Title:
BLOOD BRAIN BARRIER PERMEABILITY MODIFIER AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/151197
Kind Code:
A1
Abstract:
The present invention relates to use of SC79 or an analogue thereof in the preparation of a blood brain barrier permeability modifier. The blood brain barrier permeability modifier uses SC79 or an analogue thereof as an active ingredient to down-regulate the expression of closely linked proteins Claudin-5 and Occludin by Claudin-5 and Occludin activating signal pathways downstream of protein kinase B, thereby increasing blood brain barrier permeability, enhancing the transport efficiency of a brain-targeted drug delivery system into the brain, and particularly enhancing the transport efficiency of an Angiopep-2 modified glycolipid nano drug delivery system into the brain. The present invention also relates to a kit comprising the blood brain barrier permeability modifier and a brain-targeted drug delivery system. According to the present invention, by using said blood brain barrier permeability modifier and brain-targeted drug delivery system in combination, the transport efficiency of the brain-targeted drug delivery system into the brain can be enhanced, and the therapeutic effect of the brain-targeted drug delivery system can be improved.
Inventors:
HU FUQIANG (CN)
WEN LIJUAN (CN)
YUAN HONG (CN)
WANG KAI (CN)
MENG TINGTING (CN)
WEN LIJUAN (CN)
YUAN HONG (CN)
WANG KAI (CN)
MENG TINGTING (CN)
Application Number:
PCT/CN2019/095060
Publication Date:
July 30, 2020
Filing Date:
July 08, 2019
Export Citation:
Assignee:
UNIV ZHEJIANG (CN)
International Classes:
A61K31/337; A61K47/64; A61K31/352; A61K31/713; A61P35/00
Foreign References:
| CN107880152A | 2018-04-06 |
Other References:
GERTY SCHREIBELT, KOOIJ GIJS, REIJERKERK ARIE, DOORN RUBEN, GRINGHUIS SONJA I., POL SUSANNE, WEKSLER BABETTE B., ROMERO IGNACIO A.: "Reactive Oxygen Species Alter Brain Endothelial Tight Junction Dynamics via RhoA, PI3 kinase, and PKB Signaling", THE FASEB JOURNAL, vol. 21, no. 13, 22 July 2007 (2007-07-22), pages 3666 - 3676, XP055723600, ISSN: 0892-6638, DOI: 10.1096/fj.07-8329com
Attorney, Agent or Firm:
SHANGCHENG & PARTNERS (CN)
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