BLOOD VESSEL THICKENING INHIBITOR AND SMOOTH MUSCLE FIBER MIGRATION INHIBITOR EACH CONTAINING 7-THIAPROSTAGLANDIN E1 COMPOUND AS ACTIVE INGREDIENT

Title:

BLOOD VESSEL THICKENING INHIBITOR AND SMOOTH MUSCLE FIBER MIGRATION INHIBITOR EACH CONTAINING 7-THIAPROSTAGLANDIN E1 COMPOUND AS ACTIVE INGREDIENT

Document Type and Number:

WIPO Patent Application WO/1995/000150

Kind Code:

A1

Abstract:

A blood vessel thickening inhibitor and a smooth muscle fiber migration inhibitor each containing as the active ingredient a 7-thiaprostaglandin E1 compound represented by general formula (I) and useful for inhibiting blood vessel thickening caused mainly by the migration or proliferation of vascular smooth muscle fibers after angioplasty, arterial bypass operation, and so forth, wherein R1 represents hydrogen, etc.; R2 represents hydrogen, etc.; R3 represents linear or branched alkyl, etc.; n represents 0 or 1; and symbol * represents an asymmetric carbon atom.

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Inventors:

SEKI JIRO (JP)
KATO YASUKO (JP)
NISHIO MIE (JP)
WATANABE KUNIHITO (JP)

Application Number:

PCT/JP1994/000949

Publication Date:

January 05, 1995

Filing Date:

June 10, 1994

Export Citation:

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Assignee:

TEIJIN LTD (JP)
SEKI JIRO (JP)
KATO YASUKO (JP)
NISHIO MIE (JP)
WATANABE KUNIHITO (JP)

International Classes:

A61K31/557; A61K31/5575; (IPC1-7): A61K31/557

Foreign References:

JPS58110562A	1983-07-01
JPS6172747A	1986-04-14

Other References: