Title:
BRIDGED PIPERAZINE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO2002032901
Kind Code:
A3
Abstract:
A compound of the formula (I) or the pharmaceutically acceptable salt thereof; wherein a, c, d, k, l, m, W, X, Y Z, R1, and R4 are as defined, and useful to treat inflammation and other immune disorders.
Inventors:
BLUMBERG LAURA COOK (US)
BROWN MATTHEW FRANK (US)
GLAUDE RONALD PAUL (US)
POSS CHRISTOPHER STANLEY (US)
BROWN MATTHEW FRANK (US)
GLAUDE RONALD PAUL (US)
POSS CHRISTOPHER STANLEY (US)
Application Number:
PCT/IB2001/001844
Publication Date:
July 25, 2002
Filing Date:
October 04, 2001
Export Citation:
Assignee:
PFIZER PROD INC (US)
BLUMBERG LAURA COOK (US)
BROWN MATTHEW FRANK (US)
GLAUDE RONALD PAUL (US)
POSS CHRISTOPHER STANLEY (US)
BLUMBERG LAURA COOK (US)
BROWN MATTHEW FRANK (US)
GLAUDE RONALD PAUL (US)
POSS CHRISTOPHER STANLEY (US)
International Classes:
A61K31/46; A61K31/4995; A61P1/04; A61P1/16; A61P3/10; A61P9/04; A61P9/08; A61P9/10; A61P11/00; A61P11/04; A61P11/06; A61P11/16; A61P13/12; A61P17/00; A61P17/06; A61P19/02; A61P19/08; A61P21/00; A61P25/00; A61P27/02; A61P29/00; A61P31/04; A61P31/06; A61P31/08; A61P31/14; A61P31/16; A61P31/18; A61P31/20; A61P31/22; A61P33/06; A61P35/00; A61P37/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D209/00; C07D221/00; C07D241/00; C07D451/02; C07D471/08; C07D487/08; A61K; A61P; C07D; (IPC1-7): C07D487/08; A61K31/4995; A61P29/00; A61P37/00; C07D451/02; C07D471/08
Domestic Patent References:
| WO2000051984A1 | 2000-09-08 | |||
| WO1997040049A1 | 1997-10-30 | |||
| WO2001032179A1 | 2001-05-10 | |||
| WO1998056771A2 | 1998-12-17 |
Foreign References:
| EP0324543A2 | 1989-07-19 |
Other References:
PENNING, THOMAS D. ET AL: "Structure-Activity Relationship Studies on 1-[2-(4- Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a Potent Inhibitor of Leukotriene A4 (LTA4) Hydrolase", JOURNAL OF MEDICINAL CHEMISTRY (2000), 43(4), 721-735, XP002197495
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; NIKITSKAYA, E. S. ET AL: "Synthesis and pharmacological properties of 9-alkylaminoalkyl- substituted 3-benzyl-3,9-diazabicyclo[3.3.1]nonanes", XP002197496, retrieved from STN Database accession no. 71:30448
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; NIKITSKAYA, E. S. ET AL: "The synthesis and pharmacological study of symmetric bisquaternary salts of 3-benzyl-3,9-diazabicyclo[3.3.1]nonane", XP002197497, retrieved from STN Database accession no. 69:34567
VILLA S ET AL: "3,8-Diazabicyclo-[3.2.1]-octane derivatives as analogues of ambasilide, a Class III antiarrhythmic agent", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 36, no. 6, 1 June 2001 (2001-06-01), pages 495 - 506, XP004302689, ISSN: 0223-5234
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; NIKITSKAYA, E. S. ET AL: "Synthesis and pharmacological properties of 9-alkylaminoalkyl- substituted 3-benzyl-3,9-diazabicyclo[3.3.1]nonanes", XP002197496, retrieved from STN Database accession no. 71:30448
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; NIKITSKAYA, E. S. ET AL: "The synthesis and pharmacological study of symmetric bisquaternary salts of 3-benzyl-3,9-diazabicyclo[3.3.1]nonane", XP002197497, retrieved from STN Database accession no. 69:34567
VILLA S ET AL: "3,8-Diazabicyclo-[3.2.1]-octane derivatives as analogues of ambasilide, a Class III antiarrhythmic agent", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 36, no. 6, 1 June 2001 (2001-06-01), pages 495 - 506, XP004302689, ISSN: 0223-5234
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