Title:
BURKHOLDERIA SP. AND METHOD FOR PRODUCING FR901464 BY FERMENTATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/262874
Kind Code:
A1
Abstract:
Disclosed is Burkholderia sp. HDCC00024, which is deposited in China General Microbiological Culture Collection Center (CGMCC). The deposit number is CGMCC NO. 22290, and the deposit date is 08 May 2021. The Burkholderia sp. has a high production ability, the valence of FR901464 can reach 2360 mg/L or greater, and the ability to accumulate FR901464 by means of fermentation is greatly improved compared with other cultures in the prior art, thus facilitating industrial production.
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Inventors:
CHEN WEI (CN)
ZHENG LINGHUI (CN)
WANG XUEFENG (CN)
CHEN SHIMIN (CN)
SU YUAN (CN)
ZHU JINWEI (CN)
ZHENG LINGHUI (CN)
WANG XUEFENG (CN)
CHEN SHIMIN (CN)
SU YUAN (CN)
ZHU JINWEI (CN)
Application Number:
PCT/CN2022/106214
Publication Date:
December 22, 2022
Filing Date:
July 18, 2022
Export Citation:
Assignee:
ZHEJIANG HUIDA BIOTECH CO LTD (CN)
International Classes:
C12N1/20; C07D493/10; C12R1/38
Foreign References:
| CN113563361A | 2021-10-29 | |||
| US20200214297A1 | 2020-07-09 | |||
| CN111788208A | 2020-10-16 |
Other References:
EUSTÁQUIO ALESSANDRA S., JANSO JEFFREY E., RATNAYAKE ANOKHA S., O’DONNELL CHRISTOPHER J., KOEHN FRANK E.: "Spliceostatin hemiketal biosynthesis in Burkholderia spp. is catalyzed by an iron/α-ketoglutarate–dependent dioxygenase", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 111, no. 33, 19 August 2014 (2014-08-19), XP093015527, ISSN: 0027-8424, DOI: 10.1073/pnas.1408300111
EUSTAQUIO ALESSANDRA S.; CHANG LI-PING; STEELE GREG L.; O'DONNELL CHRISTOPHER J.; KOEHN FRANK E.: "Biosynthetic engineering and fermentation media development leads to gram-scale production of spliceostatin natural products inBurkholderiasp.", METABOLIC ENGINEERING, ACADEMIC PRESS, AMSTERDAM, NL, vol. 33, 24 November 2015 (2015-11-24), AMSTERDAM, NL, pages 67 - 75, XP029375526, ISSN: 1096-7176, DOI: 10.1016/j.ymben.2015.11.003
EUSTAQUIO ALESSANDRA S.; CHANG LI-PING; STEELE GREG L.; O'DONNELL CHRISTOPHER J.; KOEHN FRANK E.: "Biosynthetic engineering and fermentation media development leads to gram-scale production of spliceostatin natural products inBurkholderiasp.", METABOLIC ENGINEERING, ACADEMIC PRESS, AMSTERDAM, NL, vol. 33, 24 November 2015 (2015-11-24), AMSTERDAM, NL, pages 67 - 75, XP029375526, ISSN: 1096-7176, DOI: 10.1016/j.ymben.2015.11.003
Attorney, Agent or Firm:
BEIJING LINKTEC IP LAW FIRM (SPECIAL GENERAL PARTNERSHIP) (CN)
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