BRUCELLA OVIS ATTENUATED STRAIN, VACCINE COMPOSITION AND USE

Title:

BRUCELLA OVIS ATTENUATED STRAIN, VACCINE COMPOSITION AND USE

Document Type and Number:

WIPO Patent Application WO/2013/091040

Kind Code:

A3

Abstract:

The present invention describes an attenuated strain of Brucella ovis characterised in that it comprises a mutation of the gene that codes for the ABC-transporter (TMS3), and the use thereof as a live vaccine against brucellosis. More specifically, the present invention relates to the construction by directed mutagenesis of a mutant Brucella ovis strain (TMS3), by deletion of two open reading frames (ORF), BOVA0500 and BOVA0501 (GenBank), which code for proteins that form an ABC-transporter system.

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Inventors:

SANTOS RENATO DE LIMA (BR)
SILVA TEANE MILAGRES AUGUSTO DA SILVA (BR)
PAIXAO TATIANA ALVES DA (BR)
TSOLIS RENEE MARY (US)

Application Number:

PCT/BR2011/000514

Publication Date:

October 10, 2013

Filing Date:

December 23, 2011

Export Citation:

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Assignee:

UNIV MINAS GERAIS (BR)
SANTOS RENATO DE LIMA (BR)
SILVA TEANE MILAGRES AUGUSTO DA SILVA (BR)
PAIXAO TATIANA ALVES DA (BR)
TSOLIS RENEE MARY (US)

International Classes:

C12N1/21; A61K39/10; C12N15/31

Domestic Patent References:

WO2009077744A2	2009-06-25
WO2010094064A1	2010-08-26
WO1999037783A2	1999-07-29

Other References:

SILVA T.M.A. ET AL.: "Putative ATP-Binding Cassette Transporter Is Essential for Brucella ovis Pathogenesis in Mice", INFECTION AND IMMUNITY, April 2011 (2011-04-01), pages 1706 - 1717

Attorney, Agent or Firm:

DE LUCA GUIMARÃES, Raissa (6627Unidade Administrativa II, 2° Andar, Sala 2008,CEP: -901, Belo Horizonte - MG, BR)

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