Title:
BLOOD-CEREBROSPINAL FLUID BARRIER PROTECTING AGENT
Document Type and Number:
WIPO Patent Application WO/2021/261571
Kind Code:
A1
Abstract:
The present invention pertains to a vascular endothelial cell protecting agent, a blood-cerebrospinal fluid barrier protecting agent, and a central nervous system protecting agent, comprising at least one compound selected from the group consisting of mubritinib, brexpiprazole, papaverine, bismuth-containing compounds, and pharmaceutically acceptable salts thereof. Additionally, the present invention pertains to a pharmaceutical composition for preventing and/or treating diseases associated with blood-cerebrospinal fluid barrier impairments, such as damage to the central nervous system, infarction and hemorrhaging, inflammatory diseases of the central nervous system, degenerative diseases of the central nervous system, symptomatic nerve diseases, spinal cord impairments associated with spinal cord degeneration, drug-based impairments, infectious diseases, or anaphylaxis. The pharmaceutical composition comprises at least one compound selected from the group consisting of mubritinib, brexpiprazole, papaverine, bismuth-containing compounds, and pharmaceutically acceptable salts thereof.
Inventors:
KADOYA KEN (JP)
SUZUKI YUKI (JP)
SOUTOME AKIHITO (JP)
MAENAKA KATSUMI (JP)
OTSUGURO SATOKO (JP)
SUZUKI YUKI (JP)
SOUTOME AKIHITO (JP)
MAENAKA KATSUMI (JP)
OTSUGURO SATOKO (JP)
Application Number:
PCT/JP2021/024033
Publication Date:
December 30, 2021
Filing Date:
June 24, 2021
Export Citation:
Assignee:
UNIV HOKKAIDO NAT UNIV CORP (JP)
International Classes:
A61K31/422; A61K31/472; A61K31/496; A61K33/24; A61P7/04; A61P9/10; A61P9/14; A61P21/00; A61P25/00; A61P25/08; A61P25/16; A61P25/28; A61P29/00; A61P31/00; A61P37/08; A61P39/02
Domestic Patent References:
| WO2019010491A1 | 2019-01-10 | |||
| WO2019123378A1 | 2019-06-27 | |||
| WO2012081713A1 | 2012-06-21 |
Foreign References:
| JP2015535211A | 2015-12-10 | |||
| JP2015134732A | 2015-07-27 | |||
| JP2005533047A | 2005-11-04 | |||
| JPS63174926A | 1988-07-19 |
Other References:
YUKI SUZUKI, KEN KAKUYA, KEITO MAYUJO, KEN ENDO, TAKESHI ASANO, TOMOMASA IWASAKI, SHINSUKE NAKAGAWA, KATSUMI MAENAKA: "1-I-5-2. A new effect of the smooth muscle relaxant papaverine: Neuroprotection effect on spinal cord injury through the blood spinal cord barrier protection", THE HOKKAIDO JOURNAL OF ORTHOPAEDICS AND TRAUMATOLOGY, vol. 63, 30 January 2021 (2021-01-30), JP , pages 17, XP009534651, ISSN: 1343-3873
KEITO MAYU, KEN KAKUYA, YUKI SUZUKI, KEN ENDO, TAKESHI ASANO, SHINSUKE NAKAGAWA, KATSUMI MAENAKA, TOMOMASA IWASAKI: "2-7-14: Neuroprotective effect of papaverine after spinal cord injury through maintenance of blood-spinal cord barrier function", THE JOURNAL OF JAPANESE ORTHOPAEDIC SURGICAL SOCIETY, vol. 94, no. 8, 14 September 2020 (2020-09-14) - 16 November 2020 (2020-11-16), JP , pages S1837, XP009534650, ISSN: 0021-5325
TAKAGI T. ET AL., J CEREB BLOOD FLOW METAB, vol. 37, no. 1, 2017, pages 123 - 139
TAKATA F. ET AL., BIOCHEM BIOPHYS RES COMMUN, vol. 433, no. 4, 2013, pages 586 - 590
ZHAO ET AL., INFLAMMATION, vol. 42, no. 3, 2019, pages 841 - 856
CAS , no. 366017-09-6
CAS, no. 913611-97-9
NEURON, vol. 57, no. 2, 2008, pages 178 - 201
NAT MED, vol. 19, no. 12, 2013, pages 1584 - 96
PHYSIOL REV, vol. 99, no. 1, 1 January 2019 (2019-01-01), pages 21 - 78
"Japanese Pharmacopoeia"
KEITO MAYU, KEN KAKUYA, YUKI SUZUKI, KEN ENDO, TAKESHI ASANO, SHINSUKE NAKAGAWA, KATSUMI MAENAKA, TOMOMASA IWASAKI: "2-7-14: Neuroprotective effect of papaverine after spinal cord injury through maintenance of blood-spinal cord barrier function", THE JOURNAL OF JAPANESE ORTHOPAEDIC SURGICAL SOCIETY, vol. 94, no. 8, 14 September 2020 (2020-09-14) - 16 November 2020 (2020-11-16), JP , pages S1837, XP009534650, ISSN: 0021-5325
TAKAGI T. ET AL., J CEREB BLOOD FLOW METAB, vol. 37, no. 1, 2017, pages 123 - 139
TAKATA F. ET AL., BIOCHEM BIOPHYS RES COMMUN, vol. 433, no. 4, 2013, pages 586 - 590
ZHAO ET AL., INFLAMMATION, vol. 42, no. 3, 2019, pages 841 - 856
CAS , no. 366017-09-6
CAS, no. 913611-97-9
NEURON, vol. 57, no. 2, 2008, pages 178 - 201
NAT MED, vol. 19, no. 12, 2013, pages 1584 - 96
PHYSIOL REV, vol. 99, no. 1, 1 January 2019 (2019-01-01), pages 21 - 78
"Japanese Pharmacopoeia"
Attorney, Agent or Firm:
IP-ASSIST PATENT OFFICE (JP)
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