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Title:
BOTULINUM TOXIN TYPE A COMPLEX, AND FORMULATION THEREOF AND USAGE METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2021/195968
Kind Code:
A1
Abstract:
The present invention relates to a botulinum toxin type A complex, and a formulation thereof and a usage method therefor. The present invention provides the botulinum toxin type A complex, comprising an HA70 component, an HA17 component, an HA33 component, an NTNH component, and a BoNT/A1 component, wherein the botulinum toxin complex has a molecular weight of 740-790kDa. Compared with the existing botulinum toxin complexes, the botulinum toxin complex of the present invention is smaller in molecular weight and higher in safety, and has a comparable treatment effect.

Inventors:
TSAU TZU-WEN (CN)
WANG YUNG-KAI (CN)
SHEN KUAN-CHENG (CN)
WU YUEH-CHIN (CN)
YU CHENG-DER TONY (CN)
TSENG YU-CHUN (CN)
Application Number:
PCT/CN2020/082450
Publication Date:
October 07, 2021
Filing Date:
March 31, 2020
Export Citation:
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Assignee:
OBI PHARMA INC (CN)
International Classes:
A61K38/16; C07K14/33
Foreign References:
US20100168023A12010-07-01
Other References:
BENEFIELD D. A., DESSAIN S. K., SHINE N., OHI M. D., LACY D. B.: "Molecular assembly of botulinum neurotoxin progenitor complexes", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 110, no. 14, 2 April 2013 (2013-04-02), pages 5630 - 5635, XP055854963, ISSN: 0027-8424, DOI: 10.1073/pnas.1222139110
DATABASE PROTEIN 23 July 2021 (2021-07-23), ANONYMOUS: "botulinum neurotoxin hemagglutinin HA70 subunit [Clostridium botulinum]", XP055854960, retrieved from NCBI Database accession no. WP_011948507
DATABASE PROTEIN 18 July 2013 (2013-07-18), ANONYMOUS: "hemagglutinin [Clostridium botulinum]", XP055854955, retrieved from NCBI Database accession no. WP_003356711
DATABASE PROTEIN 1 December 2020 (2020-12-01), ANONYMOUS: "Chain A, HA-33", XP055854952, retrieved from NCBI Database accession no. 4LO0_A
DATABASE PROTEIN 29 August 2019 (2019-08-29), ANONYMOUS: "non-toxic nonhemagglutinin NTNH [Clostridium botulinum]", XP055854948, retrieved from NCBI Database accession no. WP_011948510
DATABASE PROTEIN 19 April 2020 (2020-04-19), ANONYMOUS: "botulinum neurotoxin type A [Clostridium botulinum]", XP055854943, retrieved from NCBI Database accession no. WP_011948511
"Botulinum Toxin Injections for Asians", 28 February 2018, LIAONING SCIENCE AND TECHNOLOGY PRESS. 2018.2, CN, ISBN: 978-7-5591-0494-6, article XU, QIUYI: "Comparison of Excipients", pages: 15 - 16, XP009531162
"Biomedical Aspects of Botulinum", 1981, ACADEMIC PRESS, pages: 143 - 150
SCOTT, OPTHALMOL, vol. 87, 1980, pages 1044 - 1049
AOKI, K. R.: "A comparison of the safety margins of botulinum neurotoxin serotypes A, B, and F in mice", TOXICON, vol. 39, no. 12, 2001, pages 1815 - 1820
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (CN)
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