Title:
BRUCINE GEL PLASTER AND PREPARATION METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/105891
Kind Code:
A1
Abstract:
A brucine gel plaster and a preparation method therefor. The brucine gel plaster comprises, calculated by weight percentage, 0.3%-2% of brucine, 3%-10% of a framework material, 20%-50% of a humectant and a co-solvent, 0.1%-2% of a crosslinking agent and a crosslinking regulator, and the balance of water, a backing layer and an anti-sticking layer. The brucine gel plaster uses simple medicinal excipients, does not use a transdermal enhancer, has good skin compatibility, is moisturizing and breathable, is non-irritating to the skin and mucous membranes, has a large drug load, and can be applied repeatedly. The paste is used for treating or ameliorating related diseases requiring anti-inflammation and analgesia such as osteoarthritis, rheumatoid arthritis and rheumatoid arthritis.
Inventors:
HU JIE (CN)
XUE CHUNMEI (CN)
ZHAO QIAN (CN)
FANG MIFEN (CN)
XUE CHUNMEI (CN)
ZHAO QIAN (CN)
FANG MIFEN (CN)
Application Number:
PCT/CN2021/131901
Publication Date:
May 27, 2022
Filing Date:
November 19, 2021
Export Citation:
Assignee:
BEIJING INCREASEPHARM CORPORATION LTD (CN)
International Classes:
A61K9/70; A61K31/475; A61K47/18; A61K47/32; A61K47/38; A61K47/40; A61K47/44; A61P19/02; A61P29/00
Foreign References:
| CN112386565A | 2021-02-23 | |||
| CN104997981A | 2015-10-28 | |||
| CN108117557A | 2018-06-05 | |||
| KR20180042707A | 2018-04-26 |
Other References:
JIANG YINGYING: "Transdermal Preparation of Alkaloids from Seeds of Strychnos Nux-vomica", CHINESE MASTER'S THESES FULL-TEXT DATABASE, 1 May 2012 (2012-05-01), XP055932085
XU JIN-HUA,CHEN JUN,CAI BAO-CHANG: "Advances in Studies on Brucine", CHINESE JOURNAL OF NEW DRUGS, vol. 18, no. 3, 15 February 2009 (2009-02-15), pages 213 - 216+221, XP055932092, ISSN: 1003-3734
YU TAO;FENG WEI;LIU YI: "Transdermal Experiment of Nux Vomica Cataplasm in Vitro and the Selection of Penetration Enhancers", CHINESE JOURNAL OF HOSPITAL PHARMACY, vol. 38, no. 3, 9 January 2018 (2018-01-09), pages 229 - 233, XP055932099, ISSN: 1001-5213, DOI: 10.13286/j.cnki.chinhosppharmacyj.2018.03.04
"General Rules", CHINA PHARMACOPOEIA, vol. IV, 2015
See also references of EP 4248953A4
XU JIN-HUA,CHEN JUN,CAI BAO-CHANG: "Advances in Studies on Brucine", CHINESE JOURNAL OF NEW DRUGS, vol. 18, no. 3, 15 February 2009 (2009-02-15), pages 213 - 216+221, XP055932092, ISSN: 1003-3734
YU TAO;FENG WEI;LIU YI: "Transdermal Experiment of Nux Vomica Cataplasm in Vitro and the Selection of Penetration Enhancers", CHINESE JOURNAL OF HOSPITAL PHARMACY, vol. 38, no. 3, 9 January 2018 (2018-01-09), pages 229 - 233, XP055932099, ISSN: 1001-5213, DOI: 10.13286/j.cnki.chinhosppharmacyj.2018.03.04
"General Rules", CHINA PHARMACOPOEIA, vol. IV, 2015
See also references of EP 4248953A4
Attorney, Agent or Firm:
LINDA LIU & PARTNERS (CN)
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