly Cys Ala Ala Thr Thr

325 330 335

Gly Thr Ala Gly Gly Gly Gly Thr Cys Gly Gly Thr Ala Ala Ala Cys

340 345 350

Ala Gly Thr Gly Gly Thr Cys Gly Gly Gly Ala Gly Cys Gly Cys Gly

355 360 365

Ala Gly Cys Ala Cys Thr Thr Gly Ala Gly Gly Cys Gly Cys Thr Gly

370 375 380

Cys Thr Gly Ala Cys Thr Gly Thr Gly Gly Cys Gly Gly Gly Thr Gly

385 390 395 400

Ala Gly Cys Thr Thr Ala Gly Gly Gly Gly Gly Cys Cys Thr Cys Cys

405 410 415

Gly Cys Thr Cys Cys Ala Gly Cys Thr Cys Gly Ala Cys Ala Cys Cys

420 425 430

Gly Gly Gly Cys Ala Gly Cys Thr Gly Cys Thr Gly Ala Ala Gly Ala

435 440 445

Thr Cys Gly Cys Gly Ala Ala Gly Ala Gly Ala Gly Gly Gly Gly Gly

450 455 460

Ala Gly Thr Ala Ala Cys Ala Gly Cys Gly Gly Thr Ala Gly Ala Gly

455 470 475 480

Gly Cys Ala Gly Thr Gly Cys Ala Cys Gly Cys Cys Thr Gly Gly Cys

485 490 495

Gly Cys Ala Ala Thr Gly Cys Gly Cys Thr Cys Ala Cys Cys Gly Gly

500 505 510

Gly Gly Cys Cys Cys Cys Cys Thr Thr Gly Ala Ala Cys Cys Thr Gly

515 520 525

Ala Cys Cys Cys Cys Ala Gly Ala Cys Cys Ala Gly Gly Thr Ala Gly

530 535 540

Thr Cys Gly Cys Ala Ala Thr Cys Gly Cys Gly Thr Cys Ala Cys Ala

545 550 555 560

Thr Gly Ala Cys Gly Gly Gly Gly Gly Ala Ala Ala Gly Cys Ala Ala

565 570 575

Gly Cys Cys Cys Thr Gly Gly Ala Ala Ala Cys Cys Gly Thr Gly Cys

580 585 590

Ala Ala Ala Gly Gly Thr Thr Gly Thr Thr Gly Cys Cys Gly Gly Thr

595 600 605

Cys Cys Thr Thr Thr Gly Thr Cys Ala Ala Gly Ala Cys Cys Ala Cys

610 615 620

Gly Gly Cys Cys Thr Thr Ala Cys Ala Cys Cys Gly Gly Ala Gly Cys

625 630 635 640

Ala Ala Gly Thr Cys Gly Thr Gly Gly Cys Cys Ala Thr Thr Gl Cys

645 650 655

Ala Ala Gly Cys Ala Ala Thr Gly Gly Gly Gly Gly Thr Gly Gly Cys

660 665 670

Ala Ala Ala Cys Ala Gly Gly Cys Thr Cys Thr Thr Gly Ala Gly Ala

675 680 685

Cys Gly Gly Thr Thr Cys Ala Gly Ala Gly Ala Cys Thr Thr Cys Thr

690 695 700

Cys Cys Cys Ala Gly Thr Thr Cys Thr Cys Thr Gly Thr Cys Ala Ala 31/65

705 710 715 720

Gly Cys Cys Cys Ala Cys Gly Gly Gly Cys Thr Gly Ala Cys Thr Cys

725 730 735

Cys Cys Gly Ala Thr Cys Ala Ala Gly Thr Thr Gly Thr Ala Gly Cys

740 745 750

Gly Ala Thr Thr Gly Cys Gly Thr Cys Cys Ala Ala Cys Gly Gly Thr

755 760 765

Gly Gly Ala Gly Gly Gly Ala Ala Ala Cys Ala Ala Gly Cys Ala Thr

770 775 780

Thr Gly Gly Ala Gly Ala Cys Thr Gly Thr Cys Cys Ala Ala Cys Gly

785 790 795 800

Gly Cys Thr Cys Cys Thr Thr Cys Cys Cys Gly Thr Gly Thr Thr Gly

805 810 815

Thr Gly Thr Cys Ala Ala Gly Cys Cys Cys Ala Cys Gly Gly Thr Thr

820 825 830

Thr Gly Ala Cys Gly Cys Cys Thr Gly Cys Ala Cys Ala Ala Gly Thr

835 840 845

Gly Gly Thr Cys Gly Cys Cys Ala Thr Cys Gly Cys Cys Ala Gly Cys

850 855 860

Cys Ala Thr Gly Ala Thr Gly Gly Cys Gly Gly Thr Ala Ala Gly Cys

865 870 875 880

Ala Gly Gly Cys Gly Cys Thr Gly Gly Ala Ala Ala Cys Ala Gly Thr

885 890 895

Ala Cys Ala Gly Cys Gly Cys Cys Thr Gly Cys Thr Gly Cys Cys Thr

900 905 910

Gly Thr Ala Cys Thr Gly Thr Gly Cys Cys Ala Gly Gly Ala Thr Cys

915 920 925

Ala Thr Gly Gly Ala Cys Thr Gly Ala Cys Cys Cys Cys Ala Gly Ala

930 935 940

Cys Cys Ala Gly Gly Thr Ala Gly Thr Cys Gly Cys Ala Ala Thr Cys

945 950 955 960

Gly Cys Gly Thr Cys Ala Cys Ala Thr Gly Ala Cys Gly Gly Gly Gly

965 970 975

Gly Ala Ala Ala Gly Cys Ala Ala Gly Cys Cys Cys Thr Gly Gly Ala

980 985 990

Ala Ala Cys Cys Gly Thr Gly Cys Ala Ala Ala Gly Gly Thr Thr Gly 995 1000 1005

Thr Thr Gly Cys Cys Gly Gly Thr Cys Cys Thr Thr Thr Gly Thr

1010 1015 1020

Cys Ala Ala Gly Ala Cys Cys Ala Cys Gly Gly Cys Cys Thr Thr

1025 1030 1035

Ala Cys Ala Cys Cys Gly Gly Ala Gly Cys Ala Ala Gly Thr Cys

1040 1045 1050

Gly Thr Gly Gly Cys Cys Ala Thr Thr Gly Cys Ala Ala Ala Thr

1055 1060 1065

Ala Ala Thr Ala Ala Cys Gly Gly Thr Gly Gly Cys Ala Ala Ala

1070 1075 1080

Cys Ala Gly Gly Cys Thr Cys Thr Thr Gly Ala Gly Ala Cys Gly

1085 1090 1095

Gly Thr Thr Cys Ala Gly Ala Gly Ala Cys Thr Thr Cys Thr Cys

1100 1105 1110

Cys Cys Ala Gly Thr Thr Cys Thr Cys Thr Gly Thr Cys Ala Ala

1115 1120 1125

Gly Cys Cys Cys Ala Cys Gly Gly Gly Cys Thr Gly Ala Cys Thr

1130 1135 1140

Cys Cys Cys Gly Ala Thr Cys Ala Ala Gly Thr Thr Gly Thr Ala

1145 1150 1155

Gly Cys Gly Ala Thr Thr Gly Cys Gly Thr Cys Cys Ala Ala Cys

1160 1165 1170

Gly Gly Thr Gly Gly Ala Gly Gly Gly Ala Ala Ala Cys Ala Ala

1175 1180 1185

Gly Cys Ala Thr Thr Gly Gly Ala Gly Ala Cys Thr Gly Thr Cys

1190 1195 1200

Cys Ala Ala Cys Gly Gly Cys Thr Cys Cys Thr Thr Cys Cys Cys

1205 1210 1215

Gly Thr Gly Thr Thr Gly Thr Gly Thr Cys Ala Ala Gly Cys Cys

1220 1225 1230

Cys Ala Cys Gly Gly Thr Thr Thr Gly Ala Cys Gly Cys Cys Thr 32/65

1235 1240 1245

Gly Cys Ala Cys Ala Ala Gly Thr Gly Gly Thr Cys Gly Cys Cys

1250 1255 1260

Ala Thr Cys Gly Cys Cys Thr Cys Gly Ala Ala Thr Gly Gly Cys

1265 1270 1275

Gly Gly Cys Gly Gly Thr Ala Ala Gly Cys Ala Gly Gly Cys Gly

1280 1285 1290

Cys Thr Gly Gly Ala Ala Ala Cys Ala Gly Thr Ala Cys Ala Gly

1295 1300 1305

Cys Gly Cys Cys Thr Gly Cys Thr Gly Cys Cys Thr Gly Thr Ala

1310 1315 1320

Cys Thr Gly Thr Gly Cys Cys Ala Gly Gly Ala Thr Cys Ala Thr

1325 1330 1335

Gly Gly Ala Cys Thr Gly Ala Cys Cys Cys Cys Ala Gly Ala Cys

1340 1345 1350

Cys Ala Gly Gly Thr Ala Gly Thr Cys Gly Cys Ala Ala Thr Cys

1355 1360 1365

Gly Cys Gly Thr Cys Ala Ala Ala Cys Gly Gly Ala Gly Gly Gly

1370 1375 1380

Gly Gly Ala Ala Ala Gly Cys Ala Ala Gly Cys Cys Cys Thr Gly

1385 1390 1395

Gly Ala Ala Ala Cys Cys Gly Thr Gly Cys Ala Ala Ala Gl Gly

1400 1405 1410

Thr Thr Gly Thr Thr Gly Cys Cys Gly Gly Thr Cys Cys Thr Thr

1415 1420 1425

Thr Gly Thr Cys Ala Ala Gly Ala Cys Cys Ala Cys Gly Gly Cys

1430 1435 1440

Cys Thr Thr Ala Cys Ala Cys Cys Gly Gly Ala Gly Cys Ala Ala

1445 1450 1455

Gly Thr Cys Gly Thr Gly Gly Cys Cys Ala Thr Thr Gly Cys Ala

1460 1465 1470

Thr Cys Cys Cys Ala Cys Gly Ala Cys Gly Gly Thr Gly Gly Cys

1475 1480 1485

Ala Ala Ala Cys Ala Gly Gly Cys Thr Cys Thr Thr Gly Ala Gly

1490 1495 1500

Ala Cys Gly Gly Thr Thr Cys Ala Gly Ala Gly Ala Cys Thr Thr

1505 1510 1515

Cys Thr Cys Cys Cys Ala Gly Thr Thr Cys Thr Cys Thr Gly Thr

1520 1525 1530

Cys Ala Ala Gly Cys Cys Cys Ala Cys Gly Gly Gly Cys Thr Gly

1535 1540 1545

Ala Cys Thr Cys Cys Cys Gly Ala Thr Cys Ala Ala Gly Thr Thr

1550 1555 1560

Gly Th Ala Gly Cys Gly Ala Thr Thr Gly Cys Gly Thr Cys Gly

1565 1570 1575

Cys Ala Thr Gly Ala Cys Gly Gly Ala Gly Gly Gly Ala Ala Ala

1580 1585 1590

Cys Ala Ala Gly Cys Ala Thr Thr Gly Gly Ala Gly Ala Cys Thr

1595 1600 1605

Gly Thr Cys Cys Ala Ala Cys Gly Gly Cys Thr Cys Cys Thr Thr

1610 1615 1620

Cys Cys Cys Gly Thr Gly Thr Thr Gly Thr Gly Thr Cys Ala Ala

1625 1630 1635

Gly Cys Cys Cys Ala Cys Gly Gly Thr Thr Thr Gly Ala Cys Gly

1640 1645 1650

Cys Cys Thr Gly Cys Ala Cys Ala Ala Gly Thr Gly Gly Thr Cys

1655 1660 1665

Gly Cys Cys Ala Thr Cys Gly Cys Cys Thr Cys Cys Ala Ala Thr

1670 1675 1680

Ala Thr Thr Gly Gly Cys Gly Gly Thr Ala Ala Gly Cys Ala Gly

1685 1690 1695

Gly Cys Gly Cys Thr Gly Gly Ala Ala Ala Cys Ala Gly Thr Ala

1700 1705 1710

Cys Ala Gly Cys Gly Cys Cys Thr Gly Cys Thr Gly Cys Cys Thr

1715 1720 1725

Gly Thr Ala Cys Thr Gly Thr Gly Cys Cys Ala Gly Gly Ala Thr

1730 1735 1740

Cys Ala Thr Gly Gly Ala Cys Thr Gly Ala Cys Cys Cys Cys Ala 33/65

17 5 1750 1755

Gly Ala Cys Cys Ala Gly Gly Thr Ala Gly Thr Cys Gly Cys Ala

1760 1765 1770

Ala Thr Cys Gly Cys Gly Thr Cys Ala Cys Ala Thr Gly Ala Cys

1775 1780 1785

Gly Gly Gly Gly Gly Ala Ala Ala Gly Cys Ala Ala Gly Cys Cys

1790 1795 1800

Cys Thr Gly Gly Ala Ala Ala Cys Cys Gly Thr Gly Cys Ala Ala

1805 1810 1815

Ala Gly Gly Thr Thr Gly Thr Thr Gly Cys Cys Gly Gly Thr Cys

1820 1825 1830

Cys Thr Thr Thr Gly Thr Cys Ala Ala Gly Ala Cys Cys Ala Cys

1835 1840 1845

Gly Gly Cys Cys Thr Thr Ala Cys Ala Cys Cys Gly Gly Ala Gly

1850 1855 1860

Cys Ala Ala Gly Thr Cys Gly Thr Gly Gly Cys Cys Ala Thr Thr

1865 1870 1875

Gly Cys Ala Ala Gly Cys Ala Ala Cys Ala Thr Cys Gly Gly Thr

1880 1885 1890

Gly Gly Cys Ala Ala Ala Cys Ala Gly Gly Cys Thr Cys Thr Thr

1895 1900 1905

Gly Ala Gly Ala Cys Gly Gly Thr Thr Cys Ala Gly Ala Gly Ala

1910 1915 1920

Cys Thr Thr Cys Thr Cys Cys Cys Ala Gly Thr Thr Cys Thr Cys

1925 1930 1935

Thr Gly Thr Cys Ala Ala Gly Cys Cys Cys Ala Cys Gly Gly Gly

1940 1945 1950

Cys Thr Gly Ala Cys Thr Cys Cys Cys Gly Ala Thr Cys Ala Ala

1955 1960 1965

Gly Thr Thr Gly Thr Ala Gly Cys Gly Ala Thr Thr Gly Cys Gly

1970 1975 1980

Thr Cys Cys Ala Ala Cys Gly Gly Thr Gly Gly Ala Gly Gly Gly

1985 1990 1995

Ala Ala Ala Cys Ala Ala Gly Cys Ala Thr Thr Gly Gly Ala Gly

2000 2005 2010

Ala Cys Thr Gly Thr Cys Cys Ala Ala Cys Gly Gly Cys Thr Cys

2015 2020 2025

Cys Thr Thr Cys Cys Cys Gly Thr Gly Thr Thr Gly Thr Gly Thr

2030 2035 2040

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2045 2050 2055

Ala Cys Gly Cys Cys Thr Gly Cys Ala Cys Ala Ala Gly Thr Gly

2060 2065 2070

Gly Thr Cys Gly Cys Cys Ala Thr Cys Gly Cys Cys Ala Gly Cys

2075 2080 2085

Cys Ala Thr Gly Ala Thr Gly Gly Cys Gly Gly Thr Ala Ala Gly

2090 2095 2100

Cys Ala Gly Gly Cys Gly Cys Thr Gly Gly Ala Ala Ala Cys Ala

2105 2110 2115

Gly Thr Ala Cys Ala Gly Cys Gly Cys Cys Thr Gly Cys Thr Gly

2120 2125 2130

Cys Cys Thr Gly Thr Ala Cys Thr Gly Thr Gly Cys Cys Ala Gly

2135 2140 2145

Gly Ala Thr Cys Ala Thr Gly Gly Ala Cys Thr Gly Ala Cys Ala

2150 2155 2160

Cys Cys Cys Gly Ala Ala Cys Ala Gly Gly Thr Gly Gly Thr Cys

2165 2170 2175

Gly Cys Cys Ala Thr Thr Gly Cys Thr Thr Cys Thr Ala Ala Thr

2180 2185 2190

Gly Gly Gly Gly Gly Ala Gly Gly Ala Cys Gly Gly Cys Cys Ala

2195 2200 2205

Gly Cys Cys Thr Thr Gly Gly Ala Gly Thr Cys Cys Ala Thr Cys

2210 2215 2220

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2240 2245 2250

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2255 2260 2265

Ala Ala Thr Gly Ala Cys Cys Ala Thr Cys Thr Gly Gly Thr Gly 2270 2275 2280

Gly Cys Gly Thr Thr Gly Gly Cys Ala Thr Gly Thr Cys Thr Thr 2285 2290 2295

Gly Gly Thr Gly Gly Ala Cys Gly Ala Cys Cys Cys Gly Cys Gly 2300 2305 2310

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2795 2800 2805

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Ala Thr Gly Gly Thr Gly Ala Gly Cys Ala Ala Gly Gly Gly Cys Gly

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35 40 45

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85 90 95

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100 105 110

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115 120 125

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130 135 140

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165 170 175

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180 185 190

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195 200 205

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210 215 220

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225 230 235 240

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245 250 255

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260 265 270

Ala Gly Gly Cys Thr Ala Cys Gly Thr Cys Cys Ala Gly Gly Ala Gly

275 280 285

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325 330 335

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340 345 350

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355 360 365

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405 410 415 36/65

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435 440 445

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450 455 460

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465 470 475 480

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485 490 495

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515 520 525

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545 550 555 560

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565 570 575

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580 585 590

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595 600 605

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610 615 620

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625 630 635 640

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660 665 670

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675 680 685

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Ala Thr Gly Ala Gly Cys Gly Ala Gly Cys Thr Gly Ala Thr Thr Ala

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20 25 30

Gly Ala Ala Gly Cys Thr Gly Thr Ala Cys Ala Thr Gly Gly Ala Gly

35 40 45

Gly Gly Cys Ala Cys Cys Gly Thr Gly Gly Ala Cys Ala Ala Cys Cys

50 55 60

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65 70 75 80

Ala Thr Cys Cys Gly Ala Gly Gly Gly Cys Gly Ala Ala Gly Gly Cys

85 90 95

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100 105 110

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130 135 140

Gly Gly Cys Cys Cys Thr Cys Thr Cys Cys Cys Cys Thr Thr Cys Gly

145 150 155 160

Cys Cys Thr Thr Cys Gly Ala Cys Ala Thr Cys Cys Thr Gly Gly Cys 37/65

165 170 175

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130 185 190

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210 215 220

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225 230 235 240

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245 250 255

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260 265 270

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290 295 300

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305 310 315 320

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325 330 335

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340 345 350

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355 360 365

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370 375 380

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405 410 415

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420 425 430

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435 440 445

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450 455 460

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465 470 475 480

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485 490 495

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500 505 510

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515 520 525

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530 535 540

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545 550 555 560

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565 570 575

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580 585 590

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595 600 605

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645 650 655

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660 665 670

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675 680 685

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690 695 38/65

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35 40 45

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50 55 60

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85 90 95

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100 105 110

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115 120 125

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130 135 140

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165 170 175

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180 185 190

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195 200 205

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210 215 220

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225 230 235 240

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245 250 255

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260 265 270

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275 280 285

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290 295 300

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325 330 335

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340 345 350

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355 360 365

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370 375 380

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385 390 395 400

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405 410 415

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420 425 430

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435 440 445

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450 455 460

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465 470 475 480 39/65

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485 490 495

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500 505 510

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515 520 525

Ala Cys Cys Cys Cys Ala Gly Ala Cys Cys Ala Gly Gly Thr Ala Gly

530 535 540

Thr Cys Gly Cys Ala Ala Thr Cys Gly Cys Gly Thr Cys Ala Cys Ala 545 550 555 560

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565 570 575

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580 585 590

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660 665 670

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675 680 685

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690 695 700

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725 730 735

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740 745 750

Gly Ala Thr Thr Gly Cys Gly Thr Cys Cys Ala Ala Cys Gly Gly Thr

755 760 765

Gly Gly Ala Gly Gly Gly Ala Ala Ala Cys Ala Ala Gly Cys Ala Thr

770 775 780

Thr Gly Gly Ala Gly Ala Cys Thr Gly Thr Cys Cys Ala Ala Cys Gly 785 790 795 800

Gly Cys Thr Cys Cys Thr Thr Cys Cys Cys Gly Thr Gly Thr Thr Gly

805 810 815

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820 825 830

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835 840 845

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850 855 860

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885 890 895

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900 905 910

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915 920 925

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965 970 975

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980 985 990

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995 1000 1005

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1070 1075 1080

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1175 1180 1185

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1220 1225 1230

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1235 1240 1245

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1250 1255 1260

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1265 1270 1275

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1280 1285 1290

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1295 1300^" 1305

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1370 1375 1380

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1385 1390 1395

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1400 1405 1410

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1415 1420 1425

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1430 1435 1440

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1460 1465 1470

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1475 1480 1485

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1490 1495 1500

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1505 1510 1515

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1520 1525 1530 Cys Ala Ala Gly Cys Cys Cys Ala Cys Gly Gly Gly Cys Thr Gly 1535 1540 1545

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Gly Thr Ala Gly Cys Gly Ala Thr Thr Gly Cys Gly Thr Cys Gly 1565 1570 1575

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Cys Ala Ala Gly Cys Ala Thr Thr Gly Gly Ala Gly Ala Cys Thr 1595 1600 1605

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Cys Ala Thr Gly Gly Ala Cys Thr Gly Ala Cys Cys Cys Cys Ala 1745 1750 1755

Gly Ala Cys Cys Ala Gly Gly Thr Ala Gly Thr Cys Gly Cys Ala 1760 1765 1770

Ala Thr Cys Gly Cys Gly Thr Cys Ala Cys Ala Thr Gly Ala Cys 1775 1780 1785

Gly Gly Gly Gly Gly Ala Ala Ala Gly Cys Ala Ala Gly Cys Cys 1790 1795 1800

Cys Thr Gly Gly Ala Ala Ala Cys Cys Gly Thr Gly Cys Ala Ala 1805 1810 1815

Ala Gly Gly Thr Thr Gly Thr Thr Gl Cys Cys Gly Gly Thr Cys

1820 1825 1830

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1835 1840 1845

Gly Gly Cys Cys Thr Thr Ala Cys Ala Cys Cys Gly Gly Ala Gly 1850 1855 1860

Cys Ala Ala Gly Thr Cys Gly Thr Gly Gly Cys Cys Ala Thr Thr 1865 1870 1875

Gly Cys Ala Ala Gly Cys Ala Ala Cys Ala Thr Cys Gly Gly Thr

1880 1885 1890

Gly Gly Cys Ala Ala Ala Cys Ala Gly Gly Cys Thr Cys Thr Thr 1895 1900 1905

Gly Ala Gly Ala Cys Gly Gly Thr Thr Cys Ala Gly Ala Gly Ala 1910 1915 1920

Cys Thr Thr Cys Thr Cys Cys Cys Ala Gly Thr Thr Cys Thr Cys 1925 1930 1935

Thr Gly Thr Cys Ala Ala Gly Cys Cys Cys Ala Cys Gly Gly Gly 1940 1945 1950

Cys Thr Gly Ala Cys Thr Cys Cys Cys Gly Ala Thr Cys Ala Ala 1955 1960 1965

Gly Thr Thr Gly Thr Ala Gly Cys Gly Ala Thr Thr Gly Cys Gly 1970 1975 1980

Thr Cys Cys Ala Ala Cys Gly Gly Thr Gly Gly Ala Gly Gly Gly 1985 1990 1995

Ala Ala Ala Cys Ala Ala Gly Cys Ala Thr Thr Gly Gly Ala Gly 2000 2005 2010

Ala Cys Thr Gly Thr Cys Cys Ala Ala Cys Gly Gly Cys Thr Cys 2015 2020 2025

Cys Thr Thr Cys Cys Cys Gly Thr Gly Thr Thr Gly Thr Gly Thr 2030 2035 2040 Cys Ala Ala Gly Cys Cys Cys Ala Cys Gly Gly Thr Thr Thr Gly 2045 2050 2055

Ala Cys Gly Cys Cys Thr Gly Cys Ala Cys Ala Ala Gly Thr Gly 2060 2065 2070

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Cys Ala Gly Gly Cys Gly Cys Thr Gly Gly Ala Ala Ala Cys Ala 2105 2110 2115

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Cys Cys Thr Gly Thr Ala Cys Thr Gly Thr Gly Cys Cys Ala Gly 2135 2140 2145

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Gly Cys Cys Ala Thr Thr Gly Cys Thr Thr Cys Thr Ala Ala Thr 2180 2185 2190

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Gly Cys Gly Thr Thr Gly Gly Cys Ala Thr Gly Thr Cys Thr Thr 2285 2290 2295

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Gly Thr Cys Ala Cys Thr Cys Ala Ala Gly Gly Ala Ala Gly Thr 2495 2500 2505

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2555 2560 2565

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2585 2590 2595

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2600 2605 2610

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2615 2620 2625

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2630 ^■ 2635 2640

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2645 2650 2655

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2660 2665 2670

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2675 2680 2685

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2690 2695 2700

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2705 2710 2715

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2720 2725 2730

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2735 2740 2745

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2750 2755 2760

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2765 2770 2775

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3125 3130 3135

Cys Cys Thr Gly Cys Gly Gly Cys Gly Cys Thr Thr Gly Gly Gly

3140 3145 3150

Ala Cys Gly Gly Thr Gly Gly Cys Thr Gly Thr Cys Ala Ala Ala

3155 3160 3165

Thr Ala Cys Cys Ala Ala Gly Ala Thr Ala Thr Gly Ala Thr Thr

3170 3175 3180

Gly Cys Gly Gly Cys Cys Cys Thr Gly Cys Cys Cys Gly Ala Ala

3185 3190 3195

Gly Cys Cys Ala Cys Gly Cys Ala Cys Gly Ala Gly Gly Cys Ala

3200 3205 3210

Ala Thr Thr Gly Thr Ala Gly Gly Gly Gly Thr Cys Gly Gly Thr

3215 3220 3225

Ala Ala Ala Cys Ala Gly Thr Gly Gly Thr Cys Gly Gly Gly Ala

3230 3235 3240

Gly Cys Gly Cys Gly Ala Gly Cys Ala Cys Thr Thr Gly Ala Gly

3245 3250 3255

Gly Cys Gly Cys Thr Gly Cys Thr Gly Ala Cys Thr Gly Thr Gly

3260 3265 3270

Gly Cys Gly Gly Gly Thr Gly Ala Gly Cys Thr Thr Ala Gly Gly

3275 3280 3285

Gly Gly Gly Cys Cys Thr Cys Cys Gly Cys Thr Cys Cys Ala Gly

3290 3295 3300

Cys Thr Cys Gly Ala Cys Ala Cys Cys Gly Gly Gly Cys Ala Gly

3305 3310 3315

Cys Thr Gly Cys Thr Gly Ala Ala Gly Ala Thr Cys Gly Cys Gly

3320 3325 3330

Ala Ala Gly Ala Gly Ala Gly Gly Gly Gly Gly Ala Gly Thr Ala

3335 3340 3345

Ala Cys Ala Gly Cys Gly Gly Thr Ala Gly Ala Gly Gly Cys Ala

3350 3355 3360

Gly Thr Gly Cys Ala Cys Gly Cys Cys Thr Gly Gly Cys Gly Cys

3365 3370 3375

Ala Ala Thr Gly Cys Gly Cys Thr Cys Ala Cys Cys Gly Gly Gly

3380 3385 3390

Gly Cys Cys Cys Cys Cys Thr Thr Gly Ala Ala Cys Cys Thr Gly

3395 3400 3405

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3410 3415 3420

Gly Thr Cys Gly Cys Ala Ala Thr Cys Gly Cys Gly Thr Cys Ala

3425 3430 3435

Ala Ala Cys Gly Gly Ala Gly Gly Gly Gly Gly Ala Ala Ala Gly

3440 3445 3450

Cys Ala Ala Gly Cys Cys Cys Thr Gly Gly Ala Ala Ala Cys Cys

3455 3460 3465

Gly Thr Gly Cys Ala Ala Ala Gly Gly Thr Thr Gly Thr Thr Gly

3470 3475 3480

Cys Cys Gly Gly Thr Cys Cys Thr Thr Thr Gly Thr Cys Ala Ala

3485 3490 3495

Gly Ala Cys Cys Ala Cys Gly Gly Cys Cys Thr Thr Ala Cys Ala

3500 3505 3510

Cys Cys Gl Gly Ala Gly Cys Ala Ala Gly Thr Cys Gly Thr Gly

3515 3520 3525

Gly Cys Cys Ala Thr Thr Gly Cys Ala Ala Gly Cys Ala Ala Thr

3530 3535 3540

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3545 3550 3555

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3560 3565 3570 45/65

Cys Ala Gly Ala Gly Ala Cys Thr Thr Cys Thr Cys Cys Cys Ala 3575 3580 3585

Gly Thr Thr Cys Thr Cys Thr Gly Thr Cys Ala Ala Gly Cys Cys 3590 3595 3600

Cys Ala Cys Gly Gly Gly Cys Thr Gly Ala Cys Thr Cys Cys Cys 3605 3610 3615

Gly Ala Thr Cys Ala Ala Gly Thr Thr Gly Thr Ala Gly Cys Gly 3620 3625 3630

Ala Thr Thr Gly Cys Gly Thr Cys Gly Ala Ala Cys Ala Thr Thr 3635 3640 3645

Gly Gly Ala Gly Gly Gly Ala Ala Ala Cys Ala Ala Gly Cys Ala 3650 3655 3660

Thr Thr Gly Gly Ala Gly Ala Cys Thr Gly Thr Cys Cys Ala Ala 3665 3670 3675

Cys Gly Gly Cys Thr Cys Cys Thr Thr Cys Cys Cys Gly Thr Gly 3680 3685 3690

Thr Thr Gly Thr Gly Thr Cys Ala Ala Gly Cys Cys Cys Ala Cys 3695 3700 3705

Gly Gly Thr Thr Thr Gly Ala Cys Gly Cys Cys Thr Gly Cys Ala 3710 3715 3720

Cys Ala Ala Gly Thr Gly Gly Thr Cys Gly Cys Cys Ala Thr Cys 3725 3730 3735

Gly Cys Cys Ala Gly Cys Cys Ala Thr Gly Ala Thr Gly Gly Cys 3740 3745 3750

Gly Gly Thr Ala Ala Gly Cys Ala Gly Gly Cys Gly Cys Thr Gly 3755 3760 3765

Gly Ala Ala Ala Cys Ala Gly Thr Ala Cys Ala Gly Cys Gly Cys 3770 3775 3780

Cys Thr Gly Cys Thr Gly Cys Cys Thr Gly Thr Ala Cys Thr Gly 3785 3790 3795

Thr Gly Cys Cys Ala Gly Gly Ala Thr Cys Ala Thr Gly Gly Ala 3800 3805 3810

Cys Thr Gly Ala Cys Cys Cys Cys Ala Gly Ala Cys Cys Ala Gly 3815 3820 3825

Gly Thr Ala Gly Thr Cys Gly Cys Ala Ala Thr Cys Gly Cys Gly 3830 3835 3840

Thr Cys Ala Ala Ala Cys Gly Gly Ala Gly Gly Gly Gly Gly Ala

3845 3850 3855

Ala Ala Gly Cys Ala Ala Gly Cys Cys Cys Thr Gly Gly Ala Ala 3860 3865 3870

Ala Cys Cys Gly Thr Gly Cys Ala Ala Ala Gly Gly Thr Thr Gly 3875 3880 3885

Thr Thr Gly Cys Cys Gly Gly Thr Cys Cys^' Thr Thr Thr Gly Thr 3890 3895 3900

Cys Ala Ala Gly Ala Cys Cys Ala Cys Gly Gly Cys Cys Thr Thr 3905 3910 3915

Ala Cys Ala Cys Cys Gly Gly Ala Gly Cys Ala Ala Gly Thr Cys 3920 3925 3930

Gly Thr Gly Gly Cys Cys Ala Thr Thr Gly Cys Ala Ala Ala Thr 3935 3940 3945

Ala Ala Thr Ala Ala Cys Gly Gly Thr Gly Gly Cys Ala Ala Ala 3950 3955 3960

Cys Ala Gly Gly Cys Thr Cys Thr Thr Gly Ala Gly Ala Cys Gly 3965 3970 3975

Gly Thr Thr Cys Ala Gly Ala Gly Ala Cys Thr Thr Cys Thr Cys 3980 3985 3990

Cys Cys Ala Gly Thr Thr Cys Thr Cys Thr Gly Thr Cys Ala Ala 3995 4000 4005

Gly Cys Cys Cys Ala Cys Gly Gly Gly Cys Thr Gly Ala Cys Thr 4010 4015 4020

Cys Cys Cys Gly Ala Thr Cys Ala Ala Gly Thr Thr Gly Thr Ala 4025 4030 4035

Gly Cys Gly Ala Thr Thr Gly Cys Gly Thr Cys Gly Cys Ala Thr

4040 4045 4050

Gly Ala Cys Gly Gly Ala Gly Gly Gly Ala Ala Ala Cys Ala Ala

4055 4060 4065

Gly Cys Ala Thr Thr Gly Gly Ala Gly Ala Cys Thr Gly Thr Cys

4070 4075 4080 46/65

Cys Ala Ala Cys Gly Gly Cys Thr Cys Cys Thr Thr Cys Cys Cys

4085 4090 4095

Gly Thr Gly Thr Thr Gly Thr Gly Thr Cys Ala Ala Gly Cys Cys

4100 4105 4110

Cys Ala Cys Gly Gly Thr Thr Thr Gly Ala Cys Gly Cys Cys Thr

4115 4120 4125

Gly Cys Ala Cys Ala Ala Gly Thr Gly Gly Thr Cys Gly Cys Cys

4130 4135 4140

Ala Thr Cys Gly Cys Cys Thr Cys Gly Ala Ala Thr Gly Gly Cys

4145 4150 4155

Gly Gly Cys Gly Gly Thr Ala Ala Gly Cys Ala Gly Gly Cys Gly

4160 4165 4170

Cys Thr Gly Gly Ala Ala Ala Cys Ala Gly Thr Ala Cys Ala Gly

4175 4180 4185

Cys Gly Cys Cys Thr Gly Cys Thr Gly Cys Cys Thr Gly Thr Ala

4190 4195 4200

Cys Thr Gly Thr Gly Cys Cys Ala Gly Gly Ala Thr Cys Ala Thr

4205 4210 4215

Gly Gly Ala Cys Thr Gly Ala Cys Cys Cys Cys Ala Gly Ala Cys

4220 4225 4230

Cys Ala Gly Gly Thr Ala Gly Thr Cys Gly Cys Ala Ala Thr Cys

4235 4240 4245

Gly Cys Gly Ala Ala Cys Ala Ala Thr Ala Ala Thr Gly Gly Gly

4250 4255 4260

Gly Gly Ala Ala Ala Gly Cys Ala Ala Gly Cys Cys Cys Thr Gly

4265 4270 4275

Gly Ala Ala Ala Cys Cys Gly Thr Gly Cys Ala Ala Ala Gly Gly

4280 4285 4290

Thr Thr Gly Thr Thr Gly Cys Cys Gly Gly Thr Cys Cys Thr Thr

4295 4300 4305

Thr Gly Thr Cys Ala Ala Gly Ala Cys Cys Ala Cys Gly Gly Cys

4310 4315 4320

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4325 4330 4335

Gly Thr Cys Gly Thr Gly Gly Cys Cys Ala Thr Thr Gly Cys Ala

4340 4345 4350

Thr Cys Cys Cys Ala Cys Gly Ala Cys Gly Gly Thr Gly Gly Cys

4355 4360 4365

Ala Ala Ala Cys Ala Gly Gly Cys Thr Cys Thr Thr Gly Ala Gly

4370 4375 4380

Ala Cys Gly Gly Thr Thr Cys Ala Gly Ala Gly Ala Cys Thr Thr

4385 4390 4395

Cys Thr Cys Cys Cys Ala Gly Thr Thr Cys Thr Cys Thr Gly Thr

4400 4405 4410

Cys Ala Ala Gly Cys Cys Cys Ala Cys Gly Gly Gly Cys Thr Gly

4415 4420 4425

Ala Cys Thr Cys Cys Cys Gly Ala Thr Cys Ala Ala Gly Thr Thr

4430 4435 4440

Gly Thr Ala Gly Cys Gly Ala Thr Thr Gly Cys Gly Thr Cys Cys

4445 4450 4455

Ala Ala Cys Gly Gly Thr Gly Gly Ala Gly Gly Gly Ala Ala Ala

4460 4465 4470

Cys Ala Ala Gly Cys Ala Thr Thr Gly Gly Ala Gly Ala Cys Thr

4475 4480 4485

Gly Thr Cys Cys Ala Ala Cys Gly Gly Cys Thr Cys Cys Thr Thr

4490 4495 4500

Cys Cys Cys Gly Thr Gly Thr Thr Gly Thr Gly Thr Cys Ala Ala

4505 4510 4515

Gly Cys Cys Cys Ala Cys Gly Gly Thr Thr Thr Gly Ala Cys Gly

4520 4525 4530

Cys Cys Thr Gly Cys Ala Cys Ala Ala Gly Thr Gly Gly Thr Cys

4535 4540 4545

Gly Cys Cys Ala Thr Cys Gly Cys Cys Ala Gly Cys Cys Ala Thr

4550 4555 4560

Gly Ala Thr Gly Gly Cys Gly Gly Thr Ala Ala Gly Cys Ala Gly

4565 4570 4575

Gly Cys Gly Cys Thr Gly Gly Ala Ala Ala Cys Ala Gly Thr Ala

4580 4585 4590 47/65

Cys Ala Gly Cys Gly Cys Cys Thr Gly Cys Thr Gly Cys Cys Thr

4595 4600 4605

Gly Thr Ala Cys Thr Gly Thr Gly Cys Cys Ala Gly Gly Ala Thr

4610 4615 4620

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4625 4630 4635

Gly Ala Cys Cys Ala Gly Gly Thr Ala Gly Thr Cys Gly Cys Ala

4640 4645 4650

Ala Thr Cys Gly Cys Gly Thr Cys Ala Cys Ala Thr Gly Ala Cys

4655 4660 4665

Gly Gly Gly Gly Gly Ala Ala Ala Gly Cys Ala Ala Gly Cys Cys

4670 4675 4680

Cys Thr Gly Gly Ala Ala Ala Cys Cys Gly Thr Gly Cys Ala Ala

4685 4690 4695

Ala Gly Gly Thr Thr Gly Thr Thr Gly Cys Cys Gly Gly Thr Cys

4700 4705 4710

Cys Thr Thr Thr Gly Thr Cys Ala Ala Gly Ala Cys Cys Ala Cys

4715 4720 4725

Gly Gly Cys Cys Thr Thr Ala Cys Ala Cys Cys Gly Gly Ala Gly

4730 4735 4740

Cys Ala Ala Gly Thr Cys Gly Thr Gly Gly Cys Cys Ala Thr Thr

4745 4750 4755

Gly Cys Ala Thr Cys Cys Cys Ala Cys Gly Ala Cys Gly Gly Thr

4760 4765 4770

Gly Gly Cys Ala Ala Ala Cys Ala Gly Gly Cys Thr Cys Thr Thr

4775 4780 4785

Gly Ala Gly Ala Cys Gly Gly Thr Thr Cys Ala Gly Ala Gly Ala

4790 4795 4800

Cys Thr Thr Cys Thr Cys Cys Cys Ala Gly Thr Thr Cys Thr Cys

4805 4810 4815

Thr Gly Thr Cys Ala Ala Gly Cys Cys Cys Ala Cys Gly Gly Gly

4820 4825 4830

Cys Thr Gly Ala Cys Thr Cys Cys Cys Gly Ala Thr Cys Ala Ala

4835 4840 4845

Gly Thr Thr Gly Thr Ala Gly Cys Gly Ala Thr Thr Gly Cys Gly

4850 4855 4860

Ala Ala Thr Ala Ala Cys Ala Ala Thr Gly Gly Ala Gly Gly Gly

4865 4870 4875

Ala Ala Ala Cys Ala Ala Gly Cys Ala Thr Thr Gly Gly Ala Gly

4880 4885 4890

Ala Cys Thr Gly Thr Cys Cys Ala Ala Cys Gly Gly Cys Thr Cys

4895 4900 4905

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4910 4915 4920

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4925 4930 4935

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4940 4945 4950

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4955 4960 4965

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4970 4975 4980

Cys Ala Gly Gly Cys Gly Cys Thr Gly Gly Ala Ala Ala Cys Ala

4985 4990 4995

Gly Thr Ala Cys Ala Gly Cys Gly Cys Cys Thr Gly Cys Thr Gly

5000 5005 5010

Cys Cys Thr Gly Thr Ala Cys Thr Gly Thr Gly Cys Cys Ala Gly

5015 5020 5025

Gly Ala Thr Cys Ala Thr Gly Gly Ala Cys Thr Gly Ala Cys Ala

5030 5035 5040

Cys Cys Cys Gly Ala Ala Cys Ala Gly Gly Thr Gly Gly Thr Cys

5045 5050 5055

Gly Cys Cys Ala Thr Thr Gly Cys Thr Thr Cys Thr Ala Ala Thr

5060 5065 5070

Gly Gly Gly Gly Gly Ala Gly Gly Ala Cys Gly Gly Cys Cys Ala

5075 5080 5085

Gly Cys Cys Thr Thr Gly Gly Ala Gly Thr Cys Cys Ala Thr Cys

5090 5095 5100 48/65

Gly Thr Ala Gly Cys Cys Cys Ala Ala Thr Thr Gly Thr Cys Cys 5105 5110 5115

Ala Gly Gly Cys Cys Cys Gly Ala Thr Cys Cys Cys Gly Cys Gly 5120 5125 5130

Thr Thr Gly Gly Cys Thr Gly Cys Gly Thr Thr Ala Ala Cys Gly 5135 5140 5145

Ala Ala Thr Gly Ala Cys Cys Ala Thr Cys Thr Gly Gly Thr Gly 5150 5155 5160

Gly Cys Gly Thr Thr Gly Gly Cys Ala Thr Gly Thr Cys Thr Thr 5165 5170 5175

Gly Gly Thr Gly Gly Ala Cys Gly Ala Cys Cys Cys Gly Cys Gly 5180 5185 5190

Cys Thr Cys Gly Ala Thr Gly Cys Ala Gly Thr Cys Ala Ala Ala 5195 5200 5205

Ala Ala Gly Gly Gly Thr Cys Thr Gly Cys Cys Thr Cys Ala Thr 5210 5215 5220

Gly Cys Thr Cys Cys Cys Gly Cys Ala Thr Thr Gly Ala Thr Cys 5225 5230 5235

Ala Ala Ala Ala Gly Ala Ala Cys Cys Ala Ala Cys Cys Gly Gly 5240 5245 5250

Cys Gly Gly Ala Thr Thr Cys Cys Cys Gly Ala Gly Ala Gly Ala

5255 5260 5265

Ala Cys Thr Thr Cys Cys Cys Ala Thr Cys Gly Ala Gly Thr Cys 5270 5275 5280

Gly Cys Gly Gly Gly Ala Thr Cys Cys Gly Ala Thr Cys Cys Ala 5285 5290 5295

Ala Ala Ala Ala Ala Gly Ala Ala Gly Ala Gly Ala Ala Ala Gly

5300 5305 5310

Gly Thr Ala Gly Cys Cys Cys Cys Cys Cys Cys Gly Ala Cys Cys

5315 5320 5325

Gly Ala Thr Gly Thr Cys Ala' Gly Cys Cys Thr Gly Gly Gly Gly 5330 5335 5340

Gly Ala Cys Gly Ala Gly Cys Thr Cys Cys Ala Cys Thr Thr Ala 5345 5350 5355

Gly Ala Cys Gly Gly Cys Gly Ala Gly Gly Ala Cys Gly Thr Gly 5360 5365 5370

Gly Cys Gly Ala Thr Gly Gly Cys Gly Cys Ala Thr Gly Cys Cys 5375 5380 5385

Gly Ala Cys Gly Cys Gly Cys Thr Ala. Gly Ala Cys Gly Ala Thr 5390 5395 5400

Thr Thr Cys Gly Ala Thr Cys Thr Gly Gly Ala Cys Ala Thr Gly 5405 5410 5415

Thr Thr Gly Gly Gly Gly Gly Ala Cys Gly Gly Gly Gly Ala Thr 5420 5425 5430

Thr Cys Cys Cys Cys Gly Gly Gly Thr Cys Cys Gly Gly Gly Ala 5435 5440 5445

Thr Thr Thr Ala Cys Cys Cys Cys Cys Cys Ala Cys Gly Ala Cys 5450 5455 5460

Thr Cys Cys Gly Cys Cys Cys Cys Cys Thr Ala Cys Gly Gly Cys 5465 5470 5475

Gly Cys Thr Cys Thr Gly Gly Ala Thr Ala Thr Gly Gly Cys Cys 5480 5485 5490

Gly Ala Cys Thr Thr Cys Gly Ala Gly Thr Thr Thr Gly Ala Gly 5495 5500 5505

Cys Ala Gly Ala Thr Gly Thr Thr Thr Ala Cys Cys Gly Ala Thr 5510 5515 5520

Gly Cys Cys Cys Thr Thr Gly Gly Ala Ala Thr Thr Gly Ala Cys 5525 5530 5535

Gly Ala Gly Thr Ala Cys Gly Gly Thr Gly Gly Gly Ala Gly Ala 5540 5545 5550

Gly Cys Cys Gly Ala Gly Gly Gly Gly Ala Gly Ala Gly Gly Ala 5555 5560 5565

Ala Gly Thr Cys Thr Thr Cys Thr Gly Ala Cys Cys Thr Gly Cys 5570 5575 5580

Gly Gly Ala Gly Ala Cys Gly Thr Cys Gly Ala Ala Gly Ala Gly

5585 5590 5595

Ala Ala Thr Cys Cys Thr Gly Gly Ala Cys Cys Cys Ala Thr Gly

5600 5605 5610 49/65

Ala Gly Cys Gly Ala Gly Cys Thr Gly Ala Thr Thr Ala Ala Gly

5615 5620 5625

Gly Ala Gly Ala Ala Cys Ala Thr Gly Cys Ala Cys Ala Thr Gly

5630 5635 5640

Ala Ala Gly Cys Thr Gly Thr Ala Cys Ala Thr Gly Gly Ala Gly

5645 5650 5655

Gly Gly Cys Ala Cys Cys Gly Thr Gly Gly Ala Cys Ala Ala Cys

5660 5665 5670

Cys Ala Thr Cys Ala Cys Thr Thr Cys Ala Ala Gly Thr Gly Cys

5675 5680 5685

Ala Cys Ala Thr Cys Cys Gly Ala Gly Gly Gly Cys Gly Ala Ala

5690 5695 5700

Gly Gly Cys Ala Ala Gly Cys Cys Cys Thr Ala Cys Gly Ala Gly

5705 5710 5715

Gly Gly Cys Ala Cys Cys Cys Ala Gly Ala Cys Cys Ala Thr Gly

5720 5725 5730

Ala Gly Ala Ala Thr Cys Ala Ala Gly Gly Thr Gly Gly Thr Cys

5735 5740 5745

Gly Ala Gly Gly Gly Cys Gly Gly Cys Cys Cys Thr Cys Thr Cys

5750 5755 5760

Cys Cys Cys Thr Thr Cys Gly Cys Cys Thr Thr Cys Gly Ala Cys

5765 5770 5775

Ala Thr Cys Cys Thr Gly Gly Cys Thr Ala Cys Thr Ala Gly Cys

5780 5785 5790

Thr Thr Cys Cys Thr Cys Thr Ala Cys Gly Gly Cys Ala Gly Cys

5795 5800 5805

Ala Ala Gly Ala Cys Cys Thr Thr Cys Ala Thr Cys Ala Ala Cys

5810 5815 5820

Cys Ala Cys Ala Cys Cys Cys Ala Gly Gly Gly Cys Ala Thr Cys

5825 5830 5835

Cys Cys Cys Gly Ala Cys Thr Thr Cys Thr Thr Cys Ala Ala Gly

5840 5845 5850

Cys Ala Gly Thr Cys Cys Thr Thr Cys Cys Cys Thr Gly Ala Gly

5855 5860 5865

Gly Gly Cys Thr Thr Cys Ala Cys Ala Thr Gly Gly Gly Ala Gly

5870 5875 5880

Ala Gly Ala Gly Thr Cys Ala Cys Cys Ala Cys Ala Thr Ala Cys

5885 5890 5895

Gly Ala Ala Gly Ala Cys Gly Gly Gly Gly Gly Cys Gly Thr Gly

5900 5905 5910

Cys Thr Gly Ala Cys Cys Gly Cys Thr Ala Cys Cys Cys Ala Gly

5915 5920 5925

Gly Ala Cys Ala Cys Cys Ala Gly Cys Cys Thr Cys Cys Ala Gly

5930 5935 5940

Gly Ala Cys Gly Gly Cys Thr Gly Cys Cys Thr Cys Ala Thr Cys

5945 5950 5955

Thr Ala Cys Ala Ala Cys Gly Thr Cys Ala Ala Gly Ala Thr Cys

5960 5965 5970

Ala Gly Ala Gly Gly Gly Gly Thr Gly Ala Ala Cys Thr Thr Cys

5975 5980 5985

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5990 5995 6000

Gly Thr Gly Ala Thr Gly Cys Ala Gly Ala Ala Gly Ala Ala Ala

6005 6010 6015

Ala Cys Ala Cys Thr Cys Gly Gly Cys Thr Gly Gly Gly Ala Gly

6020 6025 6030

Gly Cys Cys Thr Thr Cys Ala Cys Cys Gly Ala Gly Ala Cys Gly

6035 6040 6045

Cys Thr Gly Thr Ala Cys Cys Cys Cys Gly Cys Thr Gly Ala Cys

6050 6055 6060

Gly Gly Cys Gly Gly Cys Cys Thr Gly Gly Ala Ala Gly Gly Cys

6065 6070 6075

Ala Gly Ala Ala Ala Cys Gly Ala Cys Ala Thr Gly Gly Cys Cys

6080 6085 6090

Cys Thr Gly Ala Ala Gly Cys Thr Cys Gly Thr Gly Gly Gly Cys

6095 6100 6105

Gly Gly Gly Ala Gly Cys Cys Ala Thr Cys Thr Gly Ala Thr Cys

6110 6115 6120 50/65

Gly Cys Ala Ala Ala Cys Ala Thr Cys Ala Ala Gly Ala Cys Cys

6125 6130 6135

Ala C s Ala Thr Ala Thr Ala Gly Ala Thr Cys Cys Ala Ala Gly

6140 6145 6150

Ala Ala Ala Cys Cys Cys Gly Cys Thr Ala Ala Gly Ala Ala Cys

6155 6160 6165

Cys Thr Cys Ala Ala Gly Ala Thr Gly Cys Cys Thr Gly Gly Cys

6170 6175 6180

Gly Thr Cys Thr Ala Cys Thr Ala Thr Gly Thr Gly Gly Ala Cys

6185 6190 6195

Thr Ala Cys Ala Gly Ala Cys Thr Gly Gly Ala Ala Ala Gly Ala

6200 6205 6210

Ala Thr Cys Ala Ala Gly Gly Ala Gly Gly Cys Cys Ala Ala Cys

6215 6220 6225

Ala Ala Cys Gly Ala Gly Ala Cys Cys Thr Ala Cys Gly Thr Cys

6230 6235 6240

Gly Ala Gly Cys Ala Gly Cys Ala Cys Gly Ala Gly Gly Thr Gly

6245 6250 6255

Gly Cys Ala Gly Thr Gly Gly Cys Cys Ala Gly Ala Thr Ala Cys

6260 6265 6270

Thr Gly Cys Gly Ala Cys Cys Thr Cys Cys Cys Thr Ala Gly Cys

6275 6280 6285

Ala Ala Ala Cys Thr Gly Gly Gly Gly Cys Ala Cys Ala Ala Gly

6290 6295 6300

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6305

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85 90 95

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100 105 110

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115 120 125

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130 135 140

Cys Ala Ala Cys Ala Gly Cys Ala Ala Cys Ala Gly Gly Ala Gly Ala

145 150 155 160

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165 170 175

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180 185 190

Cys Ala Ala Cys Ala Cys Cys Ala Cys Gly Ala Gly Gly Cys Gly Cys

195 200 205

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210 215 220

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225 230 235 240

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245 250 255

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260 265 270

Gly Ala Cys Gly Gly Thr Gly Gly Cys Thr Gly Thr Cys Ala Ala Ala

275 280 285

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290 295 300

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305 310 315 320

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325 330 335

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340 345 350

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355 360 365

Ala Gly Cys Ala Cys Thr Thr Gly Ala Gly Gly Cys Gly Cys Thr Gly

370 375 380

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385 390 395 400

Ala Gly Cys Thr Thr Ala Gly Gly Gly Gly Gly Cys Cys Thr Cys Cys

405 410 415

Gly Cys Thr Cys Cys Ala Gly Cys Thr Cys Gly Ala Cys Ala Cys Cys

420 425 430

Gly Gly Gly Cys Ala Gly Cys Thr Gly Cys Thr Gly Ala Ala Gly Ala

435 440 445

Thr Cys Gly Cys Gly Ala Ala Gly Ala Gly Ala Gly Gly Gly Gly Gly

450 455 460

Ala Gly Thr Ala Ala Cys Ala Gly Cys Gly Gly Thr Ala Gly Ala Gly

465 470 475 480

Gly Cys Ala Gly Thr Gly Cys Ala Cys Gly Cys Cys Thr Gly Gly Cys

485 490 495

Gly Cys Ala Ala Thr Gly Cys Gly Cys Thr Cys Ala Cys Cys Gly Gly

500 505 510

Gly Gly Cys Cys Cys Cys Cys Thr Thr Gly Ala Ala Cys Cys Thr Gly

515 520 525

Ala Cys Cys Cys Cys Ala Gly Ala Cys Cys Ala Gly Gly Thr Ala Gly

530 535 540

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545 550 555 560

Cys Gly Gly Ala Gly Gly Gly Gly Gly Ala Ala Ala Gly Cys Ala Ala

565 570 575

Gly Cys Cys Cys Thr Gly Gly Ala Ala Ala Cys Cys Gly Thr Gly Cys

580 585 590

Ala Ala Ala Gly Gly Thr Thr Gly Thr Thr Gly Cys Cys Gly Gly Thr

595 600 605

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610 615 620

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625 630 635 640

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645 650 655

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660 665 670

Ala Ala Ala Cys Ala Gly Gly Cys Thr Cys Thr Thr Gly Ala Gly Ala

675 680 685

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690 695 700

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705 710 715 720

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725 730 735

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740 745 750

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755 760 765

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770 775 780

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785 790 795 800

Gly Cys Thr Cys Cys Thr Thr Cys Cys Cys Gly Thr Gly Thr Thr Gly 52/65

805 810 815

Thr Gly Thr Cys Ala Ala Gly Cys Cys Cys Ala Cys Gly Gly Thr Thr

820 825 830

Thr Gly Ala Cys Gly Cys Cys Thr Gly Cys Ala Cys Ala Ala Gly Thr

835 840 845

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850 855 860

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865 870 875 880

Ala Gly Gly Cys Gly .Cys Thr Gly Gly Ala Ala Ala Cys Ala Gly Thr

885 890 895

Ala Cys Ala Gly Cys Gly Cys Cys Thr Gly Cys Thr Gly Cys Cys Thr

900 905 910

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915 920 925

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930 935 940

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945 950 955 960

Gly Cys Gly Thr Cys Ala Ala Ala Cys Gly Gly Ala Gly Gly Gly Gly .

965 970 975

Gly Ala Ala Ala Gly Cys Ala Ala Gly Cys Cys Cys Thr Gly Gly Ala

980 985 990

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995 1000 1005

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Cys Ala Ala Gly Ala Cys Cys Ala Cys Gly Gly Cys Cys Thr Thr 1025 1030 1035

Ala Cys Ala Cys Cys Gly Gly Ala Gly Cys Ala Ala Gly Thr Cys 1040 1045 1050

Gly Thr Gly Gly Cys Cys Ala Thr Thr Gly Cys Ala Ala Ala Thr 1055 1060 1065

Ala Ala Thr Ala Ala Cys Gly Gly Thr Gly Gly Cys Ala Ala Ala 1070 1075 1080

Cys Ala Gly Gly Cys Thr Cys Thr Thr Gly Ala Gly Ala Cys Gly 1085 1090 1095

Gly Thr Thr Cys Ala Gly Ala Gly Ala Cys Thr Thr Cys Thr Cys 1100 1105 1110

Cys Cys Ala Gly Thr Thr Cys Thr Cys Thr Gly Thr Cys Ala Ala 1115 1120 1125

Gly Cys Cys Cys Ala Cys Gly Gly Gly Cys Thr Gly Ala Cys Thr 1130 1135 1140

Cys Cys Cys Gly Ala Thr Cys Ala Ala Gly Thr Thr Gly Thr Ala 1145 1150 1155

Gly Cys Gly Ala Thr Thr Gly Cys Gly Thr Cys Gly Cys Ala Thr 1160 1165 1170

Gly Ala Cys Gly Gly Ala Gly Gly Gly Ala Ala Ala Cys Ala Ala 1175 1180 1185

Gly Cys Ala Thr Th^'r Gly Gly Ala Gly Ala Cys Thr Gly Thr Cys 1190 1195 1200

Cys Ala Ala Cys Gly Gly Cys Thr Cys Cys Thr Thr Cys Cys Cys 1205 1210 1215

Gly Thr Gly Thr Thr Gly Thr Gly Thr Cys Ala Ala Gly Cys Cys 1220 1225 1230

Cys Ala Cys Gly Gly Thr Thr Thr Gly Ala Cys Gly Cys Cys Thr 1235 1240 1245

Gly Cys Ala Cys Ala Ala Gly Thr Gly Gly Thr Cys Gly Cys Cys 1250 1255 1260

Ala Thr Cys Gly Cys Cys Thr Cys Gly Ala Ala Thr Gly Gly Cys 1265 1270 1275

Gly Gly Cys Gly Gly Thr Ala Ala Gly Cys Ala Gly Gly Cys Gly 1280 1285 1290

Cys Thr Gly Gly Ala Ala Ala Cys Ala Gly Thr Ala Cys Ala Gly 1295 1300 1305

Cys Gly Cys Cys Thr Gly Cys Thr Gly Cys Cys Thr Gly Thr Ala 1310 1315 1320

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1325 1330 1335

Gly Gly Ala Cys Thr Gly Ala Cys Cys Cys Cys Ala Gly Ala Cys 1340 1345 1350

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Gly Cys Gly Ala Ala Cys Ala Ala Thr Ala Ala Thr Gly Gly Gly 1370 1375 1380

Gly Gly Ala Ala Ala Gly Cys Ala Ala Gly Cys Cys Cys Thr Gly 1385 1390 1395

Gly Ala Ala Ala Cys Cys Gly Thr Gly Cys Ala Ala Ala Gly Gly 1400 1405 1410

Thr Thr Gly Thr Thr Gly Cys Cys Gly Gly Thr Cys Cys Thr Thr 1415 1420 1425

Thr Gly Thr Cys Ala Ala Gly Ala Cys Cys Ala Cys Gly Gly Cys 1430 1435 1440

Cys Thr Thr Ala Cys Ala Cys Cys Gly Gly Ala Gly Cys Ala Ala 1445 1450 1455

Gly Thr Cys Gly Thr Gly Gly Cys Cys Ala Thr Thr Gly Cys Ala

1460 1465 1470

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1490 1495 1500

Ala Cys Gly Gly Thr Thr Cys Ala Gly Ala Gly Ala Cys Thr Thr 1505 1510 1515

Cys Thr Cys Cys Cys Ala Gly Thr Thr Cys Thr Cys Thr Gly Thr 1520 1525 1530

Cys Ala Ala Gly Cys Cys Cys Ala Cys Gly Gly Gly^' Cys Thr Gl 1535 1540 1545

Ala Cys Thr Cys Cys Cys Gly Ala Thr Cys Ala Ala Gly Thr Thr 1550 1555 1560

Gly Thr Ala Gly Cys Gly Ala Thr Thr Gly Cys Gly Thr Cys Cys 1565 1570 1575

Ala Ala Cys Gly Gly Thr Gly Gly Ala Gly Gly Gly Ala Ala Ala 1580 1585 1590

Cys Ala Ala Gly Cys Ala Thr Thr Gly Gly Ala Gly Ala Cys Thr 1595 1600 1605

Gly Thr Cys Cys Ala Ala Cys Gly Gly Cys Thr Cys Cys Thr Thr 1610 1615 1620

Cys Cys Cys Gly Thr Gly Thr Thr Gly Thr Gly Thr Cys Ala Ala 1625 1630 1635

Gly Cys Cys Cys Ala Cys Gly Gly Thr Thr Thr Gly Ala Cys Gly 1640 1645 1650

Cys Cys Thr Gly Cys Ala Cys Ala Ala Gly Thr Gly Gly Thr Cys 1655 1660 1665

Gly Cys Cys Ala Thr Cys Gly Cys Cys Ala Gly Cys Cys Ala Thr 1670 1675 1680

Gly Ala Thr Gly Gly Cys Gly Gly Thr Ala Ala Gly Cys Ala Gly 1685 1690 1695

Gly Cys Gly Cys Thr Gly Gly Ala Ala Ala Cys Ala Gly Thr Ala 1700 1705 1710

Cys Ala Gly Cys Gly Cys Cys Thr Gly Cys Thr Gly Cys Cys Thr 1715 1720 1725

Gly Thr Ala Cys Thr Gly Thr Gly Cys Cys Ala Gly Gly Ala Thr 1730 1735 1740

Cys Ala Thr Gly Gly Ala Cys Thr Gly Ala Cys Cys Cys Cys Ala 1745 1750 1755

Gly Ala Cys Cys Ala Gly Gly Thr Ala Gly Thr Cys Gly Cys Ala 1760 1765 1770

Ala Thr Cys Gly Cys Gly Thr Cys Ala Cys Ala Thr Gly Ala Cys 1775 1780 1785

Gly Gly Gly Gly Gly Ala Ala Ala Gly Cys Ala Ala Gly Cys Cys 1790 1795 1800

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1805 1810 1815

Ala Gly Gly Thr Thr Gly Thr Thr Gly Cys Cys Gly Gly Thr Cys 1820 1825 1830

Cys Thr Thr Thr Gly Thr Cys Ala Ala Gly Ala Cys Cys Ala Cys 54/65

1835 1840 1845

Gly Gly Cys Cys Thr Thr Ala Cys Ala Cys Cys Gly Gly Ala Gly 1850 1855 1860

Cys Ala Ala Gly Thr Cys Gly Thr Gly Gly Cys Cys Ala Thr Thr 1865 1870 1875

Gly Cys Ala Thr Cys Cys Cys Ala Cys Gly Ala Cys Gly Gly Thr 1880 1885 1890

Gly Gly Cys Ala Ala Ala Cys Ala Gly Gly Cys Thr Cys Thr Thr 1895 1900 1905

Gly Ala Gly Ala Cys Gly Gly Thr Thr Cys Ala Gly Ala Gly Ala 1910 1915 1920

Cys Thr Thr Cys Thr Cys Cys Cys Ala Gly Thr Thr Cys Thr Cys 1925 1930 1935 thr Gly Thr Cys Ala Ala Gly Cys Cys Cys Ala Cys Gly Gly Gly 1940 1945 1950

Cys Thr Gly Ala Cys Thr Cys Cys Cys Gly Ala Thr Cys Ala Ala 1955 1960 1965

Gly Thr Thr Gly Thr Ala Gly Cys Gly Ala Thr Thr Gly Cys Gly 1970 1975 1980

Ala Ala Thr Ala Ala Cys Ala Ala Thr Gly Gly Ala Gly Gly Gly 1985 1990 1995

Ala Ala Ala Cys Ala Ala Gly Cys Ala Thr Thr Gly Gly Ala Gly 2000 2005 2010

Ala Cys Thr Gly Thr Cys Cys Ala Ala Cys Gly Gly Cys Thr Cys 2015 2020 2025

Cys Thr Thr Cys Cys Cys Gly Thr Gly Thr Thr Gly Thr Gly Thr 2030 2035 2040

Cys Ala Ala Gly Cys Cys Cys Ala Cys Gly Gly Thr Thr Thr Gly 2045 2050 2055

Ala Cys Gly Cys Cys Thr Gly Cys Ala Cys Ala Ala Gly Thr Gly 2060 2065 2070

Gly Thr Cys Gly Cys Cys Ala Thr Cys Gly Cys Cys Ala Gly Cys 2075 2080 2085

Cys Ala Thr Gly Ala Thr Gly Gl Cys Gly Gly Thr Ala Ala Gly 2090 2095 2100

Cys Ala Gly Gly Cys Gly Cys Thr Gly Gly Ala Ala Ala Cys Ala 2105 2110 2115

Gly Thr Ala Cys Ala Gly Cys Gly Cys Cys Thr Gly Cys Thr Gly 2120 2125 2130

Cys Cys Thr Gly Thr Ala Cys Thr Gly Thr Gly Cys Cys Ala Gly 2135 2140 2145

Gly Ala Thr Cys Ala Thr Gly Gly Ala Cys Thr Gly Ala Cys Ala

2150 2155 2160

Cys Cys Cys Gly Ala Ala Cys Ala Gly Gly Thr Gly Gly Thr Cys 2165 2170 2175

Gly Cys Cys Ala Thr Thr Gly Cys Thr Thr Cys Thr Ala Ala Thr 2180 2185 2190

Gly Gly Gly Gly Gly Ala Gly Gly Ala Cys Gly Gly Cys Cys Ala

2195 2200 2205

Gly Cys Cys Thr Thr Gly Gly Ala Gly Thr Cys Cys Ala Thr Cys 2210 2215 2220

Gly Thr Ala Gly Cys Cys Cys Ala Ala Thr Thr Gly Thr Cys Cys 2225 2230 2235

Ala Gly Gly Cys Cys Cys Gly Ala Thr Cys Cys Cys Gly Cys Gly 2240 2245 2250

Thr Thr Gly Gly Cys Thr Gly Cys Gly Thr Thr Ala Ala Cys Gly 2255 2260 2265

Ala Ala Thr Gly Ala Cys Cys Ala Thr Cys Thr Gly Gly Thr Gly 2270 2275 2280

Gly Cys Gly Thr Thr Gly Gly Cys Ala Thr Gly Thr Cys Thr Thr 2285 2290 2295

Gly Gly Thr Gly Gly Ala Cys Gly Ala Cys Cys Cys Gly Cys Gly 2300 2305 2310

Cys Thr Cys Gly Ala Thr Gly Cys Ala Gly Thr Cys Ala Ala Ala 2315 2320 2325

Ala Ala Gly Gly Gly Thr Cys Thr Gly Cys Cys Thr Cys Ala Thr 2330 2335 2340

Gly Cys Thr Cys Cys Cys Gly Cys Ala Thr Thr Gly Ala Thr Cys 55/65

2350 2355

Ala Ala Ala Ala Gly Ala Ala Cys Cys Ala Ala Cys Cys Gly Gly

2360 2365 2370

Cys Gly Gly Ala Thr Thr Cys Cys Cys Gly Ala Gly Ala Gly Ala

2375 2380 2385

Ala Cys Thr Thr Cys Cys Cys Ala Thr Cys Gly Ala Gly Thr Cys

2390 2395 2400

Gly Cys Gly Gly Gly Ala Thr Cys Cys Gly Ala Thr Cys Cys Ala

2405 2410 2415

Ala Ala Ala Ala Ala Gly Ala Ala Gly Ala Gly Ala Ala Ala Gly

2420 2425 2430

Gly Thr Ala Cys Cys Ala Ala Ala Ala Ala Ala Gly Ala Ala Gly

2435 2440 2445

Ala Gly Ala Ala Ala Gly Gly Thr Cys Gly Ala Cys Gly Gly Cys

2450 2455 2460

Gly Gly Thr Gly Gly Thr Gly Cys Thr Thr Thr Gly Thr Cys Thr

2465 2470 2475

Cys Cys Thr Cys Ala Gly Cys Ala Cys Thr Cys Thr Gly Cys Thr

2480 2485 2490

Gly Thr Cys Ala Cys Thr Cys Ala Ala Gly Gly Ala Ala Gly Thr

2495 2500 2505

Ala Thr Cys Ala Thr Cys Ala Ala Gly Ala Ala Cys Ala Ala Gly

2510 2515 2520

Gly Ala Gly Gly Gly Cys Ala Thr Gly Gly Ala Thr Gly Cys Thr

2525 2530 2535

Ala Ala' Gly Thr Cys Ala Cys Thr Ala Ala Cys Thr Gly Cys Cys

2540 2545 2550

Thr Gly Gly Thr Cys Cys Cys Gly Gly Ala Cys Ala Cys Thr Gly

2555 2560 2565

Gly Thr Gly Ala Cys Cys Thr Thr Cys Ala Ala Gly Gly Ala Thr

2570 2575 2580

Gly Thr Ala Thr Thr Thr Gly Thr Gly Gly Ala Cys Thr Thr Cys

2585 2590 2595

Ala Cys Cys Ala Gly Gly Gly Ala Gly Gly Ala Gly Thr Gly Gly

2600 2605 2610

Ala Ala Gly Cys Thr Gly Cys Thr Gly Gly Ala Cys Ala Cys Thr

2615 2620 2625

Gly Cys Thr Cys Ala Gly Cys Ala Gly Ala Thr Cys Gly Thr Gly

2630 2635 2640

Thr Ala Cys Ala Gly Ala Ala Ala Thr Gly Thr Gly Ala Thr Gly

2645 2650 2655

Cys Thr Gly Gly Ala Gly Ala Ala Cys Thr Ala Thr Ala Ala Gly

2660 2665 2670

Ala Ala Cys Cys Thr Gly Gly Thr Thr Thr Cys Cys Thr Thr Gly

2675 2680 2685

Gly Gly Thr Thr Ala Thr Cys Ala Gly Cys Thr Thr Ala Cys Thr

2690 2695 2700

Ala Ala Gly Cys Cys Ala Gly Ala Thr Gly Thr Gly Ala Thr Cys

2705 2710 2715

Cys Thr Cys Cys Gly Gly Thr Thr Gly Gly Ala Gly Ala Ala Gly

2720 2725 2730

Gly Gly Ala Gly Ala Ala Gly Ala Gly Cys Cys Cys Thr Gly Gly

2735 2740 2745

Cys Thr Gly Gly Thr Gly Gly Ala Gly Ala Gly Ala Gly Ala Ala

2750 2755 2760

Ala Thr Thr Cys Ala Cys Cys Ala Ala Gly Ala Gly Ala Cys Cys

2765 2770 2775

Cys Ala Thr Cys Cys Thr Gly Ala Thr Thr Cys Ala Gly Ala Gly

2780 2785 2790

Ala Cys Thr Gly Cys Ala Thr Thr Thr Gly Ala Ala Ala Thr Cys

2795 2800 2805

Ala Ala Ala Thr Cys Ala Thr Cys Ala Gly Thr Thr Ala Gly Ala

2810 2815 2820

Gly Cys Cys Gly Ala Gly Gly Gly Gly Ala Gly Ala Gly Gly Ala

2825 2830 2835

Ala Gly Thr Cys Thr Thr Cys Thr Gly Ala Cys Cys Thr Gly Cys

2840 2845 2850

Gly Gly Ala Gly Ala Cys Gly Thr Cys Gly Ala Ala Gly Ala Gly 56/65

2855 2860 2865

Ala Ala Thr Cys Cys Thr Gly Gly Ala Cys Cys Cys Gly Ala Cys 2870 2875 2880

Thr Ala Cys Ala Ala Ala Gly Ala Cys Cys Ala Thr Gly Ala Cys 2885 2890 2895

Gly Gly Thr Gly Ala Thr Thr Ala Thr Ala Ala Ala Gly Ala Thr 2900 2905 2910

Cys Ala Thr Gly Ala Cys Ala Thr Cys Gly Ala Thr Thr Ala Cys 2915 2920 2925

Ala Ala Gly Gly Ala Thr Gly Ala Cys Gly Ala Thr Gly Ala Cys 2930 2935 2940

Ala Ala Gly Ala Thr Gly Gly Cys Cys Cys Cys Cys Ala Ala Gly 2945 2950 2955

Ala Ala Gly Ala Ala Gly Ala Gly Gly Ala Ala Gly Gly Thr Gly 2960 2965 2970

Gly Gly Cys Ala Thr Thr Cys Ala Cys Cys Gly Cys Gly Gly Gly 2975 2980 2985

Gly Thr Ala Cys Cys Thr Ala Thr Gly Gly Thr Gly Gly Ala Cys 2990 2995 3000

Thr Thr Gly Ala Gly Gly Ala Cys Ala Cys Thr Cys Gly Gly Thr 3005 3010 3015

Thr Ala Thr Thr Cys Gly Cys Ala Ala Cys Ala Gly Cys Ala Ala 3020 3025 3030

Cys Ala Gly Gly Ala Gly Ala Ala Ala Ala Thr Cys Ala Ala Gly 3035 3040 3045

Cys Cys Thr Ala Ala Gly Gly Thr Cys Ala Gly Gly Ala Gly Cys 3050 3055 3060

Ala Cys Cys Gly Thr Cys Gly Cys Gly Cys Ala Ala Cys Ala Cys 3065 3070 3075

Cys Ala Cys Gly Ala Gly Gly Cys Gly Cys Thr Thr Gly Thr Gly 3080 3085 3090

Gly Gly Gly Cys Ala Thr Gly Gly Cys Thr Thr Cys Ala Cys Thr 3095 3100 3105

Cys Ala Thr Gly Cys Gly Cys Ala Thr Ala Thr Thr Gly Thr Cys 3110 3115 3120

Gly Cys Gly Cys Thr Thr Thr Cys Ala Cys Ala Gly Cys Ala Cys 3125 3130 3135

Cys Cys Thr Gly Cys Gly Gly Cys Gly Cys Thr Thr Gly Gly Gly 3140 3145 3150

Ala Cys Gly Gly Thr Gly Gly Cys Thr Gly Thr Cys Ala Ala Ala 3155 3160 3165

Thr Ala Cys Cys Ala Ala Gly Ala Thr Ala Thr Gly Ala Thr Thr 3170 3175 3180

Gly Cys Gly Gly Cys Cys Cys Thr Gly Cys Cys Cys Gly Ala Ala 3185 3190 3195

Gly Cys Cys Ala Cys Gly Cys Ala Cys Gly Ala Gly Gly Cys Ala 3200 3205 3210

Ala Thr Thr Gly Thr Ala Gly Gly Gly Gly Thr Cys Gly Gly Thr 3215 3220 3225

Ala Ala Ala Cys Ala Gly Thr Gly Gly Thr Cys Gly Gly Gly Ala 3230 3235 3240

Gly Cys Gly Cys Gly Ala Gly Cys Ala Cys Thr Thr Gly Ala Gly 3245 3250 3255

Gly Cys Gly Cys Thr Gly Cys Thr Gly Ala Cys Thr Gly Thr Gly 3260 3265 3270

Gly Cys Gly Gly Gly Thr Gly Ala Gly Cys Thr Thr Ala Gly Gly 3275 3280 3285

Gly Gly Gly Cys Cys Thr Cys Cys Gly Cys Thr Cys Cys Ala Gly 3290 3295 3300

Cys Thr Cys Gly Ala Cys Ala Cys Cys Gly Gly Gly Cys Ala Gly 3305 3310 3315

Cys Thr Gly Cys Thr Gly Ala Ala Gly Ala Thr Cys Gly Cys Gly 3320 3325 3330

Ala Ala Gly Ala Gly Ala Gly Gly Gly Gly Gly Ala Gly Thr Ala 3335 3340 3345

Ala Cys Ala Gly Cys Gly Gly Thr Ala Gly Ala Gly Gly Cys Ala

3350 3355 3360

Gly Thr Gly Cys Ala Cys Gly Cys Cys Thr Gly Gly Cys Gly Cys 57/65

3365 3370 3375

Ala Ala Thr Gly Cys Gly Cys Thr Cys Ala Cys Cys Gly Gl Gly 3380 3385 3390

Gly Cys Cys Cys Cys Cys Thr Thr Gly Ala Ala Cys Cys Thr Gly 3395 3400 3405

Ala Cys Cys Cys Cys Ala Gly Ala Cys Cys Ala Gly Gly Thr Ala 3410 3415 3420

Gly Thr Cys Gly Cys Ala Ala Thr Cys Gly Cys Gly Thr Cys Ala 3425 3430 3435

Cys Ala Thr Gly Ala Cys Gly Gly Gly Gly Gly Ala Ala Ala Gly 3440 3445 3450

Cys Ala Ala Gly Cys Cys Cys Thr Gly Gly Ala Ala Ala Cys Cys 3455 3460 3465

Gly Thr Gly Cys Ala Ala Ala Gly Gly Thr Thr Gly Thr Thr Gly 3470 3475 3480

Cys Cys Gly Gly Thr Cys Cys Thr Thr Thr Gly Thr Cys Ala Ala 3485 3490 3495

Gly Ala Cys Cys Ala Cys Gly Gly Cys Cys Thr Thr Ala Cys Ala 3500 3505 3510

Cys Cys Gly Gly Ala Gly Cys Ala Ala Gly Thr Cys Gly Thr Gly 3515 3520 3525

Gly Cys Cys Ala Thr Thr Gly Cys Ala Ala Gly Cys Ala Ala Thr 3530 3535 3540

Gly Gly Gly Gly Gly Thr Gly Gly Cys Ala Ala Ala Cys Ala Gly 3545 3550 3555

Gly Cys Thr Cys Thr Thr Gly Ala Gly Ala Cys Gly Gly Thr Thr 3560 3565 3570

Cys Ala Gly Ala Gly Ala Cys Thr Thr Cys Thr Cys Cys Cys Ala 3575 3580 3585

Gly Thr Thr Cys Thr Cys Thr Gly Thr Cys Ala Ala Gly Cys Cys 3590 3595 3600

Cys Ala Cys Gly Gly Gly Cys Thr Gly Ala Cys Thr Cys Cys Cys 3605 3610 3615

Gly Ala Thr Cys Ala Ala Gly Thr Thr Gly Thr Ala Gly Cys Gly 3620 3625 3630

Ala Thr Thr Gly Cys Gly Thr Cys Cys Ala Ala Cys Gly Gly Thr 3635 3640 3645

Gly Gly Ala Gly Gly Gly Ala Ala Ala Cys Ala Ala Gly Cys Ala 3650 3655 3660

Thr Thr Gly Gly Ala Gly Ala Cys Thr Gly Thr Cys Cys Ala Ala 3665 3670 3675

Cys Gly Gly Cys Thr Cys Cys Thr Thr Cys Cys Cys Gly Thr Gly 3680 3685 3690

Thr Thr Gly Thr Gly Thr Cys Ala Ala Gly Cys Cys Cys Ala Cys 3695 3700 3705

Gly Gly Thr Thr Thr Gly Ala Cys Gly Cys Cys Thr Gly Cys Ala 3710 3715 3720

Cys Ala Ala Gly Thr Gly Gly Thr Cys Gly Cys Cys Ala Thr Cys 3725 3730 3735

Gly Cys Cys Ala Gly Cys Cys Ala Thr Gly Ala Thr Gly Gly Cys 3740 3745 3750

Gly Gly Thr Ala Ala Gly Cys Ala Gly Gly Cys Gly Cys Thr Gly 3755 3760 3765

Gly Ala Ala Ala Cys Ala Gly Thr Ala Cys Ala Gly Cys Gly Cys 3770 3775 3780

Cys Thr Gly Cys Thr Gly Cys Cys Thr Gly Thr Ala Cys Thr Gly 3785 3790 3795

Thr Gly Cys Cys Ala Gly Gly Ala Thr Cys Ala Thr Gly Gly Ala 3800 3805 3810

Cys Thr Gly Ala Cys Cys Cys Cys Ala Gly Ala Cys Cys Ala Gly 3815 3820 3825

Gly Thr Ala Gly Thr Cys Gly Cys Ala Ala Thr Cys Gly Cys Gly 3830 3835 3840

Thr Cys Ala Cys Ala Thr Gly Ala Cys Gly Gly Gly Gly Gly Ala 3845 3850 3855

Ala Ala Gly Cys Ala Ala Gly Cys Cys Cys Thr Gly Gly Ala Ala 3860 3865 3870

Ala Cys Cys Gly Thr Gly Cys Ala Ala Ala Gly Gly Thr Thr Gly 58/65

3875 3880 3885

Thr Thr Gly Cys Cys Gly Gly Thr Cys Cys Thr Thr Thr Gly Thr

3890 3895 3900

Cys Ala Ala Gly Ala Cys Cys Ala Cys Gly Gly Cys Cys Thr Thr

3905 3910 3915

Ala Cys Ala Cys Cys Gly Gly Ala Gly Cys Ala Ala Gly Thr Cys

3920 3925 3930

Gly Thr Gly Gly Cys Cys Ala Thr Thr Gly Cys Ala Ala Ala Thr

3935 3940 3945

Ala Ala Thr Ala Ala Cys Gly Gly Thr Gly Gly Cys Ala Ala Ala

3950 3955 3960

Cys Ala Gly Gly Cys Thr Cys Thr Thr Gly Ala Gly Ala Cys Gly

3965 3970 3975

Gly Thr Thr Cys Ala Gly Ala Gly Ala Cys Thr Thr Cys Thr Cys

3980 3985 3990

Cys Cys Ala Gly Thr Thr Cys Thr Cys Thr Gly Thr Cys Ala Ala

3995 4000 4005

Gly Cys Cys Cys Ala Cys Gly Gly Gly Cys Thr Gly Ala Cys Thr

4010 4015 4020

Cys Cys Cys Gly Ala Thr Cys Ala Ala Gly Thr Thr Gly Thr Ala

4025 4030 4035

Gly Cys Gly Ala Thr Thr Gly Cys Gly Thr Cys Cys Ala Ala Cys

4040 4045 4050

Gly Gly Thr Gly Gly Ala Gly Gly Gly Ala Ala Ala Cys Ala Ala

4055 4060 4065

Gly Cys Ala Thr Thr Gly Gly Ala Gly Ala Cys Thr Gly Thr Cys

4070 4075 4080

Cys Ala Ala Cys Gly Gly Cys Thr Cys Cys Thr Thr Cys Cys Cys

4085 4090 4095

Gly Thr Gly Thr Thr Gly Thr Gly Thr Cys Ala Ala Gly Cys Cys

4100 4105 4110

Cys Ala Cys Gly Gly Thr Thr Thr Gly Ala Cys Gly Cys Cys Thr

4115 4120 4125

Gly Cys Ala Cys Ala Ala Gly Thr Gly Gly Thr Cys Gly Cys Cys

4130 4135 4140

Ala Thr Cys Gly Cys Cys Thr Cys Gly Ala Ala Thr Gly Gly Cys

4145 4150 4155

Gly Gly Cys Gly Gly Thr Ala Ala Gly Cys Ala Gly Gly Cys Gly

4160 4165 4170

Cys Thr Gly Gly Ala Ala Ala Cys Ala Gly Thr Ala Cys Ala Gly

4175 4180 4185

Cys Gly Cys Cys Thr Gly Cys Thr Gly Cys Cys Thr Gly Thr Ala

4190 4195 4200

Cys Thr Gly Thr Gly Cys Cys Ala Gly Gly Ala Thr Cys Ala Thr

4205 4210 4215

Gly Gly Ala Cys Thr Gly Ala Cys Cys Cys Cys Ala Gly Ala Cys

4220 4225 4230

Cys Ala Gly Gly Thr Ala Gly Thr Cys Gly Cys Ala Ala Thr Cys

4235 4240 4245

Gly Cys Gly Thr Cys Ala Ala Ala Cys Gly Gly Ala Gly Gly Gly

4250 4255 4260

Gly Gly Ala Ala Ala Gly Cys Ala Ala Gly Cys Cys Cys Thr Gly

4265 4270 4275

Gly Ala Ala Ala Cys Cys Gly Thr Gly Cys Ala Ala Ala Gly Gly

4280 4285 4290

Thr Thr Gly Thr Thr Gly Cys Cys Gly Gly Thr Cys Cys Thr Thr

4295 4300 4305

Thr Gly Thr Cys Ala Ala Gly Ala Cys Cys Ala Cys Gly Gly Cys

4310 4315 4320

Cys Thr Thr Ala Cys Ala Cys Cys Gly Gly Ala Gly Cys Ala Ala

4325 4330 4335

Gly Thr Cys Gly Thr Gly Gly Cys Cys Ala Thr Thr Gly Cys Ala

4340 4345 4350

Thr Cys Cys Cys Ala Cys Gly Ala Cys Gly Gly Thr Gly Gly Cys

4355 4360 4365

Ala Ala Ala Cys Ala Gly Gly Cys Thr Cys Thr Thr Gly Ala Gly

4370 4375 4380

Ala Cys Gly Gly Thr Thr Cys Ala Gly Ala Gly Ala Cys Thr Thr 59/65

4385 4390 4395

Cys Thr Cys Cys Cys Ala Gly Thr Thr Cys Thr Cys Thr Gly Thr

4400 4405 4410

Cys Ala Ala Gly Cys Cys Cys Ala Cys Gly Gly Gly Cys Thr Gly

4415 4420 4425

Ala Cys Thr Cys Cys Cys Gly Ala Thr Cys Ala Ala Gly Thr Thr

4430 4435 4440

Gly Thr Ala Gly Cys Gly Ala Thr Thr Gly Cys Gly Thr Cys Gly

4445 4450 4455

Cys Ala Thr Gly Ala Cys Gly Gly Ala Gly Gly Gly Ala Ala Ala

4460 4465 4470

Cys Ala Ala Gly Cys Ala Thr Thr Gly Gly Ala Gly Ala Cys Thr

4475 4480 4485

Gly Thr Cys Cys Ala Ala Cys Gly Gly Cys Thr Cys Cys Thr Thr

4490 4495 4500

Cys Cys Cys Gly Thr Gly Thr Thr Gly Thr Gly Thr Cys Ala Ala

4505 4510 4515

Gly Cys Cys Cys Ala Cys Gly Gly Thr Thr Thr Gly Ala Cys Gly

4520 4525 4530

Cys Cys Thr Gly Cys Ala Cys Ala Ala Gly Thr Gly Gly Thr Cys

, 4535 4540 4545

Gly Cys Cys Ala Thr Cys Gly Cys Cys Thr Cys Cys Ala Ala Thr

4550 4555 4560

Ala Thr Thr Gly Gly Cys Gly Gly Thr Ala Ala Gly Cys Ala Gly

4565 4570 4575

Gly Cys Gly Cys Thr Gly Gly Ala Ala Ala Cys Ala Gly Thr Ala

4580 4585 4590

Cys Ala Gly Cys Gly Cys Cys Thr Gly Cys Thr Gly Cys Cys Thr

45.95 4600 4605

Gly Thr Ala Cys Thr Gly Thr Gly Cys Cys Ala Gly Gly Ala Thr

4610 4615 4620

Cys Ala Thr Gly Gly Ala Cys Thr Gly Ala Cys Cys Cys Cys Ala

4625 4630 4635

Gly Ala Cys Cys Ala Gly Gly Thr Ala Gly Thr Cys Gly Cys Ala

4640 4645 4650

Ala Thr Cys Gly Cys Gly Thr Cys Ala Cys Ala Thr Gly Ala Cys

4655 4660 4665

Gly Gly Gly Gly Gly Ala Ala Ala Gly Cys Ala Ala Gly Cys Cys

4670 4675 4680

Cys Thr Gly Gly Ala Ala Ala Cys Cys Gly Thr Gly Cys Ala Ala

4685 4690 4695

Ala Gly Gly Thr Thr Gly Thr Thr Gly Cys Cys Gly Gly Thr Cys

4700 4705 4710

Cys Thr Thr Thr Gly Thr Cys Ala Ala Gly Ala Cys Cys Ala Cys

4715 4720 4725

Gly Gly Cys Cys Thr Thr Ala Cys Ala Cys Cys Gly Gly Ala Gly

4730 4735 4740

Cys Ala Ala Gly Thr Cys Gly Thr Gly Gly Cys Cys Ala Thr Thr

4745 4750 4755

Gly Cys Ala Ala Gly Cys Ala Ala Cys Ala Thr Cys Gly Gly Thr

4760 4765 4770

Gly Gly Cys Ala Ala Ala Cys Ala Gly Gly Cys Thr Cys Thr Thr

4775 4780 4785

Gly Ala Gly Ala Cys Gly Gly Thr Thr Cys Ala Gly Ala Gly Ala

4790 4795 4800

Cys Thr Thr Cys Thr Cys Cys Cys Ala Gly Thr Thr Cys Thr Cys

4805 4810 4815

Thr Gly Thr Cys Ala Ala Gly Cys Cys Cys Ala Cys Gly Gly Gly

4820 4825 4830

Cys Thr Gly Ala Cys Thr Cys Cys Cys Gly Ala Thr Cys Ala Ala

4835 4840 4845

Gly Thr Thr Gly Thr Ala Gly Cys Gly Ala Thr Thr Gly Cys Gly

4850 4855 4860

Thr Cys Cys Ala Ala Cys Gly Gly Thr Gly Gly Ala Gly Gly Gly

4865 4870 4875

Ala Ala Ala Cys Ala Ala Gly Cys Ala Thr Thr Gly Gly Ala Gly

4880 4885 4890

Ala Cys Thr Gly Thr Cys Cys Ala Ala Cys Gly Gly Cys Thr Cys 60/65

4895 4900 4905

Cys Thr Thr Cys Cys Cys Gly Thr Gly Thr Thr Gly Thr Gly Thr

4910 4915 4920

Cys Ala Ala Gly Cys Cys Cys Ala Cys Gly Gly Thr Thr Thr Gly

4925 4930 4935

Ala Cys Gly Cys Cys Thr Gly Cys Ala Cys Ala Ala Gly Thr Gly

4940 4945 4950

Gly Thr Cys Gly Cys Cys Ala Thr Cys Gly Cys Cys Ala Gly Cys

4955 4960 4965

Cys Ala Thr Gly Ala Thr Gly Gly Cys Gly Gly Thr Ala Ala Gly

4970 4975 4980

Cys Ala Gly Gly Cys Gly Cys Thr Gly Gly Ala Ala Ala Cys Ala

4985 4990 4995

Gly Thr Ala Cys Ala Gly Cys Gly Cys Cys Thr Gly Cys Thr Gly

5000 5005 5010

Cys Cys Thr Gly Thr Ala Cys Thr Gly Thr Gly Cys Cys Ala Gly

5015 5020 5025

Gly Ala Thr Cys Ala Thr Gly Gly Ala Cys Thr Gly Ala Cys Ala

5030 5035 5040

Cys Cys Cys Gly Ala Ala Cys Ala Gly Gly Thr Gly Gly Thr Cys

5045 5050 5055

Gly Cys Cys Ala Thr Thr Gly Cys Thr Thr Cys Thr Ala Ala Thr

5060 5065 5070

Gly Gly Gly Gly Gly Ala Gly Gly Ala Cys Gly Gly Cys Cys Ala

5075 5080 5085

Gly Cys Cys Thr Thr Gly Gly Ala Gly Thr Cys Cys Ala Thr Cys

5090 5095 5100

Gly Thr Ala Gly Cys Cys Cys Ala Ala Thr Thr Gly Thr Cys Cys

5105 5110 5115

Ala Gly Gly Cys Cys Cys Gly Ala Thr Cys Cys Cys Gly Cys Gly

5120 5125 5130

Thr Thr Gly Gly Cys Thr Gly Cys Gly Thr Thr Ala Ala Cys Gly

5135 5140 5145

Ala Ala Thr Gly Ala Cys Cys Ala Thr Cys Thr Gly Gly Thr Gly

5150 5155 5160

Gly Cys Gly Thr Thr Gly Gly Cys Ala Thr Gly Thr Cys Thr Thr

5165 5170 5175

Gly Gly Thr Gly Gly Ala Cys Gly Ala Cys Cys Cys Gly Cys Gly

5180 5185 5190

Cys Thr Cys Gly Ala Thr Gly Cys Ala Gly Thr Cys Ala Ala Ala

5195 5200 5205

Ala Ala Gly Gly Gly Thr Cys Thr Gly Cys Cys Thr Cys Ala Thr

5210 5215 5220

Gly Cys Thr Cys Cys Cys Gly Cys Ala Thr Thr Gly Ala Thr Cys

5225 5230 5235

Ala Ala Ala Ala Gly Ala Ala Cys Cys Ala Ala Cys Cys Gly Gly

5240 5245 5250

Cys Gly Gly Ala Thr Thr Cys Cys Cys Gly Ala Gly Ala Gly Ala

5255 5260 5265

Ala Cys Thr Thr Cys Cys Cys Ala Thr Cys Gly Ala Gly Thr Cys

5270 5275 5280

Gly Cys Gly Gly Gly Ala Thr Cys Cys Gly Ala Thr Cys Cys Ala

5285 5290 5295

Ala Ala Ala Ala Ala Gly Ala Ala Gly Ala Gly Ala Ala Ala Gly

5300 5305 5310

Gly Thr Ala Gly Cys Cys Cys Cys Cys Cys Cys Gly Ala Cys Cys

5315 5320 5325

Gly Ala Thr Gly Thr Cys Ala Gly Cys Cys Thr Gly Gly Gly Gly

5330 5335 5340

Gly Ala Cys Gly Ala Gly Cys Thr Cys Cys Ala Cys Thr Thr Ala

5345 5350 5355

Gly Ala Cys Gly Gly Cys Gly Ala Gly Gly Ala Cys Gly Thr Gly

5360 5365 5370

Gly Cys Gly Ala Thr Gly Gly Cys Gly Cys Ala Thr Gly Cys Cys

5375 5380 5385

Gly Ala Cys Gly Cys Gly Cys Thr Ala Gly Ala Cys Gly Ala Thr

5390 5395 5400

Thr Thr Cys Gly Ala Thr Cys Thr Gly Gly Ala Cys Ala Thr Gly 61/65

5405 5410 5415

Thr Thr Gly Gly Gly Gly Gly Ala Cys Gly Gly Gly Gly Ala Thr 5420 5425 5430

Thr Cys Cys Cys Cys Gly Gly Gly Thr Cys Cys Gly Gly Gly Ala 5435 5440 5445

Thr Thr Thr Ala Cys Cys Cys Cys Cys Cys Ala Cys Gly Ala Cys 5450 5455 5460

Thr Cys Cys Gly Cys Cys Cys Cys Cys Thr Ala Cys Gly Gly Cys 5465 5470 5475

Gly Cys Thr Cys Thr Gly Gly Ala Thr Ala Thr Gly Gly Cys Cys 5480 5485 5490

Gly Ala Cys Thr Thr Cys Gly Ala Gly Thr Thr Thr Gly Ala Gly 5495 5500 5505

Cys Ala Gly Ala Thr Gly Thr Thr Thr Ala Cys Cys Gly Ala Thr 5510 5515 5520

Gly Cys Cys Cys Thr Thr Gly Gly Ala Ala Thr Thr Gly Ala Cys 5525 5530 5535

Gly Ala Gly Thr Ala Cys Gly Gly Thr Gly Gly Gly Ala Gly Ala 5540 5545 5550

Gly Cys Cys Gly Ala Gly Gly Gly Gly Ala Gly Ala Gly Gly Ala

5555 5560 5565

Ala Gly Thr Cys Thr Thr Cys Thr Gly Ala Cys Cys Thr Gly Cys 5570 5575 5580

Gly Gly Ala Gly Ala Cys Gly Thr Cys Gly Ala Ala Gly Ala Gly 5585 5590 5595

Ala Ala Thr Cys Cys Thr Gly Gly Ala Cys Cys Cys Ala Thr Gly 5600 5605 5610

Gly Thr Gly Ala Gly Cys Ala Ala Gly Gly Gly Cys Gly Ala Gly 5615 5620 5625

Gly Ala Gly Cys Thr Gly Thr Thr Cys Ala Cys Cys Gly Gly Gly 5630 5635 5640

Gly Thr Gly Gly Thr Gly Cys Cys Cys Ala Thr Cys Cys Thr Gly 5645 5650 5655

Gly Thr Cys Gly Ala Gly Cys Thr Gly Gly Ala Cys Gly Gly Cys 5660 5665 5670

Gly Ala Cys Gly Thr Ala Ala Ala Cys Gly Gly Cys Cys Ala Cys 5675 5680 5685

Ala Ala Gly Thr Thr Cys Ala Gly Cys Gly Thr Gly Thr Cys Cys 5690 5695 5700

Gly Gly Cys Gly Ala Gly Gly Gly Cys Gly Ala Gly Gly Gly Cys 5705 5710 5715

Gly Ala Thr Gly Cys Cys Ala Cys Cys Thr Ala Cys Gly Gly Cys 5720 5725 5730

Ala Ala Gly Cys Thr Gly Ala Cys Cys Cys Thr Gly Ala Ala Gly 5735 5740 5745

Thr Thr Cys Ala Thr Cys Thr Gly Cys Ala Cys Cys Ala Cys Cys 5750 5755 5760

Gly Gly Cys Ala Ala Gly Cys Thr Gly Cys Cys Cys Gly Thr Gly 5765 5770 5775

Cys Cys Cys Thr Gly Gly Cys Cys Cys Ala Cys Cys Cys Thr Cys 5780 5785 5790

Gly Thr Gly Ala Cys Cys Ala Cys Cys Thr Thr Cys Gly Gly Cys 5795 5800 5805

Thr Ala Cys Gly Gly Cys Cys Thr Gly Ala Thr Gly Thr Gly Cys 5810 5815 5820

Thr Thr Cys Gly ■Cys Cys Cys Gly Cys Thr Ala Cys Cys Cys Cys 5825 5830 5835

Gly Ala Cys Cys Ala Cys Ala Thr Gly Ala Ala Gly Cys Ala Gly 5840 5845 5850

Cys Ala Cys Gly Ala Cys Thr Thr Cys Thr Thr Cys Ala Ala Gly 5855 5860 5865

Thr Cys Cys Gly Cys Cys Ala Thr Gly Cys Cys Cys Gly Ala Ala 5870 5875 5880

Gly Gly Cys Thr Ala Cys Gly Thr Cys Cys Ala Gly Gly Ala Gly 5885 5890 5895

Cys Gly Cys Ala Cys Cys Ala Thr Cys Thr Thr Cys Thr Thr Cys 5900 5905 5910

Ala Ala Gly Gly Ala Cys Gly Ala Cys Gly Gly Cys Ala Ala Cys 62/65

5915 5920 5925

Thr Ala Cys Ala Ala Gly Ala Cys Cys Cys Gly Cys Gly Cys Cys

5930 5935 5940

Gly Ala Gly Gly Thr Gly Ala Ala Gly Thr Thr Cys Gly Ala Gly 5945 5950 5955

Gly Gly Cys Gly Ala Cys Ala Cys Cys Cys Thr Gly Gly Thr Gly 5960 5965 5970

Ala Ala Cys Cys Gly Cys Ala Thr Cys Gly Ala Gly Cys Thr Gly 5975 5980 5985

Ala Ala Gly Gly Gly Cys Ala Thr Cys Gly Ala Cys Thr Thr Cys 5990 5995 6000

Ala Ala Gly Gly Ala Gly Gly Ala Cys Gly Gly Cys Ala Ala Cys 6005 6010 6015

Ala Thr Cys Cys Thr Gly Gly Gly Gly Cys Ala Cys Ala Ala Gly 6020 6025 6030

Cys Thr Gly Gly Ala Gly Thr Ala Cys Ala Ala Cys Thr Ala Cys

6035 6040 6045

Ala Ala Cys Ala Gly Cys Cys Ala Cys Ala Ala Cys Gly Thr Cys 6050 6055 6060

Thr Ala Thr Ala Thr Cys Ala Thr Gly Gly Cys Cys Gly Ala Cys 6065 6070 6075

Ala Ala Gly Cys Ala Gly Ala Ala Gly Ala Ala Cys Gly Gly Cys 6080 6085 6090

Ala Thr Cys Ala Ala Gly Gly Thr Gly Ala Ala Cys Thr Thr Cys 6095 6100 6105

Ala Ala Gly Ala Thr Cys Cys Gly Cys Cys Ala Cys Ala Ala Cys 6110 6115 6120

Ala Thr Cys Gly Ala Gly Gly Ala Cys Gly Gly Cys Ala Gly Cys 6125 6130 6135

Gly Thr Gly Cys Ala Gly Cys Thr Cys Gly Cys Cys Gly Ala Cys 6140 6145 6150

Cys Ala Cys Thr Ala Cys Cys Ala Gly Cys Ala Gly Ala Ala Cys 6155 6160 6165

Ala Cys Cys Cys Cys Cys Ala Thr Cys Gly Gly Cys Gly Ala Cys 6170 6175 6180

Gly Gl Cys Cys Cys Cys Gly Thr Gly Cys Thr Gly Cys Thr Gly 6185 6190 6195

Cys Cys Cys Gly Ala Cys Ala Ala Cys Cys Ala Cys Thr Ala Cys

6200 6205 6210

Cys Thr Gly Ala Gly Cys Thr Ala Cys Cys Ala Gly Thr Cys Cys 6215 6220 6225

Gly Cys Cys Cys Thr Gly Ala Gly Cys Ala Ala Ala Gly Ala Cys 6230 6235 6240

Cys Cys Cys Ala Ala Cys Gly Ala Gly Ala Ala Gly Cys Gly Cys 6245 6250 6255

Gly Ala Thr Cys Ala Cys Ala Thr Gly Gly Thr Cys Cys Thr Gly 6260 6265 6270

Cys Thr Gly Gly Ala Gly Thr Thr Cys Gly Thr Gly Ala Cys Cys 6275 6280 6285

Gly Cys Cys Gly Cys Cys Gly Gly Gly Ala Thr Cys Ala Cys Thr 6290 6295 6300

Cys Thr Cys Gly Gly Cys Ala Thr Gly Gly Ala Cys Gly Ala Gly 6305 6310 6315

Cys Thr Gly Thr Ala Cys Ala Ala Gly Thr Ala Ala

6320 6325 6330

<210> 19

<211> 17

<212> DNA

<213> Unknown

<220>

<223> DNA-binding domain

<400> 19

taaagagcag aaactca

17

<210> 20

<211> 18 63/65

<212> DNA

<213> Unknown

<220>

<223> DNA-binding domain

<400> 20

tttactgctg ctcccgct

<210> 21

<211> 1762

<212> DNA

<213> Unknown

<220>

<223> pCMV-tTR: KRAB

<400> 21

gagcttggcc cattgcatac gttgtatcca tatcataata tgtacattta tattggctca 60 tgtccaacat taccgccatg ttgacattga ttattgacta gttattaata gtaatcaatt 120 acggggtcat tagttcatag cccatatatg gagttccgcg ttacataact tacggtaaat 180 ggcccgcctg gctgaccgcc caacgacccc cgcccattga cgtcaataat gacgtatgtt 240 cccatagtaa cgccaatagg gactttccat tgacgtcaat gggtggagta tttacgctaa 300 actgcccact tggcagtaca tcaagtgtat catatgccaa gtacgccccc tattgacgtc 360 aatgacggta aatggcccgc ctggcattat gcccagtaca tgaccttatg ggactttcct 420 acttggcagt acatctacgt attagtcatc gctattacca tggtgatgcg gttttggcag 480 tacatcaatg ggcgtggata gcggtttgac tcacggggat ttccaagtct ccaccccatt 540 gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg actttccaaa atgtcgtaac 600 aactccgccc cattgacgca aatgggcggt aggcgtgtac ggtgggaggt ctatataagc 660 agagctcgtt tagtgaaccg tcagatcgcc tggagacgcc atccacgctg ttttgacctc 720 catagaagac accgggaccg atccagcctc cgcggaattc gccaccatgg ctagattaga 780 taaaagtaaa gtgattaaca gcgcattaga gctgcttaat gaggtcggaa tcgaaggttt 840 aacaacccgt aaactcgccc agaagctagg tgtagagcag cctacattgt attggcatgt 900 aaaaaataag cgggctttgc tcgacgcctt agccattgag atgttagata ggcaccatac 960 tcacttttgc cctttagaag gggaaagctg gcaagatttt ttacgtaata acgctaaaag 1020 ttttagatgt gctttactaa gtcatcgcga tggagcaaaa gtacatttag gtacacggcc 1080 tacagaaaaa cagtatgaaa ctctcgaaaa tcaattagcc tttttatgcc aacaaggttt 1140 ttcactagag aatgcattat atgcactcag cgctgtgggg cattttactt taggttgcgt 1200 attggaagat caagagcatc aagtcgctaa agaagaaagg gaaacaccta ctactgatag 1260 tatgccgcca ttattacgac aagctatcga attatttgat caccaaggtg cagagccagc 1320 cttcttattc ggccttgaat tgatcatatg cggattagaa aaacaactta aatgtgaaag 1380 tgggtcccgc gcgccagatc caaaaaagaa gagaaaggta gatccaaaaa agaagagaaa 1440 ggtagatcca aaaaagaaga gaaaggtaat ggatgctaag tcactaactg cctggtcccg 1500 gacactggtg accttcaagg atgtatttgt ggacttcacc agggaggagt ggaagctgct 1560 ggacactgct cagcagatcg tgtacagaaa tgtgatgctg gagaactata agaacctggt 1620 ttccttgggt tatcagctta ctaagccaga tgtgatcctc cggttggaga agggagaaga 1680 gccctggctg gtggagagag aaattcacca agagacccat cctgattcag agactgcatt 1740 tgaaatcaaa tcatcagttt aa 1762

<210> 22

<211> 8363

<212> DNA

<213> Unknown

<220>

<223> plasmid ekdison induktor

<400> 22

cacctgacgc gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg 60 tgaccgctac acttgccagc gccctagcgc ccgctccttt cgctttcttc ccttcctttc 120 tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg ggggctccct ttagggttcc 180 gatttagtgc tttacggcac ctcgacccca aaaaacttga ttagggtgat ggttcacgta 240 gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc acgttcttta 300 atagtggact cttgttccaa actggaacaa cactcaaccc tatctcggtc tattcttttg 360 atttataagg gattttgccg atttcggcct attggttaaa aaatgagctg atttaacaaa 420 aatttaacgc gaattttaac aaaatattaa cgcttacaat ttacgcgtcc agacatgata 480 agatacattg atgagtttgg acaaaccaca actagaatgc agtgaaaaaa atgctttatt 540 tgtgaaattt gtgatgctat tgctttattt gtaaccatta taagctgcaa taaacaagtt 600 aacaacaaca attgcattca ttttatgttt caggttcagg gggaggtgtg ggaggttttt 660 taaagcaagt aaaacctcta caaatgtggt atggctgatt atgatcatga acagactgtg 720 aggactgagg ggcctgaaat gagccttggg actgtgatct aaaatacaca aacaattaga 780 64/65 atcagtagtt taacacatta tacacttaaa aattttatat ttaccttaga gctttaaatc 840 tctgtaggta gtttgtccaa ttatgtcaca ccacagaagt aaggttcctt cacaaagatc 900 gcggccgcct aagtcatttg gtgcggcgcc tccagcatct ccataaggaa ggtgtcaatg 960 ggtgtgtccc cgatgagctt gaagaagaag agatgttcca ggcatttgag cccgatggag 1020 cgcagagccg gcaggcggag caagagctta gcgaaccttc ccggctgctc tgggtacttg 1080 tgcttgcagt aggcctccaa ggacgcatag accttctccc tcagcgcctc cacctcggcc 1140 gggttcgaga gccccttgga gtcagggtta aagaggacga tggcgcgcag gcagcccagc 1200 tccgtcttgt ccatctgcat gtcccgcatc ttggacacaa gctccgtcag caccctgtca 1260 aagatggcgc ccacccctgc gctgtgggcg ctgttccggt ggacgtgcag cccggtggcc 1320 aggaggatcc cgtccttcac ggcgatggag cggtgggaga aggaggcgat gagcagctca 1380 ttccagcctg cccgcagcag gatgacctgg tcgtccaggg gcagctctga gaagtgtggg 1440 atccgcttgg cccactccac cagggtgaaa agctgtttgt cggctgcttg gcaaatgttg 1500 gtgacagggt cgttcggcga gctggggttc agccccatgt ttgcctccac gtaggtctcg 1560 gtcttgggct ccacggccag ctcagcctcc aggatcctct ccaccggcat gtcctcgttg 1620 gcgctgctgg tcgactccac ctcattctcg ttccggtcct tgccacgctg ccgctcctcc 1680 tgcacggctt cccgcttcat gcccatggcc aggcacttct ggtagcggca gtactggcac 1740 cggttccgct gccgcttgtc aatcaggcag tccttgttgt cgcggcaggt gtaggtcagg 1800 tccttgcgca ccgtccgctt gaagaagccc ttgcacccct cgcagctgta cactccatag i860 tgcttgcctg aggagcggtc cccgcagatg gcgcagatgt gcttggtgaa ggaagccatg 1920 tttcctgagg ggtgggcggg gaccttgagg acgccattga ggcccagggg gggcttgatg 1980 tcctcgctgc tgctgacggg gttcataggt gagctgagct gggggctgcc agtgctgaag 2040 cccagggtgg gtgtggtggg caccgacatg gagtgggggc ccatgg^'ggga gctgatgacc 2100 gagaaaggcg ggcccatgcc gttgatgggg gagctcaggg tgctgatggg agaatgcagc 2160 tgtcccgggg agccgatgcc aggccccagg gacgggtgca gcgagggggc agccatggag 2220 cctcgccccg tcggggaggt gagggaggag ttcacctggg tggagaaatc gagcggcagg 2280 aaatgtttgg tgtccaagtc ttcttcagaa ataagttttt gttccatatt atcgatcgtg 2340 tttttcaaag gaaaaccacg tccccgtggt tcggggggcc tagacgtttt ttaacctcga 2400 ctaaacacat gtaaagcatg tgcaccgagg ccccagatca gatcccatac aatggggtac 2460 cttctgggca tccttcagcc ccttgttgaa tacgcttgag gagagccatt tgactctttc 2520 cacaactatc caactcacaa cgtggcactg gggttgtgcc gcctttgcag gtgtatctta 2580 tacacgtggc ttttggccgc agaggcacct gtcgccaggt ggggggttcc gctgcctgca 2640 aagggtcgct acagacgttg tttgtcttca agaagcttcc agaggaactg cttccttcac 2700 gacattcaac agaccttgca ttcctttggc gagaggggaa agacccctag gaatgctcgt 2760 caagaagaca gggccaggtt tccgggccct cacattgcca aaagacggca atatggtgga 2820 aaataacata tagacaaacg cacaccggcc ttattccaag cggcttcggc cagtaacgtt 2880 aggggggggg gagggagagg ggggtaaccc tatgcagtcg tcgagtgctc cgacttaacc 2940 gccactcccc cgataagctg ctcttggtgc gaatgcaggg ctacacccat caaggccatc 3000 gccgtctggg cgttcgcata catgctgacg ttgccgccca ccccaacacc gactccaact 3060 ccgttgccca tcggtaccgc tgatgtggtg gagctagcgg taacggcagc cgtgatactg 3120 ctggtggttg ccggcgtgat gggtcctatg gccgcacttc cgcccatgta ttcgctgctc 3180 gtactgaccg cggacaagga accaggtgcg gttacggagg cgggcacggg agcggagacg 3240 ggaaggagct gtggctgtgg ttgaatctgt ggctggagtt gcgtctgaag ctgtgggtgg 3300 agctggggtt gcagttgacc ttgcagctga ggtggtagct gaggttgtag ctgcggctgt 3360 gtctggtgct gggaatcgtt ctgggtcagg gaggagggtt ggggctgggg ctgaggctga 3420 ggctgatgct gggccgcggc tgccgccgcc gaagtggagg cagagtcgca atcaatgccg 3480 gcggtaatgg cgcccccaac cgatgcccgc atacgctcag cccgctcgag acgctcgttc 3540 tcctcctggg taatctgaag gtgcgactgg accgatggcg ggatggcatg aacgtcccag 3600 atctcctcga ggaacttggg cagtttgcgg tttttgagct ttagtgagaa acacatctcg 3660 gcgttctggt tgcccagcgt acgcagctcg gtgaggatcg agagcagctt tgcgtagaag 3720 acgaggctca ttgagtcgcc gcagtggcgg ttgagtatat aaatgcgtag cgtgtcgatg 3780 tagtagctct ggatcgcttc gactagctgg gccttctcca ggcccggccg gtccgagaag 3840 atcacaatgg cagtgagaag cgcgtattcg acgttgtcca ccttcatcga gaacatttgg 3900 cggcagaaat gcagcaggtc ttcaatgtta tcagccattc cggccatttt gtaagaatcc 3960 cgcgtatatg atctattatt cgcgaagaat attgagtccg agctgtggtc atagcgtcgt 4020 gccatacgca gcatcatcac ctccgacgag caggccttta gtaacgtgat ctggtcctcc 4080 tggggtatct ttgtaaacgc tggtagacct ttagcaaact caacaatcaa ctggaccgtg 4140 agtatggtta tctcggttat atgccgaaag ctgacgtccg tttggctctc gttctcatcg 4200 ggttgactca ttatacgcct gagatcctct tcagatggct gctcatagcc atcctggtac 4260 caaattaact tgtatataac ggccaactga ttgtacgtta aggaaggtat attgcgcgct 4320 tgacacttgg ccaatatttc atcaggtagt agcggaatag tggcatgctg gggcggctcg 4380 catgtcataa ggtcaagaat ctccttctta acaaagtctt ggccgccacc agaggccaag 4440 ctgccattgc cgccatgctg agagctcggc gaagtggtca ttttgtcctt ctccttctgg 4500 gccttctttt cgcgccgctt catcgcacat tggttctccg ggacgacgca ttccggccgc 4560 atacccacgg ccaggcactt tttcaggcgg cactcctgac actttcgcct catgtacatg 4620 tccatttcgc aggcgcgccc gaacttgcag cagtagacgg cgctcttcgt aacgctgcgt 4680 cgaaagaaca ccttgcagga tccacaggtg agggcgttgt agtggtagcc ggaggccctg 4740 tcctttcgtt cgccgagtat ccgttcaagc tgctcgaagg cgagagatca tcgcgacctg 4800 aagatataga atttgatatt cttctagatg tacctagaag cttcccaccg tactcgtcaa 4860 65/65

ttccaagggc atcggtaaac atctgctcaa actcgaagtc ggccatatcc agagcgccgt 4920

agggggcgga gtcgtggggg gtaaatcccg gacctgggga atccccgtcc cccaacatgt 4980

ccagatcgaa atcgtctagc gcgtcggcat gcgccatcgc cacgtcctcg ccgtctaagt 5040

ggagttcgtc ccccaggctg acatcggtcg ggggggccaa gtcttcttca gaaataagtt 5100

tttgttccat ggtggcggcc ggccactagc ggatctgacg gttcactaaa ccagctctgc 5160

ttatatagac ctcccaccgt acacgcctac cgcccatttg cgtcaatggg gcggagttgt 5220

tacgacattt tggaaagtcc cgttgatttt ggtgccaaaa caaactccca ttgacgtcaa 5280

tggggtggag acttggaaat ccccgtgagt caaaccgcta tccacgccca ttgatgtact 5340

gccaaaaccg catcaccatg gtaatagcga tgactaatac gtagatgtac tgccaagtag 5400

gaaagtccca taaggtcatg tactgggcat aatgccaggc gggccattta ccgtcattga 5460

cgtcaatagg gggcgtactt ggcatatgat acacttgatg tactgccaag tgggcagttt 5520

accgtaaata ctccacccat tgacgtcaat ggaaagtccc tattggcgtt actatgggaa 5580

catacgtcat tattgacgtc aatgggcggg ggtcgttggg cggtcagcca ggcgggccat 5640

ttaccgtaag ttatgtaacg cggaactcca tatatgggct atgaactaat gaccccgtaa 5700

ttgattacta ttaataacta atgcaacggc gctgcagcca ctgcatggcg gtaatacggt 5760

tatccacaga atcaggggat aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg 5820

ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc ccccctgacg 5880

agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga ctataaagat 5940

accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc ctgccgctta 6000

ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcat agctcacgct 6060 m gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg cacgaacccc 6120

ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc aacccggtaa 6180 1 gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga gcgaggtatg 6240 ¾

Θ

taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact agaaggacag 6300 ; tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt 6360

gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag cagcagatta 6420

cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg tctgacgctc 6480 ¾ agtggaacga aaactcacgt taagggattt tggtcatgag attatcaaaa aggatcttca 6540

cctagatcct tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata tatgagtaac 6600

ctgaggctat ggcagggcct gccgccccga cgttggctgc gagccctggg ccttcacccg 6660

aacttggggg gtggggtggg gaaaaggaag aaacgcgggc gtattggccc caatggggtc 6720

tcggtggggt atcgacagag tgccagccct gggaccgaac cccgcgttta tgaacaaacg 6780

acccaacacc gtgcgtttta ttctgtcttt ttattgccgt catagcgcgg gttccttccg 6840

gtattgtctc cttccgtgtt tcagttagcc tccccctagg gtgggcgaag aactccagca 6900

tgagatcccc gcgctggagg atcatccagc cggcgtcccg gaaaacgatt ccgaagccca 6960

acctttcata gaaggcggcg gtggaatcga aatctcgtga tggcaggttg ggcgtcgctt 7020

ggtcggtcat ttcgaacccc agagtcccgc tcagaagaac tcgtcaagaa ggcgatagaa 7080 ■

ggcgatgcgc tgcgaatcgg gagcggcgat accgtaaagc acgaggaagc ggtcagccca 7140

ttcgccgcca agctcttcag caatatcacg ggtagccaac gctatgtcct gatagcggtc 7200

cgccacaccc agccggccac agtcgatgaa tccagaaaag cggccatttt ccaccatgat 7260

attcggcaag caggcatcgc catgggtcac gacgagatcc tcgccgtcgg gcatgctcgc 7320

cttgagcctg gcgaacagtt cggctggcgc gagcccctga tgctcttcgt ccagatcatc 7380

ctgatcgaca agaccggctt ccatccgagt acgtgctcgc tcgatgcgat gtttcgcttg 7440

gtggtcgaat gggcaggtag ccggatcaag cgtatgcagc cgccgcattg catcagccat 7500

gatggatact ttctcggcag gagcaaggtg agatgacagg agatcctgcc ccggcacttc 7560

gcccaatagc agccagtccc ttcccgcttc agtgacaacg tcgagcacag ctgcgcaagg 7620

aacgcccgtc gtggccagcc acgatagccg cgctgcctcg tcttgcagtt cattcagggc 7680

accggacagg tcggtcttga caaaaagaac cgggcgcccc tgcgctgaca gccggaacac 7740

ggcggcatca gagcagccga ttgtctgttg tgcccagtca tagccgaata gcctctccac 7800

ccaagcggcc ggagaacctg cgtgcaatcc atcttgttca atcatgcgaa acgatcctca 7860

tcctgtctct tgatcgatct ttgcaaaagc ctaggcctcc aaaaaagcct cctcactact 7920

tctggaatag ctcagaggcc gaggcggcct cggcctctgc ataaataaaa aaaattagtc 7980

agccatgggg cggagaatgg gcggaactgg gcggagttag gggcgggatg ggcggagtta 8040

ggggcgggac tatggttgct gactaattga gatgcatgct ttgcatactt ctgcctgctg 8100

gggagcctgg ggactttcca cacctggttg ctgactaatt gagatgcatg ctttgcatac 8160

ttctgcctgc tggggagcct ggggactttc cacaccctaa ctgacacaca ttccacagct 8220

ggttctttcc gcctcaggac tcttcctttt tcaatattat tgaagcattt atcagggtta 8280

ttgtctcatg agcggataca tatttgaatg tatttagaaa aataaacaaa taggggttcc 8340

gcgcacattt ccccgaaaag tgc 8363