Title:
BLOOD VESSEL MODEL
Document Type and Number:
WIPO Patent Application WO/2018/226902
Kind Code:
A3
Abstract:
The present disclosure provides a blood vessel model including: a pair of channel members, mutually opposing each other, each of which includes an opposing face in which a respective microchannel is formed; and a porous membrane that includes plural through-holes penetrating in a thickness direction, that is disposed between the opposing faces of the pair of channel members, and that partitions between the microchannels, wherein the porous membrane is provided with a vascular endothelial cell layer so as to cover one face facing one of the microchannels, an average opening diameter of the through-holes is from 1 μιη to 20 μm, and an opening coverage ratio of the through-holes is from 30% to 70%.
Inventors:
ITO KOJU (JP)
KAKINUMA CHIHAYA (JP)
HIKIMOTO DAICHI (JP)
MIMA SHINJI (JP)
SUEHIRO TAKAFUMI (JP)
NEVILLE CRAIG (US)
SUNDBACK CATHRYN (US)
KAKINUMA CHIHAYA (JP)
HIKIMOTO DAICHI (JP)
MIMA SHINJI (JP)
SUEHIRO TAKAFUMI (JP)
NEVILLE CRAIG (US)
SUNDBACK CATHRYN (US)
Application Number:
PCT/US2018/036364
Publication Date:
March 26, 2020
Filing Date:
June 07, 2018
Export Citation:
Assignee:
FUJIFILM CORP (JP)
MASSACHUSETTS GEN HOSPITAL (US)
MASSACHUSETTS GEN HOSPITAL (US)
International Classes:
B33Y80/00; B32B7/02; B33Y99/00; C08J9/36; G09B23/28
Foreign References:
| US20110053207A1 | 2011-03-03 | |||
| US8679336B2 | 2014-03-25 | |||
| US20110189475A1 | 2011-08-04 | |||
| JP4734157B2 | 2011-07-27 | |||
| JP5815643B2 | 2015-11-17 |
Other References:
SATO K ET AL.: "Microfluidics for Nano-Pathophysiology", ADV DRUG DELIV REV, vol. 74, July 2014 (2014-07-01), pages 115 - 121, XP055693785
Attorney, Agent or Firm:
HERRING, Chad M. et al. (US)
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