Title:
BRIVARACETAM AND METHOD FOR PREPARING INTERMEDIATE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/217579
Kind Code:
A1
Abstract:
Disclosed is a method for preparing a brivaracetam intermediate shown in formula B-R, comprising: reacting a compound shown in formula B-P and a resolving agent to prepare a compound shown in formula B-Q; and converting the compound shown in formula B-Q into the brivaracetam intermediate shown in formula B-R, wherein the resolving agent is a (1S,2S)-(+)-1,2-diaminocyclohexane compound. Also provided is a method for preparing brivaracetam. According to the method, a mixture of two diastereoisomers of (S)-2-3-propylpyrrolidine-1-yl butyric acid can be conveniently and effectively resolved, and the use of a chiral HPLC column is avoided, thereby greatly shortening the process time, simplifying the operation, reducing the process cost, and facilitating industrial production and environmental protection.
More Like This:
| WO/2020/148787 | ENANTIOSELECTIVE SYNTHESIS OF BRIVARACETAM AND INTERMEDIATES THEREOF |
| WO/2010/065833 | FUNCTIONALIZED N-SUBSTITUTED PYRROLIDONIUM IONIC LIQUIDS |
| WO/2010/023446 | NOVEL POTASSIUM CHANNEL BLOCKERS |
Inventors:
ZHAN YIPENG (CN)
FAN HAISHENG (CN)
YIN KAI (CN)
JI XIANG (CN)
LIU BOYANG (CN)
GUO XIAOWEN (CN)
HUANG LUNING (CN)
TAO ANPING (CN)
AN JIANGUO (CN)
GU HONG (CN)
FAN HAISHENG (CN)
YIN KAI (CN)
JI XIANG (CN)
LIU BOYANG (CN)
GUO XIAOWEN (CN)
HUANG LUNING (CN)
TAO ANPING (CN)
AN JIANGUO (CN)
GU HONG (CN)
Application Number:
PCT/CN2020/088275
Publication Date:
November 04, 2021
Filing Date:
April 30, 2020
Export Citation:
Assignee:
SHANGHAI SYNCORES TECH INC LTD (CN)
ZHEJIANG HUAHAI PHARM CO LTD (CN)
ZHEJIANG HUAHAI PHARM CO LTD (CN)
International Classes:
C07D207/27
Domestic Patent References:
| WO2005028435A1 | 2005-03-31 | |||
| WO2007065634A1 | 2007-06-14 |
Foreign References:
| CN106748950A | 2017-05-31 | |||
| JP2004182670A | 2004-07-02 | |||
| CN106748950A | 2017-05-31 | |||
| CN107513031A | 2017-12-26 | |||
| US20090030235A1 | 2009-01-29 | |||
| US4215114A | 1980-07-29 | |||
| CN106748950A | 2017-05-31 |
Other References:
KIZIRIAN, JEAN-CLAUDECAILLE, JEAN-CLAUDEALEXAKIS, ALEXANDRE, TETRAHEDRON LETTERS, vol. 44, no. 49, 2003, pages 8893 - 8895
See also references of EP 4144724A4
See also references of EP 4144724A4
Attorney, Agent or Firm:
PATENTSINO IP FIRM (CN)
Download PDF: