Title:
BORONIC ACID-CONTAINING MODIFIED POLYROTAXANE
Document Type and Number:
WIPO Patent Application WO/2023/182317
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a novel compound which can serve as a component of a boron pharmaceutical agent. The present application provides a boron-containing modified polyrotaxane comprising a plurality of cyclodextrin molecules, a single straight-chain molecule passing through the openings in the plurality of cyclodextrin molecules in a skewer-like manner, and a blocking group which is provided at both ends of the single straight-chain molecule and prevents the cyclodextrin molecules and the straight-chain molecule from separating, wherein at least some of the cyclodextrin molecules bind, via a linker, to boronic acid or a monovalent group derived therefrom.
Inventors:
HIGASHI TAISHI (JP)
MOTOYAMA KEIICHI (JP)
ONODERA RISAKO (JP)
MATSUMOTO YOSHITAKA (JP)
MOTOYAMA KEIICHI (JP)
ONODERA RISAKO (JP)
MATSUMOTO YOSHITAKA (JP)
Application Number:
PCT/JP2023/011056
Publication Date:
September 28, 2023
Filing Date:
March 22, 2023
Export Citation:
Assignee:
UNIV KUMAMOTO NAT UNIV CORP (JP)
UNIV TSUKUBA (JP)
UNIV TSUKUBA (JP)
International Classes:
A61P35/00; A61K31/69; A61K31/724; A61K41/00; C07H23/00; C08G65/32; C08G65/337
Domestic Patent References:
| WO2016006413A1 | 2016-01-14 |
Other References:
YU KOJIMA, YUYA EGAWA, TOSHINOBU SEKI: "Preparation and evaluation of sugar responsive slide-ring gels with phenylboronic acids", CYCLODEXTRIN SYMPOSIUM LECTURE ABSTRACTS, vol. 29, 30 November 2011 (2011-11-30), pages 200 - 201, XP009550614
WANG YUSHI, DONG JIYU, JIN JIAHONG, JIA YONG‐GUANG: "Polyrotaxane Crosslinked Self‐Healing Hydrogels for Switchable Bioadhesion", MACROMOLECULAR CHEMISTRY AND PHYSICS, WILEY-VCH VERLAG, WEINHEIM., DE, vol. 222, no. 8, 1 April 2021 (2021-04-01), DE , XP093095079, ISSN: 1022-1352, DOI: 10.1002/macp.202000461
EGAWA Y. ET AL.: "Sugar-responsive smart materials based on phenylboronic acid and cyclodextrin.", JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, vol. 94, 22 March 2019 (2019-03-22), pages 1 - 10, XP036805231, DOI: 10. 1007/s10847-019-00899-6
MATSUMOTO Y. ET AL.: "Folate-appended cyclodextrin improves the intratumoral accumulation of existing boron compounds.", APPLIED RADIATION AND ISOTOPES, vol. 163, 27 April 2020 (2020-04-27), pages 1 - 6, XP086190636, DOI: 10.1016/j.apradiso.2020.109201
ZHOU YI, WANG HE, WANG CHENGXI, LI YUESHAN, LU WENFENG, CHEN SHUIFANG, LUO JIANDONG, JIANG YONGNAN, CHEN JIANHAI: "Receptor-Mediated, Tumor-Targeted Gene Delivery Using Folate-Terminated Polyrotaxanes", MOLECULAR PHARMACEUTICS, AMERICAN CHEMICAL SOCIETY, US, vol. 9, no. 5, 7 May 2012 (2012-05-07), US , pages 1067 - 1076, XP093095082, ISSN: 1543-8384, DOI: 10.1021/mp200315c
HIGASHI TAISHI: "Cyclodextrin-Based Molecular Accessories for Drug Discovery and Drug Delivery", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, JP, vol. 67, no. 4, 1 April 2019 (2019-04-01), JP , pages 289 - 298, XP093095086, ISSN: 0009-2363, DOI: 10.1248/cpb.c18-00735
HONKA ISHIKI, HARUKI ARASE, KOKI MATSUMOTO, RISAKO ONODERA, KEIICHI MOTOYAMA, DAISHI TOKYO: "P1-36 Design and evaluation of borornc acid-modified polyrotaxane for boron neutron capture therapy", CYCLODEXTRIN SYMPOSIUM LECTURE ABSTRACTS; SEPTEMBER 10-11, 2022, vol. 38, 24 August 2022 (2022-08-24) - 11 September 2022 (2022-09-11), pages 165 - 166, XP009550040
WANG YUSHI, DONG JIYU, JIN JIAHONG, JIA YONG‐GUANG: "Polyrotaxane Crosslinked Self‐Healing Hydrogels for Switchable Bioadhesion", MACROMOLECULAR CHEMISTRY AND PHYSICS, WILEY-VCH VERLAG, WEINHEIM., DE, vol. 222, no. 8, 1 April 2021 (2021-04-01), DE , XP093095079, ISSN: 1022-1352, DOI: 10.1002/macp.202000461
EGAWA Y. ET AL.: "Sugar-responsive smart materials based on phenylboronic acid and cyclodextrin.", JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, vol. 94, 22 March 2019 (2019-03-22), pages 1 - 10, XP036805231, DOI: 10. 1007/s10847-019-00899-6
MATSUMOTO Y. ET AL.: "Folate-appended cyclodextrin improves the intratumoral accumulation of existing boron compounds.", APPLIED RADIATION AND ISOTOPES, vol. 163, 27 April 2020 (2020-04-27), pages 1 - 6, XP086190636, DOI: 10.1016/j.apradiso.2020.109201
ZHOU YI, WANG HE, WANG CHENGXI, LI YUESHAN, LU WENFENG, CHEN SHUIFANG, LUO JIANDONG, JIANG YONGNAN, CHEN JIANHAI: "Receptor-Mediated, Tumor-Targeted Gene Delivery Using Folate-Terminated Polyrotaxanes", MOLECULAR PHARMACEUTICS, AMERICAN CHEMICAL SOCIETY, US, vol. 9, no. 5, 7 May 2012 (2012-05-07), US , pages 1067 - 1076, XP093095082, ISSN: 1543-8384, DOI: 10.1021/mp200315c
HIGASHI TAISHI: "Cyclodextrin-Based Molecular Accessories for Drug Discovery and Drug Delivery", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, JP, vol. 67, no. 4, 1 April 2019 (2019-04-01), JP , pages 289 - 298, XP093095086, ISSN: 0009-2363, DOI: 10.1248/cpb.c18-00735
HONKA ISHIKI, HARUKI ARASE, KOKI MATSUMOTO, RISAKO ONODERA, KEIICHI MOTOYAMA, DAISHI TOKYO: "P1-36 Design and evaluation of borornc acid-modified polyrotaxane for boron neutron capture therapy", CYCLODEXTRIN SYMPOSIUM LECTURE ABSTRACTS; SEPTEMBER 10-11, 2022, vol. 38, 24 August 2022 (2022-08-24) - 11 September 2022 (2022-09-11), pages 165 - 166, XP009550040
Attorney, Agent or Firm:
OSAWA Kenichi (JP)
Download PDF:
Previous Patent: AIR CONDITIONING DEVICE
Next Patent: JOINT STRUCTURE AND METHOD FOR CONSTRUCTING JOINT STRUCTURE
Next Patent: JOINT STRUCTURE AND METHOD FOR CONSTRUCTING JOINT STRUCTURE