Title:
A BROADLY PROTECTIVE PROPHYLACTIC VACCINE AGAINST PSEUDOMONAS AERUGINOSA
Document Type and Number:
WIPO Patent Application WO/2022/246327
Kind Code:
A3
Abstract:
Disclosed are compositions comprising a fusion polypeptide comprising i) a fusion of a needle tip protein or an antigenic fragment thereof and/or a translocator protein or an antigenic fragment thereof from a Type III secretion system (T3SS) of a Gram negative bacteria and ii) the A1 subunit of the labile toxin (LTA1) from enterotoxigenic Escherichia coli or cholera toxin. and methods of their use.
Inventors:
PICKING WENDY L (US)
PICKING WILLIAM D (US)
ERNST ROBERT K (US)
PICKING WILLIAM D (US)
ERNST ROBERT K (US)
Application Number:
PCT/US2022/030565
Publication Date:
December 29, 2022
Filing Date:
May 23, 2022
Export Citation:
Assignee:
UNIV KANSAS (US)
UNIV MARYLAND (US)
UNIV MARYLAND (US)
International Classes:
A61K39/02; C07K14/21; A61K39/104; C07K14/195; C07K14/24
Domestic Patent References:
| WO2019217243A1 | 2019-11-14 |
Other References:
DAS SAYAN, HOWLADER DEBAKI R., ZHENG QI, RATNAKARAM SIVA SAI KUMAR, WHITTIER SEAN K., LU TI, KEITH JOHNATHAN D., PICKING WILLIAM D: "Development of a Broadly Protective, Self-Adjuvanting Subunit Vaccine to Prevent Infections by Pseudomonas aeruginosa", FRONTIERS IN IMMUNOLOGY, FRONTIERS MEDIA, LAUSANNE, CH, vol. 11, 17 November 2020 (2020-11-17), Lausanne, CH , XP055875204, ISSN: 1664-3224, DOI: 10.3389/fimmu.2020.583008
BASSO PAULINE, RAGNO MICHEL, ELSEN SYLVIE, REBOUD EMELINE, GOLOVKINE GUILLAUME, BOUILLOT STEPHANIE, HUBER PHILIPPE, LORY STEPHEN, : "Pseudomonas aeruginosa Pore-Forming Exolysin and Type IV Pili Cooperate To Induce Host Cell Lysis", MBIO, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 8, no. 1, 24 January 2017 (2017-01-24), US , pages 1 - 16, XP093020930, ISSN: 2161-2129, DOI: 10.1128/mBio.02250-16
BASSO PAULINE, RAGNO MICHEL, ELSEN SYLVIE, REBOUD EMELINE, GOLOVKINE GUILLAUME, BOUILLOT STEPHANIE, HUBER PHILIPPE, LORY STEPHEN, : "Pseudomonas aeruginosa Pore-Forming Exolysin and Type IV Pili Cooperate To Induce Host Cell Lysis", MBIO, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 8, no. 1, 24 January 2017 (2017-01-24), US , pages 1 - 16, XP093020930, ISSN: 2161-2129, DOI: 10.1128/mBio.02250-16
Attorney, Agent or Firm:
LANIER, J. Gibson et al. (US)
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