Title:
BROAD RANGE GENE AND GENOTYPE PAPILLOMAVIRUS TRANSCRIPTOME AS A BIOMARKER OF PAPILLOMAVIRUS-ASSOCIATED CANCER STAGES
Document Type and Number:
WIPO Patent Application WO/2016/005905
Kind Code:
A3
Abstract:
The present invention provides compositions, kits, and method for determining the levels of expression of human polyoma or papillomavirus species and RNA transcipts. These levels can be used for the prognosis of risk of developing virally-induced cancers. The ratio (R) between early and late transcripts is indicative of HPV infections associated with higher risk of developing genital neoplasia and cancer.
Inventors:
ELOIT MARC (FR)
TORNO NICOLAS (FR)
DEREGNAUCOURT JEAN (FR)
MOUTON MARION (FR)
HEARD ISABELLE (FR)
PEROT PHILIPPE (FR)
TORNO NICOLAS (FR)
DEREGNAUCOURT JEAN (FR)
MOUTON MARION (FR)
HEARD ISABELLE (FR)
PEROT PHILIPPE (FR)
Application Number:
PCT/IB2015/055136
Publication Date:
April 28, 2016
Filing Date:
July 07, 2015
Export Citation:
Assignee:
PASTEUR INSTITUT (FR)
ECOLE NATIONALE VETERINAIRE D ALFORT (FR)
PATHOQUEST (FR)
ECOLE NATIONALE VETERINAIRE D ALFORT (FR)
PATHOQUEST (FR)
International Classes:
C12Q1/68; C12Q1/70
Domestic Patent References:
| WO1999029890A2 | 1999-06-17 | |||
| WO2012116220A2 | 2012-08-30 | |||
| WO2010129941A1 | 2010-11-11 | |||
| WO2003057914A2 | 2003-07-17 | |||
| WO2011131192A1 | 2011-10-27 | |||
| WO1991008312A1 | 1991-06-13 |
Foreign References:
| EP2184368A1 | 2010-05-12 | |||
| US20060222656A1 | 2006-10-05 |
Other References:
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; 16 February 2005 (2005-02-16), CHEN QING-YUN ET AL: "[Detection of integration status of human papillomavirus 16 in cervical precancerous lesions].", XP002733700, Database accession no. NLM15854531
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; September 2003 (2003-09-01), LUKASZUK KRZYSZTOF ET AL: "[Quantity estimation of the E2/E6 HPV gene products ratio can be a prognostic marker for the stage of the cervical cancer carcinogenesis].", XP002733701, Database accession no. NLM14674126
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; August 1990 (1990-08-01), NAGAI N: "[Molecular biologic study on the carcinogenesis of HPV in uterine cervical cancer and related lesions--analysis of HPV types 16, 18 E6/E7 gene mRNA].", XP002733702, Database accession no. NLM2172419
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; September 2003 (2003-09-01), LUKASZUK KRZYSZTOF ET AL: "[Quantity estimation of the E2/E6 HPV gene products ratio can be a prognostic marker for the stage of the cervical cancer carcinogenesis].", XP002733701, Database accession no. NLM14674126
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; August 1990 (1990-08-01), NAGAI N: "[Molecular biologic study on the carcinogenesis of HPV in uterine cervical cancer and related lesions--analysis of HPV types 16, 18 E6/E7 gene mRNA].", XP002733702, Database accession no. NLM2172419
Attorney, Agent or Firm:
ORES, Béatrice et al. (36 rue de Saint-Pétersbourg, Paris, FR)
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